Buy Thio-THIP (4-5-6-7-tetrahydroisothiazolo(5-4-c]pyridin-3-ol) Cas 97164-95-9

Thio-THIP, also known as 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol, is a low-potency GABA_A receptor very weak partial agonist or antagonist related to gaboxadol (THIP).^[1][2][3] It is also a weak GABA_A-ρ receptor antagonist^[4][5] and a weak GABA reuptake inhibitor.^[2] The drug has three orders of magnitude lower potency as a GABA_A receptor modulator than gaboxadol.^[6][7] This is unlike the case of muscimol and thiomuscimol, which are almost equipotent.^[8] Like gaboxadol, thio-THIP is a zwitterion.^[1][8] It may cross the blood–brain barrier similarly to gaboxadol.^[8] Thio-THIP was developed and described by Povl Krogsgaard-Larsen and colleagues by 1981.^[6][9][7]

• Aza-THIP
• Iso-THIP
• THAZ
• THPO
• 4-PIOL
• Thio-4-PIOL