Buy Ropinirole (Requip) Cas 91374-21-9

Ropinirole, sold under the brand name Requip among others, is a medication used to treat Parkinson’s disease (PD) and restless legs syndrome (RLS).^[3] It is taken by mouth.^[4]

Common side effects include sleepiness, vomiting, and dizziness.^[4] Serious side effects may include pathological gambling, hypersexuality, low blood pressure with standing and hallucinations.^[3][4] Use in pregnancy and breastfeeding is of unclear safety.^[5] It is a dopamine agonist and works by triggering dopamine D₂ receptors.^[4]

It was approved for medical use in the United States in 1997.^[4] It is available as a generic medication.^[3] In 2023, it was the 212th most commonly prescribed medication in the United States, with more than 2 million prescriptions.^[6][7]

Ropinirole is prescribed for mainly Parkinson’s disease, restless legs syndrome, and extrapyramidal symptoms. It can also reduce the side effects caused by selective serotonin reuptake inhibitors, including Parkinsonism syndrome as well as sexual dysfunction and erectile dysfunction caused by either SSRIs^[8] or antipsychotics.

A 2008 meta-analysis found that ropinirole was less effective than pramipexole in the treatment of restless legs syndrome.^[9]

Ropinirole can cause nausea, dizziness, hallucinations, orthostatic hypotension, and sudden sleep attacks during the daytime. Unusual side effects specific to D₃ agonists such as ropinirole and pramipexole can include hypersexuality, punding and compulsive gambling, even in patients without a history of these behaviours.^[10]

Ropinirole is also known to cause an effect known as “augmentation” when used to treat restless legs syndrome, where over time treatment with dopamine agonists will cause restless legs syndrome symptoms to become more severe. This usually leads to constant dosage increases in an attempt to offset the symptom progression. Symptoms will return to the level of severity they were experienced at before treatment was initiated if the drug is stopped; however, both ropinirole and pramipexole are known to cause painful withdrawal effects when treatment is stopped and the process of taking a patient who has been using the medication long-term off these drugs is often very difficult and should be supervised by a medical professional.^[11]