Buy Fluvoxamine (Luvox) Cas 54739-18-3

Fluvoxamine, sold under the brand name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.^[8] It is primarily used to treat major depressive disorder and, perhaps more-especially, obsessive–compulsive disorder (OCD),^[9] but is also used to treat anxiety disorders^[10] such as panic disorder, social anxiety disorder, and post-traumatic stress disorder.^[11][12][13]

Fluvoxamine’s side-effect profile is similar to that of other SSRIs. Common adverse effects include constipation, gastrointestinal problems, headache, anxiety, irritation, sexual problems, dry mouth, sleep problems, and an increased risk of suicide at the start of treatment. These effects appear to be significantly weaker than with other SSRIs, with the exception of gastrointestinal side-effects.^[14]

Fluvoxamine appears to be more tolerable than other SSRIs, particularly with respect to cardiovascular complications.^[15]

It is on the World Health Organization’s List of Essential Medicines.^[16]

In many countries (e.g., Australia,^[17][18] the United Kingdom,^[19] and Russia^[20]) it is commonly used for major depressive disorder. Fluvoxamine is also approved in the United States for obsessive–compulsive disorder (OCD),^[21][9] and social anxiety disorder.^[22] In Japan, it is also approved to treat OCD, social anxiety disorder, and major depressive disorder.^[23][24] Fluvoxamine is indicated for children and adolescents with OCD.^[25] The NICE guidelines in the United Kingdom have, as of 2005, authorized its use for obsessive-compulsive disorder in adults and adolescents of any age and children over the age of 7.^{[medical citation needed]}

There is evidence that fluvoxamine is effective for generalised social anxiety in adults, although, as with other SSRIs, some of the results may be compromised by having been funded by pharmaceutical companies.^[26][27] Of the SSRIs, however, fluvoxamine, paroxetine, and sertraline do appear consistent as viable treatments for generalised social anxiety.^[28][29]

Fluvoxamine is also effective for treating a range of anxiety disorders in children and adolescents, including generalized anxiety disorder, social anxiety disorder, panic disorder, and separation anxiety disorder.^[30][31][32]

The drug works long-term, and retains its therapeutic efficacy for at least one year.^[33]

The average therapeutic dose for fluvoxamine is 100 to 300 mg/day, with 300 mg being the upper daily limit normally recommended. Obsessive-compulsive disorder, however, often requires higher doses; doses of up to 450 mg/day may be prescribed in this case.^[34][35][36] The (off-label) upper daily limits for other serotonin-reuptake inhibitors used in the treatment of obsessive-compulsive disorder, by analogy, are 400 mg for sertraline,^[37] 100 mg for paroxetine, 120 mg for both fluoxetine and citalopram, 60 mg for escitalopram and 300 mg for clomipramine.^[38][39]

In any case with fluvoxamine, treatment is generally begun at 50 mg and increased in 50 mg increments every 4 to 7 days until a therapeutic optimum is reached.^[40]

Fluvoxamine’s side-effect profile is very similar to other SSRIs. Gastrointestinal side effects are characteristic of those receiving treatment with fluvoxamine.^{[3][21][17][19][41][42]} However, compared to escitalopram and sertraline, fluvoxamine’s gastrointestinal profile may be less intense,^[43] often being limited to nausea.^[12] Mosapride has demonstrated efficacy in treating fluvoxamine-induced nausea.^[44] It is also advised practice to divide total daily doses of fluvoxamine greater than 100 mg, with the higher fraction being taken in the evening (e.g., 50 mg at the beginning of the waking day and 200 mg at bedtime). In any case, high starting daily doses of fluvoxamine rather than the recommended gradual titration (starting at 50 mg and gradually titrating, up to 300 if necessary) may increase the likelihood of nausea.^[45]