Buy Sertraline (Zoloft) Cas 79617-96-2
Buy Sertraline (Zoloft) Cas 79617-96-2
Buy Sertraline (Zoloft) Cas 79617-96-2
Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class[10] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder.[11] Although also having approval for post-traumatic stress disorder (PTSD), findings indicate it leads to only modest improvements in symptoms associated with this condition.[12][13]
The drug shares the common side effects and contraindications of other SSRIs, with high rates of nausea, diarrhea, headache, insomnia, mild sedation, dry mouth, and sexual dysfunction, but it appears not to lead to much weight gain, and its effects on cognitive performance are mild. Similar to other antidepressants, the use of sertraline for depression may be associated with a mildly elevated rate of suicidal thoughts in people under the age of 25 years old. It should not be used together with monoamine oxidase inhibitors (MAOIs): this combination may cause serotonin syndrome, which can be life-threatening in some cases. Sertraline taken during pregnancy is associated with an increase in congenital heart defects in newborns.[14][15]
Sertraline was developed by scientists at Pfizer and approved for medical use in the United States in 1991. It is on the World Health Organization’s List of Essential Medicines[16] and available as a generic medication.[10] In 2016, sertraline was the most commonly prescribed psychotropic medication in the United States.[17] It was also the eleventh most commonly prescribed medication in the United States, with more than 42 million prescriptions in 2023,[18][19] and sertraline ranks among the top 10 most prescribed medications in Australia between 2017 and 2023.[20]
Sertraline’s effectiveness is similar to that of other antidepressants in its class, such as fluoxetine and paroxetine, which are also considered first-line treatments and are better tolerated than the older tricyclic antidepressants.
Medical uses
Sertraline has been approved for major depressive disorder, obsessive–compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder, panic disorder, social anxiety disorder (SAD), and generalized anxiety disorder (GAD). Sertraline is approved for use in children with OCD.[21]
Depression
In meta-analyses, sertraline efficacy is similar to that of other SSRI antidepressants, with an odds ratio for response in clinical depression of between 1.44 and 1.67.[22][23] However, as with other antidepressants, the nature and clinical significance of this effect remain disputed.[24][25] A major study of sertraline in a broad primary care population found improvements in general mental health, quality of life, and anxiety.[26] However, it failed to find significant effects on depression in either the mildly or severely depressed, and the clinical relevance and accuracy of the positive effects found have been questioned.[27][28]
In several double-blind studies, sertraline was consistently more effective than placebo for dysthymia, a more chronic variety of depression, and comparable to imipramine in that respect. Sertraline also improves the functional impairments of dysthymia to a similar degree whether group Cognitive-Behavioral Therapy is undergone or not.[29]
Limited pediatric data also demonstrates a reduction in depressive symptoms in the pediatric population though remains a second-line therapy after fluoxetine.[30][31]
Comparison with other antidepressants
In general, sertraline efficacy is similar to that of other antidepressants.[32] For example, a meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with depression.[33] Comparative clinical trials demonstrated that sertraline is similar in efficacy against depression to moclobemide,[34] nefazodone,[35] escitalopram, bupropion,[36] citalopram, fluvoxamine, paroxetine,[33] venlafaxine,[37] and mirtazapine.[38] Sertraline may be more efficacious for the treatment of depression in the acute phase (first four weeks) than fluoxetine.
Sertraline
Content Navigation
Polymorphic variability in sertraline HCl (28+ forms) complicates salt crystallization and organic-phase synthesis. Sertraline free base (CAS 79617-96-2) offers a monomorphic, enantiomerically pure (1S,4S) starting point.
- Enables direct organic-solvent reactions (soluble in hexane, toluene) without basic hydrolysis.
- Bypasses 28+ HCl polymorphs for high-throughput salt screening (mesylate, lactate, acetate) targeting improved dissolution.
- Supports liposomal/non-aqueous delivery design with high lipophilicity and low melting point (64-67°C).
CAS Number
Product Name
IUPAC Name
Molecular Formula
Molecular Weight
InChI
InChI Key
SMILES
solubility
3.8mg/mL
Synonyms
Canonical SMILES
Isomeric SMILES
Purity
Package Size
Sertraline free base is the un-salified, enantiomerically pure (1S,4S) form of the widely utilized selective serotonin reuptake inhibitor (SSRI). Unlike its ubiquitous hydrochloride salt, the free base is typically isolated as a supercooled liquid or low-melting crystalline solid (melting point 64–67 °C) that exhibits high lipophilicity and excellent solubility in organic solvents such as hexane, toluene, and ethyl acetate[1]. In procurement and industrial contexts, this compound is rarely utilized as a direct oral dosage form; instead, it serves as a critical, low-polymorphism precursor for the synthesis of custom pharmaceutical salts, chiral resolution studies, and specialized lipophilic formulations[2].
Research Fit
References
- [1] Cui, Y., et al. ‘Sertraline Racemate and Enantiomer: Solid-State Characterization, Binary Phase Diagram, and Crystal Structures.’ Organic Process Research & Development, 14(2), 2010.
- [2] Chen, A. M., et al. ‘Salt Selection and Simultaneous Polymorphism Assessment via High-Throughput Crystallization: The Case of Sertraline.’ Organic Process Research & Development, 7(6), 2003.
Procuring sertraline hydrochloride (CAS 79559-97-0) as a generic substitute for the free base fundamentally limits formulation and synthesis pathways. The hydrochloride salt is notoriously polymorphic—with over 28 documented crystalline forms and solvates—which introduces significant batch-to-batch variability and regulatory complexity during recrystallization workflows [1]. Furthermore, the HCl salt’s rigid crystal lattice and poor solubility in non-polar solvents prevent its direct use in organic-phase reactions or the generation of alternative, high-solubility salts (such as mesylate or acetate) without first undergoing an additional, yield-reducing basic hydrolysis step to liberate the free base [2].
Substitution Risk
References
- [1] Chen, A. M., et al. ‘Salt Selection and Simultaneous Polymorphism Assessment via High-Throughput Crystallization: The Case of Sertraline.’ Organic Process Research & Development, 7(6), 2003.
- [2] Pfizer Inc. ‘Sertraline salts and sustained-release dosage forms of sertraline.’ US Patent 6517866B1, 2003.
Reduced Polymorphism in Crystallization
High-throughput crystallization studies demonstrate that sertraline hydrochloride is highly prone to polymorphic conversion, yielding over 28 distinct forms (e.g., Forms I-X) and solvates depending on processing conditions [1]. In contrast, sertraline free base exhibits significantly reduced polymorphic behavior, consistently crystallizing from non-polar solvents with a single, predictable melting endotherm at 66.5 ± 0.5 °C [2].
| Evidence Dimension | Number of documented polymorphic/solvate forms |
| Target Compound Data | Single primary crystalline form (m.p. 64-69 °C) |
| Comparator Or Baseline | Sertraline Hydrochloride (>28 documented forms/solvates) |
| Quantified Difference | >95% reduction in polymorphic variability |
| Conditions | High-throughput solvent crystallization screening |
Predictable solid-state behavior eliminates the need for extensive polymorph screening and control during the manufacturing of custom formulations.
High-Solubility Salt Precursor
The standard sertraline hydrochloride Form I exhibits poor aqueous solubility, recorded at approximately 1.6 mg/mL at room temperature, which limits its use in sustained-release or high-concentration liquid formulations [1]. Procuring the free base allows for direct, single-step salification with alternative acids. For instance, the resulting sertraline mesylate and acetate salts demonstrate significantly enhanced aqueous solubilities, exceeding 10 mg/mL, without the common-ion effect limitations of the HCl salt at low pH [2].
| Evidence Dimension | Aqueous solubility of resulting salt forms |
| Target Compound Data | >10 mg/mL (via direct conversion to acetate/mesylate salts) |
| Comparator Or Baseline | Sertraline HCl Form I (~1.6 mg/mL) |
| Quantified Difference | >6-fold increase in achievable aqueous solubility |
| Conditions | Room temperature dissolution in aqueous media |
Starting with the free base is essential for formulators needing to engineer custom salts to overcome the inherent dissolution bottlenecks of the commercial HCl API.
Enhanced Non-Polar Solvent Solubility
Sertraline free base is highly soluble in a range of non-polar and moderately polar organic solvents, such as toluene, ethyl acetate, and hexane, often existing as a supercooled liquid or easily dissolved solid [1]. Conversely, sertraline hydrochloride is highly crystalline and practically insoluble in non-polar solvents like hexane. This differential solubility allows the free base to be efficiently partitioned into organic phases during complex synthetic workups or lipid-based drug delivery formulations, where the HCl salt would precipitate [2].
| Evidence Dimension | Solubility in non-polar solvents (e.g., hexane, toluene) |
| Target Compound Data | Highly soluble (enables direct organic phase reactions) |
| Comparator Or Baseline | Sertraline Hydrochloride (Practically insoluble) |
| Quantified Difference | Binary phase behavior (soluble vs. insoluble) |
| Conditions | Standard organic synthesis and liquid-liquid extraction conditions |
High organic solubility streamlines downstream processing, purification, and integration into lipid-based or non-aqueous delivery systems.
Custom Pharmaceutical Salt Screening
Because it bypasses the polymorphic complexity of the HCl salt, the free base is the optimal starting material for high-throughput screening of novel sertraline salts (e.g., mesylate, L-lactate, acetate) aimed at improving dissolution rates and bioavailability in sustained-release formulations[1].
Lipid-Based and Non-Aqueous Formulations
The high lipophilicity and organic solvent compatibility of the free base make it the required form for developing liposomal delivery systems or non-aqueous oral concentrates where the standard HCl salt would precipitate or fail to dissolve [2].
Chiral Resolution and Phase Diagram Studies
As an enantiomerically pure (1S,4S) baseline, the free base is utilized in physical chemistry to construct binary melting point phase diagrams against sertraline racemate, aiding in the design and optimization of more efficient industrial chiral resolution processes [3].
Application Fit Matrix
References
- [1] Chen, A. M., et al. ‘Salt Selection and Simultaneous Polymorphism Assessment via High-Throughput Crystallization: The Case of Sertraline.’ Organic Process Research & Development, 7(6), 2003.
- [2] Pfizer Inc. ‘Sertraline oral concentrate.’ US Patent 6727283B2, 2004.
- [3] Cui, Y., et al. ‘Sertraline Racemate and Enantiomer: Solid-State Characterization, Binary Phase Diagram, and Crystal Structures.’ Organic Process Research & Development, 14(2), 2010.
Physical Description
XLogP3
Hydrogen Bond Acceptor Count
Hydrogen Bond Donor Count
Exact Mass
Monoisotopic Mass
Boiling Point
Heavy Atom Count
LogP
Melting Point
UNII
Related CAS
Drug Indication
Livertox Summary
CAS 79617-96-2 Sertraline | Products & Prices & Suppliers
- ChEBI: A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibito (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.
- Product Name: Sertraline
- Molecular Weight: 306.23000
- Molecular Formula: C17H17Cl2N
- Synonyms: (+)-Sertraline; (1S,4R)-4-(3,4-dichlorophenyl)-N-methyl-tetralin-1-amine; (1S,4S)-4-(3,4-dichlorophényl)-N-méthyl-1,2,3,4-tétrahydronaphtalén-1-amine; (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine; (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine; (1s,4s)-4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydro-1-naphthalenamine;
Drug Classes
Therapeutic Uses
Sertraline is indicated for the treatment of major depressive disorder. Treatment of acute depressive episodes typically requires 6 to 12 months of antidepressant therapy. Patients with recurrent or chronic depression may require long-term treatment. Sertraline showed effective maintenance of antidepressant response for up to 52 weeks of treatment in a placebo-controlled trial. /Included in US product labeling/
Sertraline is indicated for the treatment of obsession and compulsions in adults and children 6 years of age and older with obsessive-compulsive disorder. /Included in US product labeling/
Sertraline is indicated for the treatment of panic disorder with or without agoraphobia. /Included in US product labeling/
Mechanism of Action
-
Buy Sertraline | 79617-96-2
Sertraline, a chemical compound, is commonly used in scientific research.It …
-
79617-96-2 – Sertraline – Sale from Quality Suppliers – Guidechem
Explore the best Sertraline price and the most comprehensive Sertraline supplier on Guidechem. Find the chemical you need and …
-
Sertraline | 79617-96-2 – Chemicea
Buy Sertraline CAS No-79617-96-2 Online from Chemicea Pharma, Manufacturer …
CAS No.79617-96-2,Sertraline Suppliers – LookChem
Sertraline (CAS NO.79617-96-2) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was introduced to …
-
Sertraline Form 1 | CAS No- 79617-96-2 | Simson Pharma Limited
Buy High-Quality Sertraline Form 1 from Simson Pharma Limited at best competitive price. Every compound produced by Simson …
Sertraline | CAS#:79617-96-2 | Chemsrc – 化源网
Chemsrc provides Sertraline(CAS#:79617-96-2) MSDS, density, melting point, boiling point, structure, formula, …
-
Sertraline (CAS 79617-96-2), C17H17NCl2 — Molekula
What grade of Sertraline does Molekula supply? Molekula supplies Sertraline in research-grade quality suitable for laboratory use. …
-
Sertraline | 79617-96-2 | SynZeal
Buy high quality Sertraline from SynZeal Research PVT LTD. CAS 79617-96-2,306.2,C17H17Cl2N.
-
SERTRALINE | 79617-96-2 – MilliporeSigma
Find documentation for the products that you have recently purchased in the Document Library.
-
Sertraline (Cas 79617-96-2) – Parchem
Parchem supplies Sertraline and a range of specialty chemicals worldwide, CAS# 79617-96-2.
Reviews
There are no reviews yet.