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Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Levomethorphan (LVM) (INN, BAN) is an opioid analgesic of the morphinan family that has never been marketed.[2] It is the L–stereoisomer of racemethorphan (methorphan).[2] The effects of the two isomers of racemethorphan are quite different, with dextromethorphan (DXM) being an antitussive at low doses and a hallucinogen at much higher doses.[3] Levomethorphan is about five times stronger than morphine.[4]

Levomethorphan is a prodrug to levorphanol, analogously to DXM acting as a prodrug to dextrorphan or codeine behaving as a prodrug to morphine.[5] As such, levomethorphan has similar effects to levorphanol but is less potent as it must be demethylated to the active form by liver enzymes before being able to produce its effects.[5] As a prodrug of levorphanol, levomethorphan functions as a potent agonist of all three of the opioid receptors, μ, κ (κ1 and κ3 but notably not κ2), and δ, as an NMDA receptor antagonist, and as a serotonin-norepinephrine reuptake inhibitor.[5] Via activation of the κ-opioid receptor, levomethorphan can produce dysphoria and psychotomimetic effects such as dissociation and hallucinations.[6]

Levomethorphan is listed under the Single Convention on Narcotic Drugs 1961 and is regulated like morphine in most countries. In the United States it is a Schedule II Narcotic controlled substance with a DEA ACSCN of 9210 and a 2014 annual aggregate manufacturing quota of 195 grams, up from 6 grams the year before. The salts in use are the tartrate (free base conversion ratio 0.644) and hydrobromide (0.958).[7] As of February 2026[when?], no levomethorphan pharmaceuticals are marketed in the United States.[citation needed]

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

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Buy Levomethorphan (LVM) Cas 125-70-2

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Buy Levomethorphan (LVM) Cas 125-70-2

Buy Levomethorphan (LVM) Cas 125-70-2

Levomethorphan (LVM) (INN, BAN) is an opioid analgesic of the morphinan family that has never been marketed.[2] It is the L–stereoisomer of racemethorphan (methorphan).[2] The effects of the two isomers of racemethorphan are quite different, with dextromethorphan (DXM) being an antitussive at low doses and a hallucinogen at much higher doses.[3] Levomethorphan is about five times stronger than morphine.[4]

Levomethorphan is a prodrug to levorphanol, analogously to DXM acting as a prodrug to dextrorphan or codeine behaving as a prodrug to morphine.[5] As such, levomethorphan has similar effects to levorphanol but is less potent as it must be demethylated to the active form by liver enzymes before being able to produce its effects.[5] As a prodrug of levorphanol, levomethorphan functions as a potent agonist of all three of the opioid receptors, μ, κ (κ1 and κ3 but notably not κ2), and δ, as an NMDA receptor antagonist, and as a serotonin-norepinephrine reuptake inhibitor.[5] Via activation of the κ-opioid receptor, levomethorphan can produce dysphoria and psychotomimetic effects such as dissociation and hallucinations.[6]

Levomethorphan is listed under the Single Convention on Narcotic Drugs 1961 and is regulated like morphine in most countries. In the United States it is a Schedule II Narcotic controlled substance with a DEA ACSCN of 9210 and a 2014 annual aggregate manufacturing quota of 195 grams, up from 6 grams the year before. The salts in use are the tartrate (free base conversion ratio 0.644) and hydrobromide (0.958).[7] As of February 2026[when?], no levomethorphan pharmaceuticals are marketed in the United States.[citation needed]

See also

References

  1.  Anvisa (2023-03-31). “RDC Nº 784 – Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial” [Collegiate Board Resolution No. 784 – Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2.  Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springe. pp. 656–. ISBN 978-1-4757-2085-3.
  3.  Hornback JM (31 January 2005). Organic Chemistry. Cengage Learning. pp. 243–. ISBN 0-534-38951-1.
  4.  Wainer IW (1996). “Toxicology Through a Looking Glass: Stereochemical Questions and Some Answers”. In Wong SH, Sunshine I (eds.). Handbook of Analytical Therapeutic Drug Monitoring and Toxicology. CRC Press. ISBN 9780849326486.
  5.  Gudin J, Fudin J, Nalamachu S (January 2016). “Levorphanol use: past, present and future”. Postgraduate Medicine. 128 (1): 46–53. doi:10.1080/00325481.2016.1128308. PMID 26635068. S2CID 3912175.
  6.  Bruera ED, Portenoy RK (12 October 2009). Cancer Pain: Assessment and Management. Cambridge University Press. pp. 215–. ISBN 978-0-521-87927-9.
  7.  “Conversion Factors for Controlled Substances”. DEA Diversion Control Division. U.S. Department of Justice, Drug Enforcement Administration (DEA). Archived from the original on 2016-03-02. Retrieved 2014-06-18.

    CAS 125-70-2 — Levomethorphan Solution (3 x 1.2 mL) (0.1 mg/mL 3-Methoxy-17-methylmorphinan in methanol) – USP CRS

    CAS 125-70-2C18H25NOMW C18H25NO

    Levomethorphan Solution is a controlled, analytical reference standard of 3-Methoxy-17-methylmorphinan dissolved in methanol, primarily used in pharmaceutical and forensic analysis for method validation, quality control, and research. This 3 x 1.2 mL solution contains 0.1 mg/mL of levomethorphan (CAS 125-70-2) with the molecular formula C18H25NO and a molecular weight of 283.41 g/mol. Store at ambient conditions. The product carries a **Danger** signal word due to its controlled nature. Molekula supplies Levomethorphan Solution from research to bulk quantities with full documentation and ISO 9001:2015 traceability.

    View product details

    Molekula products for CAS 125-70-2

    Levomethorphan Solution (3 x 1.2 mL) (0.1 mg/mL 3-Methoxy-17-methylmorphinan in methanol) – USP CRS

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    May 28, 2026 · levomethorphan (CAS 125-70-2) information, including chemical …

    • Hazard statements: H302
    • Signal word: Warning
    • Precautionary statements: P264-P270-P301+P312-P501
    • Symbol (GHS): GHS07

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