Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Viloxazine, sold under the brand name Qelbree among others, is a selective norepinephrine reuptake inhibitor medication that is indicated in the treatment of attention deficit hyperactivity disorder (ADHD) in children and adults.[1][5] It was marketed for almost 30 years as an antidepressant for the treatment of depression before being discontinued and subsequently repurposed as a treatment for ADHD.[6][5][1] Viloxazine is taken orally.[1] It was used as an antidepressant in an immediate-release form and is used in ADHD in an extended-release form,[6][1] although current evidence indicates that it is significantly less effective at reducing ADHD symptoms compared to stimulant medications like methylphenidate.[7][8]
Side effects of viloxazine include insomnia, headache, somnolence, fatigue, nausea, vomiting, decreased appetite, dry mouth, constipation, irritability, increased heart rate, and increased blood pressure.[1] Rarely, the medication may cause suicidal thoughts and behaviors.[1] It can also activate mania or hypomania in people with bipolar disorder.[1] Viloxazine acts as a selective norepinephrine reuptake inhibitor (sNRI).[6][1][5] The immediate-release form has an elimination half-life of 2.5 hours[6][2] while the half-life of the extended-release form is 7 hours.[1]
Viloxazine was first described by 1972[9] and was marketed as an antidepressant in Europe in 1974.[6][10] It was not marketed in the United States at this time.[11] The medication was discontinued in 2002 for commercial reasons.[6][12][13] However, it was repurposed for the treatment of ADHD and was reintroduced, in the United States, in April 2021.[6][14][15] Viloxazine is a non-stimulant medication; it has no known misuse liability and is not a controlled substance.[1]
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Buy Viloxazine (Qelbree) Cas 46817-91-8
Medical uses
Attention deficit hyperactivity disorder
Viloxazine is indicated to treat attention deficit hyperactivity disorder (ADHD) in children age 6 to 12 years, adolescents age 13 to 17 years, and adults.[1]
Analyses of clinical trial data suggest that viloxazine produces moderate reductions in symptoms; it is about as effective as atomoxetine and methylphenidate but with fewer side effects.[7][8][16]
Depression
Viloxazine was previously marketed as an antidepressant for the treatment of major depressive disorder.[6][5] It was considered to be effective in mild to moderate as well as severe depression with or without co-morbid symptoms.[6] The typical dose range for depression was 100 to 400 mg per day in divided doses administered generally two to three times per day.[6]
Available forms
Viloxazine is available for ADHD in the form of 100, 150, and 200 mg extended-release capsules.[1] These capsules can be opened and sprinkled into food for easier administration.[1]
Viloxazine is a selective norepinephrine reuptake inhibitor that is used in the therapy of attention deficit/hyperactivity disorder in children. Viloxazine has been associated with uncommon and mild serum enzyme elevations during therapy but not with occurrence of clinically apparent liver injury.
Viloxazine : Pharmaceutical Reference Standard
Catalog No.: SPV032
CAS No.: 46817-91-8
Molecular Formula: C13H19NO3
Molecular Weight: 237.3 g/mol
Synonym: nan
Product Overview
It is a premium-quality pharmaceutical reference standard of the active ingredient It, meticulously manufactured and quality-assured by SRIRAMCHEM.
Engineered for precision, reliability, and consistency, this reference material complies with stringent international regulatory and pharmacopeia standards, making it an excellent choice for analytical method development, validation, and quality control in pharmaceutical and research laboratories.
Each batch is rigorously tested and fully traceable to multiple pharmacopeia references, ensuring unmatched analytical accuracy and batch-to-batch reproducibility.
Key Features
- High-Purity Reference Standard : Manufactured under controlled conditions to deliver consistent and reliable purity.
- Pharmacopeia Traceable : Reference material aligned with major international pharmacopeial specifications.
- Regulatory-Compliant Quality : Produced under robust quality management systems meeting global compliance norms.
- Reliable Analytical Performance : Trusted standard for method validation, calibration, and QC testing.
- Batch-Specific CoA Available : Detailed Certificate of Analysis provided upon request.
Applications
- Analytical method development and validation
- Routine quality control (HPLC, LC-MS, GC, etc.)
- Research and formulation studies
- Stability testing and impurity profiling
Chemical Properties
| Molecular Formula | C13H19NO3 |
| Molecular Weight | 237.29 |
| CAS Numbers | 46817-91-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O(CC1CNCCO1)C2=C(OCC)C=CC=C2 |
Storage and Handling
0C Short Term, -20C Long Term
References
Yu C, et al. New Insights into the Mechanism of Action of Viloxazine Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020;12 285-300.
Intended Use
For laboratory and analytical use only.
Not intended for human or animal consumption.
Ordering & Sample Requests
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CAS 46817-91-8 (Viloxazine) – BOC Sciences
Viloxazine is a selective norepinephrine reuptake inhibitor (NRI) used for the treatment of attention-deficit/hyperactivity disorder …
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