Buy Mifepristone (RU-486) Cas 84371-65-3
Mifepristone, also known by its developmental code name RU-486, is a drug typically used in combination with misoprostol to bring about a medical abortion during pregnancy.[7] This combination is 97% effective[8] during the first 63 days (9 weeks) of pregnancy, and is effective in the second trimester as well.[9][10] It is also used on its own to treat Cushing’s syndrome or in low doses as an emergency contraceptive.[11][12]
The most common adverse effects include abdominal pain, feeling tired, and vaginal bleeding.[7] Serious side effects may include heavy vaginal bleeding, bacterial infection, and, if pregnant, birth defects.[7] When used, appropriate follow-up care needs to be available.[7][13] Mifepristone is primarily an antiprogestogen.[7] It works by blocking the effects of progesterone, making both the cervix and uterine vessels dilate and causing uterine contraction.[7] Mifepristone also works, to a lesser extent, as an antiglucocorticoid and diminishes the effects of hypercortisolism.[14]
Mifepristone was developed in France in 1980 and came into use there in 1987.[15] It became available in the United States in 2000, for medication abortion, and in 2010, for Cushing’s syndrome.[16][9][11] It is on the World Health Organization’s List of Essential Medicines.[17] Mifepristone was approved in China in 1988, India in 2002, and Canada in 2017.[18][19]
Medical uses
Abortion
Mifepristone followed by a prostaglandin analog (misoprostol or gemeprost) is used for medical abortion.[20][21] Medical organizations have found this combination to be safe and effective. Guidelines from the Royal College of Obstetricians and Gynaecologists describe medication abortion using mifepristone and misoprostol as effective and appropriate at any gestational age.[22] The World Health Organization and the American College of Obstetricians and Gynecologists recommend mifepristone followed by misoprostol for first- and second-trimester medical abortion.[23][24][25][26] Mifepristone alone is less effective, resulting in abortion within 1–2 weeks in anywhere from 54% to 92% of pregnancies, according to review of 13 studies.[27]
Cushing’s syndrome
Mifepristone is used for the medical treatment of high blood sugar caused by high cortisol levels in the blood (hypercortisolism) in adults with endogenous Cushing’s syndrome who also have type 2 diabetes mellitus or glucose intolerance and have failed surgery or cannot have surgery.[6][14] In a Phase III trial, it improved glycemic control, increased insulin sensitivity, and reduced body weight regardless of the cause of CS.[28]
Medical management of early pregnancy loss
Mifepristone combined with misoprostol is the preferred medication regimen for management of early pregnancy loss. While misoprostol alone can be used, the addition of a dose of mifepristone twenty-four hours before misoprostol administration improves treatment efficacy.[29]
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