Buy Xylazine (Rompun) Cas 7361–61–7

Xylazine is a structural analog of clonidine and an α₂-adrenergic receptor agonist,^[1] sold under many trade names worldwide, most notably the Bayer brand name Rompun,^[2] as well as Anased, Sedazine and Chanazine.^[3]

Xylazine is a common veterinary drug used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle, and other mammals.^[2] In veterinary anesthesia, it is often used in combination with ketamine. Veterinarians also use xylazine as an emetic, especially in cats.^[4] Drug interactions vary with different animals.^[5][6][7]

Xylazine was first investigated for human use in the 1960s in West Germany for antihypertensive effects before being discontinued and marketed as a veterinary sedative. Xylazine’s mechanism of action was discovered in 1981, which led to the creation of other α₂-adrenergic receptor agonists such as medetomidine and dexmedetomidine.

Xylazine has become a commonly abused street drug in the United States where it is known by the street name “tranq“, particularly in the territory of Puerto Rico.^[8] The drug is used as a cutting agent for heroin and fentanyl.^{[9][10][11][12]}

Xylazine was discovered as an antihypertensive agent in 1962 by Farbenfabriken Bayer in Leverkusen, West Germany.^[13][14] In human trials xylazine was found to depress the central nervous system leading to the discontinuation of further research for its use in humans and it was instead marketed as a veterinary sedative. Xylazine was first used for this purpose in the late 1960s. Xylazine proved popular and in the 1970s became one of the most common large animal sedatives.^[14] In 1981 a study discovered that the cause sedation was due to xylazine’s effect on the α2-adrenergic receptor.^[15][14] This led to the development of other α₂-adrenergic receptor agonists such as detomidine, medetomidine, dexmedetomidine, and romifidine.^[14]

In the United States, xylazine was approved by the FDA only for veterinary use as a sedative, analgesic, and muscle relaxant in dogs, cats, horses, elk, fallow deer, mule deer, sika deer, and white-tailed deer.^[1][3] The sedative and analgesic effects of xylazine are related to central nervous system depression. Xylazine’s muscle relaxant effect inhibits the transmission of neural impulses in the central nervous system.^[16]

In scientific research using animal experiments, xylazine is a component of the most common anesthetic, ketamine-xylazine (see: Rodent cocktail), to anesthetize rats, mice, hamsters, and guinea pigs.^[17]