Buy Etonitazene (EA-4941) Cas 911-65-9

Etonitazene, also known as EA-4941 or CS-4640,^[2] is a benzimidazole opioid, first reported in 1957,^[3] that has been shown to have approximately 1,000 to 1,500 times the potency of morphine in animals.

Because it is characterized by a strong dependency potential and a tendency to produce profound respiratory depression, it is not used in humans. It is, however, useful in animal models for addiction studies, particularly those requiring the animals to drink or ingest the agent, because it is not as bitter as opiate salts like morphine sulfate.^{[citation needed]}

911-65-9 etonitazene
Chemical Name	etonitazene
Synonyms	1-(2-diethylaminoethyl)-2-(4-ethoxybenzyl)-5-nitrobenzimidazole;2-[2-(4-ethoxybenzyl)-5-nitro-1H-benzimidazol-1-yl]-N,N-diethylethanamine
Molecular Formula	C22H28N4O3
Molecular Weight	396.4827
InChl	InChI=1/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
CAS Registry Number	911-65-9
EINECS	213-009-1
Molecular Structure
Density	1.17g/cm3
Boiling Point	580.7°C at 760 mmHg
Refractive Index	1.591
Flash Point	305°C
Vapour Pressur	1.78E-13mmHg at 25°C
MSDS	Material Safety Data Sheet

Etonitazene is one of just two nitazenes that was banned in the UK since 1971, the other being clonitazene, as these were included in UN conventions.

Nitazenes were not seen in the UK drug market until they began to appear in heroin in the early 2020s. In 2024 Etonitazene was moved to Schedule 1 alongside 14 other nitazenes being added to the UK Misuse of Drugs Act.

Etonitazene (exempt preparation)

Item No. 43514

Exempt Product (US)

Synonyms

Synonyms

• NIH 7607

Technical Information

Formal Name

2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-5-nitro-1H-benzimidazole-1-ethanamine

CAS Number

911-65-9

Molecular Formula

C₂₂H₂₈N₄O₃

Formula Weight

396.5

Purity

≥98%

Formulation

A 1 mg/ml solution in methanol

λ_max

242 nm

SMILES

CCN(CC)CCN1C2=CC=C([N+]([O-])=O)C=C2N=C1CC3=CC=C(OCC)C=C3

InChi Code

InChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3

InChi Key

PXDBZSCGSQSKST-UHFFFAOYSA-N

Regulatory Information

DEA Exempt Notification

This product is a DEA exempt preparation of a scheduled compound – does not require DEA Controlled Substance registration or DEA 222 form. For alternate sizes please contact sales.

Shipping & Storage Information

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specification

The Etonitazene, with CAS registry number 911-65-9, has the systematic name of 2-[2-(4-ethoxybenzyl)-5-nitro-1H-benzimidazol-1-yl]-N,N-diethylethanamine. Besides this, it is also called 1-(2-(Diethylamino)ethyl)-2-(p-ethoxybenzyl)-5-nitrobenzimidazole. Its classification code is Drug / Therapeutic Agent. And the chemical formula of this chemical is C₂₂H₂₈N₄O₃. What’s more, its EINECS is 213-009-1. This chemical has a strong dependency potential similar to that of morphine, and a strong tendency to produce respiratory depression, and is therefore not used in humans. It is however useful in addiction studies on animals. It is often used in studies requiring the animals to drink or ingest the opiate because it is not as bitter as the opiate salts, i.e., morphine sulfate.

Physical properties of Etonitazene: (1)ACD/LogP: 5.16; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 2.08; (4)ACD/LogD (pH 7.4): 2.8; (5)ACD/BCF (pH 5.5): 4.08; (6)ACD/BCF (pH 7.4): 21.3; (7)ACD/KOC (pH 5.5): 12.7; (8)ACD/KOC (pH 7.4): 66.25; (9)#H bond acceptors: 7; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 10; (12)Polar Surface Area: 76.11 Å²; (13)Index of Refraction: 1.591; (14)Molar Refractivity: 113.75 cm³; (15)Molar Volume: 336.5 cm³; (16)Polarizability: 45.09×10^-24cm³; (17)Surface Tension: 44.5 dyne/cm; (18)Density: 1.17 g/cm³; (19)Flash Point: 305 °C; (20)Enthalpy of Vaporization: 86.85 kJ/mol; (21)Boiling Point: 580.7 °C at 760 mmHg; (22)Vapour Pressure: 1.78E-13 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: [O-][N+](=O)c3ccc1c(nc(n1CCN(CC)CC)Cc2ccc(OCC)cc2)c3
(2)InChI: InChI=1/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
(3)InChIKey: PXDBZSCGSQSKST-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
(5)Std. InChIKey: PXDBZSCGSQSKST-UHFFFAOYSA-N

The toxicity data is as follows:

 

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	250ug/kg (0.25mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Chimica Therapeutica. Vol. 2, Pg. 16, 1967.

Recommended Products

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Metodesnitazene (hydrochloride) (exempt preparation)

40975

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38653

Butonitazene (exempt preparation)

43515

Etonitazene-d₅ (exempt preparation)

43092

Etodesnitazene (CRM)

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

A number of analogues are known, with the only other well-known compound to come out of the original 1950s research being clonitazene, which is much weaker than etonitazene (around 3x morphine). More recently since around late 2018 a number of designer analogues have started to appear on illicit markets around the world, with the most prominent compounds being metonitazene, isotonitazene and etazene, though others have continued to appear.^[6][7]

Of these analogues, only etonitazene and clonitazene are explicitly listed under UN conventions and so are controlled throughout the world. The rest would only be illegal in countries such as the US, Australia and New Zealand that have laws equivalent to the Federal Analog Act. In the United States Etonitazene is a Schedule I narcotic controlled substance with a DEA ACSCN of 9624 and a 25 gram (7⁄8 oz) manufacturing quota as of 2022.

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