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4-METHYLPROPIOPHENONE

4′-Methylpropiophenone
Other Names: 1-(4-Methylphenyl)propan-1-one, p-Methylphenylethylketone

CAS Number: 5337-93-9
Sum Formula: C₁₀H₁₂O
Molar Mass: 148.21 g/mol
Appearance: Colorless liquid

4′-Methylpropiophenone is an aromatic ketone where a methyl group is positioned para (4′) to the carbonyl group on the phenyl ring. It is commonly used as an intermediate in organic synthesis, particularly in the preparation of fine chemicals, agrochemicals, and specialty materials.

Chemical and Physical Properties
Density: 0.993 g/mL (at 20°C)
Melting Point: 7.2°C
Boiling Point: 238°C
Solubility in Water: Insoluble
Solubility in Other Solvents: Soluble in organic solvents such as ethanol, ether, and acetone
Odor: Mild, sweet aromatic odor

Applications
Organic Synthesis: Used as an intermediate for the preparation of specialty chemicals, pharmaceuticals, and agrochemical compounds.
Material Science: Investigated for use in functionalized polymer systems and chemical surface modifications.
Analytical Chemistry: Used in the study of ketone reactivity and analytical standardization.
Research and Development: Explored in synthetic organic chemistry for building complex molecules.

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    4′-Methylpropiophenone | 5337-93-9 – ChemicalBook

    Sep 27, 2026 · 4′-Methylpropiophenone (CAS 5337-93-9) information, including chemical properties, structure, melting point, boiling …

    • Boiling point: 238-239 °C (lit.)
    • Melting point: 7.2 °C
    • Density: 0.993 g/mL at 25 °C (lit.)
    • refractive index: n 20/D 1.528 (lit.)

    -methylpropiophenone CAS No 5337-93-9

    4-methylpropiophenone CAS No 5337-93-9 for sale online at Research Chemicals Lab.

    Buy 4′-Methylpropiophenone, a chemical compound with the molecular formula C10H12O. Structurally, it consists of a propiophenone backbone with a methyl group attached to the fourth carbon of the phenyl ring. This compound falls within the class of aromatic ketones, and its structure suggests it may have applications in organic synthesis. In terms of physical properties, 4′-Methylpropiophenone is likely to be a solid at room temperature, and its solubility characteristics would depend on the specific form and functional groups present in the molecule.

    4-methylpropiophenone Specification

    Item specifications
    Appearance light yellow liquid
    Assay% 99.0%
    molecular formula C10H12O
    molecular weight 148.2
    melting point 7.2 °C
    Boiling point 238-239 °C
    density 0.993 g/mL
    Flash point 229 °F

     4-methylpropiophenone Usage:

    4 -methylpropiophenone is a chemical used for electrocarboxylation reactions

    4-methylpropiophenone Packaging and Shipping:

    25kg/barrel or as per buyer requirement.

    4-methylpropiophenone Storage:

    Store in a ventilated low-temperature dry warehouse; Store separately with oxidants, acids and alkali.

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    4′-Methylpropiophenone

    CAS No.
    5337-93-9
    Chemical Name:
    4′-Methylpropiophenone
    Synonyms
    4-METHYLPROPIOPHENONE;1-(p-Tolyl)propan-1-one;ETHYL-P-TOLYLKETON;P-METHYLPROPIOPHENONE;4-Methylpropiophenon;LABOTEST-BB LT00053050;4-Methyl Propiphenone;P-Methyl phenylethylketone;Ethyl 4-methylphenyl ketone;1-(4-methylphenyl)-propan-1-one
    CBNumber:
    CB8116040
    Molecular Formula:
    C10H12O
    Molecular Weight:
    148.2
    MDL Number:
    MFCD00009312
    MOL File:
    5337-93-9.mol
    MSDS File:
    SDS
    TDS File:
    TDS
    Last updated:2026-09-27 22:39:30
    Product description Number Pack Size Price
    4′-Methylpropiophenone 90%, technical grade 517925 100ml $86.6
    4′-Methylpropiophenone >95.0%(GC) M0768 25mL $17
    4′-Methylpropiophenone >95.0%(GC) M0768 500mL $151
    4′-Methylpropiophenone ≥97% 434050 100g $229
    4′-Methylpropiophenone ≥97% 434050 500g $352
    More product size
    Request For Quotation

    4′-Methylpropiophenone Properties

    Melting point 7.2 °C
    Boiling point 238-239 °C(lit.)
    Density 0.993 g/mL at 25 °C(lit.)
    refractive index n20/D 1.528(lit.)
    Flash point 229 °F
    storage temp. Inert atmosphere,Room Temperature
    solubility Soluble in chloroform and hexane.
    form Oil
    color Colourless
    Specific Gravity 0.99
    BRN 2042137
    InChI InChI=1S/C10H12O/c1-3-10(11)9-6-4-8(2)5-7-9/h4-7H,3H2,1-2H3
    InChIKey PATYHUUYADUHQS-UHFFFAOYSA-N
    SMILES C(C1=CC=C(C)C=C1)(=O)CC
    CAS DataBase Reference 5337-93-9(CAS DataBase Reference)
    FDA UNII 8490C17WAB
    NIST Chemistry Reference 4′-Methylpropiophenone(5337-93-9)
    UNSPSC Code 12352100
    NACRES NA.22

     

    SAFETY

    Risk and Safety Statements

    Symbol(GHS) Exclamation Mark (GHS07)
    GHS07
    Signal word Warning
    Hazard statements H302-H315-H319-H335
    Precautionary statements P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
    Safety Statements 24/25
    WGK Germany 3
    HS Code 29143990
    Storage Class 10 – Combustible liquids
    REACH Registrations Active
    NFPA 704
    1
    0 0

    4′-Methylpropiophenone price More Price(40)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich 517925 4′-Methylpropiophenone 90%, technical grade 5337-93-9 100ml $86.6 2026-04-30 Buy
    TCI Chemical M0768 4′-Methylpropiophenone >95.0%(GC) 5337-93-9 25mL $17 2026-04-30 Buy
    TCI Chemical M0768 4′-Methylpropiophenone >95.0%(GC) 5337-93-9 500mL $151 2026-04-30 Buy
    Usbiological 434050 4′-Methylpropiophenone ≥97% 5337-93-9 100g $229 2026-06-03 Buy
    Usbiological 434050 4′-Methylpropiophenone ≥97% 5337-93-9 500g $352 2026-06-03 Buy

    4′-Methylpropiophenone Chemical Properties, Uses, Production

    Chemical Properties

    clear light yellow liquid

    Uses

    4′-methylpropiophenone has been reported to be used in the synthesis of pharmaceutical compounds such as tolperisone and other muscle relaxants. The substance is also a starting material in the synthesis of 4-methylmethcathinone (mephedrone). Mephedrone has been encountered as a ‘legal high’ and on the illicit drug market masquerading as cocaine (in powder form), MDMA (in tablet form) and as an adulterant. According to the 2016 European Drugs Market Report produced by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), mephedrone has created a specific demand and carved its own distinct market share.

    Uses

    4′-Methylpropiophenone is a chemical reagent used in electrocarboxylation reactions.

    Application

    4′-Methylpropiophenone can be used as a building block to synthesize:
    N-(4-Chlorophenyl)-N′-[1-(4-methylphenyl)propyl]urea as a potential CRAC channel inhibitor.
    Mono and trinuclear cobaloxime/organocobaloxime complexes, which are used as efficient catalysts for the synthesis of cyclic carbonates.
    Tolperisone (TOL) via acid-catalyzed reaction with piperidine hydrochloride and 1,2-dioxolane.

    Definition

    ChEBI: 4-methylpropiophenone is an aromatic ketone that is propiophenone bearing a methyl group at C-4. It derives from a propiophenone.

    Synthesis

    4′-Methylpropiophenone can be synthesized through various methods. One common approach involves the reaction of propiophenone with methylmagnesium bromide or methyl lithium in the presence of a catalyst. Another method utilizes Friedel-Crafts acylation, where propiophenone is acylated with methyl chloride or methyl bromide using a Lewis acid catalyst. These methods allow for the controlled introduction of the methyl group onto the phenyl ring.

    25574-04-3
    5337-93-9
    Synthesis of 4′-Methylpropiophenone from 1-(4-Methylphenyl)-1-propanol 97

    4′-Methylpropiophenone Preparation Products And Raw materials

    Raw materials

  2. 4′-Methylpropiophenone, 94% 100 g | Buy Online

    4?-Methylpropiophenone is a chemical reagent used in electrocarboxylation …

    • CAS: 5337-93-9
    • Molecular Formula: C10H12O
    • MDL Number: MFCD00009312
    • Molecular Weight (g/mol): 148.21
  3. 4 -Methylpropiophenone 90 , technical grade 5337-93-9

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    • Appearance: light yellow liquid
    • Item: specifications
    • Assay%: 99.0%
    • molecular formula: C10H12O
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    4′-Methylpropiophenone is an aromatic ketone where a methyl group is positioned para (4′) to the carbonyl group on the phenyl ring. …

  7. CAS 5337-93-9 4-Methylpropiophenone – Alfa Chemistry

    4′-Methylpropiophenone is a chemical reagent used in electrocarboxylation reactions.

     

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    4′-Methylpropiophenone; Product No: M0768; CAS RN: 5337-93-9; Purity: >95.0%(GC); Appearance: Colorless to Light yellow to …

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