Buy Caleicine (Calea) Cas 140384-72-1

Caleicine is a unique sesquiterpene compound found exclusively in Calea ternifolia, a Mexican flowering plant known for its potential psychoactive properties.^[1] This compound has garnered interest in the field of ethnopharmacology and natural product chemistry due to its putative role as a prodrug of eugenol, a potent GABA positive modulator.

Caleicine is the p-Coumaric ester of junenol and has no lactone moiety making it distinctly unique from the other sesquiterpene lactones in Calea ternifolia.

Caleicine is a sesquiterpene that has a phenylpropanoid moiety bonded to junenol^[2]

In an investigation, lab mice were administered with an aqueous solution of Calea ternifolia in doses of 200, 400 and 800 mg and made to undergo a forced swim test. Under dosages of 400 and 800 mg, the mice showed depressive like effects.^[3]

The mechanisms of Calea ternifolia induced somnolence are not well understood, however, caleicine could play a role due to its potential metabolism.

Caleicine contains p-Coumaric acid. In the body, p-Coumaric acid is biosynthesised into many lignols and phenylpropanoids including eugenol.