Buy Phenacetin (acetophenetidin) Cas 62-44-2
Buy Phenacetin (acetophenetidin) Cas 62-44-2
Phenacetin acetophenetidin, N-(4-ethoxyphenyl)acetamide[1]) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973,[2] and by the U.S. Food and Drug Administration in 1983[3]). Buy Phenacetin (acetophenetidin) Cas 62-44-2
History
Phenacetin was introduced in 1887 in Elberfeld, Germany, by German company Bayer, and was used principally as an analgesic; it was one of the first synthetic fever reducers to go on the market. It is also known historically to be one of the first non-opioid analgesics without anti-inflammatory properties. Although paracetamol (acetaminophen) was produced earlier, a historical accident saw it ignored after Joseph von Mering‘s 1893 assessment.[4]
Prior to World War One, Britain imported phenacetin from Germany.[5] During the war, a team including Jocelyn Field Thorpe and Martha Annie Whiteley developed a synthesis in Britain.[5]
Known mechanism of action
Phenacetin’s analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.
In vivo, one of two reactions occur. Usually phenacetin’s ether linkage is cleaved to leave paracetamol (acetaminophen), which is the clinically relevant analgesic. A minority of the time the acetyl group is removed from the amine, producing carcinogenic p-phenetidine. This reaction is quite rare, however, as evidenced by the fact that the drug was on the market for almost 100 years before a statistical link was established, when Canada, followed by the United States, withdrew it from the market. Buy Phenacetin (acetophenetidin) Cas 62-44-2
Preparation
The first synthesis was reported in 1878 by Harmon Northrop Morse. Morse’s cited article describes the synthesis of paracetamol from 4-aminophenol and acetic acid.[6]
Phenacetin may be synthesized as an example of the Williamson ether synthesis: ethyl iodide, paracetamol, and anhydrous potassium carbonate are heated in 2-butanone to give the crude product, which is recrystallized from water. Buy Phenacetin (acetophenetidin) Cas 62-44-2
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Phenacetin – 1-Acetyl-p-phenetidin, 4′-Ethoxyacetanilide
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CAS RN: 62-44-2
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Glentham Code: GK3477
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EC Number: 200-533-0
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Product Categories: Biochemicals
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Item Specifications Results Appearance Should comply with standard Conforms Melting point 134℃ ～136.5℃ 134℃ ～136℃ Sulphated ash ≤0.1% 0.10% Content ≥99.0% 99.6% Parameters of Phenacetin Wholesale CAS Number 62-44-2
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