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ADB-FUBINACA (ADMB-FUBINACA^[2]) is a designer drug identified in synthetic cannabis blends in Japan in 2013.^[3]^[4] In 2018, it was the third-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Administration.^[5]

The name is an acronym for N-(1-Amino-3,3-Dimethyl-1-oxoButan-2-yl)-1-(4-FlUoroBenzyl)-1H-INdAzole-3-CarboxAmide.

The (S)-enantiomer of ADB-FUBINACA is described in a 2009 Pfizer patent^[6] and has been reported to be a potent agonist of the CB₁ receptor and the CB₂ receptor with EC₅₀ values of 1.2 nM and 3.5 nM, respectively.^[6]^[7] ADB-FUBINACA features a carboxamide group at the 3-indazole position, like SDB-001 and STS-135. ADB-FUBINACA appears to be the product of rational drug design, since it differs from AB-FUBINACA only by the replacement of the isopropyl group with a tert-butyl group.

An analogue of ADB-FUBINACA, ADSB-FUB-187, containing a more functionalized carboxamide substituent was recently reported.

Side effects

One death through coronary arterial thrombosis has been linked to ADB-FUBINACA intoxication.^[8]

Metabolism

Twenty-three ADB-FUBINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic pathways were alkyl and indazole hydroxylation, terminal amide hydrolysis, subsequent glucuronide conjugations, and dehydrogenation.^[9]

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In the United States, ADB-FUBINACA is a Schedule I controlled substance.^[10]

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Definitions

ADB-BUTINACA: a potent indazole carboxamide synthetic cannabinoid used as a reference material in laboratory research.
Certificate of Analysis: A document reporting batch-specific analytical results.
Structure-Activity Relationship: The study of how chemical structure affects biological activity.
Forensic Toxicology: The discipline focused on detecting substances in biological and environmental samples.
Pharmacokinetics: The study of how a compound is absorbed, distributed, metabolized, and excreted.

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See also

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What is ADB-BUTINACA?

What Is ADB-BUTINACA?

Why Researchers Buy ADB-BUTINACA Online

Where to Buy ADB-BUTINACA Online From a Verified Supplier

ADB-BUTINACA Research Applications

Chemical Properties and Analytical Profile

Quality Assurance and Documentation

Payment, Shipping, and Support

Safety and Compliance

How to Order

Research Ethics and Legal Compliance

Comparative Research

Building a Reference Library

International Shipping

Customer Support

Verified Supplier Network

Collaboration and Data Sharing

Getting Started

Analytical Methods

Metabolism and Detection

Pharmacology

Custom Synthesis and Bulk

Legal Status and Scheduling

Storage and Handling Best Practices

Structure-Activity Relationships

Sample Preparation for Analysis

Post-Purchase Support

History and Background

Receptor Binding Studies

Analytical Standards and Calibration

Immunological and Peripheral Research

Method Development in Analytical Labs

Educational Applications

Regulatory Reporting and Compliance

Collaborative Research Networks

Training and Education

Data Interpretation in Research

Future Directions in Research

Responsible Disposal

Choosing the Right Reference Material

Comparative Chemistry Across the Catalog

Quality Control Processes

Long-Term Research Programs

Understanding Purity Specifications

Documentation for Publications

Institutional Procurement Support

Final Considerations

Frequently Asked Questions About ADB-BUTINACA

Can I buy ADB-BUTINACA online for research?

Is ADB-BUTINACA tested for purity?

How is ADB-BUTINACA shipped?

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