Buy Dexmedetomidine (Precedex) Cas 113775-47-6
Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation.[4] Veterinarians use dexmedetomidine for similar purposes in treating cats, dogs, and horses.[10][11] It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder.[5] It is administered as an intravenous solution or as a buccal or sublingual film.[1]
Similar to clonidine, dexmedetomidine is a sympatholytic drug that acts as an agonist of α2-adrenergic receptors in certain parts of the brain.[12] It was developed by Orion Pharma.
Medical uses
Intensive care unit sedation
Studies suggest dexmedetomidine for sedation in mechanically ventilated adults may reduce time to extubation and ICU stay.[13][14]
Compared with other sedatives, some studies suggest dexmedetomidine may be associated with less delirium.[15] However, this finding is not consistent across multiple studies.[14] At the very least, when aggregating many study results together, use of dexmedetomidine appears to be associated with less neurocognitive dysfunction compared to other sedatives.[16] Whether this observation has a beneficial psychological impact is unclear.[15] From an economic perspective, dexmedetomidine is associated with lower ICU costs, largely due to a shorter time to extubation.[17]
Procedural sedation
Dexmedetomidine can also be used for procedural sedation such as during colonoscopy.[18] It can be used as an adjunct with other sedatives like benzodiazepines, opioids, and propofol to enhance sedation and help maintain hemodynamic stability by decreasing the requirement of other sedatives.[19][20] Dexmedetomidine is also used for procedural sedation in children.[21]
It can be used for sedation required for awake fibreoptic nasal intubation in patients with a difficult airway.[22]
Adjunct in general anesthesia
It has also been used as an adjunct infusion during general anesthesia. In this application, it has been shown to decrease post-operative delirium, pain, nausea and opioid use.[23][24][25][26]
Other
Dexmedetomidine may be useful for the treatment of the negative cardiovascular effects of acute amphetamines and cocaine intoxication and overdose.[27][28] Dexmedetomidine has also been used as an adjunct to neuroaxial anesthesia for lower limb procedures.[29] It has been successfully used to treat opioid withdrawal symptoms.[30]
In 2022 it was approved by the FDA for the treatment of agitation in schizophrenia and bipolar disorder.[31]
Reviews
There are no reviews yet.