Buy Seproxetine ((S)-norfluoxetine) Cas 126924-38-7

Buy Seproxetine ((S)-norfluoxetine) Cas 126924-38-7

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Buy Seproxetine ((S)-norfluoxetine) Cas 126924-38-7

Buy Seproxetine ((S)-norfluoxetine) Cas 126924-38-7

Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI).[1][2] It is the main active metabolite of the widely used antidepressant fluoxetine;[3] it is nearly 4 times more selective for stimulating neurosteroid synthesis relative to serotonin reuptake inhibition than fluoxetine.[4] It is formed through the demethylation, or removal of a methyl group, of fluoxetine.[5] Seproxetine is both an inhibitor of serotonin and dopamine transporters, 5-HT2A and 5-HT2C receptors.[6] It was being investigated by Eli Lilly and Company as an antidepressant; however, it causes cardiac arrhythmia by blocking the KvLQT1 protein, which is responsible for the management of the QT interval. This is the time it takes for the heart to contract and recover.[7] Due to this, development of the medication was discontinued.[1] Efficacy testing found that the drug was equivalent to fluoxetine, but sixteen times more powerful than the R enantiomer of norfluoxetine.

S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE is a chiral compound that is a metabolite of Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) used as an antidepressant. It is also a stereoselective inhibitor of serotonin re-uptake and phosphodiesterase. This pale yellow oil is a promising candidate for pharmaceutical applications due to its potential antidepressant properties.

126924-38-7

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  • 126924-38-7 Structure

  • Basic information

    1. Product Name: (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE
    2. Synonyms: (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE;Seproxetine [inn];Unii-25co3X0R31;(S)-Norfluoxetine
    3. CAS NO:126924-38-7
    4. Molecular Formula: C16H16F3NO
    5. Molecular Weight: 295.2995496
    6. EINECS: N/A
    7. Product Categories: Aromatics;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals;Amines
    8. Mol File: 126924-38-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 381.1°C at 760 mmHg
    3. Flash Point: 184.3°C
    4. Appearance: /
    5. Density: 1.204g/cm3
    6. Vapor Pressure: 5.21E-06mmHg at 25°C
    7. Refractive Index: 1.525
    8. Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
    9. Solubility: N/A
    10. CAS DataBase Reference: (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE(126924-38-7)
    12. EPA Substance Registry System: (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE(126924-38-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 126924-38-7(Hazardous Substances Data)

126924-38-7 Suppliers

  • (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINECas No: 126924-38-7
  • (S)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamineCas No: 126924-38-7
  • (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINECas No: 126924-38-7
  • (S)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamineCas No: 126924-38-7

126924-38-7 Usage

Uses

Used in Pharmaceutical Industry:
(S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE is used as a potential antidepressant for treating depression and related mood disorders. As a metabolite of Fluoxetine, it exhibits the ability to selectively inhibit serotonin reuptake, thereby increasing the availability of serotonin in the synaptic cleft and promoting a more balanced mood.
Additionally, as a stereoselective inhibitor of phosphodiesterase, it may contribute to the modulation of intracellular signaling pathways, which could further enhance its antidepressant effects.
Used in Research Applications:
In the field of neuroscience and psychopharmacology, (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE serves as a valuable research tool for studying the mechanisms of action of SSRIs and their metabolites. Its stereoselective properties allow for the investigation of the role of enantiomers in the pharmacological effects of these drugs, potentially leading to the development of more effective and targeted antidepressant therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 126924-38-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,9,2 and 4 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 126924-38:
(8*1)+(7*2)+(6*6)+(5*9)+(4*2)+(3*4)+(2*3)+(1*8)=137
137 % 10 = 7
So 126924-38-7 is a valid CAS Registry Number.

InChI:InChI=1/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2/t15-/m0/s1

126924-38-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) – Sixth revised edition

Buy Seproxetine ((S)-norfluoxetine) Cas 126924-38-7

1.Identification

1.1 GHS Product identifier

Product name (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

1.2 Other means of identification

Product number –
Other names UNII-25CO3X0R31

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier’s details

1.5 Emergency phone number

Emergency phone number –

(S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE(126924-38-7)

CAS Registry Number:
126924-38-7
Synonyms:
Benzenepropanamine,g-[4-(trifluoromethyl)phenoxy]-,(S)-;(S)-3-(4-Trifluoromethylphenoxy)-3-phenylpropylamine;(S)-Norfluoxetine;Seproxetine;
Molecular Formula:
C16H16 F3 N O
Molecular Weight:
295.304
EINECS:

CAS No.:126924-38-7

Name: (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:126924-38-7 SDS

  1. Cas 126924-38-7, (S)-3-PHENYL-3- (4-TRIFLUOROMETHYL …

    (S)-3-PHENYL-3- (4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE is a chiral compound that is a metabolite of Fluoxetine, a …

  2. (S)-3-Phenyl-3- (4-trifluoromethyl-phenoxy)-propylamine

    Chiral Compounds (S)-3-Phenyl-3- (4-trifluoromethyl-phenoxy)-propylamine 20R0262,20R0262S Product Detail (S)-3-Phenyl-3- (4 …

  3. (S)-3-PHENYL-3- (4-TRIFLUOROMETHYL-PHENOXY) …

    TradingChem provides information about (S)-3-PHENYL-3- (4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE, ,CAS #: 126924 …

  4. Seproxetine [inn] – 126924-38-7 – Catalog of Chemical Suppliers

    Supplier Description Reference capotchem (S)-3-Phenyl-3- (4-trifluoromethyl-phenoxy)-propylamine, NLT 98% … advtechind (S) …

  5. (S)-3-Phenyl-3- (4- (trifluoromethyl)phenoxy)propan-1-amine

    AABH303716C4-2.5MG Réf. du fournisseur: AA000TEZ-2.5MG 817,32 € Expédition sous 21 jour (s) – par un Aldrich Partner.

  6. (S)-Norfluoxetine | 126924-38-7

    (S)-Norfluoxetine is a labelled Fluoxetine (F597100) derivative,it is a stereoselective inhibitorof serotonin re-uptake and …

  7. (S)-Norfluoxetine | 126924-38-7

    (S)-Norfluoxetine is a labelled Fluoxetine (F597100) derivative,it is a stereoselective inhibitorof serotonin re-uptake and …

  8. CAS RN 126924-38-7 | Fisher Scientific

    CAS: 126924-38-7 Nom chimique ou matériau: (S)-Norfluoxetine Poids de la formule: 295.1184 Formule InChI: …

  9. CAS RN 126924-38-7 | Fisher Scientific

    CAS: 126924-38-7 Fórmula molecular: C16 H16 F3 N O Peso molecular (g/mol): 295.3 Sinónimo: Benzenepropanamine, γ- [4- …

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