Buy Thalidomide (Contergan) Cas 50-35-1

Thalidomide, sold under the brand names Contergan, Distaval and Thalomid among others, is an oral administered medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions).^[6][7] Thalidomide has been used to treat conditions associated with HIV: aphthous ulcers, HIV-associated wasting syndrome, diarrhea, and Kaposi’s sarcoma, but increases in HIV viral load have been reported.^[6]

Common side effects include sleepiness, rash, and dizziness.^[6] Severe side effects include tumor lysis syndrome, blood clots, and peripheral neuropathy.^[8] Thalidomide is a known human teratogen and carries an extremely high risk of severe, life-threatening birth defects if administered or taken during pregnancy.^[6] It causes skeletal deformities such as amelia (absence of legs and/or arms), absence of bones, and phocomelia (malformation of the limbs). A single dose of thalidomide, regardless of dosage, is enough to cause teratogenic effects.^[6]

Thalidomide was first marketed in 1957 in West Germany, where it was available as an over-the-counter drug.^[9][10] When first released, thalidomide was promoted for anxiety, trouble sleeping, “tension”, and morning sickness.^[10][11] While it was initially thought to be safe in pregnancy, thalidomide was found to cause birth defects, resulting in its removal from the market in Europe in 1961.^[9][10] The total number of infants severely harmed by thalidomide use during pregnancy is estimated at over 10,000, possibly 20,000, of whom about 40% died around the time of birth.^[6][10] Those who survived had limb, eye, urinary tract, and heart problems.^[9] Its initial entry into the US market was prevented by Frances Kelsey, a reviewer at the FDA.^[11] The birth defects caused by thalidomide led to the development of greater drug regulation and monitoring in many countries.^[9][11]

It was approved in the United States in 1998 for use as a treatment for cancer.^[6] It is on the World Health Organization’s List of Essential Medicines.^[12] It is available as a generic medication.^[8][13]

Thalidomide is used as a first-line treatment for multiple myeloma in combination with dexamethasone or with melphalan and prednisone to treat acute episodes of erythema nodosum leprosum, as well as for maintenance therapy.^[14][15]

The bacterium that causes tuberculosis (TB) is related to leprosy. Thalidomide may be helpful in some cases where standard TB drugs and corticosteroids are not sufficient to resolve severe inflammation in the brain.^[16][17]

It is used as a second-line treatment to manage graft-versus-host disease and aphthous stomatitis in children and has been prescribed for other conditions in children, including actinic prurigo and epidermolysis bullosa; the evidence for these uses is weak.^[18] It is recommended only as a third line treatment in graft-versus-host-disease in adults because of lack of efficacy and side effects observed in clinical trials.^[19][20]

Prescriptions of thalidomide are accompanied by strict measures to avoid any possibility of use during pregnancy, and thalidomide should be avoided in women wanting to conceive.^[21] In the United States, the prescribing doctor is required to ensure that contraception is being used and that regular pregnancy tests are taken.^[15][14]