Buy d2-MDMA deuterated-MDMA (D-MDMA)

d2-MDMA, also known as d2-3,4-methylenedioxymethamphetamine or as deuterated-MDMA (D-MDMA), is an entactogen and stimulant of the phenethylamine, amphetamine, and MDxx families related to MDMA (“ecstasy”).^[1]^[2]^[3]^[4]^[5]^[6] It is the deuterated isotopologue of MDMA in which the hydrogen atoms on the carbon atom of the 3,4-methylenedioxy ring have been replaced with the deuterium isotopes.^[1]^[2]^[6]

MDMA is known to produce serotonergic neurotoxicity and associated cognitive deficits and emotional and behavioral changes.^[1]^[2] The neurotoxicity of MDMA may be due in part to metabolism of MDMA via opening of the 3,4-methylenedioxy ring or O–demethylation to form catechol metabolites like 3,4-dihydroxyamphetamine (HHA; α-methyldopamine) and 3,4-dihydroxymethamphetamine (HHMA; α,N-dimethyldopamine).^[1]^[2] These metabolites may subsequently undergo further metabolism into reactive oxygen species (ROS) that damage serotonergic neurons.^[1]^[2] In relation to this, d2-MDMA is thought to be resistant to metabolism in this location due to the greater amount of energy required to break deuterium–carbon bonds compared to hydrogen–carbon bonds.^[1]^[2] As a result, d2-MDMA may have less neurotoxic potential than MDMA.^[1]^[2] On the other hand, whereas the pharmacokinetics and neurotoxicity of d2-MDMA may be altered compared to MDMA, it is thought that the drug will have similar or near-identical pharmacodynamics as MDMA, for instance interactions with monoamine transporters and serotonin receptors, aside from differing metabolites.^[1]^[2] Due to the reduced O-demethylation with d2-MDMA, N-demethylation into d2-MDA may instead predominate with this compound in contrast to MDMA.