Buy EF-1502 (GABA reuptake inhibitor) Cas 684645-54-3

EF-1502 is a GABA reuptake inhibitor. It could potentially be used to treat seizures.

Mechanism of action

Tests in mice have shown that this compound possesses and anticonvulsant effect due to its GABA reuptake inhibiting properties.^[3]^[4]

Madsen, Karsten K.; White, H. Steve; Schousboe, Arne (March 2010). “Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs”. Pharmacology & Therapeutics. 125 (3): 394–401. doi:10.1016/j.pharmthera.2009.11.007. ISSN 1879-016X. PMID 20026354.
Schousboe, Arne; Larsson, Orla M.; Sarup, Alan; White, H. Steve (2004-10-01). “Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy”. European Journal of Pharmacology. 500 (1–3): 281–287. doi:10.1016/j.ejphar.2004.07.032. ISSN 0014-2999. PMID 15464040.
Madsen, Karsten K.; Hansen, Gert H.; Danielsen, E. Michael; Schousboe, Arne (February 2015). “The subcellular localization of GABA transporters and its implication for seizure management”. Neurochemical Research. 40 (2): 410–419. doi:10.1007/s11064-014-1494-9. ISSN 1573-6903. PMID 25519681.
Schousboe, Arne; Sarup, Alan; Larsson, Orla M.; White, H. Steve (2004-10-15). “GABA transporters as drug targets for modulation of GABAergic activity”. Biochemical Pharmacology. 68 (8): 1557–1563. doi:10.1016/j.bcp.2004.06.041. ISSN 0006-2952. PMID 15451399.

EF1502 is a novel, potent and selective GAT1/BGT1 inhibitor that exhibit mechanistic differences in their ability to modulate the ataxia …

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