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So, you’re looking to buy Butonitazene online. It’s a smart move if you know what you’re doing, but it can also be a minefield. Butonitazene is a synthetic opioid that belongs to the benzimidazole class. Initially synthesized in the 1950s, it gained attention for its potent analgesic properties. However, its use has raised significant concerns due to its high potency and association with severe adverse effects. Buy butonitazene online
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Now, about its legal status. Butonitazene is under strict regulation by the DEA and FDA. Always check if it’s legal to buy Butonitazene in your area. Some places have stringent laws, while others are more lenient.
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While initially explored for its analgesic properties, butonitazene lacks approval for medical use in most countries due to safety concerns and high potential for abuse. Research into its clinical applications remains limited, focusing more on its illicit use and associated health risks.
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What is the legal status of butonitazene globally?
Legal status: Butonitazene is classified as a controlled substance due to its high potency and associated risks.
What are the primary risks associated with butonitazene use?
Primary risks: High risk of overdose, dependence, and fatalities are associated with butonitazene use.
Is butonitazene approved for medical use anywhere?
Medical approval: It is not approved for medical use in most countries due to safety concerns.
How does butonitazene compare to other opioids in terms of potency?
Potency comparison: Butonitazene is significantly more potent than traditional opioids like morphine or heroin.
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Treatment options: Addiction rehabilitation programs and support services are essential for managing butonitazene addiction.
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Harm reduction: Strategies include needle exchange programs, naloxone distribution, and safe injection sites.
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Community action: Public awareness campaigns, community education, and policy advocacy are critical in addressing the crisis.
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Long-term implications: Butonitazene misuse contributes to ongoing opioid crises, impacting public health and societal well-being.
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Butonitazene CAS:95810-54-1 Factory safety delivery quality first class
Chemical Name:Butonitazene
CAS;95810-54-1
SynonymsButonitazene;1H-Benzimidazole-1-ethanamine, 2-[(4-butoxyphenyl)methyl]-N,N-diethyl-5-nitro-
CBNumber:CB48232397
Molecular Formula:C24H32N4O3
Molecular Weight:424.54
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When you seek to Buy Butonitazene For Sale, you’re investing in a distinct opioid analgesic belonging to the benzimidazole class. This compound, a structural analogue of etonitazine, offers exceptional potency. Studies conducted on rats have consistently demonstrated that the opioid potency of Butonitazene is dozens of times superior to morphine when administered intravenously. Consequently, it functions as a potent analgesic, a hypnotic agent, and a strong sedative. It is important to note that opioid euphoria and dependence can readily arise with regular use, as evidenced by these comprehensive research studies.
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Butonitazene, also known by its synonym Butoxynitazene, is a fascinating subject within chemical research. This top-quality Butonitazene compound is chemically identified by its IUPAC name: 2-(2-(4-butoxybenzyl)-5-nitro-1H-benzo[d]imidazol-1-yl)-N,N-diethylethan-1-amine. Its formal name is specified as 2-[(4-butoxyphenyl)methyl]-N,N-diethyl-5-nitro-1H-benzimidazole-1-ethanamine. With a CAS number of 95810-54-1, its molecular structure is defined by the formula C₂₄H₃₂N₄O₃, yielding a molecular weight of 424.55 g·mol⁻¹. This precise chemical identity underscores its significance as a subject of detailed pharmacological and analytical investigation, making it an essential addition to any discerning research laboratory looking for high-purity compounds.
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Our commitment to supplying high-quality research-grade Butonitazene extends to transparent product specifications and competitive pricing. Butonitazene is offered in various formulations, predominantly as a neat solid or fine powder, and typically presents as a crystalline solid. Its solubility characteristics are well-defined, providing crucial data for laboratory preparation and experimentation:
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Butonitazene is a potent synthetic opioid analgesic derived from the benzimidazole class, often compared to etonitazene.
Butonitazene is a novel synthetic opioid and a structural analogue of etonitazene, a compound first synthesized in the 1950s. It falls under the broad category of nitazene analogues. These substances are known for their exceptional potency, often exceeding that of morphine by significant margins. Researchers classify Butonitazene as a new psychoactive substance (NPS), requiring rigorous study to understand its full impact on biological systems. Our commitment at Chem14 is to supply verified samples for this crucial research.
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Butonitazene carries CAS number 95810-54-1, with molecular formula C24H32N4O3 and a molecular weight of 424.54 g/mol.
The IUPAC name reads 2-(2-(4-butoxybenzyl)-5-nitro-1H-benzo[d]imidazol-1-yl)-N,N-diethylethan-1-amine. This structure features a benzimidazole core, a nitro group at position 5, and a butoxybenzyl substituent. PubChem lists its exact mass as 424.2474. Cayman Chemical provides analytical standards for precise identification in forensic labs. Our product at Chem14.com matches these specifications for reliable research outcomes.
(Imagine here: Chemical structure diagram of Butonitazene showing benzimidazole ring with nitro and butoxybenzyl groups.)
Why is Butonitazene Significant in Research?
The emergence of Butonitazene highlights the ongoing evolution of opioid chemistry. For researchers, it offers a unique opportunity to study structure-activity relationships (SAR) within the benzimidazole class. Understanding how the butyl substitution affects the binding affinity at opioid receptors is vital for developing antidotes and understanding toxicity profiles.
Chemical and Pharmacological Profile
It acts primarily as a full agonist at the mu-opioid receptor, exhibiting high potency and potential respiratory depression.
The chemical structure of Butonitazene features a benzimidazole core, a characteristic shared with other nitazenes. The primary distinction lies in the N-alkyl substitution, which in this case is a butyl group. This modification significantly influences its lipophilicity and receptor binding kinetics.
Mechanism of Action
Like its predecessors, Butonitazene functions primarily as a mu-opioid receptor agonist. When it binds to these receptors in the central nervous system, it mimics the effects of endogenous opioids. However, due to its high efficacy, it can induce profound physiological responses even at minute doses.
- Receptor Affinity: It binds strongly to mu-opioid receptors, with varying affinity for delta and kappa receptors.
- Metabolism: Research suggests it undergoes metabolic processing in the liver, though specific metabolic pathways are still under investigation.
- Potency: Preliminary data indicates it is significantly more potent than fentanyl in certain assays, necessitating extreme caution in laboratory settings.
How Does Butonitazene Work? Mechanism of Action Explained
Butonitazene functions as a full mu-opioid receptor agonist, producing analgesia, euphoria, and respiratory depression similar to classic opioids.
Butonitazene binds to mu-opioid receptors (MOR) with nanomolar affinity, activating G-protein pathways and recruiting β-arrestin-2. This leads to potent analgesic effects in mice, with peak activity lasting around 90 minutes. Studies show it recruits β-arrestin more than some opioids, potentially increasing side effect risks like respiratory suppression. The World Health Organization notes its efficacy matches fentanyl in certain assays. Researchers at Chem14.com value this compound for probing opioid signalling pathways.
Butonitazene Data Summary
The following table provides a quick reference for the key chemical properties of Butonitazene.
| Property | Details |
|---|---|
| IUPAC Name | 1-butyl-4-(p-nitrophenylethyl)-4,9-dihydro-3H-benzimidazol-2-one |
| Class | Synthetic Opioid / Benzimidazole |
| Molecular Formula | C19H20N4O3 |
| Molecular Weight | 352.39 g/mol |
| Appearance | Typically a yellow or off-white powder |
| Solubility | Soluble in organic solvents like DMSO and ethanol |
Note: Researchers should verify all data against specific batch certificates of analysis provided upon purchase.
Legal Status of Butonitazene in USA, UK, and EU
Legal status varies, but many countries classify it as a controlled substance analogue due to its structural similarity.
Because Butonitazene is an analogue of etonitazene, it often falls under existing analogue acts or controlled substance legislation in various jurisdictions.
- United States: In the USA, the DEA has moved to control many nitazene analogues. Butonitazene may be considered a Schedule I controlled substance under the Federal Analogue Act if intended for human consumption.
- United Kingdom: The UK has a strict Psychoactive Substances Act. Many nitazenes are classed as Class A or B drugs under the Misuse of Drugs Act.
- Germany & Europe: Germany typically controls new synthetic opioids via the BtMG (NpSG). We advise all customers to verify local regulations before attempting to buy Butonitazene online.
Disclaimer: We sell our products strictly for forensic and research purposes. It is the responsibility of the buyer to ensure compliance with all local laws.
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Potential side effects include severe respiratory depression, sedation, and pinpoint pupils, characteristic of strong opioid agonists.
While our products are not for human consumption, understanding the toxicology is essential for laboratory safety. Butonitazene is extremely potent. Accidental exposure can be life-threatening.
Safety Protocols for Handling
Researchers must adhere to strict safety guidelines when handling this powder.
- PPE: Always wear nitrile gloves, a lab coat, and a respirator to avoid inhalation or skin contact.
- Fume Hood: Handle all materials within a certified chemical fume hood.
- Naloxone Availability: Given its potency, laboratories handling synthetic opioids should have naloxone (an opioid antagonist) readily available as an emergency measure for accidental exposure.
Comparative Toxicology
Compared to other opioids like heroin or fentanyl, nitazenes like Butonitazene may present a higher risk of respiratory depression at lower doses. This makes them a major subject of study in toxicology reports regarding the opioid crisis.
“The potency of nitazene analogues requires a re-evaluation of current detection methods in forensic toxicology.” — Journal of Analytical Toxicology
Research Applications and Future Directions
The study of Butonitazene is not limited to its dangers. It provides a window into the pharmacology of pain and addiction. By analyzing how this compound interacts with opioid receptors, scientists can develop safer analgesics with fewer side effects. Furthermore, improving detection methods for Butonitazene in biological samples is a priority for public health labs.
We support this vital work by providing reference standards. If you are studying the broader class of substances, we also supply isotonitazene and protonitazene for comparative analysis.
What is Butonitazene used for in research?
Butonitazene serves as a reference standard to study opioid receptor binding, analgesia, and toxicology in controlled lab settings.
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Butonitazene falls under Class B controls in the UK. Purchase only for legitimate research with proper authorisation.
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Studies indicate Butonitazene shows comparable or higher potency in some mu-opioid assays, with significant overdose risks.
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Reported effects include respiratory depression, sedation, pinpoint pupils, and potential fatality in misuse cases.
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Butonitazene
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Forensic labs face false negatives with fentanyl assays when encountering butonitazene. This reference standard solves that with exact mass 424.5 Da and distinct retention time for unambiguous LC-QTOF-MS identification. • Calibrates high-resolution mass spectrometers to distinguish butonitazene from isotonitazene and etonitazene. • Benchmark in HLM assays with CLint 309 µL/min/mg for CYP2D6/2B6 metabolic mapping. • Validates cAMP inhibition and β-arrestin recruitment assays (MOR pEC50 7.2). Supplied with certificate of analysis; immediate global shipping.
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Butonitazene (CAS 95810-54-1) is a synthetic 2-benzylbenzimidazole opioid, commonly classified within the nitazene family, featuring a distinct butoxy chain at the para-position of the benzyl ring. In B2B procurement, it is primarily sourced as a highly pure analytical reference standard and pharmacological probe for forensic toxicology, metabolic profiling, and receptor binding assays. Unlike traditional morphinan or anilidopiperidine (fentanyl) scaffolds, butonitazene provides a specific structural configuration that dictates its distinct pharmacokinetic and pharmacodynamic profile. Procurement of this exact compound is critical for laboratories requiring precise mass spectrometry calibration and structure-activity relationship (SAR) benchmarking for emerging synthetic opioids [1].
Research Fit
Generic substitution of butonitazene with closely related nitazenes, such as isotonitazene or etonitazene, fundamentally compromises forensic attribution and metabolic assay integrity. While these compounds share the benzimidazole core, the specific butoxy moiety of butonitazene significantly alters its mu-opioid receptor (MOR) binding affinity and accelerates its hepatic clearance rate. In analytical workflows, standard fentanyl immunoassays fail to detect or differentiate nitazenes, making the exact mass and retention time of butonitazene indispensable for resolving false positives in LC-QTOF-MS panels. Substituting it with a shorter-chain analog skews calibration curves, invalidates CYP450 depletion models, and prevents accurate legal and toxicological identification [1].
Substitution Risk
MOR binding affinity decreases with longer alkoxy chains; butoxy differs markedly from methoxy or ethoxy.
EC50 and Emax values diverge across chain lengths; butoxy exhibits a distinct efficacy profile.
Antinociceptive potency scales dramatically; butoxy results in a substantially attenuated behavioral response.
Accelerated Hepatic Clearance in CYP450 Assays
In human liver microsome (HLM) assays, the butoxy chain of butonitazene drives a significantly faster metabolic breakdown compared to its shorter-chain analogs. Quantitative profiling demonstrates that butonitazene achieves an intrinsic clearance (CLint) of 309 µL/min/mg protein, alongside a 99% depletion by CYP2D6 within 30 minutes. In contrast, isotonitazene and protonitazene exhibit lower CLint values of 221 and 216 µL/min/mg, respectively, under identical assay conditions [1].
| Evidence Dimension | In vitro intrinsic clearance (CLint) in Human Liver Microsomes (HLM) |
| Target Compound Data | 309 µL/min/mg protein (99% CYP2D6 depletion at 30 min) |
| Comparator Or Baseline | Isotonitazene (221 µL/min/mg) and Protonitazene (216 µL/min/mg) |
| Quantified Difference | ~40% faster intrinsic clearance for butonitazene compared to isotonitazene |
| Conditions | HLM incubation, 60-minute total duration, CYP2D6 specific depletion tracking |
Establishes butonitazene as the necessary high-clearance reference standard for validating nitazene metabolic panels and CYP-mediated depletion models.
MOR Functional Potency Lower-Bound Anchor
Butonitazene serves as a critical lower-potency anchor in structure-activity relationship (SAR) profiling of benzimidazole opioids. In in vitro functional assays measuring Gi protein signaling via cAMP inhibition, butonitazene exhibits a pEC50 of 7.2. This is significantly lower than the potencies of etonitazene (pEC50 = 8.4) and N-pyrrolidino etonitazene (pEC50 = 8.6), demonstrating that the extended butoxy chain dampens receptor activation compared to ethoxy or pyrrolidino substitutions [1].
| Evidence Dimension | Functional potency (pEC50) at the mu-opioid receptor (MOR) |
| Target Compound Data | pEC50 = 7.2 |
| Comparator Or Baseline | Etonitazene (pEC50 = 8.4) and N-pyrrolidino etonitazene (pEC50 = 8.6) |
| Quantified Difference | >10-fold reduction in functional potency for butonitazene vs. etonitazene |
| Conditions | In vitro Gi protein signaling / cAMP inhibition assay |
Provides a necessary lower-potency calibration anchor for laboratories modeling the structure-activity relationships of emerging synthetic opioids.
Forensic LC-QTOF-MS Exact Mass Resolution
Because generic lateral flow assays (LFAs) and fentanyl test strips fail to reliably detect or differentiate nitazene subclasses, high-resolution mass spectrometry is required for definitive identification. Butonitazene yields a specific [M+H]+ exact mass of 424.5 Da, which clearly distinguishes it from isotonitazene (411.2 Da) and other closely related analogs. This 13.3 Da mass shift, driven by the butoxy versus isopropoxy moiety, is the primary metric used to resolve false positives and confirm specific legal attribution in seized drug materials and biological matrices [1].
| Evidence Dimension | Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-QTOF-MS)[M+H]+ exact mass |
| Target Compound Data | 424.5 Da |
| Comparator Or Baseline | Isotonitazene (411.2 Da) |
| Quantified Difference | 13.3 Da mass shift |
| Conditions | Forensic LC-QTOF-MS screening of biological samples or seized materials |
Ensures accurate analytical differentiation in forensic workflows where generic immunoassay screens fail to distinguish between highly regulated nitazene analogs.
Certified Reference Standard for Forensic Mass Spectrometry
Due to the inability of standard fentanyl immunoassays to cross-react with benzimidazole opioids, butonitazene is mandated as a primary reference standard for updating high-resolution mass spectrometry libraries. Its specific exact mass (424.5 Da) and retention time are utilized to calibrate LC-QTOF-MS and GC-MS instruments, ensuring that forensic laboratories can definitively distinguish the butoxy analog from isotonitazene and etonitazene in complex biological matrices or seized powders[1].
CYP450 High-Clearance Metabolism Benchmark
Because butonitazene exhibits a quantifiably higher intrinsic clearance rate (CLint = 309 µL/min/mg) compared to other nitazenes, it is deployed as a high-clearance benchmark in human liver microsome (HLM) assays. Pharmacologists and toxicologists procure this compound to map CYP2D6 and CYP2B6 metabolic pathways, using its rapid depletion profile to validate the sensitivity and accuracy of in vitro metabolic stability panels [2].
Opioid Receptor SAR Lower-Potency Anchor
In neuropharmacology research, butonitazene is utilized to establish the lower boundary of mu-opioid receptor (MOR) activation within the nitazene class. By integrating its pEC50 of 7.2 into cAMP inhibition and β-arrestin recruitment assays, researchers can accurately model how extending the alkoxy chain to a butoxy group dampens functional potency relative to the highly potent ethoxy (etonitazene) or pyrrolidino derivatives [3].
Application Fit
References
- [1] The Center for Forensic Science Research and Education (CFSRE). (2021). Butonitazene – Analytical Report.
- [2] Jadhav, G. R., & Fasinu, P. S. (2024). Metabolic characterization of the new benzimidazole synthetic opioids – nitazenes. Frontiers in Pharmacology, 15, 1434573.
- [3] Ujváry, I., et al. (2024). In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS Chemical Neuroscience, 15(4), 748-758.
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Class: Synthetic Opioid / Benzimidazole
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Molecular Weight: 352.39 g/mol
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Molecular Formula: C19H20N4O3
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