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Nandrolone Decanoate

Nandrolone Decanoate Structure

Nandrolone Decanoate structure

CAS No.
360-70-3
Chemical Name:
Nandrolone Decanoate
Synonyms
DECADURABOLIN;Anabolicum;Nandrolone Deconate;Nandrolone Decanoate (DECA);19-NORTESTOSTERONE 17-DECANOATE;17-beta-hydroxy-estr-4-en-3-ondecanoate;retabolil;Nand Deca;Cartalax1;Decanofort
CBNumber:
CB0396051
Molecular Formula:
C28H44O3
Molecular Weight:
428.65
MDL Number:
MFCD00135100
MOL File:
360-70-3.mol
MSDS File:
SDS

Nandrolone decanoate

Catalog No.
S548672
CAS No.
360-70-3
M.F
C28H44O3
M. Wt
428.6 g/mol
Availability
In Stock
* This item is exclusively intended for research purposes and is not designed for human therapeutic applications or veterinary use.
Nandrolone decanoate

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General Information

Researchers formulating long-acting depots require an API with extended half-life and minimal androgenic activity. Nandrolone decanoate (CAS 360-70-3) addresses this with its high lipophilicity (LogP 7.32) and 6-12-day half-life, enabling 2-4-week dosing intervals in oil vehicles. Its 11:1 anabolic-to-androgenic ratio avoids DHT-related virilization, making it ideal for muscle wasting and osteoporosis models. • Depot kinetics: High LogP ensures sustained release from sesame/ethyl oleate vehicles. • Selective myotrophic effect: Minimized androgenic risk vs. testosterone esters (1:1 ratio). • Reliable supply: In-stock, lot-to-lot consistency for formulation R&D. SMolecule offers analytical-grade material, inventory-ready for global shipment.

CAS Number

360-70-3

Product Name

Nandrolone decanoate

IUPAC Name

[(8R,9S,10R,13S,14S,17S)-13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] decanoate

Molecular Formula

C28H44O3

Molecular Weight

428.6 g/mol

InChI

InChI=1S/C28H44O3/c1-3-4-5-6-7-8-9-10-27(30)31-26-16-15-25-24-13-11-20-19-21(29)12-14-22(20)23(24)17-18-28(25,26)2/h19,22-26H,3-18H2,1-2H3/t22-,23+,24+,25-,26-,28-/m0/s1

InChI Key

JKWKMORAXJQQSR-MOPIKTETSA-N

SMILES

CCCCCCCCCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C

solubility

Soluble in DMSO, not in water

Synonyms

17 beta Hydroxyestr 4 en 3 one 17 decanoate, 17 beta-hydroxyestr-4-en-3-one 17-decanoate, 19 nor 4 Androstene 17 beta ol 3 one 17 decanoate, 19 Nortestosterone Decanoate, 19-nor-4-androstene-17 beta-ol-3-one 17-decanoate, 19-nortestosterone decanoate, Decadurabolin, Decadurobolin, nandrolone decanoate, Retabolil, Retabolyl

Canonical SMILES

CCCCCCCCCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C

Isomeric SMILES

CCCCCCCCCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@H]34)C

The exact mass of the compound Nandrolone decanoate is 428.32905 and the complexity rating of the compound is unknown. The solubility of this chemical has been described as Soluble in DMSO, not in water. Its Medical Subject Headings (MeSH) category is Chemicals and Drugs Category – Chemical Actions and Uses – Pharmacologic Actions – Physiological Effects of Drugs – Bone Density Conservation Agents. It belongs to the ontological category of steroid ester in the ChEBI Ontology tree. The United Nations designated GHS hazard class pictogram is Acute Toxic;Irritant;Health Hazard, and the GHS signal word is DangerThe storage condition is described as Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).. Use and application categories indicated by third-party sources: Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients. However, this does not mean our product can be used or applied in the same or a similar way.

Purity

≥98%

Package Size

50 mg, 100 mg, 250 mg

Nandrolone Decanoate Overview

Nandrolone decanoate (CAS: 360-70-3) is a highly lipophilic, synthetic 19-nortestosterone ester widely utilized as an active pharmaceutical ingredient (API) for sustained-release depot formulations. By conjugating a 10-carbon decanoate ester to the 17-beta hydroxyl group of the nandrolone base, the molecule achieves an exceptionally high partition coefficient (LogP ~7.32), making it optimally suited for parenteral oil vehicles. Upon intramuscular or subcutaneous administration, the ester slowly partitions into the aqueous interstitial fluid where it is hydrolyzed by esterases into the active nandrolone base. This compound is primarily procured for the development of long-acting injectable therapeutics, pharmacokinetic modeling of fatty acyl prodrugs, and research requiring potent myotrophic effects with minimized androgenic activity [1].

Procurement Fit

Pharmacopoeial analytical standard (USP/BP monograph-defined)
Defined purity range and impurity profile for method validation
Characterized identity attributes (melting range, optical rotation)

References

Why Nandrolone Decanoate Substitution Fails

Substituting nandrolone decanoate with unesterified nandrolone, shorter esters like nandrolone phenylpropionate (NPP), or standard testosterone esters fundamentally compromises formulation pharmacokinetics and receptor selectivity. Unesterified nandrolone is cleared rapidly (half-life <4.3 hours), failing entirely to provide a depot effect. While NPP provides a depot effect, its shorter ester chain results in an elimination half-life of only 2.7 to 4.5 days, requiring frequent dosing that is often unacceptable in long-acting formulation development. Furthermore, substituting with long-acting testosterone esters (e.g., testosterone enanthate) drastically alters the pharmacological profile; testosterone undergoes 5-alpha reduction to the highly androgenic dihydrotestosterone (DHT), whereas nandrolone reduces to the weaker 5-alpha-dihydronandrolone. This gives testosterone a 1:1 anabolic-to-androgenic ratio, compared to nandrolone decanoate’s highly selective ~11:1 ratio, making testosterone unsuitable for applications requiring strict anabolic targeting without virilizing side effects [1].

Substitution Risk

Ester-dependent release kinetics

Decanoate ester provides prolonged depot release; not interchangeable with phenylpropionate or base forms.

Divergent half-lives alter exposure

Markedly different elimination half-lives may shift plasma concentration profiles and dosing requirements.

Model endpoint considerations

Selecting an ester with inappropriate release duration may affect endpoint interpretation in long-term studies.

References

Key Differentiators of Nandrolone Decanoate

Extended Half-Life with Decanoate Ester

The primary procurement driver for the decanoate ester over shorter analogs is its extended release profile from lipid vehicles. In pharmacokinetic evaluations following intramuscular injection, nandrolone decanoate exhibits an elimination half-life of 6 to 12 days, compared to only 2.7 to 4.5 days for nandrolone phenylpropionate (NPP). This prolonged half-life allows for a sustained therapeutic window of 2 to 4 weeks per administration [1].

Evidence Dimension Elimination half-life (intramuscular depot)
Target Compound Data Nandrolone decanoate: 6 to 12 days
Comparator Or Baseline Nandrolone phenylpropionate: 2.7 to 4.5 days
Quantified Difference ~2.5-fold increase in elimination half-life.
Conditions Intramuscular injection in arachis or sesame oil vehicles.

Enables the formulation of once-every-few-weeks depot injectables, significantly reducing administration frequency compared to shorter-chain esters.

Depot Half-Life
Head-to-head
130 h (decanoate) vs. 25 h (phenylpropionate)
Reported depot release context
Rat model; single IM injection

High Myotrophic-to-Androgenic Selectivity

For research targeting muscle or bone tissue without triggering severe androgen-receptor-mediated side effects, nandrolone decanoate is vastly superior to baseline testosterone. Structural modifications—specifically the lack of a methyl group at carbon C-19 and its subsequent 5-alpha reduction to a weaker androgen (5-alpha-dihydronandrolone)—grant nandrolone an anabolic-to-androgenic ratio of approximately 11:1. In contrast, testosterone and its esters maintain a 1:1 ratio [1].

Evidence Dimension Anabolic-to-androgenic ratio
Target Compound Data Nandrolone decanoate: ~11:1
Comparator Or Baseline Testosterone enanthate/cypionate: 1:1
Quantified Difference >10-fold higher selectivity for myotrophic (anabolic) effects over androgenic effects.
Conditions In vivo receptor affinity and nitrogen balance models.

Essential for developing therapeutics or research models that require tissue anabolism (muscle/bone) while strictly minimizing virilization and prostate hypertrophy.

Lean Mass Change
Head-to-head
Decanoate: +5.8% Testosterone: +3.5% Placebo: -0.9%
Reported muscle mass endpoint context
12-month RCT, glucocorticoid-treated men

Lipophilicity for Depot Partitioning

The sustained release mechanism of parenteral oil depots relies entirely on the drug’s partition coefficient. Nandrolone decanoate possesses a highly lipophilic profile with a LogP of 7.32, which ensures high solubility in carrier oils (e.g., sesame oil, ethyl oleate) and strictly rate-limits its diffusion into the aqueous interstitial fluid. This high LogP is the fundamental physicochemical property that creates the ‘lag time’ and slow absorption rate characteristic of its depot effect, differentiating it from unesterified steroids that partition too rapidly [1].

Evidence Dimension Partition coefficient (LogP) and oil solubility
Target Compound Data Nandrolone decanoate: LogP ~7.32
Comparator Or Baseline Unesterified nandrolone: Lower LogP, rapid aqueous partitioning
Quantified Difference The 10-carbon ester chain exponentially increases lipophilicity, preventing immediate aqueous dissolution.
Conditions Subcutaneous/intramuscular oil depot formulations.

Dictates the selection of this specific ester for sustained-release parenteral manufacturing and lipophilic prodrug research.

Body Weight Gain
Head-to-head
Decanoate: +1.48 kg vs. placebo +1.00 kg vs. testosterone
Reported weight-gain endpoint context
12-week RCT, HIV wasting
Pharmacopoeial Purity
Class-level
USP/BP: 97.0–103.0% Impurity limits defined
Supports method transferability
Compendial standard vs. non-pharmacopoeial
Neuroendocrine Profile
Head-to-head
Decanoate vs. testosterone undecanoate: ↓ body weight gain, altered ACTH & corticosterone
CNS/endocrine endpoint context
Male rat model, 14-day exposure
Supply Chain Assurance
Data to verify
TGA-licensed supplier, COA provided
Procurement documentation context
Supplier-specific; verify current status

Nandrolone Decanoate Applications

Sustained-Release Depot Manufacturing

Nandrolone decanoate is the premier active pharmaceutical ingredient (API) for formulating long-acting intramuscular or subcutaneous oil depots. Its high LogP (7.32) and extended half-life (6-12 days) make it the ideal candidate for manufacturing protocols utilizing sesame, arachis, or ethyl oleate vehicles, where a slow oil-to-water partition rate is required to achieve a 2-to-4-week dosing interval [1].

Myotrophic and Osteoporosis In Vivo Models

Due to its highly favorable 11:1 anabolic-to-androgenic ratio, nandrolone decanoate is prioritized in in vivo research models studying muscle wasting (cachexia), refractory anemia, and postmenopausal osteoporosis. It allows researchers to isolate potent tissue-building and nitrogen-retaining effects without the confounding virilizing variables introduced by standard testosterone esters [2].

Fatty Acyl Prodrug Pharmacokinetic Modeling

In pharmaceutical sciences, nandrolone decanoate serves as a benchmark compound for studying the lymphatic absorption and esterase-mediated hydrolysis of fatty acyl prodrugs. Its well-documented lag time and cleavage profile in interstitial fluid make it a standard reference material for developing novel lipophilic delivery systems and nanoemulsions [3].

Application Fit Matrix

Application
Selection Property
Validation Focus
Muscle wasting model studies
Comparator androgen-response context
Muscle mass endpoint interpretation
Cachexia model studies
Weight-gain endpoint context
Catabolic model endpoint review
Analytical method development
Pharmacopoeial identity and purity specifications
System suitability and impurity profiling
Sustained-exposure model studies
Depot release kinetics and dosing interval
Plasma exposure stability review

References

Specification

Physical Description

Solid

XLogP3

7.3

Hydrogen Bond Acceptor Count

3

Exact Mass

428.32904526 g/mol

Monoisotopic Mass

428.32904526 g/mol

Heavy Atom Count

31

LogP

2.62

Others

Appearance

Solid powder

Melting Point

32-35
118 °C

Storage

Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

UNII

H45187T098

GHS Hazard Statements

Aggregated GHS information provided by 85 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;
H301 (18.82%): Toxic if swallowed [Danger Acute toxicity, oral];
H302 (23.53%): Harmful if swallowed [Warning Acute toxicity, oral];
H312 (22.35%): Harmful in contact with skin [Warning Acute toxicity, dermal];
H332 (22.35%): Harmful if inhaled [Warning Acute toxicity, inhalation];
H351 (97.65%): Suspected of causing cancer [Warning Carcinogenicity];
H360 (52.94%): May damage fertility or the unborn child [Danger Reproductive toxicity];
H362 (28.24%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation];
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Drug Indication

Nandrolone decanoate is indicated in the management of anemia of renal insufficiency. In Canada, it is also indicated as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis.

Pharmacology

Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone increases production and urinary excretion of erythropoietin. It may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth.
Nandrolone Decanoate is the decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anabolic, and erythropoietin stimulating effects. Nandrolone enters the cell and binds to and activates specific nuclear androgen receptors in responsive tissue, including the prostate, seminal vesicles, scrotum, penis, larynx, hair follicles, muscle, and bone. The resulting activated hormone receptor complex translocates into the nucleus and binds to androgen response elements (ARE) in the promoter region of targeted genes, where the complex promotes gene expression necessary for maintaining male sex characteristics. Mimicking the negative feedback mechanism of testosterone, nandrolone decanoate also suppresses the secretion of luteinizing hormone (LH). Furthermore, this agent also stimulates erythropoietin production by enhancing the production of erythropoietic stimulating factors.

MeSH Pharmacological Classification

Anabolic Agents

Mechanism of Action

Nandrolone decanoate is hydrolyzed to [nandrolone], possibly by PDE7B. Nandrolone is brought into cells by receptor mediated endocytosis, where it interacts with the androgen receptor. After binding to the androgen receptor, a conformational change occurs, the androgen receptor enters the nucleus, dimerizes, and can then bind to segments of DNA to regulate transcription. Androgens can also regulate transcription through activation of ERK, Akt, and MAPK; or binding to and competitively inhibiting transcription factors.

KEGG Target based Classification of Drugs

Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C4 (AR) [HSA:367] [KO:K08557]

Pictograms

Health Hazard Acute Toxic Irritant

Acute Toxic;Irritant;Health Hazard

Other CAS

360-70-3

Absorption Distribution and Excretion

A 50 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 2.14 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 400 h\*ng/mL. A 100 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 4.26 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 862 h\*ng/mL. A 150 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 5.16 ng/mL, with a mean Tmax of 72 hours, and a mean AUC of 1261 h\*ng/mL.
Nandrolone decanoate is eliminated as urinary metabolites, however data regarding elimination in the feces are not readily available. Data in cattle shows that [nandrolone] is 30% eliminated in the feces.
50 mg, 100 mg, and 150 mg doses of nadrolone decanoate had mean apparent clearances of 80.0 L/h, 74.3 L/h, and 76.2 L/h respectively.

Metabolism Metabolites

Nandrolone decanoate is hydrolyzed to [nandrolone], possibly by PDE7B. Nandrolone is further metabolized to the urinary metabolites 19-norandrosterone, 19-noretiocholanolone, and 19-norepiandrosterone. 19-norandrosterone is 3-O-glucuronidated by UGT2B7, UGT 1A4, UGT2B4, UGT1A3, and UGT1A1. 19-noretiocholanolone is 3-O-glucuronidated by UGT2B7, UGT2B4, UGT1A4, UGT1A10, UGT1A3, and UGT1A1.

Wikipedia

Nandrolone_decanoate
MiPT

Biological Half Life

Nandrolone decanoate has an absorption half life of 6 days and an elimination half life of 4.3 hours. Alternate studies have shown that nandrolone decanoate has a terminal half life of 7.1, 11.7, and 11.8 hours for doses of 50, 100, and 150 mg respectively.

Use Classification

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Pharmaceuticals

Reference

Bagchus WM, Smeets JMW, Verheul HAM, De Jager-Van Der Veen SM, Port A, Guerts TBP: Pharmacokinetic Evaluation of Three Different Intramuscular Doses of Nandrolone Decanoate: Analysis of Serum and Urine Samples in Healthy Men The Journal of Clinical Endocrinology & Metabolism. 2005 May 1;90(5):2624-2630.
Baume N, Avois L, Schweizer C, Cardis C, Dvorak J, Cauderay M, Mangin P, Saugy M: [13C]Nandrolone excretion in trained athletes: interindividual variability in metabolism. Clin Chem. 2004 Feb;50(2):355-64. doi: 10.1373/clinchem.2003.022848. Epub 2003 Nov 21. [PMID:14633920]
Wijnand HP, Bosch AM, Donker CW: Pharmacokinetic parameters of nandrolone (19-nortestosterone) after intramuscular administration of nandrolone decanoate (Deca-Durabolin) to healthy volunteers. Acta Endocrinol Suppl (Copenh). 1985;271:19-30. doi: 10.1530/acta.0.109s00019. [PMID:3865478]
Kuuranne T, Kurkela M, Thevis M, Schanzer W, Finel M, Kostiainen R: Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2003 Sep;31(9):1117-24. doi: 10.1124/dmd.31.9.1117. [PMID:12920167]
Strahm E, Rane A, Ekstrom L: PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2. Front Pharmacol. 2014 May 30;5:132. doi: 10.3389/fphar.2014.00132. eCollection 2014. [PMID:24910615]
Victor A, Weiner E, Johansson ED: Sex hormone binding globulin: the carrier protein for d-norgestrel. J Clin Endocrinol Metab. 1976 Jul;43(1):244-7. doi: 10.1210/jcem-43-1-244. [PMID:133117]
Calvarese S, Rubini P, Urbani G, Ferri N, Ramazza V, Zucchi M: Experimental administration of 19-nortestosterone and dexamethasone in cattle: elimination of the two drugs in different biological matrices. Analyst. 1994 Dec;119(12):2611-5. doi: 10.1039/an9941902611. [PMID:7879862]
Product description Number Pack Size Price
Nandrolone decanoate United States Pharmacopeia (USP) Reference Standard 1455000 250mg $618
Nandrolone decanoate British Pharmacopoeia (BP) Reference Standard BP425 50MG $272
Nandrolone Decanoate ≥98% 32546 1mg $36
Nandrolone Decanoate ≥98% 32546 5mg $103
Nandrolone Decanoate (~70%) TRC-N315033-10MG 10mg $66
More product size
Request For Quotation

Nandrolone Decanoate Properties

Melting point 33-37°C
Boiling point 483.46°C (rough estimate)
alpha 32 º
Density 1.0406 (rough estimate)
refractive index 1.4700 (estimate)
storage temp. 2-8°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL
form powder
color white to light yellow
Water Solubility 664ug/L(37 ºC)
InChIKey JKWKMORAXJQQSR-MOPIKTETSA-N
SMILES [C@@]12([H])CC[C@H](OC(=O)CCCCCCCCC)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H] |&1:0,4,17,21,23,33,r|
CAS DataBase Reference 360-70-3
FDA UNII H45187T098
NCI Drug Dictionary nandrolone decanoate

 

SAFETY

Risk and Safety Statements

Symbol(GHS) Health Hazard (GHS08)
GHS08
Signal word Danger
Hazard statements H351-H360FD
Precautionary statements P201-P202-P280-P308+P313-P405-P501
Hazard Codes Xn
Risk Statements 40
Safety Statements 22-36
WGK Germany 3
RTECS KG7967000
HS Code 2937290000
Toxicity LD50 intraperitoneal in mouse: > 566mg/kg
NFPA 704
0
2 0

Nandrolone Decanoate price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1455000 Nandrolone decanoate United States Pharmacopeia (USP) Reference Standard 360-70-3 250mg $618 2026-04-30 Buy
Sigma-Aldrich BP425 Nandrolone decanoate British Pharmacopoeia (BP) Reference Standard 360-70-3 50MG $272 2025-07-31 Buy
Cayman Chemical 32546 Nandrolone Decanoate ≥98% 360-70-3 1mg $36 2026-04-30 Buy
Cayman Chemical 32546 Nandrolone Decanoate ≥98% 360-70-3 5mg $103 2026-04-30 Buy
TRC TRC-N315033-10MG Nandrolone Decanoate (~70%) 360-70-3 10mg $66 2026-06-03 Buy

Nandrolone Decanoate Chemical Properties, Uses, Production

Description

Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis. The process for creating esters of [nandrolone] was patented in Spain in 1959 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other esters. Nandrolone decanoate was granted FDA approval on 5 October 1962.

Chemical Properties

White or almost white, crystalline powder.

Originator

Deca-Durabolin,Organon,US,1962

Uses

Nandrolone Decanoate is an anabolic steroid. Nandrolone decanoate is used in the treatment of osteoporosis in postmenopausal women. Nandrolone Decanoate is also used for some aplastic anemias. Control led Substance.

Definition

ChEBI: Nandrolone decanoate is a steroid ester.

Manufacturing Process

1 gram of 19-nortestosterone is dissolved in 3 ml of dry pyridine, after which the resulting solution is cooled to -20°C. A solution of 1.0 gram of decanoic acid chloride in 3 ml of dry benzene is added to the cooled solution. The mixture is maintained at -15°C for 16 hours and then poured into ice water. The aqueous liquid is extracted with benzene, the benzene solution is washed with respectively 1 N sodium hydroxide solution, 2 N hydrochloric acid and with water until neutral reaction.
Then the solution is dried on sodium sulfate, filtered, and evaporated to dryness. The residue, 1.63 grams is dissolved in hexane, this solution is filtered over 30 grams of neutral aluminum oxide, and evaporated to dryness. On paper chromatographic investigation it turned out that the obtained 19- nortestosterone 17-decanoate which at room temperature is an oil consists of a single compound, according to US Patent 2,998,423.

brand name

Durabolin (Organon);Abolon;Activin;Anabolin la 100;Anador;Anadur;Analone-50;Androlone d 100;Androlone d 50;Decabolin;Deca-durabolin decanoate;Deca-noralone;Docabolin;Fherbolico;Fortabolin;Hybolin-decanoate;Iebolan;Kabolin;Keratyl;Methybol-depot;Nandrolone decanoate;Nordecon;Stenabolin;Sterobolin;Turinabol-depot.

Therapeutic Function

Anabolic

World Health Organization (WHO)

Nandrolone decanoate, an anabolic steroid, was introduced in 1962. In 1982, low dosage preparations were prohibited in Bangladesh due to inadmissible promotion of products containing anabolic steroids for malnourished children. Higher dosage preparations of nandrolone decanoate remain available in many countries, including Bangladesh, for several highly specific but limited indications that apply to patients with chronic debilitating and emaciating diseases, particularly associated with neoplasia and some types of aplastic anaemia.

General Description

Nandrolone decanoate,17β-hydroxyestr-4-en-3-one 17-decanoate, has been used inthe management of certain anemias, but the availability oferythropoietin has greatly reduced this use.

Biochem/physiol Actions

Compared to testosterone propionate, nandrolone decanoate is considered to have strong anabolic effects but weak androgenic effects (potency ratios of 3.29–4.92 and 0.31–0.41).  In particular, nandrolone esters are thought to have the highest ratio of anabolic to androgenic effects of any AAS. The low androgenicity of nandrolone decanoate is thought to be due to the fact that nandrolone is inactivated by 5α-reductase via transformation into the low-affinity androgen receptor (AR) ligand 5α-dihydronandrolone. This is thought to result in a lower incidence and magnitude of side effects.Nandrolone decanoate (ND) injection has been classified as a Schedule III controlled substance under the Anabolic Steroids Control Act of 1990. Due to serious health risks, the nonmedical use of AASs is banned by most sports organizations[1].

Side effects

There are many effects of this drug on the human body, and the studies of its side effects can be divided into the following: categories endocrine, cardiovascular, skin, psychiatric, musculoskeletal, excretory, and gastrointestinal disorders.
Nandrolone Decanoate
The most common side effects were: endocrine disorders (virilization, gynecomastia, hormonal disorders, cholesterol and lipid disorders, genital and infertility issues); cardiovascular disorders (vascular damage, coagulation disorders, arteriosus hypertension); skin disorders (pricking, acne, skin spots); psychiatric disorders (aggressiveness, mood disorders, sleep disorders, anxiety); musculoskeletal disorders (tendon ruptures); excretory disorders (organ damage); gastrointestinal disorders (organ damage and liver adenomas); neurological disorders (seizures); immune disorders (chronic infection relapse; respiratory disorders (sleep apnea syndrome); genetic disorders (genetic damage)[1].

Safety Profile

Experimental reproductiveeffects. When heated to decomposition it emits acridsmoke and irritating fumes.

Veterinary Drugs and Treatments

The principle use of nandrolone in veterinary medicine has been to stimulate erythropoiesis in patients with certain anemias (e.g., secondary to renal failure, aplastic anemias). It has also been suggested for use as an appetite stimulant.

Nandrolone Decanoate Preparation Products And Raw materials

Raw materials

Nandrolone Decanoate

Item No. 32546

Restricted Product (Schedule III)
Synonyms
Synonyms
  • Nandrolone 17-Decanoate
  • Nortestosterone Decanoate
Technical Information
Formal Name
17β-[(1-oxodecyl)oxy]-estr-4-en-3-one
CAS Number
360-70-3
Molecular Formula
C28H44O3
Formula Weight
428.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): .25 mg/mlPBS (pH 7.2): insol
λmax
240 nm
SMILES
C[C@@]12[C@](CC[C@@H]2OC(CCCCCCCCC)=O)([H])[C@]3([H])CCC4=CC(CC[C@]4([H])[C@@]3([H])CC1)=O
InChi Code
InChI=1S/C28H44O3/c1-3-4-5-6-7-8-9-10-27(30)31-26-16-15-25-24-13-11-20-19-21(29)12-14-22(20)23(24)17-18-28(25,26)2/h19,22-26H,3-18H2,1-2H3/t22-,23+,24+,25-,26-,28-/m0/s1
InChi Key
JKWKMORAXJQQSR-MOPIKTETSA-N
Regulatory Information
DEA Schedule
III
Shipping & Storage Information
Storage
-20°C
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Nandrolone decanoate

Base Information
  • Chemical Name:Nandrolone decanoate
  • CAS No.:360-70-3
  • Molecular Formula:C28H44O3
  • Molecular Weight:428.656
  • Hs Code.:2937290000
  • European Community (EC) Number:206-639-3
  • UNII:H45187T098
  • DSSTox Substance ID:DTXSID7023352
  • Nikkaji Number:J5.698G
  • Wikipedia:Nandrolone_decanoate
  • Wikidata:Q16634231
  • NCI Thesaurus Code:C1172
  • Pharos Ligand ID:XC116264XL8T
  • Metabolomics Workbench ID:43721
  • ChEMBL ID:CHEMBL1200946
  • Mol file:360-70-3.mol
Nandrolone decanoate

Synonyms:Estr-4-en-3-one,17b-hydroxy-, decanoate (6CI,7CI,8CI);Decanoic acid, ester with 17b-hydroxyestr-4-en-3-one(8CI);17b-Hydroxy-19-norandrost-4-en-3-one 17-decanoate;17b-Hydroxyestr-4-en-3-one17-decanoate;17b-Hydroxyestr-4-en-3-one decanoate;19-Nor-17b-hydroxy-3-ketoandrost-4-ene17-decanoate;19-Norandrostenolone decanoate;19-Nortestosterone 17b-decanoate;19-Nortestosterone decanoate;Anabolicum;Anabolin Forte;Deca-Durabol;Deca-Durabolin;Deca-Hybolin;Decanofort;Extraboline;Hybolin decanoate;Nandrobolic LA;Norandrostenolone decanoate;Retabolil;Sustanon250 powder;Estr-4-en-3-one,17-[(1-oxodecyl)oxy]-, (17b)-;

Suppliers and Price of Nandrolone decanoate
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Total 164 raw suppliers

Chemical Property of Nandrolone decanoate
Chemical Property:
  • Appearance/Colour:white to light yellow powder 
  • Vapor Pressure:1.3E-11mmHg at 25°C 
  • Melting Point:33-37 °C 
  • Refractive Index:1.524 
  • Boiling Point:537.2 °C at 760 mmHg 
  • Flash Point:226.8 °C 
  • PSA：43.37000 
  • Density:1.04 g/cm3 
  • LogP:7.18070 
  • Storage Temp.:2-8°C 
  • Solubility.:45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL 
  • Water Solubility.:664ug/L(37 oC) 
  • XLogP3:7.3
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:10
  • Exact Mass:428.32904526
  • Heavy Atom Count:31
  • Complexity:680
Purity/Quality:
99% *data from raw suppliers

Nandrolone decanoate British Pharmacopoeia (BP) Reference Standard *data from reagent suppliers

Safty Information:
  • Pictogram(s):HarmfulXn 
  • Hazard Codes:Xn 
  • Statements:40 
  • Safety Statements:22-36 
MSDS Files:
Total 1 MSDS from other Authors
Useful:
  • Canonical SMILES:CCCCCCCCCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C
  • Isomeric SMILES:CCCCCCCCCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@H]34)C
  • Recent ClinicalTrials:Anabolic Steroid and Propranolol in Paediatric Burn
  • Recent EU Clinical Trials:Preliminary effect and safety of physiotherapy with strength training and protein-dense nutritional supplement in combination with anabolic steroids in cross-continuum rehabilitation of patients with hip fracture – a randomized controlled pilot trial. (The HIP-SAP trial)
  • DescriptionNandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis. The process for creating esters of [nandrolone] was patented in Spain in 1959 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other esters. Nandrolone decanoate was granted FDA approval on 5 October 1962.
  • UsesNandrolone Decanoate is an anabolic steroid. Nandrolone decanoate is used in the treatment of osteoporosis in postmenopausal women. Nandrolone Decanoate is also used for some aplastic anemias. Control led Substance.
  • Therapeutic FunctionAnabolic

  1. Nandrolone Decanoate | 360-70-3 – ChemicalBook

    Sep 10, 2026 · Nandrolone Decanoate (CAS 360-70-3) information, including chemical properties, structure, melting point, boiling …

    • alpha: 32 º
    • Density: 1.0406 (rough estimate)
    • Boiling point: 483.46°C (rough estimate)
    • Melting point: 33-37°C

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