74-89-5

CH5N
CH3NH2

31.057 g/mol

greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
Very soluble in water
1 volume of water at 12.5 °C dissolves 1154 volumes of gas; at 25 °C dissolves 959 volumes of gas; 10.5 g is contained in 100 mL saturated benzene solution
Soluble in ethanol, benzene, and acetone; miscible with ether
Solubilities in various solvents at 1 atm and 20 °C.
Table: 255Q [Table#2189]
1080 mg/mL at 25 °C
Solubility in water at 25 °C: very good
Soluble

aminomethane, methylamine, methylamine bisulfite, methylamine hydride, methylamine hydrobromide, methylamine hydrochloride, methylamine hydrochloride, 14C-labeled, methylamine hydrofluoride, methylamine hydrogen cyanide, methylamine hydroiodide, methylamine ion (1-), methylamine nitrate, methylamine perchlorate, methylamine sulfate (1:1), methylamine sulfate (2:1), methylamine, 13C-labeled, methylamine, 14C-labeled, methylamine, 15N-labeled, methylamine, cesium salt, methylamine, monopotassium salt, methylamine, monosodium salt, methylammonium, methylammonium ion, monomethylamine, monomethylammonium ion

The exact mass of the compound Methylamine is unknown and the complexity rating of the compound is unknown. The solubility of this chemical has been described as greater than or equal to 100 mg/ml at 70° f (ntp, 1992)1080000 mg/l (at 25 °c)34.78 mvery soluble in water1 volume of water at 12.5 °c dissolves 1154 volumes of gas; at 25 °c dissolves 959 volumes of gas; 10.5 g is contained in 100 ml saturated benzene solutionsoluble in ethanol, benzene, and acetone; miscible with ether[‘solubilities in various solvents at 1 atm and 20 °c.’, ‘table: 255q [table#2191]’][]1080 mg/ml at 25 °csolubility in water at 25 °c: very goodsoluble. Its Medical Subject Headings (MeSH) category is Chemicals and Drugs Category – Organic Chemicals – Amines – Methylamines – Supplementary Records. It belongs to the ontological category of methylamines in the ChEBI Ontology tree. The United Nations designated GHS hazard class pictogram is Flammable;Compressed Gas;Corrosive;Irritant, and the GHS signal word is DangerThe storage condition is unknown. Please store according to label instructions upon receipt of goods.Use and application categories indicated by third-party sources: Fire Hazards -> Flammable – 4th degree. However, this does not mean our product can be used or applied in the same or a similar way.

40 wt% in H2O

25 ml, 100 ml, 500 ml, 1 l

Methylamine, anhydrous appears as a colorless gas or a liquid. Pungent fishy odor resembling odor of ammonia. The liquid boils at cold temperatures, hence it vaporizes rapidly when unconfined. Vapors are heavier than air and may collect in low-lying areas. Easily ignited under most conditions. Under prolonged exposure to intense heat the containers may rupture violently and rocket. Used for making pharmaceuticals, insecticides, paint removers, surfactants, rubber chemicals.
Methylamine, aqueous solution appears as a colorless to yellow aqueous solution of a gas. Odor ranges from fishlike to ammonia-like as the vapor concentration increases. Flash point (of 30% solution) 34 °F. Corrosive to skin and eyes. Less dense than water; vapors heavier than air. Produces toxic oxides of nitrogen during combustion.
Liquid; Gas or Vapor, Liquid
Colorless gas with a fish- or ammonia-like odor; Note: A liquid below 21 degrees F. Shipped as a liquefied compressed gas; [NIOSH]
Liquid
COLOURLESS COMPRESSED LIQUEFIED GAS WITH CHARACTERISTIC ODOUR.
COLOURLESS SOLUTION IN WATER WITH PUNGENT ODOUR.
Colorless gas with a fish- or ammonia-like odor.
Colorless gas with a fish- or ammonia-like odor. [Note: A liquid below 21 °F. Shipped as a liquefied compressed gas.]

Colorless gas [Note: A liquid below 21 degrees F. Shipped as a liquefied compressed gas]
Flammable gas at ordinary temperature and pressure. Fuming liquid when cooled in ice and salt mixture.

-0.7

1

1

31.042199164 g/mol

31.042199164 g/mol

20.3 °F at 760 mmHg (USCG, 1999)
20.66 °F at 760 mmHg (USCG, 1999)
-6.4 °C
BP: -6.3 °C at 760 mm Hg; -19.7 °C at 400 mm Hg; -32.4 °C at 200 mm Hg; -43.7 °C at 100 mm Hg; -73.8 °C at 10 mm Hg
-6 °C
48 °C
20.3 °F
21 °F

14 °F (Liquid) (NIOSH, 2024)
32 °F (USCG, 1999)
The Guide from the Emergency Response Guidebook is for “methylamine, anhydrous.” 32 °F
-10 °C (14 °F) – closed cup /Methylamine solution 30-50%/
32 °F (closed cup)
Flammable gas
-10 °C
NA (Gas) 14 °F (Liquid)

2

1.1 (USCG, 1999) – Heavier than air; will sink (Relative to Air)
Saturated vapor density: 0.21270 lb/cu ft at 60 °F (Methylamine, anhydrous)
Relative vapor density (air = 1): 1.07
Relative vapor density (air = 1): 1.08
1.08

0.693 at 20.3 °F (USCG, 1999) – Less dense than water; will float
0.6624 g/cu cm at 25 °C; 0.0014 g/cu cm at 101.33 kPa
Density: 0.656 g/cu cm at 25 °C (p>1 atm)
Saturated liquid density: 43.260 lb/cu ft; liquid heat capacity: 0.803 Btu/lb-F; liquid thermal conductivity: 1.516 Btu-inch/hr-sq ft-F; liquid viscosity: 0.250 Centipoise (all at 20 °F) (Methylamine anhydrous)
Relative density (water = 1): 0.7 (liquid)
Relative density (water = 1): 0.89
0.693 at 20.3 °F
0.70 (Liquid at 13 °F)
1.08(relative gas density)

-0.57
-0.57 (LogP)
log Kow = -0.57
-0.71
-0.6

Fish or ammonia-like odor

Odor Threshold Low: 0.0009 [ppm]
Odor Threshold High: 4.68 [ppm]
Detection odor threshold from AIHA (mean = 4.7 ppm)
The odor of methylamine is faint but readily detectable at less than 10 ppm, becomes strong at from 20 to 100 ppm and intolerably ammoniacal at 100 to 500 ppm.
Odor recognition in air= 2.10X10-2 ppm (purity not specified)
Low: 0.0252 mg/cu m; High: 12.0 mg/cu m

Hazardous decomposition products formed under fire conditions: Carbon oxides, nitrogen oxides (NOx) /Methylamine solution 30-50%/
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

-134.5 °F (USCG, 1999)
-93.42 °C
-93.4 °C
-93 °C
-39 °C
-136 °F

BSF23SJ79E

14965-49-2 (hydriodide)
17000-00-9 (hydride)
22113-87-7 (nitrate)
33689-83-7 (sulfate[2:1])
593-51-1 (hydrochloride)
6876-37-5 (hydrobromide)

Aggregated GHS information provided by 2202 companies from 32 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;
H220 (67.03%): Extremely flammable gas [Danger Flammable gases];
H224 (32.88%): Extremely flammable liquid and vapor [Danger Flammable liquids];
H225 (17.76%): Highly Flammable liquid and vapor [Danger Flammable liquids];
H280 (16.76%): Contains gas under pressure;
may explode if heated [Warning Gases under pressure];
H302 (32.7%): Harmful if swallowed [Warning Acute toxicity, oral];
H314 (32.79%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation];
H315 (84.88%): Causes skin irritation [Warning Skin corrosion/irritation];
H318 (91.14%): Causes serious eye damage [Danger Serious eye damage/eye irritation];
H319 (17.71%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];
H332 (96.41%): Harmful if inhaled [Warning Acute toxicity, inhalation];
H335 (93.69%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure;
Respiratory tract irritation];
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

IDENTIFICATION: Methylamine is a colorless, flammable gas. It has a fish or ammonia-like odor. It mixes easily with water. USE: Methylamine is used as an intermediate in the synthesis of many products, including pharmaceuticals, insecticides, explosives, surfactants, and accelerators. It is commonly used in the tanning and dyeing industries. It is used as a fuel additive and as a photographic developer. It occurs naturally in a variety of vegetables and other foods, and has been found in cigarette smoke. Workers that produce or use methylamine may breathe in the gas or have direct skin contact. The general population may be exposed by breathing in contaminated air, or consumption of foods and contaminated drinking water. If methylamine is released to the environment, it will be broken down in air by reaction with hydroxyl radicals and ozone. It is not expected to be broken down in the air by sunlight. It will not volatilize into air from moist soil or water surfaces. It may volatilize into the air from dry soil surfaces. It is expected to move moderately through soil. It will be broken down by microorganisms. It is not expected to build up in fish. RISK: Temporary eye, nose, and throat irritation has been reported in humans following brief exposures to low-to-moderate levels of methylamine in the air. Data on the potential for methylamine to produce other toxic effects in humans were not available. Liquid methylamine liquid is a severe skin and eye irritant in laboratory animals, with severe damage following direct contact with undiluted liquid methylamine. Difficulty breathing, gasping for breath, congestion in the lungs and liver, damage to the eyes and skin, and death occurred in laboratory animals exposed briefly to extremely high air levels. Damage to the nasal tissues, mild liver changes, changes in the blood, and decreased body weights, were reported in laboratory animals following repeated exposure to high air levels of methylamine. Irritation to the gastrointestinal tract was observed following exposure to a high oral dose. Some animals died. Damage to the heart was reported in some laboratory animals following repeated exposure to moderate-to-high oral doses of methylamine. No evidence of infertility or abortion was observed in laboratory females exposed to low oral doses of methylamine prior to mating and throughout pregnancy, but the number of offspring born per mother was decreased. Data on the potential for methylamine to cause birth defects were not available. Data on the potential for methylamine to induce tumors in laboratory animals were not available. The potential for methylamine to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens. (SRC)

1972.92 mmHg at 60 °F (USCG, 1999)
2.65X10+3 mm Hg at 25 °C
Vapor pressure, kPa at 20 °C: 304
Vapor pressure, kPa at 20 °C: 31
3.0 atm

Flammable;Compressed Gas;Corrosive;Irritant

Typical commercial specifications.
Table: Specifications for Anhydrous Monomethylamine [Table#2184]
Table: Specifications for Aqueous Methylamine Solutions, Wt% [Table#2185]

74-89-5

Methylamine can be converted by semicarbazide-sensitive amine oxidase (SSAO) to formaldehyde and hydrogen peroxide, which have been proven to be toxic towards cultured endothelial cells. /The authors/ investigated whether or not these deaminated products from methylamine can exert potentially hazardous toxic effects in vivo. Long lasting residual radioactivity in different tissues was detected following administration of [14C]-methylamine in the mouse. Approximately 10% of the total administered radioactivity could even be detected 5 days after injection of [14C]-methylamine. Eighty percent of the formation of irreversible adducts can be blocked by a highly selective SSAO inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine hydrochloride (MDL-72974A). The residual radioactivity was primarily associated with the insoluble tissue components and the soluble macromolecules. Radioactively labelled macromolecules were fragmented following enzymatic proteolysis. Results suggest that the formaldehyde derived from methylamine interacts with proteins in vivo. In the streptozotocin-induced diabetic mice, both SSAO activity and the formation of residual radioactivity were found to be significantly increased in the kidney. Chronic administration of methylamine enhances blood prorenin level, which strongly suggests that uncontrolled deamination of methylamine may be a risk factor for initiation of endothelial injury, and subsequent genesis of atherosclerosis.
/MILK/ …The presence of volatile aliphatic amines … in human breast milk and amniotic fluid /was measured/ to assess their role in neonatal hypergastrinemia. These volatile nitrogenous amino acid metabolites have been previously demonstrated to stimulate gastrin release in in vivo and in vitro laboratory preparations. … The present study … demonstrated that these gastrin-stimulatory volatile amines were present in significant concentrations in breast milk during the first several weeks after parturition and in amniotic fluid. The individual amines that were identified in both human milk and amniotic fluid samples were methylamine, dimethylamine, ethylamine, trimethylamine, propylamine, isobutylamine, and butylamine. This study provides indirect evidence to support the possibility that the hypergastrinemia measured in the fetus/neonate during the period immediately before and after birth may be attributable, in part, to the ingestion of fluid containing high concentrations of gastrin-stimulating amines.
BACKGROUND: Dialysis adequacy is currently judged by measures of urea clearance. However, urea is relatively non-toxic and has properties distinct from large classes of other retained solutes. In particular, intracellularly sequestered solutes are likely to behave differently than urea. METHODS: We studied an example of this class, the aliphatic amine monomethylamine (MMA), in stable hemodialysis outpatients (n = 10) using an HPLC-based assay. RESULTS: Mean MMA levels pre-dialysis in end-stage renal disease subjects were 76 +/- 15 ug/L compared to 32 +/- 4 ug/L in normal subjects (n = 10) (P < 0.001). Mean urea reduction was 62% while the reduction ratio for MMA was 43% (P < 0.01). MMA levels rebounded in the 1 hour post-dialytic period to 85% of baseline, whereas urea levels rebounded only to 47% of baseline. MMA had a much larger calculated volume of distribution compared to urea, consistent with intracellular sequestration. Measures of intra-red blood cell (RBC) MMA concentrations confirmed greater levels in RBCs than in plasma with a ratio of 4.9:1. Because of the intracellular sequestration of MMA, we calculated its clearance using that amount removed from whole blood. Clearances for urea averaged 222 +/- 41 mL/min and for MMA 121 +/- 14 mL/min, while plasma clearance for creatinine was 162 +/- 20 mL/min (P < 0.01, for all differences). Using in vitro dialysis, in the absence of RBCs, solute clearance rates were similar: 333 +/- 6, 313 +/- 8 and 326 +/- 4 mL/min for urea, creatinine and MMA, respectively. These findings suggest that the lower MMA clearance relative to creatinine in vivo is a result of MMA movement into RBCs within the dialyzer blood path diminishing its removal by dialysis. CONCLUSION: In conclusion, we find that, in conventional hemodialysis, MMA is not cleared as efficiently as urea or creatinine and raise the possibility that RBCs may limit its dialysis not merely by failing to discharge it, but by further sequestering it as blood passes through the dialyzer.
In this study, we examined the effect of two creatine monohydrate supplementation regimes on 24-hr urinary creatine and methylamine excretion. Nine male participants completed two trials, separated by 6 weeks. Participants ingested 4 x 5 g x day(-1) creatine monohydrate for 5 days in one trial and 20 x 1 g x day(-1) for 5 days in the other. We collected 24-hr urine samples on 2 baseline days (days 1-2), during 5 days of supplementation (days 3-7), and for 2 days post-supplementation (days 8-9). Urine was assayed for creatine using high-performance liquid chromatography and methylamine using gas chromatography. Less creatine was excreted following the 20 x 1 g x day(-1) regime (49.25 +/- 10.53 g) than the 4 x 5 g x day(-1) regime (62.32 +/- 9.36 g) (mean +/- s; P < 0.05). Mean total excretion of methylamine (n = 6) over days 3-7 was 8.61 +/- 7.58 mg and 24.81 +/- 25.76 mg on the 20 x 1 g x day(-1) and 4 x 5 g x day(-1) regimes, respectively (P < 0.05). The lower excretion of creatine using 20 x 1 g x day(-1) doses suggests a greater retention in the body and most probably in the muscle. Lower and more frequent doses of creatine monohydrate appear to further attenuate formation of methylamine.
For more Absorption, Distribution and Excretion (Complete) data for Methylamine (8 total), please visit the HSDB record page.