Buy Promethazine (Phenergan) Cas 60-87-7

Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, nausea, and vomiting. It may also help with some symptoms associated with the common cold^[9] and may also be used for sedating people who are agitated or anxious, an effect that has led to some recreational use (especially with codeine).^[10][11][12] Promethazine is taken by mouth (oral), as a rectal suppository, or by injection into a muscle (IM).^[9]

Common side effects of promethazine include confusion and sleepiness;^[9] consumption of alcohol or other sedatives can make these symptoms worse.^[9] It is unclear if use of promethazine during pregnancy or breastfeeding is safe.^[9][11] Use of promethazine is not recommended in those less than two years old, due to potentially negative effects on breathing.^[9] Use of promethazine by injection into a vein is not recommended, due to potential skin damage.^[9] Promethazine is in the phenothiazine family of medications.^[9] It is also a strong anticholinergic and at high or toxic doses can act as a deliriant.^[13]

Promethazine was made in the 1940s by a team of scientists from Rhône-Poulenc laboratories.^[14] It was approved for medical use in the United States in 1951.^[9] It is a generic medication and is available under many brand names globally.^[1] In 2023, it was the 230th most commonly prescribed medication in the United States, with more than 1 million prescriptions;^[15][16] and the combination with dextromethorphan was the 252nd most commonly prescribed medication in the United States, with more than 1 million prescriptions.^[17][18]

Promethazine has a variety of medical uses, including:

• Sedation^[19]
• In Germany, it is approved for the treatment of agitation and agitation associated with underlying psychiatric disorders with a maximum daily dose of 200 mg.^[20]
• For nausea and vomiting associated with anesthesia or chemotherapy. It is commonly used postoperatively as an antiemetic. The antiemetic activity increases with increased dosing; however, side effects also increase, which often limits maximal dosing.^[19]
• For moderate to severe morning sickness and hyperemesis gravidarum: In the UK, promethazine is the drug of first choice. Promethazine is preferred during pregnancy because it is an older drug and there is more data regarding the use of it during pregnancy. Second-choice medications, which are used if promethazine isn’t tolerated or the patient cannot take it, are metoclopramide or prochlorperazine.^[21][19]
• For allergies such as hay fever and together with other medications in anaphylaxis^[9]
• To aid with symptoms of the common cold^[9]
• Motion sickness,^[9] including space sickness^[22]
• Hemolytic disease of the newborn^[9]
• Anxiety before surgery^[9]