Buy Lortalamine (LM-1404) Cas 70384-91-7

Lortalamine (LM-1404) is an antidepressant which was synthesized in the early 1980s.^[1]^[2] It acts as a potent and highly selective norepinephrine reuptake inhibitor.^[3]^[4] Lortalamine was under development for clinical use but was shelved, likely due to the finding that it produced ocular toxicity in animals.^[5]^[6] It has been used to label the norepinephrine transporter in positron emission tomography studies.

Lortalamine is a novel and potent antidepressant agent

Biological Activity I Assay Protocols (From Reference)

Additional Infomation	Lortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. This drug has never passed clinical trials, likely due to its ocular toxicity in animals, but it has been used in positron emission tomography (PET) studies to label norepinephrine transporters.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Physicochemical Properties

Molecular Formula	C15H17CLN2O2
Molecular Weight	292.7607
Exact Mass	292.097
CAS #	70384-91-7
PubChem CID	51047
Appearance	Typically exists as solid at room temperature
LogP	1.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Heavy Atom Count	20
Complexity	432
Defined Atom Stereocenter Count	1
SMILES	CN1CC[C@]23C(C1)C(CC(=O)N2)C4=C(O3)C=CC(=C4)Cl
InChi Key	MJRPHRMGEKCADU-QHAMSDLMSA-N
InChi Code	InChI=1S/C15H17ClN2O2/c1-18-5-4-15-12(8-18)10(7-14(19)17-15)11-6-9(16)2-3-13(11)20-15/h2-3,6,10,12H,4-5,7-8H2,1H3,(H,17,19)/t10?,12?,15-/m0/s1
Chemical Name	(1S)-6-chloro-12-methyl-2-oxa-12,15-diazatetracyclo[7.5.3.01,10.03,8]heptadeca-3(8),4,6-trien-16-one
Synonyms	Lortalamine LM 1404 LM-1404 LM1404
HS Tariff Code	2934.99.9001
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Solubility Data

Solubility (In Vitro)	May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
Solubility (In Vivo)	Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples. Injection Formulations (e.g. IP/IV/IM/SC) Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline) Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2:* DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Injection Formulation 5:* 2-Hydroxypropyl-β-cyclodextrin : Saline = 50 : 50 (i.e. 500 μL 2-Hydroxypropyl-β-cyclodextrin → 500 μL Saline) Injection Formulation 6: DMSO : PEG300 : castor oil : Saline = 5 : 10 : 20 : 65 (i.e. 50 μL DMSO → 100 μLPEG300 → 200 μL castor oil → 650 μL Saline) Injection Formulation 7: Ethanol : Cremophor : Saline = 10： 10 : 80 (i.e. 100 μL Ethanol → 100 μL Cremophor → 800 μL Saline) Injection Formulation 8: Dissolve in Cremophor/Ethanol (50 : 50), then diluted by Saline Injection Formulation 9: EtOH : Corn oil = 10 : 90 (i.e. 100 μL EtOH → 900 μL Corn oil) Injection Formulation 10: EtOH : PEG300：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL EtOH → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Oral Formulations Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More Oral Formulation 3: Dissolved in PEG400 Oral Formulation 4: Suspend in 0.2% Carboxymethyl cellulose Oral Formulation 5: Dissolve in 0.25% Tween 80 and 0.5% Carboxymethyl cellulose Oral Formulation 6: Mixing with food powders Note: Please be aware that the above formulations are for reference only. InvivoChem strongly recommends customers to read literature methods/protocols carefully before determining which formulation you should use for in vivo studies, as different compounds have different solubility properties and have to be formulated differently. (Please use freshly prepared in vivo formulations for optimal results.)

Solubility (In Vitro)

May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples

Solubility (In Vivo)

Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.

Injection Formulations
(e.g. IP/IV/IM/SC)

Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)
*Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution.
Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline)
Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil)
Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals).

View More

Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)]
*Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.
Injection Formulation 5: 2-Hydroxypropyl-β-cyclodextrin : Saline = 50 : 50 (i.e. 500 μL 2-Hydroxypropyl-β-cyclodextrin → 500 μL Saline)
Injection Formulation 6: DMSO : PEG300 : castor oil : Saline = 5 : 10 : 20 : 65 (i.e. 50 μL DMSO → 100 μLPEG300 → 200 μL castor oil → 650 μL Saline)
Injection Formulation 7: Ethanol : Cremophor : Saline = 10： 10 : 80 (i.e. 100 μL Ethanol → 100 μL Cremophor → 800 μL Saline)
Injection Formulation 8: Dissolve in Cremophor/Ethanol (50 : 50), then diluted by Saline
Injection Formulation 9: EtOH : Corn oil = 10 : 90 (i.e. 100 μL EtOH → 900 μL Corn oil)
Injection Formulation 10: EtOH : PEG300：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL EtOH → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline)

Oral Formulations

Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium)
Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose
Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals).

View More

Oral Formulation 3: Dissolved in PEG400
Oral Formulation 4: Suspend in 0.2% Carboxymethyl cellulose
Oral Formulation 5: Dissolve in 0.25% Tween 80 and 0.5% Carboxymethyl cellulose
Oral Formulation 6: Mixing with food powders

Note: Please be aware that the above formulations are for reference only. InvivoChem strongly recommends customers to read literature methods/protocols carefully before determining which formulation you should use for in vivo studies, as different compounds have different solubility properties and have to be formulated differently.

(Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.4158 mL	17.0788 mL	34.1577 mL
	5 mM	0.6832 mL	3.4158 mL	6.8315 mL
	10 mM	0.3416 mL	1.7079 mL	3.4158 mL

Buy Lortalamine (LM-1404) Cas 70384-91-7

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70384-91-7

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Basic information
1. Product Name: Lortalamine
2. Synonyms: Lortalamine;LM-1404
3. CAS NO:70384-91-7
4. Molecular Formula: C15H17ClN2O2
5. Molecular Weight: 292.764
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 70384-91-7.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: 482.3°C at 760 mmHg
3. Flash Point: 245.5°C
4. Appearance: /
5. Density: 1.38g/cm³
6. Vapor Pressure: 1.86E-09mmHg at 25°C
7. Refractive Index: 1.644
8. Storage Temp.: N/A
9. Solubility: N/A
10. CAS DataBase Reference: Lortalamine(CAS DataBase Reference)
11. NIST Chemistry Reference: Lortalamine(70384-91-7)
12. EPA Substance Registry System: Lortalamine(70384-91-7)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 70384-91-7(Hazardous Substances Data)

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70384-91-7 Usage

Uses

Antidepressant.

Check Digit Verification of cas no

The CAS Registry Mumber 70384-91-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,3,8 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 70384-91:
(7*7)+(6*0)+(5*3)+(4*8)+(3*4)+(2*9)+(1*1)=127
127 % 10 = 7
So 70384-91-7 is a valid CAS Registry Number.

InChI:InChI=1/C15H17ClN2O2/c1-18-5-4-15-12(8-18)10(7-14(19)17-15)11-6-9(16)2-3-13(11)20-15/h2-3,6,10,12H,4-5,7-8H2,1H3,(H,17,19)/t10?,12?,15-/m0/s1

70384-91-7Upstream product

Buy Lortalamine (LM-1404) Cas 70384-91-7

Lortalamine

Lortalamine structure

CAS No.: 70384-91-7

Chemical Name:: Lortalamine

Synonyms: LM-1404;Lortalamine;4a,10-(Iminoethano)-4aH-[1]benzopyrano[3,2-c]pyridin-12-one, 8-chloro-1,2,3,4,10,10a-hexahydro-2-methyl-, (4aR,10R,10aS)-rel-

CBNumber:: CB41179071

Molecular Formula:: C15H17ClN2O2

Molecular Weight:: 292.76

MDL Number:

MOL File:: 70384-91-7.mol

MSDS File:: SDS

Last updated:2026-04-21 10:31:43

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Lortalamine Properties

Boiling point	482.3±45.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
pka	14.22±0.20(Predicted)
FDA UNII	9GIR4SV22T

Lortalamine Chemical Properties, Uses, Production

Uses

Antidepressant.

Lortalamine Preparation Products And Raw materials

Raw materials

Preparation Products

Lortalamine Suppliers

Global Suppliers ( 3)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

View Latest Price from Lortalamine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-21	Lortalamine 70384-91-7	$1520.00-2500.00			10g	TargetMol Chemicals Inc.

70384-91-7 (Lortalamine) Related Search:

4-(3-Chlorophenyl)piperidine 4-(4-Chloro-phenoxy)-piperidine 4-(2-Methylphenoxy)piperidine hydrochloride 1-(3,4-Dihydro-2H-chromen-3-yl)methanamine hydrochloride Chroman-3-yl-methylamine

[3-(4-Chloro-phenoxy)-propyl]-methyl-amine (6-Chloro-chroman-3-yl)-methylamine 5-(Aminomethyl)piperidin-2-one 4-Phenoxypiperidine hydrochloride 4-Phenoxypiperidine

3-Benzylpiperidine AKOS BC-0317 Lortalamine 3-(4-chlorophenoxy)propan-1-amine 4-(o-tolyloxy)piperidine

Lortalamine LM-1404 4a,10-(Iminoethano)-4aH-[1]benzopyrano[3,2-c]pyridin-12-one, 8-chloro-1,2,3,4,10,10a-hexahydro-2-methyl-, (4aR,10R,10aS)-rel- 70384-91-7

Buy Lortalamine (LM-1404) Cas 70384-91-7

LORTALAMINE

Norepinephrine ReuptakeAntidepressant PharmacologyIn Vitro Assay

Researchers requiring complete pharmacological isolation of the norepinephrine transporter without serotonergic, dopaminergic, or histaminergic off-target confounds face a critical gap with traditional NRIs. Lortalamine addresses this with its benzopyrano-iminoethano-piperidine scaffold.

Selective NET inhibition with negligible SERT/DAT activity – confirmed in rat brain cortex synaptosomal assays
No anticholinergic or antihistaminic properties, unlike tricyclic antidepressants
Validated PET radioligand scaffold ([11C]Lortalamine) for NET imaging studies
High purity ≥98%, suitable for ex vivo/in vitro experimental paradigms

Molecular FormulaC15H17ClN2O2

Molecular Weight292.76 g/mol

CAS No.70384-91-7

Cat. No.B1675143

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Technical Parameters

Basic Identity

Product Name	LORTALAMINE
CAS	70384-91-7
Synonyms	4a-amino-8-chloro-2-methyl-1,2,3,4,4a,10a-hexahydro-10H-benzopyrano(3,2-c)pyridin-10-ylacetic acid lactam, LM 1404, LM-1404, lortalamine, lortalamine, (4aR,10R,10aR)-isome
Molecular Formula	C15H17ClN2O2
Molecular Weight	292.76 g/mol

Structural Identifiers

SMILES	CN1CCC23C(C1)C(CC(=O)N2)C4=C(O3)C=CC(=C4)Cl
InChI	InChI=1S/C15H17ClN2O2/c1-18-5-4-15-12(8-18)10(7-14(19)17-15)11-6-9(16)2-3-13(11)20-15/h2-3,6,10,12H,4-5,7-8H2,1H3,(H,17,19)/t10-,12?,15+/m0/s1
InChIKey	MJRPHRMGEKCADU-PJRDJYAKSA-N

Commercial & Availability

Standard Pack Sizes	25 mg / 100 mg / 500 mg / Bulk Custom
Availability	In Stock
Custom Synthesis	Available on request

Handling Information

Appearance	Solid powder
Solubility	Soluble in DMSO
Storage	Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Structure & Identifiers

Lortalamine: Selective NRI for Research & PET Tracers

Lortalamine (LM-1404) is an experimental, non-tricyclic antidepressant compound from the structural class of 4a,10-(iminoethano)-4aH-[1]benzopyrano[3,2-c]pyridin-12-ones [1]. Functionally, it acts as a highly potent and selective norepinephrine reuptake inhibitor (NRI) [2]. Synthesized in the early 1980s, its clinical development was discontinued after preclinical findings of ocular toxicity in animals, redirecting its life-cycle toward its current role as a bioactive chemical probe and a carbon-11 radioligand for imaging norepinephrine transporters (NET) via positron emission tomography (PET) [3].

Selective NRI toolNET inhibition without SERT/DAT or receptor-level off-target activity

PET radioligand scaffold¹¹C-labeled comparator for NET tracer development programs

Ex vivo / in vitro contextSystemic in vivo use may require ocular-safety endpoint review

Lortalamine Differentiation from Other NRIs

Within the class of norepinephrine reuptake inhibitors, lortalamine’s differentiable value is rooted in a unique convergence of its potent NET binding, high functional monoamine selectivity, and non-tricyclic structure, which collectively separate it from both first-generation tricyclic antidepressants (e.g., imipramine) and other structurally distinct NRIs [1]. Importantly, lortalamine’s off-target receptor profile is markedly cleaner, being devoid of the anticholinergic and antihistaminic properties that confound experiments with tricyclics [1]. Furthermore, its established synthetic pathway to a carbon-11 radioligand enables direct comparative PET neuroimaging of the NET, a methodological bridge not available for all NRI analogs [2]. Consequently, simple within-class substitution without rigorous re-validation would introduce uncontrolled variability in receptor occupancy, pharmacokinetics, or imaging signal specificity, as detailed in the quantitative evidence below.

Target: Lortalamine

Potential substitute may differ

NET-selective; no anticholinergic/antihistaminic activityClean noradrenergic signal isolation

Tricyclic NRIs (imipramine)Anticholinergic and antihistaminic confounds may alter endpoint interpretation

Striatal-predominant PET uptake; high non-specific bindingDefined comparator baseline for tracer evaluation

(S,S)-[¹¹C]MRB / reboxetine analogsThalamus-predominant PET pattern; higher specific-to-nonspecific ratio may not transfer

Reported ocular toxicity in beagle dog at 10 mg/kg/dayMandatory in vivo exclusion review

Clinically used NRIs (reboxetine, atomoxetine)No corneal toxicity reported; model-safety context may differ

Lortalamine Quantitative Evidence

NE Uptake Inhibition vs. Imipramine

In a direct pharmacological head-to-head comparison, lortalamine demonstrated greater potency than the tricyclic antidepressant imipramine in inhibiting norepinephrine uptake in rat brain cortex slices [1]. The data indicate a superior functional blockade of the norepinephrine transporter under identical experimental conditions, supporting lortalamine’s role as a more potent molecular probe for NET-dependent mechanisms.

NE uptake vs. imipramine

Head-to-head

Lortalamine: NE uptake inhibition only; no 5-HT uptake; DA uptake only at high concentration

Imipramine: NE + 5-HT uptake inhibition; anticholinergic and antihistaminic activity present

Supports pharmacological NET isolation without serotonergic or cholinergic confounds

Rat brain cortex synaptosomes; exact IC50 ratio not reported

Norepinephrine ReuptakeAntidepressant PharmacologyIn Vitro Assay

In Vivo Reserpine Antagonism vs. Imipramine

In direct contrast with the tricyclic antidepressant class, lortalamine is devoid of anticholinergic and antihistaminic properties, as demonstrated in a comprehensive in-vivo pharmacological screen [1]. This differentiation is critical, as antagonism at muscarinic acetylcholine or histamine H1 receptors introduces confounding variables in behavioral and physiological studies.

Reserpine reversal

Reported

▲▲Reported rank: lortalamine >> imipramine in reserpine-induced ptosis and hypothermia reversal

Supports functional in vivo NET engagement validation at whole-organism level

Mouse reserpine model; exact ED50 ratio not available

Receptor SelectivityOff-Target ProfilingIn Vivo Pharmacology

Cardiovascular Safety vs. Imipramine

Lortalamine does not inhibit serotonin uptake by rat midbrain slices and interferes with the dopaminergic system only negligibly, as evidenced by its lack of interaction with apomorphine or amphetamine in mice and its inhibition of dopaminergic uptake by rat striatum synaptosomes only at very high concentrations [1]. This clean monoamine selectivity profile provides a definitive advantage over non-selective agents like imipramine, which broadly inhibits both serotonin and norepinephrine uptake.

Cardiac conduction

Head-to-head

Lortalamine: heart conduction reported far less impaired; no local anesthetic properties

Imipramine: significant conduction slowing via sodium channel blockade; measurable local anesthetic activity

Supports cleaner cardiac endpoint profiling in ex vivo cardiovascular studies

Anesthetized dog preparation; endpoint context requires species-specific review

Monoamine TransportersNeurotransmitter SelectivityFunctional Assay

Human Pharmacokinetics vs. Class-Average NRIs

Following an oral dose of 5 mg of radiolabeled lortalamine in humans, plasma concentrations peaked at approximately 44 ng equiv./mL (1.5-3 h), with unchanged drug exhibiting a half-life of about 5 hours [1]. Excretion was almost exclusively renal (98% within 5 days), and the major metabolite was identified by mass spectrometry as the N-demethylated compound, alongside a keto derivative from piperidine ring oxidation [1]. This clear, well-defined human pharmacokinetic signature is not universally established for all NRI analogs and supports its use in translational neuroimaging and pharmacology research.

Human PK profile

Class-level

~5 ht½

98% urinary recovery; N-demethylation as major clearance route; Cmax ~17 ng/mL at 1.5–3 h

Supports rapid-washout tracer study design vs. hepatically cleared NRIs with longer half-lives

Single 5 mg oral dose; n and study design require source review

Human PharmacokineticsADMEMetabolite Profiling

PET Imaging vs. (S,S)-[¹¹C]MRB

In a direct comparative PET evaluation in baboons, [11C]lortalamine was benchmarked against other NET radioligands including (R)-[11C]nisoxetine and [11C]oxaprotiline [1]. All three ligands displayed high uptake in the striatum (higher than in the thalamus), but their utility was limited by high non-specific binding and relatively low specific signal [1]. Consequently, the study concluded that the reboxetine analog (S,S)-[11C]MRB was the superior PET ligand, outperforming the lortalamine-based tracer by providing a more favorable specific-to-non-specific binding ratio [1].

PET brain uptake

Head-to-head

[¹¹C]Lortalamine: striatum > thalamus; high non-specific binding; radiochemical yield 63–97%

(S,S)-[¹¹C]MRB: thalamus > striatum (physiological NET pattern); higher specific signal

Supports comparator use in NET PET ligand development; non-physiological striatal bias requires review

Baboon PET; rank: MRB > fluoro-reboxetine > lortalamine ≈ nisoxetine

PET ImagingNeuroimagingRadiotracer Development

Lortalamine Validated Applications

Noradrenergic System Studies (Ex Vivo/In Vitro)

Use lortalamine as a selective norepinephrine reuptake inhibitor in behavioral or physiological studies where the cholinergic adverse effects of tricyclic antidepressants (e.g., imipramine) would confound results. Its quantitative advantage—a complete absence of anticholinergic and antihistaminic properties—ensures that observed outcomes are attributable to NET-specific modulation [1].

PET Tracer Development Reference

Employ lortalamine as a reference standard in experiments designed to distinguish between NET, SERT, and DAT functionality. Lortalamine’s demonstrated inability to block serotonin uptake and its negligible effect on dopamine uptake at therapeutic concentrations make it an ideal pharmacological tool for isolating norepinephrine transport activity [1].

Scaffold for NET-Selective Analog Design

Utilize lortalamine as a reference compound in human in-vitro metabolism or species-comparison studies. Its well-defined human ADME profile (oral bioavailability, ~5 h half-life, 98% renal elimination, major N-demethylation metabolite) provides a solid quantitative framework for comparative pharmacokinetic modeling [2].

Behavioral Pharmacology Positive Control

Apply [11C]lortalamine in PET studies as a second-line or validation radiotracer for imaging the cerebral norepinephrine transporter. While its in-vivo specific-to-non-specific binding ratio is suboptimal compared to (S,S)-[11C]MRB, its reliable C-11 labeling chemistry and well-characterized in-vivo regional brain uptake pattern make it a valuable counter-ligand for head-to-head radiopharmaceutical development [3].

Noradrenergic ex vivo/in vitro studies

NET selectivity without SERT/DAT/receptor confounds

SERT and off-target receptor exclusion in isolated tissue preparations

PET tracer development reference

Defined striatal-predominant baseline with high non-specific binding

Specific-to-nonspecific binding ratio improvement over comparator ligands

Medicinal chemistry scaffold

Benzopyrano-iminoethano-piperidine chemotype orthogonal to reboxetine

Ocular-toxicity liability elimination via structural modification

Behavioral pharmacology control

Reported high-effect-size NET engagement in acute dosing models

Model responsiveness validation with species-appropriate ocular monitoring

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Norepinephrine reuptake inhibitor

Buy Lortalamine (CAS 70384-91-7) – Selective NRI for NET Research

High-purity Lortalamine (≥98%), a non-tricyclic, highly selective norepinephrine reuptake inhibitor. Free of anticholinergic & …
Lortalamine 70384-91-7 | MedChemExpress

MedChemExpress provides Lortalamine CAS 70384-91-7, related Reference Standards, Isotope-Labeled or GMP Grade …
Lortalamine (LM 1404) | Norepinephrine Transporter …

Lortalamine (LM 1404) is a selective norepinephrine transporter inhibitor with an …
CAS No.: 70384-91-7

IC 50 & Target: IC 50: <1 nM (norepinephrine transporter) [1]

Formula: C 15 H 17 ClN 2 O 2

Molecular Weight: 292.76
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Lortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. This drug never made it past clinical …
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Alias: Lortalamine LM 1404 LM-1404 LM1404 Cat No.:V5492Purity: ≥98% COA Product Data Instructions for use SDS Lortalamine is …

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Buy Lortalamine (LM-1404) Cas 70384-91-7

70384-91-7

Basic information

Chemical Properties

Safety Data

70384-91-7 Suppliers

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Buy Lortalamine (LM-1404) Cas 70384-91-7

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Buy Lortalamine (LM-1404) Cas 70384-91-7

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70384-91-7 Usage

Uses

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Lortalamine

Lortalamine Properties

Lortalamine Chemical Properties, Uses, Production

Uses

Lortalamine Preparation Products And Raw materials

Raw materials

Preparation Products

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LORTALAMINE

Technical Parameters

Structure & Identifiers

Lortalamine: Selective NRI for Research & PET Tracers

Lortalamine Differentiation from Other NRIs

Lortalamine Quantitative Evidence

NE Uptake Inhibition vs. Imipramine

In Vivo Reserpine Antagonism vs. Imipramine

Cardiovascular Safety vs. Imipramine

Human Pharmacokinetics vs. Class-Average NRIs

PET Imaging vs. (S,S)-[¹¹C]MRB

Lortalamine Validated Applications

Noradrenergic System Studies (Ex Vivo/In Vitro)

PET Tracer Development Reference

Scaffold for NET-Selective Analog Design

Behavioral Pharmacology Positive Control

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Product Requirements

Buy Lortalamine (LM-1404) Cas 70384-91-7

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Buy Lortalamine (LM-1404) Cas 70384-91-7

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