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CAS 521-12-0 Drostanolone propionate | Products & Prices & Suppliers

• Dromostanolone propionate (Drostanolone propionate) is a compound has antitumor activity against breast carcinoma[1]. Dromostanolone propionate inhibits the uptake of oestradiol-17? by the tumour but has no apparent effect on the uptake by normal breast tissue [2]. Dromostanolone propionate implant pellet produces weight gains in animals and suppresses estrus in female animals[3].

• Product Name: Drostanolone propionate
• Molecular Weight: 360.53
• Molecular Formula: C₂₃H₃₆O₃
• Synonyms: (2α,5α,17Β)-2-methyl-3-oxoandrostan-17-yl propanoate; (2α,5α,17Β)-2-Methyl-3-oxoandrostan-17-yl propionate; 17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate; 17β-Hydroxy-2α-methyl-5α-androstan-3-one propionate; 17β-Hydroxy-2α-methylandrostan-3-one propionate; 2a-Methyl-17b-(1-oxopropoxy)-5a-androstan-3-one;cccccc3

Buy Dromostanolone Propionate (CAS 521-12-0)

Drostanolone Propionate

Item No. 32777

Restricted Product (Schedule III)

Synonyms

Synonyms

• Dromostanolone Propionate
• Masteron
• Prometholon

Technical Information

Formal Name

(2α,5α,17β)-2-methyl-17-(1-oxopropoxy)-androstan-3-one

CAS Number

521-12-0

Molecular Formula

C₂₃H₃₆O₃

Formula Weight

360.5

Purity

≥98%

Formulation(Request formulation change)

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 2 mg/ml

SMILES

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])CC([C@@H](C2)C)=O)([H])[C@@]4([H])[C@](CC3)([C@H](CC4)OC(CC)=O)C

InChi Code

InChI=1S/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/m1/s1

InChi Key

NOTIQUSPUUHHEH-UXOVVSIBSA-N

Regulatory Information

DEA Schedule

III

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Drostanolone propionate

Drostanolone propionate structure

CAS No.

521-12-0

Chemical Name:

Drostanolone propionate

Synonyms

Masterone;DROMOSTANOLONE PROPIONATE;Masteron Propionate;MDHT;DroMostanolone Enanthate(Masteron);2α-Methylandrostan-17β-ol-3-one propionate;32379;2MDTP;Mast P;357429

CBNumber:

CB0239590

Molecular Formula:

C23H36O3

Molecular Weight:

360.54

MDL Number:

MFCD01669961

MOL File:

521-12-0.mol

MSDS File:

SDS

TDS File:

TDS

Last updated:2026-07-22 17:56:16

Product description	Number	Pack Size	Price
Drostanolone propionate NMI Australia	NMIS025	20MG	$191
Drostanolone Propionate ≥98%	32777	1mg	$36
Drostanolone Propionate ≥98%	32777	5mg	$103
Drostanolone Propionate	TRC-D689595-50MG	50mg	$118
Drostanolone Propionate	TRC-D689595-100MG	100mg	$183
More product size

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Drostanolone propionate Properties

Melting point	114-120°C
alpha	D +24°
Boiling point	432.53°C (rough estimate)
Density	1.0669 (rough estimate)
refractive index	1.4700 (estimate)
storage temp.	Controlled Substance, -20°C Freezer
solubility	DMF:30.0(Max Conc. mg/mL);83.21(Max Conc. mM) DMSO:24.0(Max Conc. mg/mL);66.57(Max Conc. mM) Ethanol:2.0(Max Conc. mg/mL);5.55(Max Conc. mM)
form	A crystalline solid
InChI	InChI=1/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/s3
InChIKey	NOTIQUSPUUHHEH-DEMPVMEFNA-N
SMILES	C[C@]12C[C@@H](C)C(=O)C[C@]1([H])CC[C@@]1([H])[C@]3([H])CC[C@H](OC(=O)CC)[C@@]3(C)CC[C@]21[H] |&1:1,3,8,12,14,18,24,28,r|
CAS DataBase Reference	521-12-0(CAS DataBase Reference)
FDA UNII	X20UZ57G4O
NIST Chemistry Reference	Dromostanolone propionate(521-12-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H351-H360FD
Precautionary statements	P201-P202-P280-P308+P313-P405-P501
Toxicity	LD50 subcutaneous in mouse: > 2gm/kg

Drostanolone propionate price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	NMIS025	Drostanolone propionate NMI Australia	521-12-0	20MG	$191	2023-06-20	Buy
Cayman Chemical	32777	Drostanolone Propionate ≥98%	521-12-0	1mg	$36	2026-04-30	Buy
Cayman Chemical	32777	Drostanolone Propionate ≥98%	521-12-0	5mg	$103	2026-04-30	Buy
TRC	TRC-D689595-50MG	Drostanolone Propionate	521-12-0	50mg	$118	2026-06-03	Buy
TRC	TRC-D689595-100MG	Drostanolone Propionate	521-12-0	100mg	$183	2026-06-03	Buy

Drostanolone propionate Chemical Properties, Uses, Production

Antiestrogenic effects

Dromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness.
Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group.Drostanolone Propionate is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone.

Physiological effect

Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle.

Description

17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate, also known as drostanolone propionate, is a synthetic anabolic-androgenic steroid. It has similar properties to dihydrotestosterone. It had been used for the treatment of breast cancer in the past. However, it is now mainly used by athletes and bodybuilder as an anabolic steroid. It has two major effects including enhancing the physical/athletic performance (such as endurance and strength) and enhancing physical health (muscle buildup and fat loss). It should be administrated via intramuscular injection instead of oral taking.

Chemical Properties

White Solid

Originator

Drolban,Lilly,US,1961

Uses

Drostanolone propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. It is used as an antineoplastic for use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal. Now it is used to help improve athletic performance and muscle gain.

Definition

ChEBI: Drostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It is functionally related to a metholone.

Preparation

Drostanolone propionate is prepared from 9,11-dehydro-17a-methyl-testosterone raw material, reacts with lithium chloride and N-chlorosuccinimide to generate 9a,11-dichloro-17a-methyl- 95 testosterone is further prepared by esterification with propionin.

Manufacturing Process

A suspension of 10 grams of dihydrotestosterone in 500 cc of anhydrous benzene free of thiophene was mixed with10 cc of ethyl formate and 3 grams of sodium hydride and the mixture was stirred for 5 hours under an atmosphere of nitrogen and at a temperature of approximately 25°C. The resulting suspension was filtered, the resulting mixture of the sodium salt of the hydroxymethylene compound and the excess of sodium hydride was washed with benzene and dried. This mixture was slowly added to a vigorously stirred solution of 20 cc of concentrated hydrochloric acid in 500 cc of water, and the stirring was continued for 30 minutes at the end of which the precipitate was collected and well washed with distilled water. After drying in vacuo, there was obtained 9.7 grams of 2-hydroxymethylenedihydrotestosterone.
A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of pyridine and 2 cc of propionic anhydride was allowed to react at room temperature for 16 hours and then poured into water. The resulting suspension was heated for 1 hour on the steam bath to hydrolyze the excess of propionic anhydride, cooled and extracted with methylene dichloride. The extract was consecutively washed with dilute hydrochloric acid, sodium bicarbonate solution and water, dried over anhydrous sodium sulfate and evaporated to dryness under vacuum. There was thus obtained the dipropionate of 2-hydroxymethylenedihydrotestosterone which was treated with hydrogen, in methanol solution.
When the uptake of hydrogen ceased, the catalyst was filtered and the solution was evaporated to dryness under vacuum. The residue was dissolved in a mixture of benzene-hexane, transferred to a chromatographic column with neutral alumina and the product was eluted with mixtures of benzenehexane, gradually increasing the proportion of benzene in the mixture. Crystallization of the eluates from acetone-hexane yielded the propionate of 2α-methyldihydrotestosterone.

brand name

Drolban (Lilly).

Therapeutic Function

Cancer chemotherapy

Side effects

As to be expected with all steroids, it’s essential that you’re aware of all potential side effects of Drostanolone propionate, before you consider a cycle. Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It has no risk of liver damage

Drostanolone propionate Preparation Products And Raw materials

Raw materials

Stanolone Propionic anhydride Ethyl formate Sodium hydride

Preparation Products

Dromostanolone propionate API Suppliers – Manufacturers and Distributors

Find verified Dromostanolone propionate API manufacturers, suppliers, and distributors across the globe. Explore companies that offer high-purity Dromostanolone propionate for pharmaceutical use, along with product details, certifications, and reliable sourcing options. Compare prices, check availability, and connect directly with trusted suppliers for Dromostanolone propionate API.

Dromostanolone propionate

Alternate Names: Masteron, Permastril

CAS No: 521-12-0

PubChem CID: 224004

Mol Formula: C₂₃H₃₆O₃

Mol Weight: 360.5 g/mol

Controlled Drug Substance: Yes (Schedule III)

IUPAC Name: [(2R,5S,8R,9S,10S,13S,14S,17S)-2,10,13-trimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] propanoate

Commercial / Development Status: Discontinued APIs

Source / Manufacturing Origin: Semi-synthetic APIs

API Description: Dromostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It is functionally related to a metholone.

              

List of Dromostanolone propionate API Suppliers – Manufacturers and Distributors

Certificates

CoA

---

Dromostanolone enanthate

Dromostanolone

China

cGMPFDAISO 9001

AASraw Biochemical Technology Co Ltd

CDMOManufacturer

AASraw Biochemical Technology Co., Ltd. is a leading global API CDMO manufacturer that integrates the research, development, production, processing, and sales of chemical active pharmaceutical ingredients (APIs) and intermediates. The company is committed to delivering high-quali – Show More

API: Dromostanolone propionate

Physical Form: Powder

CoA

Argentina, Mexico

Syntex Laboratories Inc

Manufacturer

Syntex Laboratories Inc, originally formed in Mexico City in 1944 as Syntex, S.A., was a pharmaceutical company specializing in the synthesis of steroid-based drugs derived from Mexican yams. It became notable for pioneering oral contraceptives and other steroid drugs, and later – Show More

API: Dromostanolone propionate

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   • Hazard statements: H351-H360FD
   • Signal word: Danger

   • Precautionary statements: P201-P202-P280-P308+P313-P405-P501
   • Symbol (GHS): GHS08
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   • Hazard statements: H351-H360FD
   • Signal word: Danger

   • Precautionary statements: P201-P202-P280-P308+P313-P405-P501
   • Symbol (GHS): GHS08
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