Buy Methyldopa (α-methyl) Cas 41372-08-1

Methyldopa, also known as α-methyl-L-DOPA and sold under the brand name Aldomet among others, is a medication used for high blood pressure.^[1] It is one of the preferred treatments for high blood pressure in pregnancy.^[1] For other types of high blood pressure including very high blood pressure resulting in symptoms other medications are typically preferred.^[1] It can be given by mouth or injection into a vein.^[1] Onset of effects is around 5 hours and they last about a day.^[1]

Common side effects include sleepiness.^[1] More severe side effects include red blood cell breakdown, liver problems, and allergic reactions.^[1] Methyldopa is in the alpha-2 adrenergic receptor agonist family of medication. It works by stimulating the brain to decrease the activity of the sympathetic nervous system.^[1]

Methyldopa was discovered in 1960.^[2] It is on the World Health Organization’s List of Essential Medicines.^[3]

Methyldopa is used in the clinical treatment of the following disorders:

• • • Hypertension (or high blood pressure)
    • Gestational hypertension (or pregnancy-induced hypertension) and pre-eclampsia.^[4]

Methyldopa is capable of inducing a number of adverse side effects, which range from mild to severe. Nevertheless, they are generally mild when the dose is less than 1 gram per day.^[5] Side effects may include:

• • Psychological^{[citation needed]}
    • Depression
    • Suicidal ideation
    • Nightmares
    • Apathy, anhedonia, or dysphoria
    • Anxiety, especially social anxiety
    • Decreased alertness, awareness, and wakefulness
    • Impaired attention and concentration
    • Fatigue
    • Malaise
    • Drowsiness
    • Restlessness
    • Cognitive and memory impairment
    • Derealization or depersonalization, as well as mild psychosis
    • Sexual dysfunction including impaired libido, desire, and drive
  • Physiological^{[citation needed]}
    • Dizziness, lightheadedness, or vertigo
    • Miosis or pupil constriction
    • Xerostomia or dry mouth
    • Gastrointestinal disturbances such as diarrhea or constipation
    • Headache or migraine
    • Myalgia or muscle aches, arthralgia or joint pain, or paresthesia (“pins and needles”)
    • Restless legs syndrome (RLS)
    • Parkinsonian symptoms such as muscle tremors, rigidity, hypokinesia, or balance or postural instability
    • Akathisia, ataxia, dyskinesia, as well as even tardive dyskinesia or dystonia
    • Bell’s palsy or facial paralysis
    • Sexual dysfunction
    • Hyperprolactinemia
      • Gynecomastia in males, amenorrhoea or absence of menstrual cycles in females
    • Bradycardia
    • Hypotension
    • Orthostatic hypotension
    • Hepatitis, hepatotoxicity, or liver dysfunction or damage
    • Pancreatitis
    • Warm autoimmune hemolytic anemia or deficiency in red blood cells (RBCs)
    • Myelotoxicity or bone marrow suppression, potentially leading to thrombocytopenia, blood platelet deficiency, leukopenia, or white blood cell deficiency
    • Hypersensitivity (e.g., lupus erythematosus, myocarditis, or pericarditis)
    • Lichenoid reactions (e.g., skin lesions or rashes)