Buy Fluphenazine(Prolixin) Cas 69-23-8

Fluphenazine, sold under the brand name Prolixin among others, is a high-potency typical antipsychotic medication of the phenothiazine class.^[2] It is used in the treatment of chronic psychoses such as schizophrenia,^[2][3] and is about equal in effectiveness to low-potency antipsychotics like chlorpromazine.^[4] It is also used to treat depression in combination with nortriptyline.^[5][6] In addition to the oral form, fluphenazine comes in decanoate and enanthate depot injection versions for increased adherence.^[7] Fluphenazine is given by mouth, intramuscularly, or just under the skin.^[2]

Common side effects include movement problems, sleepiness, depression and increased weight.^[2] Serious side effects may include neuroleptic malignant syndrome, low white blood cell levels, and the potentially permanent movement disorder tardive dyskinesia.^[2] In older people with psychosis as a result of dementia it may increase the risk of dying.^[2] It may also increase prolactin levels which may result in milk production, enlarged breasts in males, impotence, and the absence of menstrual periods.^[2] It is unclear if it is safe for use in pregnancy.^[2] Fluphenazine decanoate should not be used by people with severe depression.^[8][9] In up to 40% of those on long term phenothiazines, liver function tests become mildly abnormal.^[10]

Fluphenazine is a dopamine antagonist, blocking mesolimbic dopamine receptors.^[2][5] Fluphenazine inhibits tubulin polymerization, a property shared with other phenothiazine derivatives including perphenazine, chlorpromazine, trifluoperazine, and triflupromazine.^[11]

Fluphenazine was the third antipsychotic FDA approved in the United States in 1959, and 9 years later was the first FDA approved injectable antipsychotic.^[12][13] The injectable form is on the World Health Organization’s List of Essential Medicines.^[14] It is available as a generic medication.^[2] It was discontinued in Australia in 2017.^[15]

A 2018 Cochrane review found that fluphenazine was an imperfect treatment and other inexpensive drugs less associated with side effects may be an equally effective choice for people with schizophrenia.^[16] Another 2018 Cochrane review found that there was limited evidence that newer atypical antipsychotics were more tolerable than fluphenazine.^[17] Intramuscular depot injection forms are available as both the decanoate and enanthate esters.^[18]

The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse.^[19] Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite.^[20] Other symptoms may include restlessness, increased sweating, and trouble sleeping.^[20] Less commonly there may be a feeling of the world spinning, numbness, or muscle pains.^[20] Symptoms generally resolve after a short period of time.^[20]

There is tentative evidence that discontinuation of antipsychotics can result in psychosis.^[21] It may also result in reoccurrence of the condition that is being treated.^[22] Rarely tardive dyskinesia can occur when the medication is stopped.^[20]