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Paroxetine, sold under the brand name Paxil among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class[6] used to treat major depressive disorder, obsessive–compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, and premenstrual dysphoric disorder.[6] It has also been used in the treatment of premature ejaculation,[7] and hot flashes due to menopause.[6][8] It is taken orally (by mouth).[6]
Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction.[6] Serious side effects may include suicidal thoughts in those under the age of 25, serotonin syndrome, and mania.[6] While the rate of side effects appears similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndrome may occur more often.[9][10] Use in pregnancy is not recommended, while use during breastfeeding is relatively safe.[11] It is believed to work by blocking the reuptake of the chemical serotonin by neurons in the brain.[6]
Paroxetine was approved for medical use in the United States in 1992 and initially sold by GlaxoSmithKline.[6][12] It is on the World Health Organization’s List of Essential Medicines.[13] It is available as a generic medication.[14] In 2023, it was the 72nd most commonly prescribed medication in the United States, with more than 9 million prescriptions.[15][16] In 2018, it was in the top 10 of most prescribed antidepressants in the United States.[17]
Medical uses
Paroxetine is primarily used to treat major depressive disorder, obsessive–compulsive disorder, post-traumatic stress disorder, social anxiety disorder, and panic disorder. It is also occasionally used for agoraphobia, generalized anxiety disorder, premenstrual dysphoric disorder, and menopausal hot flashes.[18][19][20][21][22]
Depression
A variety of meta-analyses have been conducted to evaluate the efficacy of paroxetine in depression. They have variously concluded that paroxetine is superior to placebo and that it is equivalent to other antidepressants.[23][24][25] Despite this, there was no clear evidence that paroxetine was better or worse compared with other antidepressants at increasing response to treatment at any point in time.[26]
Anxiety disorders
Paroxetine was the first antidepressant approved in the United States for the treatment of panic disorder.[27][page needed] Several studies have concluded that paroxetine is superior to placebo in the treatment of panic disorder.[25][28]
Paroxetine has demonstrated efficacy for the treatment of social anxiety disorder in adults and children.[29][30] It is also beneficial for people with co-occurring social anxiety disorder and alcohol use disorder.[31] It appears to be similar to a number of other SSRIs.[32]
Paroxetine is used in the treatment of obsessive-compulsive disorder.[33] Comparative efficacy of paroxetine is equivalent to that of clomipramine and venlafaxine.[34][35] Paroxetine is also effective for children with obsessive-compulsive disorder.[36]
Paroxetine is approved for the treatment of PTSD in the United States, Japan, and Europe.[37][38][39] In the United States, it is approved for short-term use.
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Buy Paroxetine (Paxil ) Online
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Paroxetine, sold under the brand name Paxil among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class[6] used to treat major depressive disorder, obsessive–compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, and premenstrual dysphoric disorder.[6] It has also been used in the treatment of premature ejaculation,[7] and hot flashes due to menopause.[6][8] It is taken orally (by mouth).[6]
Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction.[6] Serious side effects may include suicidal thoughts in those under the age of 25, serotonin syndrome, and mania.[6] While the rate of side effects appears similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndrome may occur more often.[9][10] Use in pregnancy is not recommended, while use during breastfeeding is relatively safe.[11] It is believed to work by blocking the reuptake of the chemical serotonin by neurons in the brain.[6]
Paroxetine was approved for medical use in the United States in 1992 and initially sold by GlaxoSmithKline.[6][12] It is on the World Health Organization’s List of Essential Medicines.[13] It is available as a generic medication.[14] In 2023, it was the 72nd most commonly prescribed medication in the United States, with more than 9 million prescriptions.[15][16] In 2018, it was in the top 10 of most prescribed antidepressants in the United States.[17]
Medical uses
Paroxetine is primarily used to treat major depressive disorder, obsessive–compulsive disorder, post-traumatic stress disorder, social anxiety disorder, and panic disorder. It is also occasionally used for agoraphobia, generalized anxiety disorder, premenstrual dysphoric disorder, and menopausal hot flashes.[18][19][20][21][22]
Depression
A variety of meta-analyses have been conducted to evaluate the efficacy of paroxetine in depression. They have variously concluded that paroxetine is superior to placebo and that it is equivalent to other antidepressants.[23][24][25] Despite this, there was no clear evidence that paroxetine was better or worse compared with other antidepressants at increasing response to treatment at any point in time.[26]
Anxiety disorders
Paroxetine was the first antidepressant approved in the United States for the treatment of panic disorder.[27][page needed] Several studies have concluded that paroxetine is superior to placebo in the treatment of panic disorder.[25][28]
Paroxetine has demonstrated efficacy for the treatment of social anxiety disorder in adults and children.[29][30] It is also beneficial for people with co-occurring social anxiety disorder and alcohol use disorder.[31] It appears to be similar to a number of other SSRIs.[32]
Paroxetine is used in the treatment of obsessive-compulsive disorder.[33] Comparative efficacy of paroxetine is equivalent to that of clomipramine and venlafaxine.[34][35] Paroxetine is also effective for children with obsessive-compulsive disorder.[36]
Paroxetine is approved for the treatment of PTSD in the United States, Japan, and Europe.[37][38][39] In the United States, it is approved for short-term use.[38]
Paroxetine is also FDA-approved for generalized anxiety disorder.[40]
Menopausal hot flashes
In 2013, low-dose paroxetine was approved in the US for the treatment of moderate-to-severe vasomotor symptoms such as hot flashes and night sweats associated with menopause.[8] At the low dose used for menopausal hot flashes, side effects are similar to placebo and dose tapering is not required for discontinuation.
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Paroxetine (Paxil)
Paroxetine, widely recognized under the brand name Paxil, is a prescription medication used to treat several mood and anxiety disorders. It belongs to the class of medications known as selective serotonin reuptake inhibitors (SSRIs), which influence serotonin signaling within the brain.
Serotonin plays an important role in emotional regulation, stress response, sleep patterns, and cognitive processing. When serotonin communication becomes disrupted, individuals may experience persistent anxiety, depressive symptoms, or emotional instability.
By increasing the availability of serotonin in neural pathways, paroxetine may help restore more balanced communication between brain regions responsible for mood and emotional processing.
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