Buy 4-Methylthioamphetamine (para) Cas 14116-06-4

Buy 4-Methylthioamphetamine (para) Cas 14116-06-4

4-Methylthioamphetamine (4-MTA), also known as para-methylthioamphetamine (MTA), is a designer drug of the substituted amphetamine class developed in the 1990s by a team led by David E. Nichols, an American pharmacologist and medical chemist, at Purdue University. It acts as a non-neurotoxic highly selective serotonin releasing agent (SSRA) in animals.^[2][3][4] 4-MTA is the methylthio derivative of amphetamine.

4-MTA is a strong serotonin releaser similar to para-methoxyamphetamine (PMA), which can cause pronounced hyperthermia potentially resulting in organ failure and death.^{[5][6][7][8][better source needed]} Therefore, the major neuropharmacological effect is an increased release of serotonin, and the inhibition of serotonin uptake of monoamine oxidase A (MAO-A). The combination of the releasing of serotonin from neurons and the prevention of breaking this neurotransmitter down again, leads to dangerous serotonin syndrome. The serotonin syndrome is a hyper serotonergic state, which can become fatal and is a side effect of serotonergic drugs. The symptoms of serotonin syndrome caused by 4-MTA are described in the Report on the Risk Assessment of 4-MTA

Symptoms of the serotonin syndrome caused by 4-MTA

• Euphoria
• Drowsiness
• Sustained rapid eye movement
• Hyperreflexia – overreaction of the reflexes
• Agitation
• Restlessness
• Tachycardia – fast heart rate
• Headache
• Clumsiness
• Disorientation
• Intoxication – feeling drunk and dizzy
• Rigidity
• Rapid muscle contraction and relaxation in the ankle causing abnormal movements of the foot
• Muscle contraction and relaxation in the jaw
• Muscle twitching leading to hyperthermia
• Shivering
• High body temperature
• Sweating
• Altered mental status (including confusion and hypomania – a ‘happy drunk state’)

14116-06-4

• 

• Basic information

  1. Product Name: 4-METHYLTHIOAMPHETAMIN
  2. Synonyms: 4-METHYLTHIOAMPHETAMIN;P 1882;p-MethylthioaMphetaMine;α-Methyl-4-(Methylthio)benzeneethanaMine;4-MTA;1-(4-methylsulfanylphenyl)propan-2-amine
  3. CAS NO:14116-06-4
  4. Molecular Formula: C₁₀H₁₅NS
  5. Molecular Weight: 181.3
  6. EINECS: N/A
  7. Product Categories: Amines;Aromatics;Sulfur & Selenium Compounds
  8. Mol File: 14116-06-4.mol

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 289°C at 760 mmHg
  3. Flash Point: 128.6°C
  4. Appearance: /
  5. Density: 1.04g/cm³
  6. Vapor Pressure: 0.00226mmHg at 25°C
  7. Refractive Index: 1.568
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. PKA: 9.96±0.10(Predicted)
  11. CAS DataBase Reference: 4-METHYLTHIOAMPHETAMIN(CAS DataBase Reference)
  12. NIST Chemistry Reference: 4-METHYLTHIOAMPHETAMIN(14116-06-4)
  13. EPA Substance Registry System: 4-METHYLTHIOAMPHETAMIN(14116-06-4)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 14116-06-4(Hazardous Substances Data)

• Suppliers
• Usage
• Upstream product
• Downstream Products
• Article

14116-06-4 Suppliers

This product is a nationally controlled contraband or patented product, and the Lookchem platform doesn’t provide relevant sales information.

14116-06-4 Usage

Uses

Used in Forensic Applications:
4-METHYLTHIOAMPHETAMIN is used as a forensic tool for the detection and analysis of 4-METHYLTHIOAMPHETAMIN in cases related to illicit drug use and distribution. Its identification helps in understanding the prevalence and circulation of this substance in the drug market.
Used in Pharmaceutical Research:
4-METHYLTHIOAMPHETAMIN is used as a research compound for studying its effects on serotonin release and its potential as a monoamine oxidase-A (MAO-A) inhibitor. This research can contribute to the development of new treatments for various psychiatric and neurological disorders.
Used in Illicit Drug Market:
Although not a legitimate use, 4-METHYLTHIOAMPHETAMIN is used as a recreational drug in the form of “ecstasy” or “flatliners” on the illicit drug market.

Check Digit Verification of cas no

The CAS Registry Mumber 14116-06-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,1,1 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 14116-06:
(7*1)+(6*4)+(5*1)+(4*1)+(3*6)+(2*0)+(1*6)=64
64 % 10 = 4
So 14116-06-4 is a valid CAS Registry Number.

InChI:InChI=1/C10H15NS/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6,8H,7,11H2,1-2H3

14116-06-4Upstream product

• 713-78-01-(4-methylthiophenyl)-2-nitro-1-propene 
• 88356-92-71-[4-(methylthio)phenyl]-2-propanone 
• 1236220-48-61-(4-methylthiophenyl)-2-propanone oxime 
• 77287-34-4formamide 
• 94784-92-64-Methylthioamphetamine hydrochloride 
• 3446-89-74-(Methylthio)benzaldehyde 
• 79-24-3Nitroethane 

14116-06-4Downstream Products

• 94784-92-64-Methylthioamphetamine hydrochloride 

14116-06-4Relevant academic research and scientific papers

In vitro neuronal and vascular responses to 5-hydroxytryptamine: Modulation by 4-methylthioamphetamine, 4-methylthiomethamphetamine and 3,4-methylenedioxymethamphetamine

Murphy, James E.J.,Flynn, James J.,Cannon, Dara M.,Guiry, Patrick J.,McCormack, Peter,Baird, Alan W.,McBean, Gethin J.,Keenan, Alan K.

, p. 61 – 67 (2002)

4-Methylthioamphetamine and 4-methylthiomethamphetamine are thioarylethylamines structurally related to 3,4-methylenedioxymethamphetamine (MDMA, ‘Ecstasy’). This study compared effects of these agents and MDMA on 5-hydroxytryptamine (5-HT) signalling systems in the brain and vasculature in vitro. Both 4-methylthioamphetamine and 4-methylthiomethamphetamine (100 μM) reduced the rate of specific high affinity [3H]5-HT reuptake in isolated rat brain synaptosomes to 14% and 10% of control, respectively. The concentration required for half-maximal inhibition (IC50) of [3H]5-HT reuptake by 4-methylthioamphetamine (0.27 μM) was significantly lower (P3H]5-HT from synaptosomes, but were significantly less effective than MDMA at the concentrations tested (1-100 μM). In isolated rat aorta, a 15-min preincubation with 4-methylthioamphetamine or 4-methylthiomethamphetamine significantly reduced the maximal contraction (Emax) induced by 5-HT to 71% or 91% of control (P50) from 4.13 to 20.08 μM (Pmax or the EC50 of 5-HT-induced aortic contraction. It is concluded that both 4-methylthioamphetamine and 4-methylthiomethamphetamine are potent inhibitors of [3H]5-HT reuptake in the brain. Furthermore, unlike MDMA, they both directly inhibit 5-HT-mediated vascular contraction. These results suggest that these compounds may be potentially more harmful than MDMA in the context of human misuse.

Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted α-alkylthioamphetamines

Cloonan, Suzanne M.,Keating, John J.,Corrigan, Desmond,O’Brien, John E.,Kavanagh, Pierce V.,Williams, D. Clive,Meegan, Mary J.

experimental part, p. 4009 – 4031 (2010/08/06)

4-Methylthioamphetamine (4-MTA) is recognised as a 3,4-methylenedioxymethamphetamine (MDMA)-like drug of abuse. Such amphetamine-type drugs often contain byproducts of uncontrolled, illegal clandestine synthetic processes. We report the isolation and stru

Synthesis and serotonin transporter activity of sulphur-substituted α-alkyl phenethylamines as a new class of anticancer agents

Cloonan, Suzanne M.,Keating, John J.,Butler, Stephen G.,Knox, Andrew J.S.,Jorgensen, Anne M.,Peters, Guenther H.,Rai, Dilip,Corrigan, Desmond,Lloyd, David G.,Williams, D. Clive,Meegan, Mary J.

experimental part, p. 4862 – 4888 (2010/01/16)

4-METHYLTHIOAMPHETAMIN

CAS Registry Number:

14116-06-4

Synonyms:

4-METHYLTHIOAMPHETAMIN

Molecular Formula:

C₁₀H₁₅NS

Molecular Weight:

181.302

The discovery that some serotonin reuptake transporter (SERT) ligands have the potential to act as pro-apoptotic agents in the treatment of cancer adds greatly to their diverse pharmacological application. 4-Methylthioamphetamine (MTA) is a selective ligand for SERT over other monoamine transporters. In this study, a novel library of structurally diverse 4-MTA analogues were synthesised with or without N-alkyl and/or C-α methyl or ethyl groups so that their potential SERT-dependent antiproliferative activity could be assessed. Many of the compounds displayed SERT-binding activity as well as cytotoxic activity. While there was no direct correlation between these two effects, a number of derivatives displayed anti-tumour effects in lymphoma, leukaemia and breast cancer cell lines, showing further potential to be developed as possible chemotherapeutic agents.

4-Methylthioamphetamine

Base Information

• Chemical Name:4-Methylthioamphetamine
• CAS No.:14116-06-4
• Molecular Formula:C₁₀H₁₅NS
• Molecular Weight:181.302
• Hs Code.:
• UNII:6JP2T8KXTR
• DSSTox Substance ID:DTXSID90894854
• Nikkaji Number:J1.114.643K
• Wikipedia:4-Methylthioamphetamine
• Wikidata:Q230013
• Pharos Ligand ID:1R6MFJSH2XHZ
• ChEMBL ID:CHEMBL6467
• Mol file:14116-06-4.mol

Synonyms:4-methylthioamphetamine;alpha-methyl-p-(methylthio)phenethylamine;p-methylthioamphetamine

 This product is a nationally controlled contraband, and the Lookchem platform doesn’t provide relevant sales information.

Chemical Property of 4-Methylthioamphetamine

Chemical Property:

• Vapor Pressure:0.00226mmHg at 25°C 
• Boiling Point:289°C at 760 mmHg 
• PKA:9.96±0.10(Predicted) 
• Flash Point:128.6°C 
• PSA：51.32000 
• Density:1.04g/cm³ 
• LogP:2.99850 
• XLogP3:2.3
• Hydrogen Bond Donor Count:1
• Hydrogen Bond Acceptor Count:2
• Rotatable Bond Count:3
• Exact Mass:181.09252066
• Heavy Atom Count:12
• Complexity:119

Purity/Quality:

Safty Information:

• Pictogram(s): 
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES:CC(CC1=CC=C(C=C1)SC)N
• Description4-MTA is a methylthio analog of para-methoxyamphetamine (PMA), a hallucinogenic drug that has been scheduled in many countries. In animal models, the effects of 4-MTA are qualitatively and quantitatively indistinguishable from those of PMA. The metabolism of 4-METHYLTHIOAMPHETAMIN has recently been described. This product is intended for forensic applications.
• UsesIt is a potent non-neurotonic serotonin-releasing agent, and a potent, selective and reversible monoamine oxidase-A (MAO-A) inhibitor. 4-Methylthioamphetamine (4-MTA) belongs to a group of new amphetamine derivatives that is usually sold as “ecstasy” or “flatliners” on the illicit drug market.

Technology Process of 4-Methylthioamphetamine

There total 10 articles about 4-Methylthioamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

S-oxidation products of alkylthioamphetamines

Rezende, Marcos Caroli,Nunez, Christian,Sepulveda-Boza, Silvia,Cassels, Bruce K.,Hurtado-Guzman, Claudio

, p. 2741 – 2750 (2007/10/03)

The preparation of the sulfoxides and the sulfones of two centrally active alkylthioamphetamine salts, (±)-1-(4-methylthiophenyl)-2-aminopropane hydrochloride (2) (MTA · HCl) and (±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane hydrochloride (

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