Buy Mirtazapine (Remeron) Cas 85650-52-8

Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression.^[10][11] Its effects may take up to four weeks but can also manifest as early as one to two weeks.^[11][12] It is often used in cases of depression complicated by anxiety or insomnia.^[10][13] The effectiveness of mirtazapine is comparable to other commonly prescribed antidepressants.^[14] It is taken by mouth.^[11]

Common side effects include sleepiness, dizziness, increased appetite, and weight gain.^[11] Serious side effects may include mania, low white blood cell count, and increased suicide among children.^[11] Withdrawal symptoms may occur when stopping.^[15] It is not recommended together with a monoamine oxidase inhibitor,^[11] although evidence supporting the danger of this combination has been challenged.^[16] It is unclear if use during pregnancy is safe.^[11] How it works is not clear, but it may involve blocking certain adrenergic and serotonin receptors.^[10][11] Chemically, it is a tetracyclic antidepressant,^[11] and is closely related to mianserin. It also has strong antihistaminergic effects.^[10][11]

Mirtazapine came into medical use in the United States in 1996.^[11] The patent expired in 2004, and generic versions are available.^[11][17] In 2023, it was the 99th most commonly prescribed medication in the United States, with more than 6 million prescriptions.^[18][19]

Mirtazapine is approved by the United States Food and Drug Administration for the treatment of major depressive disorder in adults.^[20]

Mirtazapine is primarily used for major depressive disorder and other mood disorders.^[21][22] Onset of action appears faster than some selective serotonin reuptake inhibitors and similar to tricyclic antidepressants.^[12][23]

In 2010, the National Institute for Health and Care Excellence recommended generic selective serotonin reuptake inhibitors as first-line choices, as they are “equally effective as other antidepressants and have a favourable risk–benefit ratio.”^[24] For mirtazapine, it found “no difference between mirtazapine and other antidepressants on any efficacy measure, although in terms of achieving remission mirtazapine appears to have a statistical though not clinical advantage. In addition, mirtazapine has a statistical advantage over selective serotonin reuptake inhibitors in terms of reducing symptoms of depression, but the difference is not clinically significant. However, there is strong evidence that patients taking mirtazapine are less likely to leave treatment early because of side effects, although this is not the case for patients reporting side effects or leaving treatment early for any reason.”^[25]