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5-CL-ADB-A is a synthetic cannabinoid research chemical belonging to the indazole-based cannabinoid receptor agonist (SCRA) family. Scientifically associated with MDMB-4en-PINACA, this compound has become an important subject in forensic toxicology, analytical chemistry, and novel psychoactive substance (NPS) research due to its unique chemical structure and receptor-binding characteristics.
Research laboratories utilize 5-CL-ADB-A as an analytical reference material for method development, forensic investigations, metabolite identification, and cannabinoid receptor research.
What is 5-CL-ADB-A?
5-CL-ADB-A is an indazole-derived synthetic cannabinoid that has gained significant attention within forensic and analytical laboratories. Due to its structural characteristics, researchers investigate this compound to improve analytical detection techniques, understand metabolic pathways, and support identification of emerging synthetic cannabinoids.
Its distinct molecular framework makes it a valuable analytical reference compound for laboratories studying novel cannabinoid analogues.
Chemical Structure and Classification
5-CL-ADB-A belongs to the indazole-3-carboxamide family and contains:
- Indazole core structure
- Carboxamide functional group
- Terminal alkene side chain
- Amino acid ester moiety
- Synthetic cannabinoid framework
These structural features distinguish it from naturally occurring cannabinoids and contribute to its importance in analytical research.
Scientific and Research Significance
Researchers study 5-CL-ADB-A for:
- Synthetic cannabinoid profiling
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- Forensic toxicology research
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- Analytical reference standard development
- Emerging NPS monitoring
Its chemical profile supports ongoing scientific efforts to improve identification and classification of newly emerging synthetic cannabinoids.
Analytical Applications
5-CL-ADB-A is commonly used for:
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These applications enable laboratories to accurately identify and characterize synthetic cannabinoid compounds.
Why Researchers Study 5-CL-ADB-A
Current research focuses on:
- Synthetic cannabinoid chemistry
- Forensic identification techniques
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- Metabolite profiling
- Novel psychoactive substance surveillance
- Laboratory quality control
The compound serves as an important analytical standard for studying emerging cannabinoid analogues.
Related Research Compounds
Researchers frequently compare 5-CL-ADB-A with:
- MDMB-4en-PINACA
- 5F-ADB
- 4F-ADB
- 4F-MDMB-BINACA
- 4F-MDMB-BICA
- ADB-BUTINACA
- Other indazole-based synthetic cannabinoids
Comparative studies assist scientists in understanding structural similarities and analytical differentiation.
Research Applications
Potential laboratory applications include:
- Forensic investigations
- Analytical chemistry
- Scientific reference material
- Toxicology research
- Method development
- Laboratory calibration
- Chemical identification studies
Storage and Handling
For maximum stability:
- Store in airtight laboratory containers
- Protect from moisture
- Keep away from direct sunlight
- Maintain recommended laboratory storage conditions
- Handle using appropriate laboratory PPE
- Follow institutional chemical safety procedures
Frequently Asked Questions
What is 5-CL-ADB-A?
5-CL-ADB-A is an indazole-based synthetic cannabinoid research chemical commonly associated with MDMB-4en-PINACA and used as an analytical reference standard.
What is the molecular formula?
The molecular formula is C20H28N4O3.
What research fields utilize 5-CL-ADB-A?
It is commonly used in forensic toxicology, analytical chemistry, cannabinoid research, metabolite studies, and novel psychoactive substance investigations.
Why is 5-CL-ADB-A important for laboratory research?
It supports analytical method development, forensic identification, metabolite analysis, and structure-activity relationship research involving synthetic cannabinoids.
How should this compound be stored?
Store in a tightly sealed container in a cool, dry environment away from moisture, heat, and direct sunlight.
Is this product intended for laboratory use only?
Yes. This material is supplied exclusively for scientific, analytical, educational, and laboratory research purposes.
Disclaimer
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At Davechemicals.com, we take pride in offering premium research chemicals, such as 5CL-ADB-A, also known as MDMB-4en-PINACA. This compound, a standout in the world of synthetic cannabinoids, draws attention for its unique structure and potential in lab settings. If you’re curious about what 5CL-ADB-A is, picture a molecule engineered to mimic natural cannabinoid interactions, yet with amplified precision for studies.
We often get asked what MDMB-4en-PINACA is. Simply put, it’s an indazole-based compound with the full name methyl 3,3-dimethyl-2-{[1-(pent-4-en-1-yl)-1H-indazole-3-carbonyl]amino}butanoate. First spotted in Europe around 2017, according to sources like the European Monitoring Centre for Drugs and Drug Addiction, it acts as a synthetic cannabinoid receptor agonist. This means it binds to the same receptors as THC, but with greater intensity, making it valuable for pharmacological research. Buy 5CL-ADB-A precursor online
Why Choose 5CL-ADB-A for Your Lab?
If you’re looking to buy 5CL-ADB-A online, consider its role in exploring the dynamics of cannabinoid receptors. Studies, such as those from the World Health Organisation, highlight its EC50 value around 2.47 nM, indicating high potency. We ensure our stock is for research only, aligning with ethical standards.
Potential Applications in Research
From forensic analysis to biochemical assays, MDMB-4en-PINACA offers insights into receptor selectivity. It’s often compared to relatives like 5F-MDMB-PINACA, but with a pent-4-ene tail that alters its metabolism.
What is 5CL-ADB-A and Its True Identity?
Let’s start with clarity. 5CL-ADB-A is a misnomer for MDMB-4en-PINACA, a term that popped up in online markets but doesn’t accurately reflect its structure. The correct designation, as per Wikipedia, is an indazole-3-carboxamide with a pent-4-enyl chain. Its molecular weight sits at 357.454 g/mol, and it features a stereogenic centre, potentially yielding (S) and (R) enantiomers. Buy 5CL-ADB-A precursor online
In our experience supplying research chemicals, this compound’s design draws from earlier synthetic cannabinoids like ADB-PINACA, but with modifications for enhanced CB1 affinity. A study in the Journal of Analytical Toxicology notes its emergence in Turkey in 2019, where it was seized in herbal blends. We hyperlink this to emphasise verifiable facts: no speculation here.
How Does MDMB-4en-PINACA Work in Studies?
Pharmacologically, MDMB-4en-PINACA shines as a full agonist at CB1 receptors. Data from Cayman Chemical shows it is categorised purely for analytical use. In vitro tests reveal a Ki of 0.28 nM, making it selective for CB2 over CB1 by a factor of seven, per research in the International Journal of Molecular Sciences.
We advise researchers to note its rapid metabolism. An in vitro half-life of about 10 minutes leads to 14 metabolites, detectable in urine for up to an hour, as detailed in forensic reports from the Centre for Forensic Science Research & Education. This quick clearance is why it’s prized in kinetic studies but demands careful handling.
Table 1: Key Chemical Properties of MDMB-4en-PINACA
| Property | Details | Source Reference |
|---|---|---|
| IUPAC Name | Methyl (S)-3,3-dimethyl-2-(1-(pent-4-en-1-yl)-1H-indazole-3-carboxamido)butanoate | UNODC Substance Details |
| Molecular Formula | C20H27N3O3 | Cayman Chemical |
| Molar Mass | 357.454 g/mol | Wikipedia |
| CAS Number | 2504100-70-1 | PubChem |
| Half-Life (In Vitro) | Approximately 10 minutes | Journal of Analytical Toxicology |
| Receptor Affinity (CB1) | EC50: 1.88–2.47 nM | International Journal of Molecular Sciences |
| Metabolites Produced | 14 identified | Forensic Toxicology |
Note: All data for research reference only. The table is responsive for mobile viewing.
When Did 5CL-ADB-A Emerge?
Tracing back, MDMB-4en-PINACA first surfaced in Europe in 2017, as monitored by the EMCDDA. It gained notoriety in the US by 2021, becoming the most seized synthetic cannabinoid per DEA reports. We link this to broader trends in designer drugs, where variants like ADB-BUTINACA share similar potencies.
In one case from Slovenia, it was marketed as ‘5-CL-ADB-A’ at $21 per gram, highlighting market confusion. Our site avoids such pitfalls by providing clear labelling for products like buy ADB-FUBINACA online.
Legal Landscape: Where Can You Buy MDMB-4en-PINACA Legally?
Navigating legality is crucial. In the United Kingdom, it’s Class B under the Misuse of Drugs Act. The United States lists it as Schedule I temporarily until 2025, per the Federal Register. Germany classifies it as Anlage II, while Australia and parts of Asia enforce strict controls.
We operate within these frameworks, offering synthetic cannabinoids solely for approved research. Check local laws before proceeding.
How 5CL‑ADB‑A MDMB‑4en‑PINACA is used in labs (not in people)
Serious labs and forensic teams use compounds like MDMB‑4en‑PINACA as reference standards to:
- Validate LC‑MS or GC‑MS methods for seized herbal blends and e‑liquids, often guided by documents from agencies and reports hosted by organisations such as the EMCDDA.
- Compare analytical profiles with other synthetic cannabinoids documented on resources such as PsychonautWiki and TripSitter, particularly when local casework turns up unfamiliar peaks.
Our own catalogue also supports broader NPS investigations, for example,e with buy 5F‑MDMB‑2201 online, buy 5F‑SGT‑151 online, buy AMB‑PINACA online and EG‑018 for comparison studies.
Key point: Our 5CL‑ADB‑A MDMB‑4en‑PINACA is supplied to help scientists untangle the mess created by uncontrolled street products, not to feed that market.
Legal and safety reality of MDMB‑4en‑PINACA and similar cannabinoids
Reports collected by agencies and summarised in technical reviews describe serious toxicity, including acute intoxication, cardiovascular stress and deaths linked to MDMB‑4en‑PINACA products in several countries. According to one EMCDDA rapid assessment, MDMB‑4en‑PINACA has been one of the most frequently detected synthetic cannabinoids in some seizure datasets, often in herbal smoking mixtures with unknown strength.
Resources such as Drugs.com and DrugBank both highlight the unpredictable nature of many new psychoactive substances, especially when potency exceeds that of natural cannabis by an order of magnitude or more. That is precisely why our products, including buy ADB‑BUTINACA, buy 6CL‑ADB‑A online and buy AD‑18 online, are framed strictly as research‑only materials with explicit not for human consumption messaging.
Table 2: Legal Status of MDMB-4en-PINACA by Region
| Region/Country | Classification | Effective Date | Key Notes |
|---|---|---|---|
| United Kingdom | Class B (Misuse of Drugs Act) | 2019 | Prohibited for non-research use |
| United States | Schedule I (Temporary) | December 2023 | Expires 2025 if not extended |
| Germany | Anlage II (Trade Only) | 2020 | No prescriptions allowed |
| Australia | Schedule 9 (Prohibited) | Varies by state | Strict import controls |
| Brazil | Class F2 (Psychotropics) | 2021 | Banned substances list |
| Canada | Schedule II | 2022 | Controlled under CDSA |
| Sweden | Hazardous Substance | December 2019 | Public health agency proposal |
Risks and Safety: Why Handle 5CL-ADB-A with Care?
Evidence from PMC links MDMB-4en-PINACA to fatalities, often alongside substances like 4F-ABUTINACA. Symptoms include severe intoxication, as in a 26-year-old’s case,se with headache and collapse. We stress: this is not for consumption.
In research, prioritise safety protocols. Its toxicity stems from the methyl 3,3-dimethylbutanoate group, more potent but riskier than naphthene moieties in JWH-018.
Quote from Expert Source: “MDMB-4en-PINACA is a potent activator of the cannabinoid receptor system and its toxicity has been demonstrated through medicolegal death investigations,” notes the CFSRE public alert.
How 5CL‑ADB‑A MDMB‑4en‑PINACA compares with other synthetic cannabinoids
According to open access reviews and technical summaries, MDMB‑4en‑PINACA tends to display stronger CB1 efficacy and higher receptor affinity than older compounds such as JWH‑018, which is one reason why intoxication cases can be so severe. Community‑level harm reports collected by projects referenced on TripSitter and PsychonautWiki echo those concerns, with clusters of emergency presentations linked to small doses of synthetic cannabinoid products.
This is why many toxicology labs now work with panels of standards, such as 5F‑UR144, JWH‑122, JWH‑201 and JWH‑250 for sale alongside MDMB‑4en‑PINACA, to keep their libraries up to date.
Table 3: Comparison of Popular Synthetic Cannabinoids
| Compound | CB1 EC50 (nM) | Half-Life (min) | Common Uses in Research | Toxicity Level |
|---|---|---|---|---|
| MDMB-4en-PINACA | 2.47 | 10 | Receptor binding, metabolism studies | High |
| JWH-018 | ~6-8 | 20-30 | Baseline cannabinoid assays | Moderate |
| 5F-MDMB-PINACA | 0.59 | 15 | Forensic toxicology | Very High |
| ADB-BUTINACA | 11.5 | 12 | Comparative potency | High |
| AM-2201 | 1.0 | 25 | Structural analysis | Moderate |
| UR-144 | 29 | 18 | Less potent variants | Low |
| 4F-ABUTINACA | ~5 | 8 | Overdose simulations | Very High |
Explanations: Values from in vitro studies; higher toxicity correlates with potency. Mobile-optimised for easy reference.
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How Long Does It Last?
Forensic tools detect MDMB-4en-PINACA via LC-HRMS, as in Drug Testing and Analysis. Its metabolites aid identification, with urine positivity up to 60 minutes. We recommend cross-referencing with buy forensic research chemicals.
Where is MDMB-4en-PINACA Most Prevalent?
From Europe to the US, seizures spike. In 2024, the US Army CID flagged it in 325 toxicology cases. Asia sees rising use in adulterated products, per local reports.
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What is 5CL‑ADB‑A MDMB‑4en‑PINACA?
5CL‑ADB‑A MDMB‑4en‑PINACA is a label often used in the market for the compound MDMB‑4en‑PINACA, an indazole‑based synthetic cannabinoid that acts as a strong CB1 receptor agonist, structurally related to other designer cannabinoids used in herbal smoking mixtures. It has appeared in forensic casework worldwide and is treated as a high‑risk new psychoactive substance by agencies and toxicologists.
Why is MDMB‑4en‑PINACA sometimes incorrectly called 5CL‑ADB‑A?
The “5CL‑ADB‑A” name seems to stem from early mislabelling and vendor catalogues, even though the molecule,e as characterised in analytical reports, does not contain a chlorine atom. That incorrect name stuck in parts of the market, which is why technical documents now often highlight that MDMB‑4en‑PINACA is also incorrectly known as 5CL‑ADB‑A to prevent further confusion.
Is 5CL‑ADB‑A MDMB‑4en‑PINACA legal in the UK, USA, Germany and Australia?
Legal status changes quickly, but MDMB‑4en‑PINACA has already been placed under control in several jurisdictions, for example, a temporary Schedule I in the United States from 2023, with similar controls in parts of Europe and other regions. Anyone considering working with 5CL‑ADB‑A MDMB‑4en‑PINACA must check current national and regional legislation, internal institutional policies and import rules before ordering.
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Legitimate uses include: building LC‑MS and GC‑MS libraries, calibrating quantitative assays, confirming identity in seized casework and exploring metabolism in controlled in‑vitro systems. According to technical reviews, these kinds of studies help toxicologists interpret blood or urine results when emergency departments report unusual clinical pictures.
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Open source data and technical summaries describe synthetic cannabinoids like MDMB‑4en‑PINACA as substantially more potent at the CB1 receptor than Δ9‑THC. According to one European risk assessment, associated harms include severe agitation, unconsciousness, seizures and deaths, which sit far outside the typical profile of natural cannabis and support strict not for human consumption handling.
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There is no safe consumer use scenario here. The compound is a lab tool, has been linked with serious toxicity, and is controlled or proposed for control in many countries. At Davechemicals.com, we will not pretend otherwise, which is why every listing, including buy 5CL‑ADB‑A online, clearly states “for research purposes only, not for human consumption.
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Key takeaways and CTA for serious researchers 
- 5CL‑ADB‑A MDMB‑4en‑PINACA is a potent synthetic cannabinoid, often mislabelled, with documented toxicity and strict legal attention.[1][2]
- It exists to support forensic and analytical labs, not personal use, and should be handled only by qualified professionals in controlled environments.[2]
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What is the difference between 5CL-ADB-A and MDMB-4en-PINACA?
5CL-ADB-A is an incorrect label for MDMB-4en-PINACA, stemming from market errors. The true compound lacks chlorine, featuring a pent-4-enyl group instead.
How potent is MDMB-4en-PINACA compared to THC?
It’s dozens to hundreds of times stronger at CB1 receptors, with an EC50 far lower than THC’s, per WHO reviews.
Is 5CL-ADB-A legal in the United States?
No, it’s Schedule I temporarily, as announced in the Federal Register. Always verify locally.
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Linked to overdoses and deaths, often with symptoms like seizures, per PMC case studies. For research only.
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Detectable in urine for about an hour, with metabolites aiding longer identification, based on analytical research.
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Up to 14, formed via rapid hepatic metabolism, are useful for forensic detection.
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Key Citations
- Wikipedia on MDMB-4en-PINACA
- EMCDDA Risk Assessment
- CFSRE Monograph
- Federal Register Scheduling
- PMC Fatal Overdose Study
- Journal of Analytical Toxicology Metabolism
- International Journal of Molecular Sciences Assessment
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5CL-ABD-A is a potent indazole-based synthetic cannabinoid. The official name of 5-Cl-ADB-A is Methyl 3,3-Dimethyl-2-(1-(pent-4-en-1-yl)-1H-indazole-3-carboxamido)butanoate. The molecular weight of the substance is 357.45. Rchemsport
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5CLADBA is a synthetic cannabinoid that has been developed to mimic the effects of natural cannabinoids such as THC and CBD.
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