Buy Prochlorperazine (Compazine) Cas 58-38-8

Prochlorperazine, formerly^[4] sold under the brand name Compazine among others, is a medication used to treat nausea, migraines, schizophrenia, psychosis and anxiety.^[5][6][7][8] It is a less preferred medication for anxiety.^[5] It may be taken by mouth, rectally, injection into a vein, or injection into a muscle.^[5]

Common side effects include sleepiness, blurry vision, low blood pressure, and dizziness.^[5] Serious side effects may include movement disorders including tardive dyskinesia and neuroleptic malignant syndrome.^[5] Use in pregnancy and breastfeeding is generally not recommended.^[9] It is a typical antipsychotic which is believed to work by reducing the action of dopamine in the brain.^[5]

Prochlorperazine was approved for medical use in the United States in 1956.^[5] It is available as a generic medication.^[6] In 2020, it was the 355th most commonly prescribed medication in the United States, with more than 600 thousand prescriptions.^[10][11]

Prochlorperazine is used to prevent vomiting caused by chemotherapy, radiation therapy and in the pre- and postoperative setting.^[12] A 2015 Cochrane review found no differences in efficacy among drugs commonly used for this purpose in emergency rooms.^[13]

Prochlorperazine, generally by intravenous, is used to treat migraine.^[14][15] Such use is recommended by The American Headache Society.^[7] A 2019 systematic review found prochlorperazine was nearly three times more likely than metoclopramide to relieve headache within 60 minutes of administration.^[14]

In the UK prochlorperazine maleate has been used for labyrinthitis, which includes nausea and vertigo.^[16]

Sedation is very common, and extrapyramidal side effects are common and include restlessness, dystonic reactions, pseudoparkinsonism, and akathisia; the extrapyramidal symptoms can affect 2% of people at low doses, whereas higher doses may affect as many as 40% of people.^[17][18]

Prochlorperazine can also cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include high fever, stiff muscles, neck muscle spasms, confusion, irregular pulse or blood pressure, fast heart rate (tachycardia), sweating, and abnormal heart rhythms (arrhythmias). Research from the Veterans Administration and the United States Food and Drug Administration show injection site reactions. Adverse effects are similar in children.^[12]

The FDA-approved label for prochlorperazine includes a warning for increased risk of mortality in elderly patients with dementia-related psychosis.^[19]