Buy 4′-Fluorococaine Cas 134507-62-3
4′-Fluorococaine is a tropane derivative drug which is a synthetic analogue of cocaine. Unlike related compounds such as the corresponding 4′-fluorophenyltropane derivative CFT and the 2′-hydroxy analogue salicylmethylecgonine, 4′-fluorococaine has only around the same potency as cocaine as an inhibitor of dopamine reuptake, but conversely it is a much stronger serotonin reuptake inhibitor than cocaine, resulting in a significantly altered pharmacological profile in animal studies.[1]
-
4′-fluorococaine｜134507-62-3｜lookchem
We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the …
4′-fluorococaine
Base Information- Chemical Name:4′-fluorococaine
- CAS No.:134507-62-3
- Molecular Formula:C17H20FNO4
- Molecular Weight:321.3434
- Hs Code.:
- UNII:6045353J3C
- DSSTox Substance ID:DTXSID10928640
- Nikkaji Number:J373.270C
- Wikipedia:4%E2%80%B2-Fluorococaine
- Mol file:134507-62-3.mol
Synonyms:8-Azabicyclo[3.2.1]octane-2-carboxylicacid, 3-[(4-fluorobenzoyl)oxy]-8-methyl-, methyl ester, [1R-(exo,exo)]-;
This product is a nationally controlled contraband, and the Lookchem platform doesn’t provide relevant sales information.Chemical Property of 4′-fluorococaineChemical Property:- Boiling Point:398.92 °C at 760 mmHg
- PKA:8.71±0.60(Predicted)
- Flash Point:195.06 °C
- PSA：55.84000
- Density:1.272 g/cm3
- LogP:1.94470
- XLogP3:2.4
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:5
- Exact Mass:321.13763628
- Heavy Atom Count:23
- Complexity:464
- Purity/Quality:
Safty Information:- Pictogram(s):
- Hazard Codes:
- MSDS Files:
- SDS file from LookChem
Useful:- Canonical SMILES:CN1C2CCC1C(C(C2)OC(=O)C3=CC=C(C=C3)F)C(=O)OC
- Isomeric SMILES:CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=C(C=C3)F)C(=O)OC
- UsesA related compound of Cocaine (C633500), as substrate and inhibitor of plasma butyrylcholinesterase. Controlled substance.
Technology Process of 4′-fluorococaineThere total 1 articles about 4′-fluorococaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:Reference yield: 85.2%
- Guidance literature:
-
With dmap; triethylamine; In dichloromethane; at 0 – 20 ℃; for 8h;
Reference yield:
- Guidance literature:
-
Multi-step reaction with 2 steps1: potassium carbonate / benzene / 80 °C2: zinc; formic acid / N,N-dimethyl-formamide / 20 °CWith formic acid; potassium carbonate; zinc; In N,N-dimethyl-formamide; benzene;
Reference yield:
4′-Fluorococaine
CAS No.:
Cat. No.: VC1906050
Molecular Formula: C17H20FNO4
Molecular Weight: 321.34 g/mol
* For research use only. Not for human or veterinary use.
Specification
Molecular Formula C17H20FNO4 Molecular Weight 321.34 g/mol IUPAC Name methyl 3-(4-fluorobenzoyl)oxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate Standard InChI InChI=1S/C17H20FNO4/c1-19-12-7-8-13(19)15(17(21)22-2)14(9-12)23-16(20)10-3-5-11(18)6-4-10/h3-6,12-15H,7-9H2,1-2H3 Standard InChI Key JRPRINGETIYVSV-UHFFFAOYSA-N Canonical SMILES CN1C2CCC1C(C(C2)OC(=O)C3=CC=C(C=C3)F)C(=O)OC Introduction
Chemical Properties and Identification
4′-Fluorococaine is identified by the CAS number 134507-62-3 and has a molecular formula of C17H20FNO4 with a molecular weight of 321.34 g/mol. The compound’s structure maintains the tropane skeleton characteristic of cocaine while incorporating the critical fluorine substitution that alters its physiological effects and metabolic profile.
Chemical Structure Specifications
The compound features several key structural components:
- A tropane ring system (8-azabicyclo[3.2.1]octane)
- A methyl group attached to the nitrogen atom
- A 4-fluorobenzoyloxy group at position 3
- A methyl ester group at position 2
The specific stereochemistry (1R,2R,3S,5S) is essential for its biological activity, similar to other tropane derivatives. This stereochemical configuration enables proper binding to neurotransmitter transporters, particularly those associated with serotonin reuptake.
Pharmacological Mechanism of Action
4′-Fluorococaine exhibits a unique pharmacological profile that distinguishes it from cocaine and other related compounds. Unlike cocaine, which primarily affects dopamine reuptake, 4′-Fluorococaine demonstrates a stronger effect on serotonin reuptake inhibition.
Neurotransmitter Effects
4′-Fluorococaine exerts its effects primarily through the inhibition of serotonin reuptake. It binds to the serotonin transporter, preventing the reabsorption of serotonin into presynaptic neurons. This mechanism leads to increased serotonin concentration in the synaptic cleft, enhancing serotonergic neurotransmission. Additionally, it demonstrates moderate inhibitory effects on dopamine reuptake, contributing to some stimulant properties, though these effects are less pronounced than with cocaine.
Comparative Pharmacology
The following table presents a comparison between 4′-Fluorococaine and related compounds:
Property Cocaine 4′-Fluorococaine Primary Action Dopamine reuptake inhibition Serotonin reuptake inhibition Secondary Action Moderate serotonin & norepinephrine effects Moderate dopamine effects Duration of Action Relatively short Significantly longer Metabolic Stability Low (rapid hydrolysis) Lower (faster ester cleavage) Oxidative Susceptibility Prone to N-oxidation Enhanced resistance to oxidation This distinctive pharmacological profile suggests potential applications that differ from those of traditional stimulants, particularly in research contexts examining serotonergic pathways.
Metabolism and Pharmacokinetics
4′-Fluorococaine undergoes metabolic processes similar to cocaine but with important distinctions due to its fluorine substitution.
Metabolic Pathways
The compound undergoes rapid ester hydrolysis in vivo, producing multiple metabolites through cleavage of its methyl ester and benzoyl ester groups. The primary metabolic products include:
Reaction Enzymes Involved Major Metabolites Methyl ester hydrolysis Hepatic esterases 4′-Fluorobenzoylecgonine Benzoyl ester hydrolysis Plasma esterases 4′-Fluoroecgonine methyl ester Pharmacokinetic Profile
Based on reported experiential data, 4′-Fluorococaine demonstrates distinctive pharmacokinetic properties:
- Onset: Approximately 4 hours after initial administration (significantly delayed compared to cocaine)
- Time to peak effects: Approximately 7 hours from initial dose
- Duration: Extended, lasting approximately 24 hours from onset until return to baseline
- Half-life: Shorter than cocaine due to enhanced susceptibility to esterases, yet paradoxically produces longer-lasting subjective effects
This unusual pharmacokinetic profile, particularly the delayed onset and prolonged duration, suggests complex absorption, distribution, metabolism, and excretion dynamics that warrant further investigation.
Research Applications
4′-Fluorococaine serves several important functions in scientific research, primarily as a tool to understand serotonergic systems and develop potential therapeutic applications.
Neurochemical Research
The compound enables researchers to selectively study serotonin reuptake mechanisms with reduced dopaminergic confounds compared to cocaine. This selectivity makes it valuable for examining the specific contribution of serotonergic pathways to various neurological and psychiatric conditions.
Structural-Activity Relationship Studies
As a fluorinated tropane derivative, 4′-Fluorococaine provides important data points for understanding how fluorine substitution affects:
This information contributes to rational drug design efforts targeting serotonergic systems while minimizing undesired interactions.
Human Experience Reports
Limited human experience reports provide valuable insights into the subjective effects of 4′-Fluorococaine, though these reports should be interpreted with appropriate caution given their anecdotal nature.
Documented Effects
Based on available experience reports, the subjective effects of 4′-Fluorococaine differ substantially from cocaine and other traditional stimulants :
- Unlike cocaine’s immediate euphoric stimulation, 4′-Fluorococaine produces delayed effects beginning approximately 4 hours after administration
- Primary reported effects include confusion, dysphoria, and sensory alterations rather than stimulation or euphoria
- Physical symptoms include coldness, shivering, and gastrointestinal distress
- Effects appear dose-dependent, with higher doses (50mg total) producing more pronounced negative experiences
4-Fluorococaine CAS # 134507-62-3 is a tropane derivative drug which is a synthetic analogue of cocaine.
As 4′-Fluorococaine CAS # 134507-62-3 is very similar to cocaine and costs much less it is commonly used as a dilutant in cocaine.
4-Fluorococaine for Sale – Trusted by Bisman Pharma
4-Fluorococaine is a research chemical that has gained recognition among scientific communities for its structural similarity to cocaine. Known for its potential use in laboratory studies and chemical analysis, this compound is often utilized in research focused on pharmacology and neuroscience.
At Bisman Pharma, we specialize in providing premium-grade 4-Fluorococaine for research purposes. Our commitment to quality, purity, and customer satisfaction has made us a trusted supplier in the industry. Whether you’re a research institution, scientist, or chemical analyst, you can rely on Bisman Pharma for safe and reliable products.
Why Buy 4-Fluorococaine from Bisman Pharma?
- Top-Quality Products: Our 4-Fluorococaine is lab-tested to ensure exceptional purity and consistency.
- Secure Transactions: We prioritize your privacy with encrypted payment methods and a secure ordering process.
- Discreet Delivery: All orders are shipped in plain, secure packaging for confidentiality.
- Customer Support: Our experienced team is ready to assist with any inquiries regarding our products or services.
FAQs about 4-Fluorococaine
1. What is 4-Fluorococaine?
4-Fluorococaine is a synthetic research chemical structurally similar to cocaine. It is primarily used in laboratory studies to explore its chemical properties and potential pharmacological effects.
2. Can I buy 4-Fluorococaine from Bisman Pharma?
Yes, Bisman Pharma offers 4-Fluorococaine for research purposes. We ensure high-quality products and a secure purchasing process for our customers.
3. Is 4-Fluorococaine legal to purchase?
The legality of 4-Fluorococaine varies depending on local regulations. It is essential to confirm the legal status of this compound in your country or region before making a purchase.
4. How do I place an order for 4-Fluorococaine?
You can visit our website, select the desired quantity, and proceed with the secure checkout process. If you have any questions, our customer support team is here to assist.
5. Does Bisman Pharma ship internationally?
Yes, we provide worldwide shipping. All orders are packaged discreetly to ensure safety and confidentiality during transit.
6. Can I contact Bisman Pharma for more information?
Absolutely. Our knowledgeable support team is available to answer your questions and guide you through the ordering process.
At Bisman Pharma, we are committed to providing top-tier research chemicals like 4-Fluorococaine. Shop with confidence and trust our expertise to deliver quality products and exceptional service every time.
7. What does “buy 4-fluorococaine” refer to?
This phrase is usually seen in online searches or listings linked to unregulated markets. 4-fluorococaine is a synthetic compound, and references to purchasing it are generally not connected to legitimate medical or pharmaceutical channels.
8. Is 4-fluorococaine approved for medical use?
4-fluorococaine is not approved for medical use in recognized healthcare systems. It is mainly discussed in research or regulatory contexts, rather than as a substance used in standard medical treatment.
9. Why is 4-fluorococaine considered a concern?
It is considered a concern due to limited research, an unknown safety profile, and potential for misuse. Synthetic analogs can have unpredictable effects on the body, increasing risks of adverse reactions or toxicity.
10. How is 4-fluorococaine typically studied?
It is typically studied in controlled laboratory or forensic settings to understand its chemical properties and potential effects. Research is usually limited and conducted under strict regulatory and ethical guidelines.
4-Fluorococaine CAS # 134507-62-3 is a tropane derivative drug which is a synthetic analogue of cocaine.
As 4′-Fluorococaine CAS # 134507-62-3 is very similar to cocaine and costs much less it is commonly used as a dilutant in cocaine.
11. What are the risks associated with synthetic stimulant analogs?
Synthetic stimulant analogs can pose serious risks, including increased heart rate, anxiety, toxicity, and unpredictable reactions. Because they are often unregulated, their composition and strength may vary, which increases the potential for harm.
Experiential Timeline
One detailed report documents the following progression of effects :
Time Point Reported Effects T+0 to T+4hr No perceived effects despite multiple administrations (10mg, 10mg, 30mg) T+4:15hr Mild consciousness alteration, visual brightness enhancement T+4:30hr Rapid intensification, confusion, without euphoria or stimulation T+4:40hr Pronounced dysphoria, sensory discomfort, physical discomfort T+21:00hr Diminished but persistent negative effects, gastrointestinal distress T+24:00hr Return to baseline -
4′-Fluorococaine () for sale
4′-Fluorococaine serves several important functions in scientific research, primarily as a tool to understand serotonergic systems and …
-
4′-fluorococaine | 134507-62-3 – ChemicalBook
Dec 21, 2022 · 4′-fluorococaine (CAS 134507-62-3) information, including chemical properties, structure, melting point, boiling point, …
-
4′-Fluorococaine | CAS#:134507-62-3 | Chemsrc – 化源网
Jul 3, 2026 · Chemsrc provides 4′-Fluorococaine(CAS#:134507-62-3) MSDS, density, melting point, boiling point, structure, formula, …
-
Boiling Point: 398.9±42.0 °C at 760 mmHg
-
Density: 1.3±0.1 g/cm3
-
-
Buy 4 Fluorococaine Powder Online – Bisman Pharma
Buy 4 fluorococaine powder online from Bisman Pharma, tailored for research needs. Unlock new possibilities in your studies with …
-
CAS No.134507-62-3,4′-fluorococaine Suppliers – LookChem
The 4′-Fluorococaine is an organic compound with the formula C 17 H 20 FNO 4. The systematic name of this chemical is methyl …
-
4-Fluorococaine CAS # 134507-62-3 – bismanpharma.com
4-Fluorococaine CAS # 134507-62-3 is a tropane derivative drug which is a synthetic analogue of cocaine. As 4′-Fluorococaine CAS …
-
4′-Fluorococaine – 134507-62-3 – Catalog of Chemical Suppliers
ChemExper Chemical Directory is a free service that allows to find a chemical by its molecular formula, IUPAC name, common …
-
4′-FLUOROCOCAINE (CAS No. 134507-62-3) Suppliers
We are an ISO 9001 certified company. We specialize in mercury, sodium cyanide, and activated carbon for minin more…
-
4′-fluorococaine | 134507-62-3 – ChemicalBook
Visit ChemicalBook To find more 4′-fluorococaine (134507-62-3) information like chemical properties,Structure,melting point,boiling …
Reviews
There are no reviews yet.