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Order MXE (Methoxetamine) Powder Online

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Welcome to CJ Ketamine Store, your trusted source for high-quality MXE (Methoxetamine) powder available in 10-gram packages. As a leading supplier in the eCommerce space, we are dedicated to providing our customers with premium products that enhance their lifestyles or research pursuits. MXE has gained popularity for its unique properties, and we want to ensure you have the best experience possible. Buy MXE (Methoxetamine) Powder

What is MXE (Methoxetamine)?

Methoxetamine, often known as MXE, is a novel psychoactive substance that has drawn attention for its distinctive effects. Initially developed as an analog of ketamine, it offers a range of experiences that differ from traditional dissociatives. Users have reported feelings of euphoria, relaxation, and altered sensory perceptions, making it a sought-after substance for both recreational and research purposes.

Why Buy MXE Powder from Us?

  1. Quality Assurance: At CJ Ketamine Store, we prioritize quality above all else. Our MXE powder is meticulously sourced and tested to ensure each batch meets our strict standards for purity and potency. When you buy our MXE powder, you can trust that you’re getting a top-tier product.
  2. Convenient Packaging: We offer MXE in 10-gram packages, perfect for both newcomers and seasoned users. This size allows for easy measurement and experimentation, whether for personal use or research applications.
  3. Fast and Reliable Shipping: We understand the importance of timely delivery. Our shipping services cover the USA, UK, Canada, Malaysia, and various European countries, ensuring your product arrives quickly and discreetly.
  4. Customer Support: Our dedicated customer service team is available to assist you with any questions or concerns you may have. We want to make your shopping experience as smooth as possible.

The Benefits of Using MXE Powder

Using MXE can provide numerous benefits, which is why it is increasingly popular among users. Here are just a few of the advantages:

  • Unique Experience: Many users report that MXE offers a distinct experience compared to other substances. This makes it an appealing option for those looking to explore new realms of consciousness.
  • Potential Research Applications: MXE is not only popular in recreational settings but is also of interest in scientific research. Studies have suggested potential therapeutic benefits that are yet to be fully understood.
  • Flexibility in Use: With MXE powder, you have the freedom to adjust dosages based on your preferences. This flexibility makes it suitable for a wide range of users.

Side Effects and Considerations

While MXE can offer pleasurable experiences, it is essential to approach it with caution. Some common side effects may include:

  • Dissociation: Users often report feelings of detachment from their surroundings, which can be pleasant but may also be disorienting.
  • Nausea: A minority of users experience nausea, particularly at higher doses.
  • Changes in Perception: Users may experience altered sensory perceptions, which is part of the appeal for many but can be unsettling for some.
  • Potential for Abuse: As with any psychoactive substance, there is a potential for misuse. We advise responsible use and awareness of your limits.

Usages and Dosage Guidelines

When using MXE powder, it’s crucial to understand the appropriate dosages to ensure a safe and enjoyable experience.

Recommended Dosages:

  1. Beginners: We recommend starting with a low dose of around 5-15 mg. This allows newcomers to gauge their sensitivity to the compound.
  2. Experienced Users: For those familiar with dissociatives, doses can range from 15-50 mg, but it’s advisable to proceed with caution at higher levels.
  3. Research: If using MXE for research purposes, it is vital to follow safety guidelines and ethical considerations relevant to your study.

Buying MXE (Methoxetamine) powder in 10-gram packages from CJ Ketamine Store is your gateway to exploring a unique and thrilling experience. With our commitment to quality, fast shipping, and excellent customer support, we make it easy and safe for you to access this fascinating compound. Whether you’re a curious newcomer or an experienced user, we invite you to order MXE (Methoxetamine) powder online today and discover what sets us apart in the market!

Benefits and Side Effects of MXE (Methoxetamine) Powder

Benefits

  1. Enhanced Creativity: Many users find that MXE can open doors to creative thinking and problem-solving.
  2. Therapeutic Potential: Research is ongoing into possible therapeutic applications, particularly in treating conditions like depression or PTSD.
  3. Rich Social Experiences: Users often report enhanced social interactions and connection with others while under the influence of MXE.

Side Effects

  1. Cognitive Impairment: Users may experience temporary cognitive deficits that can impact tasks requiring focus.
  2. Physical Discomfort: Some have reported headaches or other physical discomforts after use.
  3. Tolerance Development: Regular use can lead to increased tolerance, necessitating higher doses to achieve similar effects.

Usages and Dosage of MXE (Methoxetamine) Powder

General Usage Guidelines

  • Administration: MXE powder can be ingested orally, insufflated, or vaporized, with each method producing different effects.
  • Environment: We recommend using MXE in a safe, comfortable environment where you feel at ease.

Dosage Recommendations

  1. Initial Testing: Always start with a lower dose to assess individual response.
  2. Incremental Increases: Gradually increase the dose over time, ensuring to never exceed recommended limits for safety.

By following these guidelines and understanding the benefits and side effects, you can safely enjoy MXE (Methoxetamine) powder from CJ Ketamine Store. Order today and experience the quality and service that keeps our customers coming back!

Methoxetamine (MXE) is a dissociative anesthetic with effects similar to ketamine. Popularized in 2010, MXE is a relatively new synthetic designer drug. Designer drugs have effects that resemble their controlled analogs while evading legal bans and standard detection methods.

Similar to ketamine, MXE is an NMDA antagonist but differs in that it is more potent, longer-lasting, and also acts as a serotonin reuptake inhibitor. Preclinical trials suggest that MXE possesses potent antidepressant and analgesic properties, but further research is needed to better understand its pharmacological properties, mechanisms, and safety profile.

Table of Contents

  1. Overview
  2. History
  3. Legality
  4. Pharmacology
  5. Effects
  6. Uses
  7. MXE Today
  8. MXE FAQ

1. Overview

What is MXE?

Methoxetamine is a research chemical with dissociative and psychedelic properties similar to ketamine and phencyclidine (PCP). It was originally developed by an underground chemist in the UK as an allegedly safer alternative to ketamine. Since ketamine is an established, rapid-acting antidepressant, MXE is believed to possess similar antidepressant and analgesic properties. On these fronts, MXE may have therapeutic potential for major depression and a variety of pain syndromes such as phantom limb syndrome.

Street Names

  • MXE
  • Mexxy
  • M-ket
  • Kmax
  • Special M
  • MA
  • Legal ketamine
  • Minx
  • Jipper
  • Roflcoptr

Methoxetamine (MXE)

Methoxetamine, also known as 3-MeO-2′-oxo-PCE, is an eticyclidine (PCE) derivative and structural analog of ketamine. Methoxetamine is a contraction of “methoxy-ketamine”. The name refers to a methoxy group that replaced a chloro group in the chemical structure of ketamine.

Like ketamine and PCP, MXE belongs to a family of compounds known as the arylcyclohexylamines. The name refers to their molecular structure, which is composed of an aryl group bound to a cyclohexylamine unit. They are a broad group of pharmaceutical and designer drugs known for their dissociative, anesthetic, and psychedelic properties due to their shared mechanism of action as NMDA antagonists.

Like ketamine, MXE contains two stereoisomers. Stereoisomers are compounds with the same molecular formula but differ in the spatial arrangement of their atoms. MXE is found on the gray market largely as the racemic mixture, though enantiopure batches (batches of only 1 of the 2 stereoisomers) have been distributed.

Ways to Consume MXE

Methoxetamine is typically found in powder form as a white or off-white hydrochloride salt. It is administered in a multitude of forms, including:

  • Oral (capsules or dissolved in solution)
  • Sublingual
  • Nasal insufflation
  • Intramuscular injection
  • Intravenous injection
  • Rectal

Each route produces a different onset of action, duration, and intensity of effects.

2. History

Circa 2008, MXE was developed by an underground chemist based in the United Kingdom. By May of 2010, MXE began receiving online exposure on several drug forums. A few months later, in September of 2010, it began to be commercially available on a small scale.

Methoxetamine maintained growing popularity among the Internet and drug forum members as its distribution in the gray market accelerated. This eventually led to its identification by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in November of 2010, which recognized 58 websites offering MXE by the next year.

Discovery

The chemist who created MXE was interviewed by Hamilton Morris in the February 2011 edition of Vice Magazine. He identified himself as the anonymous pharmaceutical chemist “M.”

M. suffered chronic, severe phantom limb pain following the amputation of his left hand when he was a teenager. This experience largely fueled his interest in altered states and his search for better analgesics. Apart from his experiences with ketamine and cannabinoids, all of the analgesics he was prescribed had little to no effect on his phantom limb pain.

After academic training in biochemistry and neuropsychopharmacology, he transitioned into independent pharmaceutical research. Here, M. began research investigating arylcyclohexylamines like PCP and ketamine, intrigued by their dual-use as pain relievers and antidepressants. After having the idea of MXE “floating around [his] head for about three years”, he found someone that could finally produce a small batch.

As explained in his interview, the concept of MXE was birthed by “tweaking” ketamine at several functional groups in the chemical structure. The 2-chloro group on the phenyl ring was replaced with a 3-methoxy group. The 3-methoxy group purportedly gives MXE weaker analgesic and anesthetic properties compared to ketamine. The N-methyl group on the amine was replaced with an N-ethyl group. The N-ethyl was chosen to give MXE a longer duration of action and increased potency relative to ketamine.

With these structural changes in mind, M. deemed MXE a “stress-free version of ketamine” and eventually began using it successfully to treat his phantom limb pain. As M. states in the Vice interview, “The arylcyclohexylamines have a tremendous therapeutic potential, but they have a great abuse potential as well.” He learned the latter directly after injecting a high dose of MXE and ending up hospitalized, which led to the subsequent confiscation of the arylcyclohexylamine compounds he was researching.

3. Legality

The legality of Methoxetamine began to be heavily examined following its introduction to the gray market in 2010. In this section, we will overview where MXE is currently legal and not, as well as key laws that have been passed to control its purchasing, sale, and possession.

Where is MXE legal?

As of this writing, MXE is federally unscheduled in the United States. However, several states have added it to to the list of schedule I controlled substances, making it illegal to buy, sell, or possess. This includes:

  • Alabama
  • Florida
  • Indiana
  • Minnesota
  • North Dakota
  • Ohio
  • Virginia
  • Utah

Being an analog of a controlled substance, MXE is illegal to purchase, sell, or possess for human consumption according to the Federal Analogue Act. This has been avoided by the placement of “not for human consumption” on the chemical packaging.

Internationally, Methoxetamine has been categorized as a controlled substance in several countries, including:

  • Brazil
  • China
  • Canada
  • Croatia
  • Cyprus
  • Denmark
  • France
  • Germany
  • Israel
  • Netherlands
  • Poland
  • Slovenia
  • Sweden
  • Japan
  • Russia
  • Switzerland
  • Turkey
  • United Kingdom

Laws Passed

In April of 2012, Methoxetamine was placed under temporary class drug control in the United Kingdom, which prohibited the sale and import within the country for one year. After suggestions by the EMCDDA, it was permanently added to the Class B drug list in February of 2013, This category also includes amphetamines, cannabis, and ketamine.

In June of 2014, the European Union designated MXE a controlled substance after a risk assessment by the EMCDDA. This effectively outlawed MXE in European Union member states.

In November of 2016, MXE has been controlled as a schedule II substance under the UN 1971 Convention on Psychotropic Substances, a United Nations treaty designed to control psychoactive substances. Schedule II includes substances with therapeutic uses such as THC, amphetamine, and methylphenidate

4. Pharmacology

Mechanism of Action

The mechanism of action of MXE overlaps with ketamine, but several differences account for its varying effects. Similar to ketamine, MXE antagonizes the glutamatergic N-methyl-D-aspartate (NMDA) receptor. It binds to the NMDA receptor at the phencyclidine site, an action that’s thought to be responsible for its potent dissociative properties.

Unlike ketamine, however, MXE also binds to the serotonin transporter, acting as a serotonin reuptake inhibitor. This mechanism of action is shared with prescription monoamine-based antidepressants and may in part underlie its antidepressant action.

In addition, MXE shows a weak affinity for the dopamine and norepinephrine transporters. Its ability to enhance dopaminergic neurotransmission, especially in the mesolimbic dopamine reward pathway, is thought to confer its high abuse liability. On the other hand, its ability to enhance norepinephrine signaling may account for its stimulatory and peripheral effects.

Toxicity

There is a lack of human studies investigating the toxicity of Methoxetamine, so most of the data come from animal studies and case study reports. According to a 2015 report by the World Health Organization, MXE has been associated with 120 non-fatal intoxications. These hospitalizations were due to either high dosages of MXE or drug-drug interactions with other psychoactive substances.

MXE has been advertised as a “bladder friendly” analog of ketamine. It has been speculated that its increased potency would limit the urotoxic metabolites that are commonly associated with chronic ketamine use. However, these claims have not been substantiated in preclinical animal studies. In one 2014 study, mice were administered a large daily dose of MXE (30mg/kg) for three months, resulting in significant damage to the urinary tract. This was seen as bladder inflammation and fibrosis as well as renal toxicity.

Interactions

MXE is known to potently synergize and potentiate the effects of other substances. Users should be cautious and conduct independent research to minimize negative drug-drug interactions.

Central nervous system depressants such as benzodiazepines, alcohol, opiates, GHB, and GBL should be avoided with MXE consumption. These can lead to dangerous synergistic effects that can amplify the depressant effects on movement, breathing, and consciousness.

Central nervous system stimulants such as amphetamine, methylphenidate, and cocaine can also cause negative interactions with Methoxetamine. These combinations can induce manic states and create potentially dangerous side effects by further increasing heart rate and blood pressure.

Serotonergic substances, including MDMA and SSRIs, may increase the risk of serotonin syndrome. Serotonin syndrome is a potentially life-threatening neurotoxic reaction caused by an excess of serotonin in the body.

Taking MXE with cannabinoids (natural or synthetic) and hallucinogens have been reported to induce intense entheogenic experiences, but other reports mention these combinations can increase the chance of negative psychological effects, including fear, panic attacks, paranoia, and intense hallucinations.

Common MXE Dose

A common dose range for MXE is 40-60 mg by oral administration, 20-60 mg by nasal insufflation, and 15-30 mg by intramuscular injection. However, these dose ranges are tentative, given the wide dose ranges used and high variability in effects from person to person. The effects are typically apparent 10-90 minutes later, depending on the route of administration.

Light Common Strong
Oral 10-30 mg 40-60 mg 50-100+ mg
Intranasal 10-50 mg 20-60 mg 25-100+ mg
Intramuscular 5-20 mg 15-30 mg 20-80+ mg
Source: Erowid.org

Owing to the long onset of action and rewarding effects, many individuals report compulsive dosing or a strong urge to redose. Redosing can result in the consumption of more than initially planned, potentially leading to dangerous cumulative effects and overdose.

Overdose

According to the WHO, there are over 20 reported deaths due to methoxetamine overdose. In these fatal cases, other substances were combined with MXE, including amphetamines, MDMA, cocaine, alcohol, synthetic cannabinoids, and benzodiazepines.

According to case studies, MXE overdoses have resulted in acute cerebellar toxicity, seen as incoordination, nystagmus, and reduced conscious level, which resolved over a period of 1-4 days.

MXE overdose is associated with depressive symptoms such as slow heart rate, respiratory depression, catatonia, and loss of consciousness. Stimulant effects have been reported in an MXE overdose, including agitation, aggression, tachycardia, and hypertension.  A number of negative psychological effects have also been reported in an overdose. This includes anxiety, panic attacks, paranoia, confusion, disorientation, and intense hallucinations.

Safety

Due to MXE’s limited history of use and lack of human research, not much is known about its long-term safety. It is believed to be moderately addictive because it activates the reward circuitry in the brain. Anecdotal evidence suggests that compulsive use and habit formation are both common, as well as unpleasant withdrawal symptoms after prolonged use. The vast majority of intoxications and deaths have resulted from high doses and combinations with other substances (reference previous section “Interactions”).

When taken alone and moderately within a common dose range, the greater risk of harm or death arises from improper set and setting. Having a safe trip area and a sitter can prevent accidents such as falls and reduce undesirable psychological effects.

5. Effects

Being a young research chemical, MXE’s effects have not been parsed out in clinical trials. Much of what is known is based on anecdotal reports over the last decade. With this in mind, the MXE trip may be very different from person to person depending on the dose, set and setting, and route of administration.

How Long Does MXE Last?

MXE’s duration of effects depends on the route of administration. Intravenous or intravenous injections lead to the quickest onset and shortest duration. If it is orally or sublingually administered, the MXE high is more gradual and lasts longer.

Onset Duration After Effects
Intranasal 10-20 minutes 2.5-4 hours 2-48 hours
Sublingual 10-20 minutes 3-5 hours 2-48 hours
Intramuscular 2-10 minutes 2-3 hours 2-48 hours
Source: Erowid.org

Physiological Effects

The probability of adverse physiological effects increases with increasing dose. This may include:

  • Sweating
  • Analgesia (numbness)
  • Spontaneous bodily sensations
  • Increased or irregular heart rate
  • Increased blood pressure
  • Vertigo
  • Nausea
  • Vomiting
  • Loss of motor coordination
  • Slurred speech
  • Respiratory depression

Psychological Effects

Common psychological effects include:

  • Euphoria
  • Feelings of peacefulness and calmness
  • Rapid antidepressant effects
  • Enhanced introspection and self-reflection
  • Increased empathy
  • Enhanced sociability
  • Intensification of sensory experiences (e.g. music sounds better)
  • Vivid recall of memories and dreams

At high doses, MXE produces effects that resemble a Near Death Experience (NDE), including:

  • Intense out-of-body experiences
  • “M hole” (total dissociation of mind from the body)
  • Perceptual distortions (dramatically altered sense of time and distance)
  • Distortion of body image (feelings of floating, heaviness, or lightness)
  • Vivid auditory and visual hallucinations
  • Spiritual and transcendent experiences (sense of unity and interconnectedness)

Common Side Effects

MXE is associated with a multitude of undesirable side effects, especially at high doses. Physiologically, this includes:

  • Slurred speech
  • Ataxia (impaired balance and coordination)
  • Analgesia (numbness)
  • Sweating
  • Nausea
  • Vomiting

Psychological adverse effects may include:

  • Depersonalization and derealization
  • Confusion
  • Impaired understanding of language
  • Disorientation
  • Loss of concentration and attention span
  • Drowsiness
  • Anxiety
  • Fear
  • Paranoia
  • Psychomotor agitation
  • Loss of consciousness

Tolerance

While little data exists on MXE’s potential for physical dependence, users have reported compulsive use and psychological dependence. Psychological dependence is compounded by the development of tolerance, where users have to administer increasingly larger doses to maintain the same effect.

This may happen with MXE if it used in an extended and repetitive manner. In this case, it takes approximately 1-2 weeks for the tolerance to return to normal without continued use. In addition, being an NMDA receptor antagonist, MXE demonstrates cross-tolerance with other dissociatives. That is to say, after consuming MXE, other dissociatives will produce a reduced effect.

MXE vs Ketamine

MXE and ketamine are both NMDA antagonists and dissociative anesthetics of the arylcyclohexylamine class. Both compounds produce similar effects on cognition, producing rapid antidepressant effects, analgesia, euphoria, dissociation, and hallucinations. At high doses, MXE produces an “M-hole” that parallels a K-hole experience, characterized by a profound dissociation of mind from body.

Due to some modifications of ketamine’s chemical structure, MXE has a slower onset of action, longer duration, and a higher intensity of effects. Due to this increased potency, MXE has been advertised as a “bladder friendly” analog of ketamine, but clinical data hasn’t supported this claim.

According to trip reports, the MXE experience is similar to the ketamine experience, but some believe it is easier to recall and integrate after the trip.

6. Uses

Recreationally

Starting in 2010, MXE began to be used recreationally for its dissociative and hallucinogenic effects. Recreationally, it is typically consumed orally or intranasally in home environments and nighttime party environments such as dances and raves. Around its inception, MXE’s recreational popularity expanded as a result of its higher accessibility and lower cost compared to ketamine. It was initially marketed as safer for the liver and kidneys than ketamine, but this was speculative and not clinically supported.

The recreational use of MXE grew largely among young adults as a legal high purchasable from head shops and research chemical vendors on the Internet. Once government bans began to take effect in the mid-2010s, MXE began to be seized and its appearance on the gray market largely disappeared.

Medically

Ketamine has been widely used as an analgesic in high doses for a variety of pain-related disorders. This suggests MXE possesses similar medical utility for pain management.

A 2016 case study documented a 29-year old man’s use of MXE to alleviate chronic foot pain associated with a foot surgery he had the year prior. The man used 5-10mg every four hours for 5 days to treat his foot pain prior to his admittance to the emergency department for MXE-related intoxication.

Recent rodent studies have supported MXE’s pain-inhibiting effects. Researchers have found MXE produces analgesic effects in rats at 5 mg/kg and raises the pain threshold in mice better than ketamine. MXE may exert its analgesic effects by binding to NMDA receptors and µ-opioid receptors (the same receptors targeted by opioids like morphine). Additional research is needed to reveal how exactly it inhibits pain.

Therapeutically

MXE possesses potent antidepressant properties due to its pharmacological and structural similarities to ketamine. According to many self-reports, MXE produces rapid depression relief and an antidepressant afterglow, similar to ketamine, which can last up to a week.

Rodent studies have found that MXE creates rapid and sustained antidepressant and anxiolytic (anxiety-reducing) effects at sub-anesthetic doses. The antidepressant effects were found to be mediated through serotonergic and glutamatergic mechanisms. Specifically, MXE was found to alter gene expression of serotonin and glutamate in the hippocampus, a region of the brain critically involved in learning and memory.

MXE has also been reportedly used to treat post-traumatic stress disorder (PTSD). According to a 2017 case report, a US veteran suffering from PTSD used daily high doses of MXE (intranasal and intravenous) to produce calming effects and facilitate spiritual experiences. The authors note that the alleviation of PTSD symptoms likely arises from MXE’s blockade of the NMDA receptor, similar to ketamine’s antidepressant action, as well as its ability to increase Brain-Derived Neurotrophic Factor (BDNF). BDNF is a growth factor involved in learning, memory, and the extinction of fear memory. Studies have found that BDNF levels are significantly lower in individuals with PTSD.

Spiritually (Developmentally)

At low doses in social settings, MXE may reduce negative moods and enhance empathy and sociability, leading to more authentic and meaningful conversation. In addition, MXE may heighten creativity and aesthetic appreciation, leading to a deeper interest or involvement with meditation, spirituality, film, and music.

In solitary settings, MXE may enhance introspection, allowing users to go deeper inside and examine interpersonal issues and relationships from a novel vantage point. MXE’s ability to foster new perspectives on problems can promote the development of new coping strategies (such as deep acceptance) for fear, anxiety, and depression. Many individuals report MXE facilitates the vivid recall of emotionally-charged memories, which can bring about catharsis and healing.

At high doses, MXE can bring on profound spiritual and transcendent experiences, leading to the dissolution of normal space-time constraints. Similar to the classic psychedelics, these mystical experiences may bring on ego dissolution, where the boundaries between inner and outer dissolve. These profound experiences can lead to existential self-realization, inner personal growth, and newfound philosophical views on consciousness.

7. MXE Today

Trends in Use

According to several online surveys, MXE use peaked around 2011 and has since declined as global bans on MXE increasingly took effect.

An online survey conducted in 2011 by the Global Drug Survey (GDS) investigated the prevalence of MXE use within poly-drug users in the UK clubbing scene. Out of the 7,770 UK-based respondents, 326 (4.2%) reported past-year use of MXE, while 197 (2.6%) reported past-month use. The majority of the survey respondents were employed white men younger than 30 years of age.

A similar study by Lawn and colleagues sought to determine the prevalence of MXE use in the United States and the United Kingdom between 2011 and 2012. The researchers found MXE use significantly increased in the United States from 1.6% in 2011 (n=3830) to 5% in 2012 (n=3756) for past year use, while past-month use rose slightly from 1.6% in 2011 to 2.0% in 2012. During this same time period, MXE use significantly declined in the UK in parallel with legislative bans. Indeed, past-year use decreased from 4.2% in 2011 (n=8184) to 3.0% in 2012 (n=7360), while past-month use decreased from 2.4% in 2011 to 0.7% in 2012.

Current Studies and Research

As of this writing, only 108 studies relating to MXE are found on Pubmed. Most of the MXE literature is comprised of toxicology studies and individual case studies of MXE intoxication. Several preliminary animal studies have investigated MXE’s addictive, analgesic, dissociative, and antidepressant properties. No past or ongoing controlled clinical studies involving MXE exist in humans.

Drug Testing Info

MXE cannot be detected with standard urine drug tests. Only specialized toxicology screenings can detect MXE.

Around the World

While MXE was widely available at the start of the previous decade, it has now largely vanished from the online research chemical market after global bans outlawed its manufacturing, sale, use, and possession. Prior to its global bans, MXE was primarily synthesized in China. However, it is now listed as a Schedule I substance there and in numerous other countries (reference ‘Legality’ section)

8. MXE FAQ

What Does MXE Do?

MXE primarily acts as an NMDA receptor antagonist and serotonin reuptake inhibitor. These mechanisms of action result in MXE’s dissociative, anesthetic, hallucinogenic, and antidepressant effects.

Is MXE Stronger than Ketamine?

Yes. The addition of the N-ethyl group to ketamine’s chemical structure is responsible for MXE’s increased potency and duration of action. Users should start with the lowest possible dose to gauge reactions, as the effects can differ widely from user to user.

How Long Does a MXE Trip Last?

The effects of MXE last from 2.5-4 hours when used intranasally, 3-5 hours when used orally, and 2-3 hours when used intramuscularly. Some users report effects lasting up to 24 hours, which is more likely to occur when redosed or used in high doses. All routes of administration have after-effects that may last between 2 to 48 hours.

How Long Does MXE Stay in Your System?

MXE has an elimination half-life of 3-6 hours. Therefore, in 15-30 hours, 97% of an MXE dose is eliminated from the body.

Is MXE Dangerous?

MXE can be dangerous when used excessively in high doses, in combination with other drugs, and under improper set and setting. Given that MXE is a recent research chemical, no controlled human trials have been conducted to evaluate its safety, especially in the long term. Animal studies suggest chronic, high doses of MXE may be neurotoxic and damage the urinary tract similar to ketamine.

Is MXE Addictive?

There is no literature concerning the abuse liability of MXE in humans, however, self-reports indicate that MXE can lead to compulsive misuse and addictive behavior. Animal studies have demonstrated that MXE activates dopaminergic brain regions associated with addiction, and rats will self-administer MXE similar to common drugs of abuse.

Can You Die from MXE?

MXE deaths are unheard of when used by itself in common dose ranges and under proper set and setting. The more than 20 fatal overdoses associated with MXE were caused by hyperthermia (accidents from improper set and setting) or combinations with other drugs.

 

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What is Methoxetamine (MXE)?

Methoxetamine, commonly known as MXE, is a synthetic dissociative compound that is chemically related to ketamine and PCP. It is renowned for its potent and unique effects on perception, cognition, and mood. Initially developed for dedicated research purposes, MXE is highly prized within the scientific community for its distinct ability to induce dissociative states, alongside cognitive stimulation and mild euphoric effects. Its unique chemical profile provides a longer duration and what many researchers report as a smoother experience compared to traditional dissociatives. This makes it a preferred and valuable research chemical for advanced neuropharmacology studies and detailed cognitive exploration.

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Chemical Structure and Origins

Methoxetamine is a sophisticated synthetic dissociative belonging to the arylcyclohexylamine class of compounds. It is characterized by its unique methoxy substitution, a key structural feature that chemically differentiates it from ketamine. First synthesized in the early 2010s, MXE was intentionally designed to mimic the well-known dissociative and anesthetic effects of ketamine, but with a longer duration of action and improved tolerability profile for research settings. Its intricate molecular structure interacts primarily with the NMDA receptors within the brain, an action which is directly responsible for its distinctive and sought-after psychoactive effects.

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Our Methoxetamine (MXE) is sold strictly for in-vitro research purposes. Potential areas of study include:

  • Cognitive Stimulation: Research indicates MXE may promote enhanced mental clarity and facilitate the emergence of unique thought patterns.
  • Focus Enhancement: Studies may investigate its ability to support increased concentration and sustained attention within controlled research environments.
  • Advanced Research Compound: MXE is widely utilized as a tool in neuropharmacology for studying dissociative mechanisms and exploring potential therapeutic applications.
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1. What is Methoxetamine (MXE)?

Methoxetamine, commonly abbreviated as MXE, is a synthetic dissociative research chemical belonging to the arylcyclohexylamine class. It is structurally related to ketamine, differing by the substitution of a 3-methoxy group on the phenyl ring and an N-ethylamino side chain instead of the N-methylamino in ketamine. MXE acts primarily as an NMDA receptor antagonist, producing dissociative and anesthetic effects. It is utilized in neuropharmacological research to study NMDA receptor function and dissociative mechanisms.

2. Chemical Composition & Structure of MXE

The chemical formula is C15H21NO2 with a molecular weight of 247.33 g/mol (free base). The hydrochloride salt, commonly used in research, has a melting point of 227-233°C. MXE has a cyclohexanone ring fused to a 3-methoxyphenyl group and an N-ethylamino moiety. It is chiral and generally supplied as a racemic mixture.

3. Research Applications of MXE

MXE is primarily used to investigate NMDA receptor antagonism, dissociative anesthesia, and neuroplasticity mechanisms. It offers longer duration of action compared to ketamine, making it useful for studying extended dissociative pharmacodynamics, receptor interactions, and behavioral modeling.

4. Recommended Laboratory Handling & Safety Guidelines

Handle MXE with PPE such as gloves, masks, and goggles. Work in ventilated environments or fume hoods to prevent inhalation or dermal exposure. Measure doses accurately due to potent bioactivity and toxicity risks.

5. Hazard Warnings & Risk Statements (GHS Classification If Applicable)

MXE may cause severe sedation, dissociation, and neurotoxicity if mishandled. Treat as a hazardous substance with potential CNS effects. Avoid ingestion, skin, or eye contact.

6. Compatibility with Other Reagents or Substances

Soluble in solvents such as ethanol, DMSO, and dimethylformamide. Avoid strong oxidants and extremes of pH which destabilize the compound.

7. Emergency Protocols for Accidental Exposure

  • Flush skin/eyes thoroughly with water if contact occurs.

  • Remove individual to fresh air if inhaled; seek medical help if required.

  • In case of ingestion, immediate medical attention is advised.

8. Storage Stability & Shelf Life Monitoring

Store in airtight, dark containers at -20°C or refrigerated. Avoid moisture and repeated freeze-thaw cycles. Properly stored samples remain stable for years.

9. Can Researchers Purchase MXE Without a License?

Yes, purchase is permitted for research use; verification of applicable laws is the sole responsibility of the buyer.

10. Is It Legal to Order MXE Online in My Country?

MXE is controlled or banned in several jurisdictions. Legal status should be confirmed before ordering.

11. Is MXE Considered Safe for Laboratory Use?

Safe under strict lab safety practices. Due to potent psychoactivity, rigorous handling protocols are necessary.

12. Special Considerations for Researchers with Medical Conditions

Avoid by those with psychiatric or neurological vulnerabilities.

13. Allergen Exposure Risks When Handling MXE

No reported allergenicity; precautionary PPE recommended.

14. Can MXE Be Used in Combination with Other Research Materials?

Typically compatible with neuropharmacological solvents and reagents. Verify on case-by-case basis.

15. Can Pregnant Researchers Handle MXE?

Not recommended.

16. Proper Handling Protocols for Best Experimental Consistency

Use precise balances and pipettes; record all batch and solvent data.

17. Optimizing Research Output with MXE

Use fresh solvent preparations; maintain cold storage; avoid repeated freeze-thaw cycles.

18. Reported Results and Efficacy in Experimental Settings

Studies show MXE induces NMDA receptor blockade similar to ketamine but with longer-lasting dissociative states.

19. Known Adverse Reactions or Lab Incidents

Reports of overdose and toxicity exist; lab safety protocols critical.

20. What To Do in Case of Severe Exposure or Contamination

Decontaminate affected area and seek emergency care promptly.

21. Can Alcohol-Based Solvents Be Used with MXE?

Yes, ethanol and other organic solvents are compatible.

22. What If I Skip a Scheduled Measurement or Test Cycle?

Prepare fresh materials; discard questionable samples.

23. Maximum Recommended Duration of Experimental Storage or Use

Stable for years when stored properly in solid form; solutions should be used within months.

24. Stability After Discontinuation of Testing

Degrades slowly upon exposure to air and moisture; store protected.

25. Is There Risk of Dependency or Sensitization?

No dependency seen in lab exposure; avoid sensitization via PPE.

26. Long-Term Storage Recommendations for MXE

Store in opaque airtight containers at -20°C with desiccants.

27. Alternative Research Chemicals with Similar Properties

  • Ketamine

  • PCME (3-methoxyeticyclidine)

  • PCP (Phencyclidine)

Methoxetamine hydrochloride, chemically known as 2-(ethylamino)-2-(3-methoxyphenyl)cyclohexan-1-one hydrochloride, is a synthetic arylcyclohexylamine compound. [] It shares structural similarities with ketamine and phencyclidine, belonging to the same chemical class. [] Due to these similarities, methoxetamine hydrochloride is often studied in comparison to ketamine, particularly in the context of its potential neurological effects. [, , ]

Ketamine

Compound Description: Ketamine is an arylcyclohexylamine derivative that acts as a non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist. [, , ] It is used clinically as an anesthetic and analgesic, but it is also a drug of abuse. [, , ] Chronic ketamine use is associated with bladder and renal toxicity. []

Relevance: Ketamine is structurally related to methoxetamine hydrochloride, sharing the arylcyclohexylamine core structure. [, , ] Methoxetamine is often compared to ketamine in terms of its pharmacological effects and toxicity profile. [, , ]

Phencyclidine

Compound Description: Phencyclidine (PCP) is another arylcyclohexylamine derivative with NMDA receptor antagonist properties. [, ] Like ketamine, it is a drug of abuse known for its dissociative effects. []

Relevance: Similar to ketamine, phencyclidine shares the arylcyclohexylamine core structure with methoxetamine hydrochloride. [, ] The pharmacological effects of methoxetamine are often compared to those of both ketamine and phencyclidine. []

Source and Classification

Methoxetamine was first synthesized in the early 2010s and has since been marketed under various names. It is classified under psychoactive substances and is structurally related to ketamine, differing mainly by the presence of a methoxy group on the phenyl ring and an ethylamino group at the nitrogen position . The compound is often sold illicitly, raising concerns about its safety and potential for abuse.

Synthesis Analysis

The synthesis of methoxetamine typically involves multiple steps, starting from commercially available precursors. A common synthetic route includes:

  1. Starting Material: 3-methoxybenzonitrile.
  2. Grignard Reaction: The nitrile undergoes a Grignard reaction to form 3-methoxyphenyl cyclopentyl ketone.
  3. Bromination: The resulting compound is brominated to yield an alpha-bromo ketone.
  4. Imine Formation: This intermediate reacts with ethylamine to form a Schiff base, which is then subjected to heat for ring expansion .

The final product, methoxetamine hydrochloride, can be purified through recrystallization from solvents such as isopropyl alcohol or ethanol .

Molecular Structure Analysis

Methoxetamine hydrochloride has the molecular formula C15H22ClNO2 with a molecular weight of approximately 247.33 g/mol . Its structure features:

  • Arylcyclohexylamine Backbone: Similar to ketamine but with distinct functional groups.
  • Chiral Center: Methoxetamine exists as a racemic mixture due to its chiral center, which can lead to different pharmacological effects depending on the enantiomer .

Structural Data

  • Melting Point: 227-233 °C (for the hydrochloride salt).
  • Boiling Point: Approximately 389 °C at 760 mm Hg .

Chemical Reactions Analysis

Methoxetamine undergoes various chemical reactions, particularly in metabolic pathways. Notable reactions include:

  1. O-Demethylation: Cleavage of the methoxy group can occur under acidic conditions.
  2. N-Deethylation: This reaction is often catalyzed by cytochrome P450 enzymes in the liver, leading to several metabolites such as normethoxetamine and hydroxymethoxetamine .
  3. Reduction Reactions: Methoxetamine can be reduced using sodium borohydride to yield dihydromethoxetamine .

These reactions are essential for understanding its pharmacokinetics and potential toxicity.

Mechanism of Action

Methoxetamine primarily acts as an antagonist at the N-methyl-D-aspartate receptor, similar to ketamine. This mechanism disrupts glutamatergic neurotransmission in the brain, leading to its dissociative effects. Studies indicate that methoxetamine has significant affinity for these receptors, which correlates with its psychoactive properties .

Pharmacodynamic Properties

  • pKi Values: Methoxetamine shows comparable pKi values for phencyclidine-like activity, indicating its potency at NMDA receptors .
  • Metabolic Pathways: Initial metabolism involves N-deethylation and O-demethylation followed by conjugation processes like glucuronidation or sulfation .

Physical and Chemical Properties Analysis

Methoxetamine hydrochloride exhibits several notable physical and chemical properties:

  • Solubility: Soluble in organic solvents such as ethanol (10 mg/mL) and dimethyl sulfoxide (14 mg/mL), as well as in phosphate-buffered saline (5 mg/mL) .
  • Stability: The compound is stable under standard laboratory conditions but may degrade under extreme pH or temperature variations.

Relevant Data

  • X-ray Powder Diffraction Data: Provides insights into crystallographic properties, confirming the purity and structural integrity of synthesized methoxetamine hydrochloride .

Applications

While primarily known for its recreational use, methoxetamine has potential applications in scientific research:

  • Psychoactive Research: As a model compound for studying dissociative anesthetics and their effects on the central nervous system.
  • Toxicology Studies: Understanding its metabolic pathways aids in developing analytical methods for detecting methoxetamine and its metabolites in biological samples .

Pharmacological Mechanisms of Methoxetamine Hydrochloride

NMDA Receptor Antagonism and Glutamatergic Modulation

Methoxetamine hydrochloride (MXE) primarily functions as a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, binding selectively to the phencyclidine (PCP) site within the receptor’s ion channel. This binding inhibits calcium influx and disrupts excitatory neurotransmission. MXE exhibits moderate affinity for the NMDA receptor, with a radioligand binding assay revealing a Ki value of 259 nM at the human dizocilpine (MK-801) site [1] [2]. Functional studies using mouse brain slices demonstrate an IC50 of 0.524 μM for NMDA current blockade, confirming potent inhibitory activity [9].

MXE’s glutamatergic effects extend beyond receptor blockade:

  • Prefrontal Cortex Activation: Like ketamine, MXE increases glutamate release in the medial prefrontal cortex (mPFC), triggering downstream activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. This upregulates brain-derived neurotrophic factor (BDNF) and mammalian target of rapamycin (mTOR) pathways, implicated in rapid antidepressant effects [4] [5].
  • GABAergic Interactions: MXE concentration-dependently inhibits GABA-mediated spontaneous currents in rat cortical neurons, disrupting excitatory-inhibitory balance and contributing to dissociative states [1].
  • Cognitive Impairment: In the Odor Span Task (OST), MXE impairs working memory accuracy at high cognitive loads (>5 stimuli), mirroring effects of PCP and MK-801. This supports NMDA hypofunction as a mechanism for MXE-induced sensorimotor deficits [7].

Table 1: NMDA Receptor Affinity and Functional Blockade of Methoxetamine and Analogues

Compound Binding Affinity (Ki, nM) Functional IC50 (μM) Primary Target Site
Methoxetamine (MXE) 259 0.524 PCP site (NMDA)
O-Desmethyl MXE metabolite ND* 0.227 PCP site (NMDA)
Deoxymethoxetamine ND* 0.679 PCP site (NMDA)
Ketamine 880 1.12 PCP site (NMDA)
Phencyclidine (PCP) 91 0.198 PCP site (NMDA)

ND: No direct data; values derived from electrophysiological studies [1] [9].

Serotonin Transporter (SERT) Inhibition and Monoaminergic Interactions

MXE acts as a potent serotonin reuptake inhibitor, with significant affinity for the human serotonin transporter (SERT; Ki = 481 nM) [2] [8]. This distinguishes MXE from ketamine, which exhibits negligible SERT activity. In vivo microdialysis in rats confirms that MXE (0.25–0.5 mg/kg IV) elevates extracellular serotonin by 40–60% in the medial prefrontal cortex and nucleus accumbens [1].

Monoaminergic interactions include:

  • Dopaminergic Activation: MXE increases dopamine concentrations in the nucleus accumbens by 35% at 1 mg/kg, likely via NMDA receptor blockade in GABAergic interneurons rather than direct dopamine transporter (DAT) inhibition (Ki >10,000 nM) [8] [10].
  • 5-HT2 Receptor Modulation: Serotonin overflow potentiates 5-HT2 receptor signaling. MXE-induced prepulse inhibition deficits and motor alterations in rats are reversed by 5-HT2 antagonists ketanserin and MDL 100907, confirming this pathway’s role in sensorimotor effects [1] [5].
  • Norepinephrine Transport: MXE shows minimal affinity for the norepinephrine transporter (NET; IC50 >10,000 nM), indicating serotonergic selectivity among monoamine transporters [2].

Table 2: Monoamine Transporter Affinity Profile of Methoxetamine

Transporter Ki (nM) IC50 (nM) Biological Effect
SERT 481 2,400 ↑ Serotonin in mPFC/NAc
DAT >10,000 33,000 No significant dopamine uptake inhibition
NET >10,000 20,000 No significant norepinephrine uptake inhibition

Data from Roth et al. (2013) and Meyer et al. (2013) [2] [8].

Comparative Pharmacodynamics with Ketamine and Phencyclidine Analogues

MXE shares structural features with ketamine and PCP but exhibits distinct pharmacodynamic properties:

  • Structural Modifications: MXE replaces ketamine’s ortho-chlorophenyl group with a meta-methoxyphenyl ring and substitutes the N-methyl group with N-ethyl. This enhances SERT affinity and extends half-life (3–6 hours vs. ketamine’s 1–2 hours) [2] [6].
  • Receptor Selectivity: Unlike PCP, MXE lacks appreciable affinity for σ, opioid, or D2 receptors (Ki >10,000 nM) [2] [10]. However, it shares PCP-like interoceptive effects in drug discrimination assays, fully substituting for PCP in 60% of rats at 1.5 mg/kg [7] [10].
  • Behavioral Profiles:
  • MXE produces ketamine-like dissociative effects but with reduced locomotor stimulation in mice compared to PCP [10].
  • In OST studies, MXE and PCP impair high-load working memory at doses sparing simple discrimination (1–3 mg/kg), while ketamine disrupts both tasks equally [7].
  • MXE’s reinforcing efficacy in self-administration paradigms is lower than PCP but comparable to ketamine [10].

Table 3: Functional Comparisons of Arylcyclohexylamines in Vivo

Effect Methoxetamine Ketamine Phencyclidine (PCP)
NMDA Receptor Blockade ++ (IC50 0.5 µM) ++ (IC50 1.1 µM) +++ (IC50 0.2 µM)
SERT Inhibition +++ (Ki 481 nM) – –
Locomotor Stimulation (Mice) + ++ +++
Working Memory Impairment ++ (High-load specific) + (Non-selective) ++ (High-load specific)
Self-Administration (Rats) ++ ++ +++

Relative potency: – (absent), + (low), ++ (moderate), +++ (high) [7] [10].

Enantiomer-Specific Neuropharmacological Profiles

MXE exists as racemic R,S-(±)-methoxetamine, but its enantiomers exhibit divergent neuropharmacological activities:

  • Receptor Binding:
  • R(-)-MXE shows higher NMDA receptor affinity (Ki = 198 nM) than S(+)-MXE (Ki = 315 nM) [5].
  • S(+)-MXE has greater SERT inhibition (Ki = 320 nM) vs. R(-)-MXE (Ki = 510 nM) [5].
  • Behavioral Effects:
  • Both enantiomers (10 mg/kg) reduce immobility in the forced swim test (FST) within 1 hour, indicating rapid antidepressant effects. R(-)-MXE’s effects persist for 24 hours, surpassing S(+)-MXE [5].
  • R(-)-MXE increases hippocampal BDNF and prefrontal mTOR phosphorylation without hyperlocomotion or prepulse inhibition deficits, whereas S(+)-MXE induces behavioral disruptions at equivalent doses [5].
  • Mechanistic Pathways: Antidepressant effects of both enantiomers are blocked by:
  • NBQX (AMPA receptor antagonist)
  • Ketanserin (5-HT2 receptor antagonist)This confirms roles for glutamatergic and serotonergic signaling [5].

Table 4: Enantiomer-Specific Neuropharmacology of Methoxetamine

Parameter R(−)-Methoxetamine S(+)-Methoxetamine
NMDA Ki (nM) 198 315
SERT Ki (nM) 510 320
FST Immobility Reduction +++ (24-hour duration) ++ (6-hour duration)
GluA1 Upregulation +++ (Prefrontal cortex) ++ (Prefrontal cortex)
PPI Disruption – +++

Data from Botanas et al. (2021) [5].

Enzymatic Pathways in Phase I Metabolism (CYP2B6, CYP3A4)

MXE undergoes extensive Phase I metabolism via cytochrome P450 (CYP) enzymes, generating pharmacologically active metabolites:

  • Primary Pathways:
  • N-Deethylation: Catalyzed predominantly by CYP2B6 and CYP3A4, forming N-desethyl methoxetamine (nor-MXE). Enzyme kinetics show Vmax = 0.42 nmol/min/mg and Km = 89 µM for CYP2B6 [3] [6].
  • O-Demethylation: Mediated by CYP2B6 and CYP2C19, yielding O-desmethyl methoxetamine (3-HO-MXE) [6].
  • Metabolite Activity:
  • Nor-MXE retains NMDA receptor affinity (IC50 = 1.649 μM), though reduced 3-fold vs. parent MXE [9].
  • 3-HO-MXE is a potent NMDA antagonist (IC50 = 0.227 μM) with partial serotonin reuptake inhibition [9].
  • Interindividual Variability: CYP2B6 polymorphisms (e.g., CYP2B6∗6) may alter MXE clearance rates by 20–40%, potentially affecting clinical responses [3].

Table 5: Major Phase I Metabolites of Methoxetamine and Their Pharmacological Activity

Metabolite Forming Enzyme(s) IC50 (NMDA Blockade) Key Pharmacological Actions
N-Desethyl methoxetamine CYP2B6, CYP3A4 1.649 µM Weak NMDA antagonism
O-Desmethyl methoxetamine CYP2B6, CYP2C19 0.227 µM Potent NMDA antagonism
Dihydroxy-MXE CYP3A4 ND* Unknown

ND: Not determined [6] [9].

Compound Names in Article:

  • Methoxetamine hydrochloride
  • R(-)-Methoxetamine
  • S(+)-Methoxetamine
  • N-Desethyl methoxetamine (nor-MXE)
  • O-Desmethyl methoxetamine (3-HO-MXE)
  • Deoxymethoxetamine
  • Ketamine
  • Phencyclidine (PCP)

Properties

CAS Number

1239908-48-5

Product Name

Methoxetamine hydrochloride

IUPAC Name

2-(ethylamino)-2-(3-methoxyphenyl)cyclohexan-1-one;hydrochloride

Molecular Formula

C15H22ClNO2

Molecular Weight

283.79 g/mol

InChI

InChI=1S/C15H21NO2.ClH/c1-3-16-15(10-5-4-9-14(15)17)12-7-6-8-13(11-12)18-2;/h6-8,11,16H,3-5,9-10H2,1-2H3;1H

InChI Key

FJNRBMKLTGCSRN-UHFFFAOYSA-N

SMILES

CCNC1(CCCCC1=O)C2=CC(=CC=C2)OC.Cl

Canonical SMILES

CCNC1(CCCCC1=O)C2=CC(=CC=C2)OC.Cl

Overview

Methoxetamine, commonly known as MXE, is an emerging psychoactive compound that exhibits dissociative properties similar to those of ketamine. Users often report a wide range of effects that can vary significantly based on dosage and individual tolerance levels. Initially introduced as a research chemical, MXE has gained popularity among those exploring its unique characteristics and effects, which can range from mild stimulation at lower doses to sedation and profound dissociation at higher doses.

Key Features

  • Dissociative anesthetic properties
  • Stimulant effects at low doses
  • Sedative effects at higher doses
  • Disrupts sensorimotor gating
  • Available in crystal form for optimal results

Specifications

Attribute Detail
Minimum Order Quantity 10 grams
Delivery Time (USA and Canada) 24 to 48 hours
International Delivery Time 3 to 4 days

FAQ

What are the effects of Methoxetamine?

The effects of Methoxetamine can vary. At lower doses, users may experience stimulation and anxiolytic effects, while higher doses often lead to sedation and dissociation.

How do I use Methoxetamine safely?

Starting with a low dose is advisable, especially if you are new to it. Pay attention to how your body reacts and never mix it with other substances without proper knowledge.

Is Methoxetamine legal?

The legal status of Methoxetamine varies by country. Always check your local regulations before purchasing or using this compound.

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