Buy Trifluoperazine (Stelazine) Cas 117-89-5

Trifluoperazine, marketed under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia.^[2] It may also be used short term in those with generalized anxiety disorder but is less preferred to benzodiazepines.^[2] It is of the phenothiazine chemical class. It was approved for medical use in the United States in 1959.^[3]

Trifluoperazine is an effective antipsychotic for people with schizophrenia condition.^[4] There is low-quality evidence that trifluoperazine increases the chance of being improved when compared to placebo when people are followed up for 19 weeks.^[4] There is low-quality evidence that trifluoperazine reduces the risk of relapse when compared with placebo when people are followed for 5 months.^[4] As of 2014 there was no good evidence for a difference between trifluoperazine and placebo with respect to the risk of experiencing intensified symptoms over a 16-week period nor in reducing significant agitation or distress.^[4]

There is no good evidence that trifluoperazine is more effective for schizophrenia than lower-potency antipsychotics like chlorpromazine, chlorprothixene, thioridazine and levomepromazine, but trifluoperazine appears to cause more adverse effects than these drugs.^[5]

It appears to be effective for people with generalized anxiety disorder but the benefit–risk ratio was unclear as of 2005.^[6]

It has been experimentally used as a drug to kill eukaryotic pathogens such as Balamuthia in humans.^[7]

Its use in many parts of the world has declined because of highly frequent and severe early and late tardive dyskinesia, a type of extrapyramidal symptom. The annual development rate of tardive dyskinesia may be as high as 4%.^{[citation needed]}

A 2004 meta-analysis of the studies on trifluoperazine found that it is more likely than placebo to cause extrapyramidal side effects such as akathisia, dystonia, and Parkinsonism.^[8] It is also more likely to cause somnolence and anticholinergic side effects such as red eye and xerostomia (dry mouth).^[8] All antipsychotics can cause the rare and sometimes fatal neuroleptic malignant syndrome.^[9] Trifluoperazine can lower the seizure threshold.^[10] The antimuscarinic action of trifluoperazine can cause excessive dilation of the pupils (mydriasis), which increases the chances of patients with hyperopia developing glaucoma.^[11]