Buy Suxamethonium (succinylcholine) Cas​ 306-40-1

Suxamethonium (or succinylcholine ) is the only depolarizing muscle relaxant used in medicine, in the form of suxamethonium chloride or suxamethonium iodide (Anectine, Celocurine). Its potency and very short onset of action allow for rapid and successful endotracheal intubation , making it a drug of choice in emergency medicine , intensive care , and anesthesia . Its short duration of action allows for a rapid return of breathing, making it a useful agent in cases of difficult intubation . However, its rare but serious adverse effects limit its indications.

Suxamethonium is a dimer of acetylcholine . It acts by binding non-competitively to nicotinic receptors within the neuromuscular junction , causing prolonged depolarization of the muscle membrane and thus rendering it inexcitable. Suxamethonium’s unique characteristic is its resistance to the action of acetylcholinesterase , which, under physiological conditions, degrades acetylcholine and abolishes its effect within milliseconds. In contrast, suxamethonium remains bound to the receptor, only being inactivated by plasma pseudocholinesterases after several minutes.

Suxamethonium induces total paralysis of voluntary muscles within 30 to 60 seconds and for a short duration, not exceeding 10 minutes (except in cases of constitutional ^[ 2 ] or acquired pseudocholinesterase ^[ 3 ] deficiency ). Due to its depolarizing activity, its first clinical sign of action is the appearance of muscle fasciculations .

Due to its exceptionally short onset of action and brief duration of action, suxamethonium is the preferred neuromuscular blocking agent for rapid sequence intubation in a previously sedated patient , in the absence of contraindications and in certain well-defined situations (particularly patients at risk of gastric fluid aspiration, such as during an emergency cesarean section ). Suxamethonium is indicated for neuromuscular blockade in patients treated with electroconvulsive therapy (ECT ). It is also possible, but not recommended by the French Society of Anesthesia and Intensive Care (SFAR ) ^[ 4 ] , to use it for intubation in short, scheduled surgical procedures. Conversely, a non-depolarizing neuromuscular blocking agent should be preferred or used in conjunction with it for procedures requiring neuromuscular blockade lasting more than ten minutes