Buy Tiotixene (Navane) Cas 3313-26-6
Tiotixene, or thiothixene, is a typical antipsychotic sold under the brand name Navane which is predominantly utilised to treat schizophrenia.[2] Beyond its primary indication, it can exhibit a variety of effects common to neuroleptic drugs including anxiolytic, anti-depressive, and anti-aggressive properties.[3]
The drug was first synthesized and marketed in 1967 under the pharmaceutical company Pfizer.[2][4][5][6] While the usage of the drug has declined in recent decades, the drug continues to be manufactured and prescribed in the US and Canada.[6]
Being a member of the thioxanthene class, it is chemically related to other typical neuroleptic agents such as chlorprothixene, clopenthixol, flupenthixol, and zuclopenthixol. Tiotixene also shares structural similarities with thioproperazine and pipotiazine, which are members of the phenothiazine class.
Medical uses
Tiotixene is a widely used drug for the treatment of various psychiatric disorders such as schizophrenia, bipolar disorder, mania, and behavioural disturbances.[7] The drug regulates behaviour and thoughts, and can also exhibit an anti-depressive effect.[3][8]
The side effect profile is similar to related antipsychotic agents, displaying weight gain, mental distress, and inability to sit still. Other possible symptoms include anticholinergic side effects such as insomnia, blurred vision, and dry mouth.[9][10] Less frequently encountered side effects are drug-induced movement disorders such as Parkinsonism and tardive dyskinesia.[11][12]
The results of various dose-response studies (10–60 mg) indicate a stimulating effect at lower doses, which diminishes as higher doses are administered.[13] Overall, the efficacy of thiothixene when compared to other antipsychotic drugs was evaluated to be at least as effective regardless of the optimum dosage.[13][14][15]
Pharmacology
Pharmacokinetics
As common with tricyclic psychotherapeutic agents, tiotixene is rapidly and extensively absorbed.[16] Peak serum concentration of the drug is achieved after 1–3 hours.[17] After absorption, the compound and its metabolites are spread widely throughout the body.
The drug’s metabolism proceeds rapidly and primarily in the liver.[2][16] Although N-demethyltiotixene was identified as its major metabolite, the metabolic mechanisms remain elusive.[2][18] After metabolism, most of the material is excreted through the faeces.[16]
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