Buy Ciclazindol (anorectic) Cas 37751-39-6

Ciclazindol (WY-23409) is an antidepressant and anorectic^[2] drug of the tetracyclic^{[citation needed]} chemical class that was developed in the mid to late 1970s, but was never marketed.^[3][4] It acts as a norepinephrine reuptake inhibitor, and to a lesser extent as a dopamine reuptake inhibitor.^[3][5] Ciclazindol has no effects on the SERT, 5-HT receptors, mACh receptors, or α-adrenergic receptors, and has only weak affinity for the H₁ receptor.^[5][6][7] As suggested by its local anesthetic properties,^[6] ciclazindol may also inhibit sodium channels. It is known to block potassium channels as well.^[8][9]

The dosage in human volunteers is stated to be 25 mg daily.^[1] However, doses of up to 200 mg have also been reported.^[2] This is surprising since the dosage of mazindol is only 2-4 mg per day.

Ciclazindol is reported to have an IC₅₀ of 1.3 nM for the dopamine transporter (cmp 23).^[10]

• Mazindol
• Setazindol