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Isotonitazene is a synthetic opioid analgesic drug from the nitazene class and structural homolog of etonitazene,[3][4][5] which has been sold as a designer drug.[6][7][8] It has only around half the potency of etonitazene in animal studies,[3][9][10][11][12][13][14] but it is likely even less potent in humans as was seen with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans).[3] Isotonitazene (obtained from an online vendor) was fully characterized in November 2019 in a paper where the authors performed a full analytical structure elucidation in addition to determination of the potency at the μ-opioid receptor using a biological functional assay in vitro. While isotonitazene was not compared directly to morphine in this assay, it was found to be around 2.5 times more potent than hydromorphone and slightly more potent than fentanyl.[3][15]
Side effects
Side effects of benzimidazole derived opioids are likely to be similar to those of fentanyl, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening.[16]
Isotonitazene has been detected in multiple fatalities in Europe since March 2019[17] and in the U.S. since August 2019, as reported by NPS Discovery, the Center for Forensic Science Research and Education, and NMS Labs.[18][19]
Legal status
The US Drug Enforcement Administration issued a notice of intent to publish a temporary order to schedule isotonitazene in Schedule I of the Controlled Substances Act,[20] which came into effect on 20 August 2020.[21]
See also
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Isotonitazene is a highly potent synthetic opioid belonging to the 2-benzylbenzimidazole class (nitazenes). It was first synthesized in the 1950s by the pharmaceutical research department of Ciba AG as part of an investigation into structure-activity relationships for analgesic compounds . However, it was never approved for medical use due to its narrow therapeutic window and pronounced risk of respiratory depression . Today, Isotonitazene is exclusively utilized as a certified reference material for analytical and forensic toxicology applications. Buy Isotonitazene (nitazene) Cas 14188-81-9
This product is classified as a DEA Schedule I controlled substance in the United States and is listed in Schedule I of the UN Single Convention on Narcotic Drugs . Buy Isotonitazene (nitazene) Cas 14188-81-9
2. Key Chemical & Physical Properties
-
IUPAC Name: N,N-diethyl-2-[2-({4-[(propan-2-yl)oxy]phenyl}methyl)-5-nitro-1H-benzimidazol-1-yl]ethan-1-amine
-
Form: Solid powder (freebase); also available as hydrochloride salt
-
Melting Point (Hydrochloride): 172–173 °C
-
Solubility: Soluble in methanol, chloroform, and DMSO; salts are expected to be sufficiently water-soluble for injectable administration
-
LogP (Lipophilicity): 4.85 (calculated)
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Appearance in Seized Samples: Brown, yellow, and white powders; also identified in liquid form
3. Pharmacological Profile
Isotonitazene acts as a highly potent mu-opioid receptor (MOR) agonist and has been characterized as a superagonist . Buy Isotonitazene (nitazene) Cas 14188-81-9
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Potency: In pre-clinical studies (mice), Isotonitazene demonstrated approximately four times the analgesic potency of fentanyl, with affinity at the mu-opioid receptor approximately 10 times higher than fentanyl .
-
Mechanism: It activates Gi-protein signaling pathways and recruits β-arrestin-2 . Isotonitazene exhibits a preference for the G-protein pathway over the β-arrestin-2 pathway, but notably can cause GPCR kinase-independent β-arrestin recruitment .
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Onset & Duration: The drug induces rapid-onset, long-lasting respiratory depression, which is dose-dependent and can be life-threatening even at sub-milligram doses . Buy Isotonitazene (nitazene) Cas 14188-81-9
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Antagonist: Naloxone blocks Isotonitazene’s activation of the mu-opioid receptor .
4. Regulatory & Legal Status
Due to its high abuse potential and lack of accepted medical use, Isotonitazene is strictly controlled worldwide:
-
United States: DEA Schedule I controlled substance. The DEA issued an emergency scheduling order in August 2020, which was made permanent effective December 6, 2021 .
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International: Recommended for Schedule I of the UN Single Convention on Narcotic Drugs (1961) by the WHO Expert Committee on Drug Dependence . Buy Isotonitazene (nitazene) Cas 14188-81-9
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Germany: Listed in Annex II of the Narcotics Act (BtMG) since May 22, 2021 (verkehrsfähiges, aber nicht verschreibungsfähiges Betäubungsmittel) . Buy Isotonitazene (nitazene) Cas 14188-81-9
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Canada & UK: Controlled as a benzimidazole-opioid class substance .
Note: Related substances, including N-desethyl isotonitazene (an active metabolite), have also been permanently placed in Schedule I effective January 22, 2026 . Buy Isotonitazene (nitazene) Cas 14188-81-9
5. Forensic & Research Applications
This product is intended for in vitro laboratory research, forensic analysis, and clinical toxicology only. Not for human or veterinary use.
-
Analytical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of nitazenes in biological matrices (blood, urine) and seized materials .
-
LC-MS/MS & GC-MS: Isotonitazene has a detection limit of 0.1 ng/ml and a quantification limit of 0.5 ng/ml using liquid chromatography-mass spectrometry . It is not detected by standard immunoassay-based drug tests .
-
Metabolite Identification: Key biomarkers for toxicological testing include:
-
In urine: N- and O-dealkylation products . Buy Isotonitazene (nitazene) Cas 14188-81-9
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In blood: 5-Aminoisotonitazene (formed by reduction of the nitro group), which is detected in most blood samples . Buy Isotonitazene (nitazene) Cas 14188-81-9
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Active Metabolite: N-Desethyl isotonitazene also exhibits superagonist activity .
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Pharmacological Research: Used to study structure-activity relationships of benzimidazole-opioids, G-protein signaling bias, and mechanisms of opioid-induced respiratory depression . Buy Isotonitazene (nitazene) Cas 14188-81-9
6. Safety & Hazard Information (GHS)
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Signal Word: Danger
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Hazard Statements: Buy Isotonitazene (nitazene) Cas 14188-81-9
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H370: Causes damage to organs
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H225: Highly Flammable liquid and vapour (for methanolic solutions)
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Precautionary Statements:
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P260: Do not breathe dust/fume/gas/mist/vapours/spray
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P264: Wash hands thoroughly after handling
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P270: Do not eat, drink or smoke when using this product
-
P280: Wear protective gloves/protective clothing/eye protection/face protection
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P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
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P307+P311: IF exposed: call a POISON CENTER or doctor/physician
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P405: Store locked up Buy Isotonitazene (nitazene) Cas 14188-81-9
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7. Storage & Handling
-
Storage Temperature: -20°C (long-term stability ≥ 1 year)
-
Formulation: Available as a neat solid or as a 1 mg/ml solution in methanol
-
Stability: Stable for at least 1 year when stored at -20°C
Disclaimer: This information is for scientific and educational reference only.
Buy Isotonitazene 14188 Online – Ultra-Pure Nitazene Opioid Research Chemical
Isotonitazene 14188 – Advanced Research-Grade Synthetic Opioid
Isotonitazene 14188 is a high-purity benzimidazole derivative belonging to the potent nitazene class of synthetic opioids. Designed for professional research and laboratory use, this compound provides exceptional reliability and consistency for pharmacological studies. Researchers seeking to buy Isotonitazene 14188 online or order Isotonitazene 14188 online can utilize this product as a reference standard in advanced opioid research, toxicology, and receptor-binding investigations.
Renowned in scientific forums like Isotonitazene Reddit, this compound is recognized for its ultra-high mu-opioid receptor (MOR) affinity, making it a critical tool for exploring opioid pharmacodynamics, metabolism, and safety profiles.
Chemical Characteristics and Specifications
- Chemical Name: N,N-diethyl-2-(2-(4-isopropoxybenzyl)-5-nitro-1H-benzimidazol-1-yl)acetamide
- Synonyms: Isotonitazene 14188, Iso-Nitazene Reference Standard
- CAS Number: 1400742-17-7
- Molecular Formula: C₂₃H₂₈N₄O₄
- Molecular Weight: 424.5 g/mol
- Appearance: Fine, crystalline white to off-white powder
- Purity: ≥98% (HPLC-verified with full chromatographic documentation)
- Solubility: 35 mg/mL in DMSO, 20 mg/mL in ethanol
- Storage Conditions: -20°C in argon-purged amber vials
- Stability: Maintains stability up to 24 months when stored under recommended conditions
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- Conduct structure-activity relationship (SAR) studies to explore opioid potency
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Equally Important, Isotonitazene N,N-Diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H-benzimidazole-1-ethanamine (isotonitazene) is a synthetic opioid analgesic. It is a member of the benzimidazole family of opioids which includes etonitazene, a potent internationally controlled opioid analgesic.
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Technical Data of Isotonitazene Powder
Product Name: Isotonitazene Powder
Synonyms: Isotonitazene
IUPAC: N,N-diethyl-2-[2-[(4-isopropoxyphenyl)methyl]-5-nitro-benzimidazol-1-yl]ethanamine
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Isotonitazene (CAS 14188-81-9): A High-Potency Benzimidazole Opioid for Advanced Research
Product Name: Isotonitazene
Synonyms: ISO; Isotonitazene
CAS Number: 14188-81-9
Chemical Name: N,N-diethyl-2-[[(4-ethoxyphenyl)methyl]-5-nitro-1H-benzimidazol-1-yl]ethanamine
Molecular Formula: C₂₁H₂₇N₅O₃
Molar Mass: 421.52 g/mol
Introduction: A Potent Subject for Specialized Research
Isotonitazene is a synthetic compound belonging to the benzimidazole class, a group of chemicals known for their high affinity and potency at opioid receptors. First identified in scientific literature in the late 1950s, this compound has garnered significant attention in modern research due to its complex pharmacological profile. It is structurally distinct from classical opioids like morphine or fentanyl, featuring a benzimidazole core, which is a critical area of study for understanding structure-activity relationships (SAR) in opioid receptor binding.
This compound is provided exclusively for the purpose of in vitro research and chemical analysis by qualified professionals in controlled laboratory environments.
Key Characteristics and Research Properties
-
Exceptional Potency: Isotonitazene is characterized in preclinical literature as an extremely potent agonist at the μ-opioid receptor (MOR). Its potency is a primary subject of research, with studies indicating it may be significantly more potent than morphine. This high potency demands the utmost respect for precision in handling, measurement, and dilution. Research must be conducted using advanced, calibrated analytical equipment.
-
Benzimidazole Class Compound: As part of the benzimidazole opioid family, its mechanism of action and metabolic pathways are a key focus of comparative pharmacological studies. Researchers utilize Isotonitazene to investigate the binding motifs and efficacy of non-traditional opioid structures.
-
Receptor Binding Studies: This compound is a vital tool for in vitro assays aimed at elucidating the complexities of G-protein-coupled receptor (GPCR) signaling, particularly at the μ-opioid receptor site. It is used to study receptor activation, G-protein coupling, and the beta-arrestin recruitment pathways associated with opioid agonists.
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Metabolic Pathway Analysis: Isotonitazene serves as a parent compound for studying in vitro metabolic pathways. Researchers analyze it to identify potential metabolites using techniques like LC-HRMS/MS (Liquid Chromatography – High-Resolution Tandem Mass Spectrometry), which is crucial for forensic toxicology and pharmacological profiling.
Intended Applications and Research Use
Isotonitazene (CAS 14188-81-9) is a chemical for controlled scientific investigation and is not for human or veterinary use.
Its primary applications include, but are not limited to:
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Forensic Toxicology: Used as a high-purity reference standard for the development and validation of analytical methods to detect and quantify this substance and its potential metabolites in forensic samples.
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Pharmacological Research: Studying the in vitro efficacy, potency, and binding kinetics of novel synthetic opioids at human opioid receptors.
-
Metabolic Studies: Investigation of cytochrome P450 metabolism and the identification of major and minor metabolic pathways in hepatic microsome models.
-
Structure-Activity Relationship (SAR) Studies: Essential for researchers mapping how specific molecular modifications on the benzimidazole scaffold affect binding affinity, efficacy, and selectivity at opioid receptor subtypes.
Handling, Storage, and Safety Information
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Purity: >98% (HPLC verified)
-
Appearance: Typically supplied as a white to off-white powder or crystalline solid.
-
Solubility: Soluble in common organic solvents such as dimethyl sulfoxide (DMSO), ethanol, and methanol. Limited solubility in water.
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Storage: Must be stored in a cool, dry, and dark environment, ideally between +2°C and +8°C. The container must be tightly sealed and protected from moisture and light to ensure long-term stability.
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Handling: EXTREME CAUTION. This is a highly potent substance that poses a severe health risk even in microgram quantities. It must only be handled by trained researchers in a fully equipped laboratory using appropriate personal protective equipment (PPE), including gloves, lab coats, and safety glasses. A fume hood is strongly recommended for any handling of the pure
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