Buy Lidocaine/prilocaine (eutectic) Cas 101362-25-8

Lidocaine/prilocaine is a eutectic mixture of equal (by weight) amounts of lidocaine and prilocaine . A 5% emulsion preparation, each containing 2.5% lidocaine/prilocaine, is marketed under the trade name EMLA (short for ”  Eutectic Mixture of Local Anesthetics  “ ) ^[ 1 ] and is used as a local anesthetic . There is also an off-label use of the product, marketed as a spray under the name Tempe (short for ”  Topical eutectic – like mixture for premature ejaculation  ” ) , used by men to treat premature ejaculation ^[ 2 ] .

Separately, lidocaine and prilocaine are solid bases. When mixed in equal amounts by weight, however, they form a eutectic mixture—that is, the melting point of the mixture is lower than the melting points of the individual components. The lidocaine/prilocaine eutectic mixture is an oil with a melting point of 18  °C and can be formulated into preparations without the use of a non- aqueous solvent ^[ 3 ] . This allows higher concentrations of anesthetic to be formulated in the preparation and maintained during application.

The lidocaine/prilocaine combination is indicated for cutaneous anesthesia . More specifically, it is used to prevent pain associated with intravenous catheter insertion , blood sampling , superficial surgical procedures, and topical anesthesia of leg ulcers for cleaning or debridement ^[ 4 ] . In addition, it can be used to numb the skin before tattooing and laser hair removal. It is also sometimes used before the injection of local anesthetics for minor surgical procedures and biopsies.

A topical spray containing lidocaine and prilocaine has been evaluated for use in the treatment of premature ejaculation . The spray is applied to the skin of the penis before sexual intercourse. This formulation has not been approved by the FDA ^[ 5 ] . A similar product, Promescent , is available over the counter in the United States ^{[citation needed]} .

The lidocaine/prilocaine eutectic mixture is marketed as a 5% oil-in-water emulsion incorporated into a cream base (EMLA cream) or a cellulose pad (EMLA patch). The cream is applied under an occlusive dressing, while the patch incorporates an occlusive dressing to facilitate the absorption of lidocaine and prilocaine into the area where anesthesia is required. Local dermal anesthesia is achieved after approximately one hour, at which point the occlusive dressing (or patch) is removed. The duration of anesthesia is approximately two hours after removal of the occlusive dressing ^{[citation needed]} .