Buy Ergotamine (Ergomar) Cas 113-15-5

Ergotamine, sold under the brand name Ergomar among others, is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline.^[9] It is structurally similar to several neurotransmitters, and it acts as a vasoconstrictor. It is used for acute migraines, sometimes with caffeine as the combination ergotamine/caffeine.^[10][11]

The drug is a non-selective modulator or agonist of serotonin receptors and other receptors.^[12][13][14] It is peripherally selective and crosses into the brain in minimal amounts.^[14]

Medicinal use of ergot fungus began in the 16th century, for the induction of childbirth; but dosage uncertainty discouraged its use. It has been used to prevent post-partum hemorrhage (bleeding after childbirth). It was first isolated from the ergot fungus by Arthur Stoll, at Sandoz in 1918, and was marketed as Gynergen in 1921.^[15]

Ergotamine is indicated as therapy to abort or prevent vascular headache.^[2][16]

Ergotamine is available as a suppository and as a tablet, sometimes in combination with caffeine.^{[2][5][10][11]}

Contraindications include: atherosclerosis, Buerger’s syndrome, coronary artery disease, hepatic disease, pregnancy, pruritus, Raynaud’s syndrome, and renal disease.^[17] It’s also contraindicated if patient is taking macrolide antibiotics (e.g., erythromycin), certain HIV protease inhibitors (e.g., ritonavir, nelfinavir, indinavir), certain azole antifungals (e.g., ketoconazole, itraconazole, voriconazole) delavirdine, efavirenz, or a 5-HT₁ receptor agonist (e.g., sumatriptan).^[18]

Side effects of ergotamine include nausea and vomiting. At higher doses, it can cause raised arterial blood pressure, vasoconstriction (including coronary vasospasm) and bradycardia or tachycardia. Severe vasoconstriction may cause symptoms of intermittent claudication.^[19][16]

Ergotamine interacts with serotonin, adrenergic, and dopamine receptors.^[12][13][14] It is an agonist of serotonin receptors including the serotonin 5-HT₁ and 5-HT₂ subtypes.^[12][14][20] Ergotamine is an agonist of the serotonin 5-HT_2B receptor and has been associated with cardiac valvulopathy.^[21] Despite acting as a potent serotonin 5-HT_2A receptor agonist, ergotamine is said to be non-hallucinogenic similarly to lisuride.^[14][22][23] This has been posited to be due to functional selectivity at the serotonin 5-HT_2A receptor.^[22][23] However, ergotamine is also peripherally selective, which may instead account for its lack of psychedelic effects.^[14][24][25]