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5F-ADB (also known as MDMB-5F-PINACA. 5F-ADB (also known as MDMB-5F-PINACA using systematic EMCDDA nomenclature[2] and 5F-MDMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products and has been sold online as a designer drug.[3][4] 5F-ADB is a potent agonist of the CB1 receptor,[5] though it is unclear whether it is selective for this target.

5F-ADB was first identified in November 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance. Subsequent testing identified 5F-ADB to have been present in a total of ten people who had died from unexplained drug overdoses in Japan between September 2014 and December 2014. 5F-ADB is believed to be extremely potent based on the very low levels detected in tissue samples, and appears to be significantly more toxic than earlier synthetic cannabinoid drugs that had previously been sold.[6]

In 2018, 5F-ADB was the most common synthetic cannabinoid to be identified in Drug Enforcement Administration seizures.[7] 5F-ADB was also identified in cannabidiol (CBD) products from a US-based CBD manufacturer in 2018.[8]

Deaths

5F-MDMB-PINACA has been associated with 25 deaths in Europe between 2015 and 2017.[9]

In the United States, 5F-ADB is a schedule I controlled substance.[10]

5F-ADB was added to the Japanese banned drug list in December 2014.

See also

The positional isomer, 4F-MDMB-PINACA has been characterised and is sometimes known as 4F-ADB,[11] despite “ADB” not having been used as a name for MDMB-PINACA. This is distinct from 4F-MDMB-BINACA which is a notable compound in its own right.

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Buy 5F-ADB Powder Online (also known as 5F-MDMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family. It is widely used as an active ingredient in synthetic cannabis products.

Buy 5F-ADB is a potent agonist of the CB1 receptor, though it is unclear whether it is selective for this target. 5F-ADB is believed to be extremely potent based on the very low levels detected in tissue samples.

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5F-ADB also called MDMB-5F-PINACA and 5F-MDMB-PINACA is an indazole-primarily based synthetic cannabinoid from the indazole-3-carboxamide circle of relatives. Furthermore, it is used as an energetic factor in artificial cannabis merchandise, thus Buy 5F-ADB Powder Online is a designer drug. 5F-ADB is an effective agonist of the CB1 receptor, though it’s far unclear whether it is selective for this target. Nevertheless, it was first identified in November 2014 from post-mortem samples taken from a man or woman who had died after the use of a product containing this substance.

Furthermore, subsequent testing proved that it had been found in a total of ten folks who had died from unexplained drug overdoses. Nevertheless, it is assumed to be extraordinarily potent. Moreso, being totally in the very low stages detected in tissue samples and appears to be appreciably more poisonous than earlier artificial cannabinoid tablets that had previously been sold, Buy 5F-ADB Powder Online.

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We have premium 5F-ADB powder that is sourced from trusted providers and is lab-tested for purity with purity and potency verified. Sourced from trusted providers, our product ensures premium quality guaranteed. Whether you’re a researcher or a chemical fanatic, our powder is the satisfactory choice for your desires. Enjoy fast delivery worldwide and discreet international shipping. Furthermore, we additionally have multiple payment options and secure payment methods to ensure a smooth purchasing experience. Our customer support available for any questions. Lastly, if you have any worries about a certain product, please do not hesitate to Get in touch with us for more information.

Cannabinoids and their effects

The term “cannabinoid” refers to any synthetic substance that binds to cannabinoid receptors in the body and has effects similar to those found in plants of the genus Cannabis sativa. The primary cannabinoids include delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC has strong psychoactive effects, while CBD attenuates these effects Buy 5F-ADB Powder Online.

Side effects

The safety and long-term effects of recreational use of 5F-ADB have not been adequately studied. There is evidence that an overdose can cause physical symptoms such as palpitations (risk of palpitations), dizziness warning, and sedation. Individuals with a history of mental illness should exercise particular caution. Dosage should be in the milligram range dosing with doses less than 5 mg to avoid adverse effects.

5F-ADB – Adaptability and search potential

The use of 5F-ADB can lead to psychological dependence. With prolonged use, tolerance may develop, requiring larger doses to achieve similar effects.

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The detection of highly potent indazole-3-carboxamides in complex biological matrices presents a unique analytical bottleneck for modern forensic toxicology laboratories. 5F-ADB (systematically known as 5F-MDMB-PINACA), characterized by its tert-leucine moiety and terminal fluoropentyl chain, requires highly optimized extraction protocols. For analytical chemists and toxicology researchers who need to buy 5f-adb online to establish baseline recovery rates for Solid Phase Extraction (SPE) or Liquid-Liquid Extraction (LLE), securing a reference standard with unassailable purity is a foundational requirement for defensible casework. Buy 5f adb

Core Physicochemical Reference Parameters

  • Target Compound: 5F-ADB (5F-MDMB-PINACA)
  • IUPAC Name: Methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate
  • CAS Registry Number: 1715016-75-3 [[10]]
  • Molecular Formula: C20H28FN3O3
  • Molar Mass: 389.45 g/mol
  • Verified Purity: >= 99.0% (Independent HPLC & GC-MS)
  • Physical State: Fine, white to off-white crystalline powder
  • Format: Analytical reference unit Buy 5f adb

Matrix Isolation & Metabolite Mapping Challenges

When toxicology labs choose to buy 5f-adb online for panel validation, they are primarily addressing the rapid metabolic clearance of the parent compound. In urine and blood matrices, 5F-ADB undergoes extensive biotransformation, primarily via ester hydrolysis (yielding the M1 metabolite) and tert-butyl hydroxylation. Independent analytical communities, such as those documented on PsychonautWiki and the extensive harm-reduction archives at Erowid, frequently highlight the critical need for a pure parent standard to accurately map the mass shifts and retention time drifts of these major metabolites during LC-MS/MS analysis. Buy 5f adb

Mass Spectrometry Deconvolution & Isobaric Separation

In electron impact (EI) or electrospray ionization (ESI) mass spectrometry, 5F-ADB yields highly diagnostic fragment ions that allow for clean separation from isobaric interferences. The most prominent diagnostic feature is the cleavage of the tert-leucine methyl ester, alongside fragments resulting from the loss of the fluoropentyl chain. This specific spectral fingerprint allows analysts to definitively separate 5F-ADB from closely related analogs like 5F-MDMB-2201 or ADB-FUBINACA, which share similar core scaffolds but exhibit distinct fragmentation pathways. Cross-referencing these laboratory observations with data shared on independent research forums, like Reddit’s r/ResearchChemicals and the Bluelight analytical discussion boards, helps forensic labs proactively refine their screening panels for unexpected metabolic variants. Buy 5f adb

Sourcing Integrity & Analytical Guarantee

Procuring certified reference materials is the primary defense against the rampant structural substitution prevalent in the unregulated research chemical market. By choosing to buy 5f-adb online from ChemNexis Pharma, laboratories secure a material backed by rigorous, transparent quality control. We do not provide generic certificates; every shipment includes a batch-matched Certificate of Analysis (CoA) featuring full HPLC purity integration and complete GC-MS spectral traces, guaranteeing independent verification of identity and purity upon receipt.

Environmental Control & Statutory Compliance

Maintaining the physicochemical stability of complex indazole-3-carboxamides requires strict environmental controls. The reference material must be stored sealed in its original light-resistant, airtight amber glass vial at 2-8°C, rigorously protected from UV exposure and atmospheric moisture to prevent oxidative degradation. Buy 5f adb

COMPLIANCE NOTICE: This material is sold exclusively for laboratory analysis, forensic reference work, and educational collector purposes. It is strictly not intended for human or veterinary consumption. Furthermore, any entity choosing to buy 5f-adb online through our platform explicitly agrees to our terms of service and confirms that all handling will comply with applicable local, state, and federal regulations regarding scheduled substances.

Researcher Frequently Asked Questions

Q: What is the most reliable way to differentiate 5F-ADB from 5F-MDMB-2201 in a routine screen?
A: While both feature a fluoropentyl chain and an amino acid ester, the definitive differentiation relies on the core scaffold and the specific amino acid. 5F-ADB utilizes an indazole core with a tert-leucine methyl ester, whereas 5F-MDMB-2201 utilizes an indole core with a valine methyl ester, resulting in entirely different molecular weights and fragmentation cascades.Buy 5f adb

Q: Why is community discussion relevant to forensic laboratory standards?
A: Independent research forums often serve as early warning systems for emerging structural analogs and unexpected metabolic pathways. Cross-referencing these community observations with official mass spectrometry data helps forensic labs refine their screening panels proactively and cost-effectively.

Q: What documentation accompanies the reference standard?
A: Every order includes a lot-specific Certificate of Analysis (CoA) detailing HPLC integration and spectral data. For baseline comparative research, databases like PubChem serve as excellent supplementary resources for structural validation.

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Product Name: 5F-ADB (also known as 5F-MDMB-PINACA)
Chemical Name: Methyl (S)-2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate
CAS Number: 1715016-75-3
Molecular Formula: C20H28FN3O3
Molecular Weight: 377.46 g/mol

Overview
5F-ADB is a synthetic cannabinoid belonging to the indazole-3-carboxamide family. Originally identified in late 2014 by forensic authorities in Japan, it was found to be an active ingredient in “herbal incense” products. It is structurally characterized by a fluorinated pentyl chain and a tert-leucinate moiety, which contribute to its high affinity for cannabinoid receptors .

Pharmacological Profile
As a full agonist of the cannabinoid CB1 receptor, 5F-ADB exhibits significantly higher potency than natural THC or earlier generations of synthetic cannabinoids. Binding affinity studies indicate a Kᵢ value in the low nanomolar range (e.g., 1.5 nM), making it substantially more potent than many controlled substances . Unlike THC, which is a partial agonist, the full agonism of 5F-ADB is associated with a higher risk of severe adverse effects, including toxicity and fatality .

Legal Status
Due to its high abuse potential and lack of accepted medical treatment use, 5F-ADB is strictly regulated:

  • United States: Schedule I Controlled Substance (DEA) .

  • International: Recommended for Schedule II by the WHO (ECDD) under the UN Convention on Psychotropic Substances of 1971 .

  • Japan: Added to the banned drug list in December 2014 .

Forensic & Research Applications
This product is intended for in vitro research and forensic toxicology applications only. It is not for human or veterinary use. Analytical standards like 5F-ADB are critical for:

  • Urine Drug Testing: Identifying metabolites (specifically the 3,3-dimethylbutanoic acid metabolite) in biological matrices .

  • Mass Spectrometry: Use as a reference standard in LC-MS/MS and GC-MS for the identification of novel psychoactive substances (NPS) in seized materials and biological samples .

  • Metabolite Studies: Understanding the metabolic degradation pathways to aid in clinical toxicology .

Safety & Hazards
5F-ADB is classified as extremely hazardous. Toxicology reports highlight a rapid onset of severe symptoms including tachycardia, psychomotor agitation, seizure, acute psychosis, and loss of consciousness. It has been linked to numerous fatalities and hospitalizations globally . Warning: This compound is rapidly metabolized and degrades in blood; forensic analysis often requires monitoring of specific metabolites rather than the parent compound .

Storage & Handling

  • Appearance: Solid powder .

  • Purity: ≥99% .

  • Storage: Store at -20°C (freezer) for long-term stability (up to 3 years). For short-term storage (2 years), keep at 4°C. Protect from light and moisture .

Disclaimer: This information is for scientific and educational reference only. 

Mdmb-pinaca

CB1 Receptor PharmacologyFunctional Assayβ-Arrestin Recruitment

⚠ Attention: For research use only. Not for human or veterinary use.
Molecular FormulaC20H29N3O3
Molecular Weight359.5 g/mol
Cat. No.B10860639

Technical Parameters

Basic Identity
Product Name Mdmb-pinaca
Molecular Formula C20H29N3O3
Molecular Weight 359.5 g/mol
Structural Identifiers
SMILES CCCCCN1C2=CC=CC=C2C(=N1)C(=O)NC(C(=O)OC)C(C)(C)C
InChI InChI=1S/C20H29N3O3/c1-6-7-10-13-23-15-12-9-8-11-14(15)16(22-23)18(24)21-17(19(25)26-5)20(2,3)4/h8-9,11-12,17H,6-7,10,13H2,1-5H3,(H,21,24)/t17-/m1/s1
InChIKey QSNCKXRHFRDPRX-QGZVFWFLSA-N
Commercial & Availability
Standard Pack Sizes 10 mg / 50 mg / 1 ml / Bulk Custom
Availability In Stock
Custom Synthesis Available on request

Structure & Identifiers

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MDMB-PINACA: Pharmacological Profile & Industrial Relevance

MDMB-PINACA, also commonly referred to as 5F-MDMB-PINACA or 5F-ADB, is a third-generation synthetic cannabinoid receptor agonist (SCRA) of the indazole-3-carboxamide structural class [1]. It functions as a highly potent and efficacious full agonist at both the cannabinoid type 1 (CB1) and type 2 (CB2) receptors, with functional potency measured at an EC50 of 0.59 nM for the CB1 receptor in β-arrestin2 recruitment assays [2]. As a controlled substance in many jurisdictions due to its established association with adverse health events and its lack of therapeutic utility, its primary procurement context lies within forensic toxicology, analytical chemistry research, and the development of diagnostic reference standards [1].

Forensic toxicology reference standard workflows
CB1 / CB2 receptor pharmacology probe
Chiral analytical method development

Why MDMB-PINACA Substitution Fails

The indazole-3-carboxamide class of SCRAs exhibits substantial pharmacodynamic divergence driven by minor modifications to the tail and head group moieties. For instance, the presence of a terminal fluorine atom, as seen in 5F-MDMB-PINACA, results in an EC50 value of 0.59 nM at CB1, compared to 2.47 nM for its non-fluorinated analog MDMB-4en-PINACA [1]. Such differences in in vitro potency translate to significant variations in in vivo pharmacodynamics, including the onset, magnitude, and duration of behavioral effects such as hypolocomotion and hypothermia [2]. Furthermore, metabolic pathways and resultant active metabolite profiles are not conserved across even closely related structures, leading to critical discrepancies in toxicological detection windows and the interpretation of biological sample data. Substitution based on class alone, without considering these quantifiable differences, invalidates experimental reproducibility and compromises the accuracy of forensic or clinical analytical conclusions [3].

Fluorine substitution alters CB1 potency and metabolic stability; analogs with different tail groups may not reproduce assay sensitivity requirements.
In vivo behavioral duration and ED50 profiles differ substantially across indazole-3-carboxamides; locomotor endpoints may shift with analog.
Active metabolite profiles are not conserved; exclusion of M2 from analytical targets may compromise toxicological interpretation.

MDMB-PINACA Evidence Matrix

CB1 Receptor Potency Comparison

5F-MDMB-PINACA demonstrates markedly higher functional potency at the human CB1 receptor compared to the closely related analog MDMB-4en-PINACA and the reference cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC). In β-arrestin2 recruitment assays, the EC50 value for 5F-MDMB-PINACA is 0.59 nM [1]. This is approximately 4.2-fold more potent than MDMB-4en-PINACA (EC50 = 2.47 nM) and 456-fold more potent than Δ9-THC (EC50 = 269 nM) under the same assay conditions [1].

CB1 Receptor Potency Comparison
Head-to-head
4.2-fold higher potency vs. MDMB-4en-PINACA; 456-fold vs. Δ9-THC
Supports lower detection limit requirements in forensic assays.
Reported EC50 0.59 nM (β-arrestin2 recruitment).
CB1 Receptor PharmacologyFunctional Assayβ-Arrestin RecruitmentIn Vitro Potency

In Vivo Locomotor Potency & Duration

The in vivo potency and duration of action of 5F-MDMB-PINACA differ substantially from other indazole-3-carboxamide SCRAs. In a mouse locomotor activity assay, 5F-MDMB-PINACA produced a short-acting (30-minute) depression of activity with an ED50 of 1.1 mg/kg [1]. In contrast, MDMB-CHIMICA, a structurally distinct analog, was approximately 46-fold more potent (ED50 = 0.024 mg/kg) but also exhibited a short 30-minute duration [1]. MDMB-FUBINACA, another analog, displayed a dramatically longer duration of action (150 minutes) at a higher potency (ED50 = 0.04 mg/kg) [1]. The shorter duration and distinct ED50 of 5F-MDMB-PINACA relative to these comparators define a unique in vivo behavioral signature.

In Vivo Locomotor Potency
Head-to-head
ED50 1.1 mg/kg, 30 min duration; 46-fold less potent than MDMB-CHIMICA, 5-fold shorter than MDMB-FUBINACA
Behavioral endpoint selection may require model-specific review.
Mouse model, IP administration, locomotor monitoring.
In Vivo PharmacologyBehavioral PharmacologyLocomotor ActivityED50

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