Buy Pentobarbital  (pentobarbitone) Cas 76-74-4

Pentobarbital (US) or pentobarbitone (British and Australian) is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions in emergencies.^[3] It can also be used for short-term treatment of insomnia but has been largely replaced by the benzodiazepine family of drugs.

In high doses, pentobarbital causes death by respiratory arrest. It is frequently used for veterinary euthanasia, and is used by some US states and the United States federal government for executions of convicted criminals by lethal injection.^[4] In some countries and states, it is also used for physician-assisted suicide.^[5][6]

Pentobarbital was developed by Ernest H. Volwiler and Donalee L. Tabern [de] at Abbott Laboratories in 1930.^[7] The drug was widely abused beginning in the late 1930s, and it is sometimes known as “yellow jackets” due to the yellow color of Nembutal-branded capsules.^[8]

Typical applications for pentobarbital are sedative, short term hypnotic, preanesthetic, insomnia treatment, and control of convulsions in emergencies.^[3] Abbott Pharmaceutical discontinued manufacture of their Nembutal brand of pentobarbital capsules in 1999, largely replaced by the benzodiazepine family of drugs.

Pentobarbital can reduce intracranial pressure in Reye syndrome, treat traumatic brain injury and induce coma in cerebral ischemia patients.^[9] Pentobarbital-induced coma has been advocated in patients with acute liver failure refractory to mannitol.^[10]

Pentobarbital is also used as a veterinary anesthetic agent and euthanasia drug.^[11]

Pentobarbital can cause death when used in high doses. It is used for euthanasia for humans as well as animals. It is taken alone, or in combination with complementary agents such as phenytoin, in commercial animal euthanasia injectable solutions.^[5][6] As of 2021, the sodium salt of pentobarbital was considered the “drug of choice” for animal euthanasia in the United States and Canada.^[12]

In the Netherlands, pentobarbital is part of the standard protocol for physician-assisted suicide for self-administration by the patient.^[13] It is given in liquid form, in a solution of sugar syrup and alcohol, containing 9 grams of pentobarbital. This is preceded by an antiemetic to prevent vomiting.^[13]

It is taken by mouth for physician-assisted death in the United States states of Oregon, Washington, Vermont, and California (as of January 2016).^[14][15] The oral dosage of pentobarbital indicated for physician-assisted suicide in Oregon is typically 10 g of liquid.^[14][15]