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new p
Cas 20320-59-6
new bmk 20320-59-6
Diethyl(phenylacetyl)malonate
2-(2-phenylacetyl)propanedioate
Diethyl(phenylacetyl)malonate(new bmk)
phenylacetyl-malonic acid diethyl ester
White Powder New P Pharmaceutical Grade
diethyl 2-(2-phenylacetyl)propanedioate
diethyl 2-(2-phenylacetyl)propanedioatec
White Powder Diethyl(phenylacetyl)malonate
Diethyl(phenylacetyl)malonate White Powder
Propanedioic acid, (phenylacetyl)-, diethyl ester
Diethyl 2-(2-phenylacetyl)propanedioate 99% Purity
diethyl 2-(2-phenylacetyl)propanedioate wickr bettyml
Propanedioic acid, 2-(2-phenylacetyl)-, 1,3-diethyl ester
Pharmaceutical intermediates Diethyl(phenylacetyl)malonate
Diethyl 2-(2-phenylacetyl)propanedioate Pharmaceutical Grade
High Purity Propanedioic acid, 2-(2-phenylacetyl)-, 1,3-diethyl ester

 

[EINECS(EC#)]

205-854-1

[Molecular Formula]

C15H18O5

[MDL Number]

MFCD28989869

[MOL File]

20320-59-6.mol

[Molecular Weight]

278.3

Chemical Properties Back Directory
[Boiling point ]

120 °C(Press: 0.01 Torr)

[density ]

1.148±0.06 g/cm3(Predicted)

[form ]

Brown liquid

[pka]

8.76±0.59(Predicted)

[InChI]

InChI=1S/C15H18O5/c1-3-19-14(17)13(15(18)20-4-2)12(16)10-11-8-6-5-7-9-11/h5-9,13H,3-4,10H2,1-2H3

[InChIKey]

ZASPDQDIPTZTQQ-UHFFFAOYSA-N

[SMILES]

C(OCC)(=O)C(C(CC1=CC=CC=C1)=O)C(OCC)=O

Raw materials And Preparation Products Back Directory
Hazard Information Back Directory
[Physical properties]

Diethyl(phenylacetyl)malonate has a boiling point of 120 °C. Its density is predicted to be 1.148±0.06 g/cm3.

[Uses]

Organic synthesis intermediates.

[Preparation]

The anhydrous ethanol co-vaporized with diethyl phthalate and sodium metal is added dropwise to the mixture of diethyl malonate, carbon tetrachloride and magnesium, heated to start the reaction, and the temperature is controlled to smooth the reaction. Then add anhydrous diethyl ether, heat for 1h, add the diethyl ether solution of phenylacetyl chloride (add slowly, not to make the reaction too intense). After the reaction is completed, cool and add water, separate the oil layer, and evaporate the diethyl ether under reduced pressure to obtain diethyl(phenylacetyl)malonate.

[storage]

Dry and cool place and keep away from strong light.

 

Diethyl(phenylacetyl)malonate

Another name:phenylacetyl-malonic acid diethyl ester;Phenylacetyl-malonsaeure-diaethylester;Phenylacetylmalonsaeurediethylester;

CasNo: 20320-59-6 Purity: ≥98% Molecular Structure: C15H18O5

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Diethyl(phenylacetyl)malonate Basic Product Information

Product NameCASSynonymsMolecular FormulaEINECS NumberMolecular StructureAppearance PuritySupply Ability

Diethyl(phenylacetyl)malonate 20320-59-6
phenylacetyl-malonic acid diethyl ester;

Phenylacetyl-malonsaeure-diaethylester;

Phenylacetylmalonsaeurediethylester;

C15H18O5
205-854-1
Wine red oily liquid
≥98%
1T / Per Month

Diethyl(phenylacetyl)malonate Quality documents

20320-59-6 COA.pdf

20320-59-6 MSDS.pdf

Diethyl(phenylacetyl)malonate Appearance/Package/Shipping/Storage

Package

25kg/drum

Storage condition

Store in a cool, dry, and sealed place;

Diethyl(phenylacetyl)malonate Application

Organic synthesis intermediates, pharmaceutical intermediates;

Diethyl(phenylacetyl)malonate literature

Comprehensive study on excited state intramolecular proton transfer in 2-(benzo[d]thiazol-2-yl)-3-methoxynaphthalen-1-ol and 2-(benzo[d]thiazol-2-yl)naphthalene-1,3-diol: Effect of solvent, aggregation, viscosity and TDDFT study

Warde, Umesh,Nagaiyan, Sekar

, p. 33 – 43 (2017)

Three compounds DMT, MMT and DHT having dimehtoxy, mono-hydroxy and di-hydroxy groups respectively were prepared. Environmental interactions dependent photophysical properties especially excited state intramolecular proton transfer (ESIPT), solvatochromism, aggregation induced emission enhancement (AIEE) and viscosity dependent emission characteristics were studied. The effect of solvent polarity on ESIPT dynamics were studied using UV–vis and emission spectroscopy along with aggregation induced enhanced emission and viscosity effect. MMT and DHT showed unexpected and contrasting behavior in the solvents which are in good agreement with the density functional theory and time dependent density functional theory findings. Aggregation and viscosity study showed that cis-keto emission increased drastically in the aggregate state and highly viscous state due to restricted intramolecular rotation increasing the population of required cis enol rotamer (E). The study directs the potential applications of such molecules for advanced optoelectronics and viscosity based investigations.

The Interrupted Pummerer Reaction in a Sulfoxide-Catalyzed Oxidative Coupling of 2-Naphthols

He, Zhen,Pulis, Alexander P.,Procter, David J.

supporting information, p. 7813 – 7817 (2019/05/15)

A benzothiophene S-oxide catalyst, generated in situ by sulfur oxidation with H2O2, mediates the oxidative coupling of 2-naphthols. Key to the catalytic process is the capture and inversion of reactivity of a 2-naphthol partner, using an interrupted Pummerer reaction of an unusual benzothiophene S-oxide, followed by subsequent coupling with a second partner. The new catalytic manifold has been showcased in the synthesis of the bioactive natural products, (±)-nigerone and (±)-isonigerone. Although Pummerer reactions are used widely, their application in catalysis is rare, and our approach represents a new catalytic manifold for metal-free C?C bond formation.

INDOLIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS

–

, (2013/11/05)

A novel class of indoline-2-one derivatives are disclosed. These compounds are protein kinase inhibitors which are useful for treating hyperproliferative diseases such as cancer.

Novel Inhibitors of Hepatitis C Virus Replication

–

Page/Page column 52-53, (2009/10/21)

The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Diethyl(phenylacetyl)malonate Upstream and downstream

20320-59-6 Upstream product

  • 996-82-7
  • sodium diethylmalonate
  • 103-80-0
  • phenylacetyl chloride
  • 105-53-3
  • diethyl malonate
  • 570-08-1
  • diethyl acetylmalonate
  • 137786-67-5
  • ethyl 3-amino-2-ethoxycarbonyl-2-butenoate
  • 2033-24-1
  • cycl-isopropylidene malo

Buy Diethyl(phenylacetyl)malonate

Diethyl(phenylacetyl)malonate, also known as diethyl phenylacetylmalonate, is an organic compound classified as a complex ester. This compound is a derivative of malonic acid where one of the hydrogens is replaced by a phenylacetyl group.

Synonyms:

Diethyl 2-(2-phenylacetyl)propanedioate
20320-59-6
diethyl 2-(phenylacetyl)malonate
Diethyl (phenylacetyl)propanedioate
Propanedioic acid, 2-(2-phenylacetyl)-, 1,3-diethyl ester
Propanedioic acid, (phenylacetyl)-, diethyl ester

Key Features:

  1. Chemical formula : C15H18O5
  2. CAS number: 20320-59-6
  3. Molecular weight : 278.30 g/mol
  4. Physical state : Typically an oily liquid.
  5. Solubility : Soluble in organic solvents such as ether, ethanol, and acetone.

Applications:

Diethyl(phenylacetyl)malonate is used in organic synthesis, predominantly as a precursor or reagent in the synthesis of various chemical compounds. It can be used to create a variety of pharmaceutical products, including active pharmaceutical ingredients.

This compound can also play a role in the synthesis of peptides and other complex organic molecules, including narcotic analogs, making it an important component in chemical research.

Additional Information

Not for food, drug, human, animal or household use. For laboratory, R&D, industrial or manufacturing only.

 

Diethyl(phenylacetyl)malonate

CAS No.
20320-59-6
Chemical Name:
Diethyl(phenylacetyl)malonate
Synonyms
Cas 20320-59-6;new p;Propanedioic;20320 59 6;Phenylacetylmalonsaeurediethylester;diethyl 2-(2-phenylacetyl)propanedioate;diethyl 2-(2-phenylacetyl)propanedioate wickr bettyml;New BMK Oil;BMK Oil/powder;bmk Lliquid oil
CBNumber:
CB61075043
Molecular Formula:
C15H18O5
Molecular Weight:
278.3
MDL Number:
MFCD28989869
MOL File:
20320-59-6.mol
MSDS File:
SDS
Last updated:2026-03-01 21:15:31
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Diethyl(phenylacetyl)malonate Properties

Boiling point 120 °C(Press: 0.01 Torr)
Density 1.148±0.06 g/cm3(Predicted)
pka 8.76±0.59(Predicted)
form Brown liquid
InChI InChI=1S/C15H18O5/c1-3-19-14(17)13(15(18)20-4-2)12(16)10-11-8-6-5-7-9-11/h5-9,13H,3-4,10H2,1-2H3
InChIKey ZASPDQDIPTZTQQ-UHFFFAOYSA-N
SMILES C(OCC)(=O)C(C(CC1=CC=CC=C1)=O)C(OCC)=O

Diethyl(phenylacetyl)malonate Chemical Properties, Uses, Production

Chemical Properties

Diethyl phenylacetylmalonate contains two ester bonds, which are relatively unreactive, but which can be hydrolyzed in the presence of a suitable catalyst to produce compounds such as phenylacetic acid and ethanol. The compound can also be esterified with other alcohols to produce different ester compounds, e.g., with methanol to give methyl phenylacetylmalonate. By acid-catalyzed hydrolysis, the compound can generate phenylacetylmalonic acid, and further addition of water can obtain phenylacetic acid and diethyl malonate.

Physical properties

Diethyl(phenylacetyl)malonate has a boiling point of 120 °C. Its density is predicted to be 1.148±0.06 g/cm3.

Uses

Organic synthesis intermediates.

Preparation

The anhydrous ethanol co-vaporized with diethyl phthalate and sodium metal is added dropwise to the mixture of diethyl malonate, carbon tetrachloride and magnesium, heated to start the reaction, and the temperature is controlled to smooth the reaction. Then add anhydrous diethyl ether, heat for 1h, add the diethyl ether solution of phenylacetyl chloride (add slowly, not to make the reaction too intense). After the reaction is completed, cool and add water, separate the oil layer, and evaporate the diethyl ether under reduced pressure to obtain diethyl(phenylacetyl)malonate.

storage

Dry and cool place and keep away from strong light.

64-17-5
74965-87-0
20320-59-6
Synthesis of Diethyl(phenylacetyl)malonate from Ethanol and 1,3-Dioxane-4,6-dione, 2,2-dimethyl-5-(2-phenylacetyl)-

Diethyl(phenylacetyl)malonate Preparation Products And Raw materials

Global Suppliers ( 71)
Supplier Tel Email Country ProdList Advantage

Rongchuang International

+86-13175533356 +86-13175533356 kevin@rongchuangintl.com China 256 58

Wuhan Aoliqisi New Material Technology Co., Ltd.

+86-13545906766; 13545906766 sales@whaop.com China 257 58

Zhejiang J&C Biological Technology Co.,Limited

+1-2135480471 sales@sarms4muscle.com China 10378 58

GIHI CHEMICALS CO.,LIMITED

+86-571-86217390; +8618058761490 info@gihichemicals.com China 49856 58

DEI MEI YI YAO KE JI LLC

+852-52854821 +852-52854821 cici71684@gmail.com China 878 58

HANGZHOU LEAP CHEM CO., LTD.

+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Zhengzhou HongSheng Pharmaceutical Co., Ltd. 0371-0371-13526885213 15637198702 hsyykjchem@163.com China 1854 58
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 4988 55
Shaoguan Mingtu Chemical Co., Ltd 13411131983 2407385074@qq.com China 2046 58
Guangzhou Yunmen Biotechnology Co., Ltd 0751-18902340975/189023400307 18902340307 3356812514@qq.com China 9225 58

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View Latest Price from Diethyl(phenylacetyl)malonate manufacturers

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Diethyl(phenylacetyl)malonate pictures 2026-10-01 Diethyl(phenylacetyl)malonate

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Diethyl(phenylacetyl)malonate pictures 2025-08-20 Diethyl(phenylacetyl)malonate

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Diethyl(phenylacetyl)malonate pictures 2025-07-29 Diethyl(phenylacetyl)malonate

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  1. Diethyl (phenylacetyl)malonate | 20320-59-6 – ChemicalBook

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    • Molecular Formula: C 15 H 18 O 5
    • Name: diethyl 2- (2-phenylacetyl)propanedioate
    • Molecular Weight: 278.30000
  4. Diethyl (phenylacetyl)malonate – Ozon Chemical

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    • CAS number: 20320-59-6
    • Molar mass: 278.3 g/mol
    • Formula: C15H18O5
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