Buy Methamnetamine (methylnaphetamine) Cas 1178720-66-5
Methamnetamine (also known as methylnaphetamine, MNA, MNT, MNAP, PAL-1046, and MY-10) is a triple monoamine releasing agent of the amphetamine and naphthylaminopropane families. It is the N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine.[2][3][4] It has been sold online as a designer drug between 2015 and 2016.[5][6][7]
Pharmacology
Pharmacodynamics
Methamnetamine acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 13 nM, 34 nM, and 10 nM, respectively.[2] It is also a lower-potency partial agonist of the serotonin 5-HT2A receptor.[8]
| Compound | NETooltip Norepinephrine | DATooltip Dopamine | 5-HTTooltip Serotonin | Ref |
|---|---|---|---|---|
| d-Amphetamine | 6.6–10.2 | 5.8–24.8 | 698–1,765 | [9][10][11][12][13] |
| Naphthylaminopropane (NAP; PAL-287) | 11.1 | 12.6 | 3.4 | [14][11] |
| d-Methamphetamine | 12.3–14.3 | 8.5–40.4 | 736–1,292 | [9][15][11][13] |
| Methylnaphthylaminopropane (MNAP; PAL-1046) | 34 | 10 | 13 | [16][17] |
| l-Methcathinone | 13.1 | 14.8 | 1,772 | [18][12] |
| 2-Naphthylmethcathinone (BMAPN; βk-MNAP) | 94% at 10 μM | 34 | 27 | [19][20] |
| d-Ethylamphetamine | 28.8 | 44.1 | 333.0 | [21][22] |
| Ethylnaphthylaminopropane (ENAP; PAL-1045) | 137 | 46 a | 12 a | [16] |
| Phenmetrazine | 29–50.4 | 70–131 | 7,765–>10,000 | [23][11][24][25] |
| Naphthylmetrazine (PAL-704) | 203 | 111 | RI (105) | [25] |
| Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Footnotes: a ENAPTooltip Ethylnaphthylaminopropane is a partial releaser of serotonin (EmaxTooltip maximal efficacy = 66%) and dopamine (Emax = 78%). Refs:[26][27] | ||||
Society and culture
Legal status
Methamnetamine is illegal in Japan.[28]
Reviews
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