Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

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Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Etodesnitazene (also known as desnitroetonitazene, etazen, etazene, and etazone) is a benzimidazole-derived opioid analgesic drug, which was originally developed in the late 1950s alongside etonitazene and a range of related derivatives.[1] It is many times less potent than etonitazene itself, but still 70 times more potent than morphine in animal studies. Corresponding analogues where the N,N-diethyl group is replaced by piperidine or pyrrolidine rings also retain significant activity (10 times and 20 times morphine, respectively).[2] Etodesnitazene has been sold as a designer drug,[3] first being identified in both Poland and Finland in March 2020.[4][5] Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

United Kingdom

Since 15 January 2025 it is covered by the UK’s generic definition on 2-benzyl benzimidazole derived opioids[6][7] because it contains the 2-(2-benzyl-benzimidazol-1-yl)ethanamine backbone with only the following modification:[8]

  • The phenyl ring of the benzyl system is substituted by an alkoxy group containing two carbon atoms.

See also

Desnitroetonitazene, commonly known as Etazene, is a high-purity benzimidazole opioid analytical reference standard used in forensic toxicology, analytical chemistry, medicinal chemistry, pharmaceutical research, and analytical method development. It belongs to the benzimidazole class of synthetic opioids and is structurally related to compounds such as etonitazene, isotonitazene, metonitazene, and protonitazene.

Due to its well-characterized chemical profile, Etazene serves as an important laboratory reference material for the identification, detection, metabolism, and analytical characterization of emerging synthetic opioids. It is supplied exclusively for scientific and laboratory research and has no approved medical or therapeutic use.

What is Desnitroetonitazene (Etazene)?

Desnitroetonitazene is a synthetic benzimidazole derivative originally developed during investigations into opioid receptor pharmacology. Although structurally related to other nitazene compounds, it lacks the nitro group found in several closely related analogues, making it valuable for comparative structure–activity relationship (SAR) studies.

Today, Etazene is primarily utilized as an analytical reference compound for forensic laboratories investigating novel synthetic opioids and for researchers studying receptor interactions, metabolism, and analytical identification.

Chemical Structure and Properties

Desnitroetonitazene possesses several defining structural characteristics:

  • Benzimidazole core
  • Diethylamino side chain
  • Ethoxybenzyl substituent
  • High analytical stability
  • Crystalline laboratory-grade material
  • Suitable for reference standard applications

These molecular features support reproducible analytical performance across modern laboratory instrumentation.

Pharmacological Research

Experimental research has shown that Desnitroetonitazene interacts with the μ-opioid receptor (MOR), making it useful in opioid receptor pharmacology and medicinal chemistry research.

Current scientific investigations include:

  • Opioid receptor binding studies
  • Structure–activity relationship (SAR) analysis
  • Drug metabolism research
  • Analytical characterization
  • Medicinal chemistry investigations
  • Comparative studies of benzimidazole opioids
  • Toxicological reference development

These applications contribute to understanding the chemistry and analytical behavior of emerging synthetic opioids.

Scientific Research Applications

Desnitroetonitazene is widely used in:

  • Forensic toxicology laboratories
  • Academic research institutions
  • Pharmaceutical research facilities
  • Medicinal chemistry laboratories
  • Analytical chemistry laboratories
  • Clinical toxicology method development
  • Drug identification programs
  • Reference material production
  • Laboratory quality assurance

Analytical Applications

Professional laboratories utilize Desnitroetonitazene for:

  • LC-MS/MS calibration
  • GC-MS analysis
  • LC-QTOF-MS identification
  • High-Resolution Mass Spectrometry (HRMS)
  • HPLC method development
  • Method validation
  • Analytical quality control
  • Forensic screening panels
  • Certified reference library development

Its consistent analytical characteristics make it valuable for identifying and differentiating emerging synthetic opioids.

Why Researchers Choose Desnitroetonitazene

Researchers value Desnitroetonitazene because it offers:

  • Well-defined molecular structure
  • High analytical purity
  • Reliable chromatographic performance
  • Consistent reference material quality
  • Broad forensic applicability
  • Valuable SAR comparison compound
  • Excellent analytical reproducibility

These qualities make Etazene an important analytical standard within forensic and pharmaceutical research laboratories.

Related Research Compounds

Researchers frequently compare Desnitroetonitazene with:

  • Etonitazene
  • Isotonitazene
  • Metonitazene
  • Protonitazene
  • Butonitazene
  • Etodesnitazene
  • Nitazene analogues
  • Other benzimidazole opioid derivatives

Comparative research supports investigations into receptor pharmacology, analytical identification, metabolism, and medicinal chemistry.

Storage and Handling

For optimal laboratory stability:

  • Store in airtight laboratory containers.
  • Protect from moisture and humidity.
  • Avoid prolonged exposure to direct sunlight.
  • Maintain recommended laboratory storage temperatures.
  • Handle using appropriate laboratory personal protective equipment (PPE).
  • Follow institutional laboratory safety procedures.

Frequently Asked Questions

What is Desnitroetonitazene?

Desnitroetonitazene (Etazene) is a benzimidazole opioid analytical reference standard used in forensic toxicology, medicinal chemistry, pharmaceutical research, and analytical chemistry.

Which laboratories use Desnitroetonitazene?

It is commonly used by forensic laboratories, pharmaceutical researchers, analytical chemistry laboratories, academic institutions, and toxicology research facilities.

Which analytical techniques are used with Desnitroetonitazene?

Researchers commonly analyze Desnitroetonitazene using LC-MS/MS, LC-QTOF-MS, GC-MS, HPLC, and HRMS for compound identification, calibration, and analytical method validation.

Why is Desnitroetonitazene important in research?

Its defined molecular structure and analytical consistency make it valuable for studying synthetic opioid chemistry, metabolism, analytical detection, and structure–activity relationships.

Is Desnitroetonitazene intended only for research?

Yes. This product is supplied exclusively for laboratory, analytical, scientific, and educational research purposes.

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Buy Etodesnitazene (desnitroetonitazene) Cas 14030-76-3

Etodesnitazene

Catalog No.
S13273491
CAS No.
14030-76-3
M.F
C22H29N3O
M. Wt
351.5 g/mol
Availability
In Stock
* This item is exclusively intended for research purposes and is not designed for human therapeutic applications or veterinary use.
Etodesnitazene

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General Information

Forensic labs require exact desnitro reference materials to avoid false negatives when differentiating emerging nitazenes. Etodesnitazene delivers distinct chromatographic and metabolic fingerprints that cannot be replicated by nitro-analogs.

  • 1.920 min retention time & [M+H]+ 352.2383 exact mass enable robust LC-MS/MS panel calibration.
  • Generates >20 unique Phase I/II metabolites for comprehensive biomarker library construction.
  • μ-opioid receptor Ki = 1.02 nM in [3H]DAMGO displacement and β-arrestin2 assays.

Supplied as a certified reference material for toxicology, ADME, and receptor pharmacology studies.

CAS Number

14030-76-3

Product Name

Etodesnitazene

IUPAC Name

2-[2-[(4-ethoxyphenyl)methyl]benzimidazol-1-yl]-N,N-diethylethanamine

Molecular Formula

C22H29N3O

Molecular Weight

351.5 g/mol

InChI

InChI=1S/C22H29N3O/c1-4-24(5-2)15-16-25-21-10-8-7-9-20(21)23-22(25)17-18-11-13-19(14-12-18)26-6-3/h7-14H,4-6,15-17H2,1-3H3

InChI Key

BMLPNUNXHUGDOI-UHFFFAOYSA-N

Canonical SMILES

CCN(CC)CCN1C2=CC=CC=C2N=C1CC3=CC=C(C=C3)OCC

2-(2-(4-ethoxybenzyl)-1H-benzimidazol-1-yl)-N,N-diethylethan-1-amine is a DEA Schedule I controlled substance. Substances in the DEA Schedule I have no currently accepted medical use in the United States, a lack of accepted safety for use under medical supervision, and a high potential for abuse. It is a Opiates substance.

Synonyms

Etazene, Desnitroetonitazene, N,N-Diethyl-2-[(4-ethoxyphenyl)methyl]-1H-benzimidazole-1-ethanamine, 2-(4-Ethoxybenzyl)-1-(2-(diethylamino)ethyl)-1H-benzo[d]imidazole

Purity

≥98%

Package Size

1 mg, 5 mg, 10 mg, 25 mg

Etodesnitazene Baseline Procurement Overview

Etodesnitazene (CAS 14030-76-3), also known as etazene or desnitroetonitazene, is a synthetic 2-benzylbenzimidazole opioid characterized by the absence of the 5-nitro substitution present in its parent class [1]. In industrial and laboratory procurement, it serves as a critical certified reference material (CRM) and pharmacological standard. Its unique physicochemical properties—specifically its altered polarity, high lipophilicity, and distinct metabolic footprint compared to nitro-bearing nitazenes—make it indispensable for forensic toxicology, liquid chromatography-mass spectrometry (LC-MS/MS) method development, and in vitro receptor binding studies [2]. Buyers prioritize this specific desnitro analog to accurately map structure-activity relationships, validate complex metabolic biomarkers, and calibrate toxicological screening panels for emerging non-fentanyl opioids [3].

Research Fit

Mu-opioid receptor agonist research compound; 2-benzylbenzimidazole class
5-Desnitro structure distinguishes from higher-potency nitro-containing analogs
Forensic toxicology reference standard and opioid pharmacology research tool

References

Generic Substitution Failure for Etodesnitazene

Substituting etodesnitazene with its nitrated analog (etonitazene) or a generic opioid benchmark (fentanyl) critically compromises analytical and pharmacological workflows [1]. The absence of the 5-nitro group fundamentally shifts the molecule’s lipophilicity and polarity, resulting in drastically different chromatographic retention times and ionization behaviors in mass spectrometry [2]. Furthermore, etodesnitazene produces a highly specific, complex array of over 20 unique metabolites (predominantly via O-dealkylation and N-deethylation) that cannot be modeled or extrapolated from closely related analogs like isotonitazene or metonitazene [3]. Consequently, forensic laboratories and ADME researchers must procure the exact desnitro compound to avoid false negatives in toxicological screening, ensure accurate peak identification, and establish precise receptor affinity baselines [1].

Substitution Risk

Intra-class potency varies >300-fold; 5-nitro absence correlates with lower potency versus nitro-analogs.
Metabolic pathways differ markedly (22 vs 9 metabolites for metonitazene), altering assay specificity.
Analog substitution may yield divergent MOR activation and in vivo behavioral profiles.

References

Etodesnitazene Differentiation Evidence

Retention Time and Polarity Shift

In standardized LC-qTOF-MS forensic validation protocols, the absence of the 5-nitro group in etodesnitazene causes a massive shift in polarity and column interaction compared to its nitrated counterparts. Etodesnitazene elutes at 1.920 minutes, whereas etonitazene elutes significantly later at 4.435 minutes [1]. This 2.515-minute difference dictates that etonitazene cannot be used as a proxy for retention time mapping.

Evidence Dimension LC-qTOF-MS Retention Time
Target Compound Data 1.920 min
Comparator Or Baseline Etonitazene (4.435 min)
Quantified Difference 2.515 minutes earlier elution
Conditions Standardized LC-qTOF-MS forensic validation protocol (positive ionization mode)

The massive shift in polarity necessitates the exact desnitro standard to prevent misidentification and ensure accurate retention time mapping in multiplexed toxicology panels.

MOR Potency vs Fentanyl
Head-to-head
~4× lower
Reported in vitro potency context
5-Desnitro structure reduces MOR activation

MOR Binding Affinity Calibration

Receptor binding assays utilizing [3H]DAMGO displacement in rat brain tissue homogenates demonstrate that etodesnitazene possesses a Ki of 1.02 nM. This indicates an approximately 5-fold lower affinity than its 5-nitro analog etonitazene (Ki = 0.21 nM), yet it maintains a slightly higher affinity than the industry benchmark fentanyl (Ki = 1.26 nM) [1]. This distinct mid-tier potency profile is unique to the desnitro structure.

Evidence Dimension MOR Binding Affinity (Ki)
Target Compound Data 1.02 nM
Comparator Or Baseline Etonitazene (0.21 nM) and Fentanyl (1.26 nM)
Quantified Difference ~5-fold lower affinity than etonitazene; ~1.2-fold higher than fentanyl
Conditions [3H]DAMGO displacement assay in rat brain tissue homogenates

Procurement of the exact compound is vital for calibrating in vitro functional assays to accurately reflect the distinct potency profile of desnitro-nitazenes versus their nitro-bearing counterparts.

Analgesic Potency vs Morphine
Reported
70× higher
Reported in vivo model-response context
Animal analgesia models; not a clinical potency benchmark

Metabolic Complexity and Biomarker Generation

When incubated with 10-donor-pooled human hepatocytes and analyzed via LC-HRMS, etodesnitazene generates an exceptionally complex profile of 22 distinct Phase I and Phase II metabolites. In direct contrast, closely related analogs isotonitazene and metonitazene yield only 12 and 9 metabolites, respectively [1]. The generation of specific O-dealkyl and N-deethyl-O-dealkyl biomarkers is exclusive to the etodesnitazene metabolic pathway.

Evidence Dimension Number of distinct human metabolites generated
Target Compound Data 22 metabolites
Comparator Or Baseline Isotonitazene (12 metabolites) and Metonitazene (9 metabolites)
Quantified Difference Generates 10 to 13 more distinct metabolites than closely related nitazenes
Conditions 10-donor-pooled human hepatocyte incubation analyzed via LC-HRMS

The high metabolic complexity requires the specific parent CRM to synthesize and validate the unique biomarkers required for definitive forensic urine and blood screening.

Metabolic Profile vs Analogues
Reported
22 metabolites
Supports forensic assay specificity
LC-HRMS/MS hepatocyte incubation; 9–12 metabolites for comparators

CYP450 Inhibition and Efflux Transport

In silico and in vitro ADME profiling reveals that etodesnitazene acts as a broad-spectrum inhibitor of CYP1A2, CYP2C19, CYP2D6, and CYP3A4 [1]. Furthermore, unlike the baseline opioid morphine, etodesnitazene is not a substrate for the p-glycoprotein (p-gp) efflux transporter, fundamentally altering its blood-brain barrier penetration and accumulation dynamics [1].

Evidence Dimension CYP inhibition and p-glycoprotein (p-gp) affinity
Target Compound Data Inhibits CYP1A2, 2C19, 2D6, 3A4; non-p-gp substrate
Comparator Or Baseline Morphine (p-gp substrate, lacks identical pan-CYP inhibition)
Quantified Difference Broad-spectrum CYP inhibition and lack of p-gp efflux
Conditions In silico and in vitro ADME profiling

Essential for toxicologists and pharmacologists modeling specific drug-drug interactions and blood-brain barrier penetration mechanisms unique to benzimidazole opioids.

Dopamine Elevation vs Saline
Head-to-head
~200% baseline at 40 min
Reported neurochemical endpoint context
In vivo microdialysis, nucleus accumbens shell

Etodesnitazene Industrial & Analytical Applications

LC-HRMS Forensic Method Development

Utilizing the distinct 1.920 min retention time and [M+H]+ 352.2383 exact mass to build and validate multiplexed screening panels that reliably differentiate desnitro-opioids from classic nitazenes in complex biological matrices [1].

In Vitro ADME and Metabolite Synthesis

Serving as the parent substrate in human hepatocyte incubations to generate, isolate, and characterize its 22 unique Phase I/II metabolites (especially O-dealkylated forms) for the creation of clinical biomarker libraries [2].

Pharmacological Receptor Assay Calibration

Acting as a mid-potency benchmark (Ki = 1.02 nM) in [3H]DAMGO displacement and beta-arrestin 2 recruitment assays to map the structure-activity relationships (SAR) of the benzimidazole core lacking the 5-nitro group [3].

Drug-Drug Interaction (DDI) Modeling

Employing the compound in CYP450 inhibition assays to study the toxicological implications of its pan-CYP (CYP1A2, 2C19, 2D6, 3A4) suppression in poly-drug use scenarios, leveraging its non-p-glycoprotein substrate status [4].

Application Fit

Application
Selection Property
Validation Focus
Forensic toxicology biomarker assays
Unique metabolite profile (22 metabolites)
Assay specificity for etodesnitazene vs other nitazenes in forensic samples
MOR structure-activity relationship studies
5-Desnitro intermediate-potency benchmark
Quantitative SAR model calibration
Reward circuit neurochemical studies
Reported dopamine elevation ~200% baseline
Temporal and quantitative dopamine response benchmarking

References

  1. Etodesnitazene (CAS 14030-76-3) | μ-Opioid Agonist | SMolecule

    Buy Etodesnitazene (CAS 14030-76-3) from SMolecule. High-purity desnitro opioid standard for LC-MS/MS method validation & …

  2. Etodesnitazene | 14030-76-3 – ChemicalBook

    Dec 10, 2023 · Etodesnitazene (CAS 14030-76-3) information, including chemical properties, structure, …

  3. Etodesnitazene | CS-O-48327 | CAS 14030-76-3 | Clearsynth

    Buy Etodesnitazene from Clearsynth. View CAT No. CS-O-48327, CAS No. 14030-76-3, molecular formula, molecular weight, stock …

  4. Etodesnitazene CAS#: 14030-76-3 – ChemicalBook

    Apr 15, 2024 · Etodesnitazene is a new synthetic opioid bearing structural resemblance to etonitazene, a synthetic opioid that is …

    • CAS: 14030-76-3
    • MW: 351.49
    • MF: C22H29N3O
    • Product Name: Etodesnitazene

  5. Etodesnitazene (CRM) (CAS 14030-76-3)

    Etodesnitazene (CRM) (Item No. 43092) is a certified reference material categorized as an opioid. 1 Etodesnitazene has been found …

  6. Etodesnitazene (citrate) (Desnitroetonitazene, Etazene, Etazone …

    Etodesnitazene (citrate): An Analytical Reference Standard. Synonyms: Desnitroetonitazene, Etazene, Etazone. Purity: ≥98%.

  7. Etazene – TeamChemists.com supplier of research chemicals. Shop …

    You can buy Etazene online at teamchemists.com. Etazen or Etazene (Etodesnitazene (Desnitroetonitazene, Etazone) is a designer …

  8. Desnitroetonitazene (Etazene) – Best Research Chemicals

    Desnitroetonitazene (Etazene) is exclusively sold for scientific research, analytical testing, and forensic study. It is not approved for …

  9. Etazene Etodesnitazene for sale | Buy Etodesnitazene CAS: 14030-76-3

    Etazene | Buy Etodesnitazene, an opioid analgesic developed as a designer drug replacement for etonitazene, has a similar effect …

  10. Etazene – Chemical Route

    Etodesnitazene is a benzimidazole-based opioid analgesicthat was originally developed alongside etonitazene during the 1950s. …

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