Buy Paroxetine (Paxil) Cas 61869-08-7

Paroxetine, sold under the brand name Paxil among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class^[6] used to treat major depressive disorder, obsessive–compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, and premenstrual dysphoric disorder.^[6] It has also been used in the treatment of premature ejaculation,^[7] and hot flashes due to menopause.^[6][8] It is taken orally (by mouth).^[6]

Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction.^[6] Serious side effects may include suicidal thoughts in those under the age of 25, serotonin syndrome, and mania.^[6] While the rate of side effects appears similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndrome may occur more often.^[9][10] Use in pregnancy is not recommended, while use during breastfeeding is relatively safe.^[11] It is believed to work by blocking the reuptake of the chemical serotonin by neurons in the brain.^[6]

Paroxetine was approved for medical use in the United States in 1992 and initially sold by GlaxoSmithKline.^[6][12] It is on the World Health Organization’s List of Essential Medicines.^[13] It is available as a generic medication.^[14] In 2023, it was the 72nd most commonly prescribed medication in the United States, with more than 9 million prescriptions.^[15][16] In 2018, it was in the top 10 of most prescribed antidepressants in the United States.^[17]

Paroxetine is primarily used to treat major depressive disorder, obsessive–compulsive disorder, post-traumatic stress disorder, social anxiety disorder, and panic disorder. It is also occasionally used for agoraphobia, generalized anxiety disorder, premenstrual dysphoric disorder, and menopausal hot flashes.^{[18][19][20][21][22]}

A variety of meta-analyses have been conducted to evaluate the efficacy of paroxetine in depression. They have variously concluded that paroxetine is superior to placebo and that it is equivalent to other antidepressants.^[23][24][25] Despite this, there was no clear evidence that paroxetine was better or worse compared with other antidepressants at increasing response to treatment at any point in time.^[26]

Paroxetine was the first antidepressant approved in the United States for the treatment of panic disorder.^{[27][page needed]} Several studies have concluded that paroxetine is superior to placebo in the treatment of panic disorder.^[25][28]

Paroxetine has demonstrated efficacy for the treatment of social anxiety disorder in adults and children.^[29][30] It is also beneficial for people with co-occurring social anxiety disorder and alcohol use disorder.^[31] It appears to be similar to a number of other SSRIs.^[32]

Paroxetine is used in the treatment of obsessive-compulsive disorder.^[33] Comparative efficacy of paroxetine is equivalent to that of clomipramine and venlafaxine.^[34][35] Paroxetine is also effective for children with obsessive-compulsive disorder.^[36]

Paroxetine is approved for the treatment of PTSD in the United States, Japan, and Europe.^[37][38][39] In the United States, it is approved for short-term use.^[38]