Buy Dimethocaine larocaine (DMC) Cas 94-15-5
Buy Dimethocaine larocaine (DMC) Cas 94-15-5
Dimethocaine, also known as DMC or larocaine, is a compound with local anesthetic and stimulatory effects. The stimulatory effect resembles that of cocaine, although less potent. Similarly to cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. However, dimethocaine is a legal cocaine replacement in some countries and is listed by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) under the “synthetic cocaine derivatives” category.[1] The structure of dimethocaine, being a 4-aminobenzoic acid ester, resembles that of procaine. It is found as a white powder at room temperature.[2]
When a product sold online in the UK in June 2010, advertised as dimethocaine was tested, it was found to be a mixture of caffeine and lidocaine,[3] and the lack of any dopaminergic stimulant ingredient in such mixes may explain the limited recreational effects reported by many users. Other samples tested have however been shown to contain genuine dimethocaine, and one branded “bath salt” product containing primarily dimethocaine as the active ingredient, was noted to have been particularly subject to abuse by intravenous drug users in Ireland.[4]
History
Dimethocaine was originally synthesized by the Hoffmann-La Roche company in 1930. It was sold under the market name larocaine. During the 1930s dimethocaine gained popularity in the US as a local anesthetic. Just like cocaine and procaine, it was used during surgery, primarily in dentistry, ophthalmology and otolaryngology. However, in the 1940s, it was removed from the market because of its psychoactive effects and risk of addiction. Nowadays dimethocaine is abused for these psychoactive effects. It is sold as a cocaine surrogate to circumvent legislation issues.[1][5][6]
Pharmacology
Pharmacodynamics
Dimethocaine and structurally related local anesthetics such as cocaine and procaine inhibit the uptake of dopamine (DA) by blocking dopamine transporters (DAT).[7] The dopamine transporter controls the dynamics of the neurotransmitter dopamine. This neurotransmitter controls many functions including movement, cognition and mood. Drugs such as cocaine and dimethocaine induce dopamine overflow by inhibiting dopamine transporters and thus creating a euphoric effect.[8] In addition to inhibiting dopamine uptake, dimethocaine was also shown to inhibit the binding of CFT, a different dopamine uptake inhibitor.[7] These inhibitory properties are responsible for the stimulatory effects of dimethocaine on the central nervous system.[5] Both in vivo and in vitro measurements of dopamine transporter activity showed that dimethocaine is a potent and efficacious dopaminergic reuptake inhibitor (also called a dopamine indirect agonist).[7] These effects were mainly observed in the nucleus accumbens, a region in the basal forebrain.[5] Comparison of the pharmacological potencies of different local anesthetics revealed the following potency order:[5]
cocaine > dimethocaine > tetracaine > procaine > chloroprocaine
Furthermore, the administration of dimethocaine has been shown to lead to antinociceptive responses at nontoxic doses in mice.[9] These responses are suggested to be at least partially caused by the effects of dimethocaine on the central nervous system. A memory impairing effect observed in mice after administration of dimethocaine has been proposed to be a result of a non-anesthetic mechanism of action.[10]
Pharmacokinetics
When inhaled, dimethocaine starts working in 10–30 minutes, with highest effects at 60–120 minutes and until 4–6 hours there is a period of action with the ‘after-effects’.[11] The after effects include fatigue and slight mental impairment.[6]
Metabolism
The exact metabolic pathways of dimethocaine have not been researched, but the different metabolites have been examined in Wistar rats. After administration of dimethocaine, different metabolites have been found and identified in their urine. Due to these metabolites, different metabolic pathways could have been postulated. The main phase I reactions are ester hydrolysis, deethylation, hydroxylation of the aromatic system, or a combination of these three.[1] The main phase II reactions are N-acetylation, glucuronidation and a combination of both.[5][1] Different cytochrome P450 isozymes are involved in the initial steps of human metabolism. The N-acetylation is catalyzed by the NAT2 isozyme.[12]
Efficacy and side effects
Just like cocaine, dimethocaine inhibits the uptake of dopamine in the brain by interfering with the dopamine transporters.[13] The potency of these drugs is linked to their affinity for the dopamine transporters, and their potency to inhibit dopamine uptake.[7]
In studies with rhesus monkeys the affinity of dimethocaine for dopamine transporters is smaller than that of cocaine, whereas dimethocaine’s potency to inhibit dopamine uptake is similar. This means that more of dimethocaine is needed to reach a similar response. The peak effects occurred within 10 to 20 minutes after the injection and decreased to baseline levels within an hour.[13]
Dimethocaine is often abused as a legal substitute for cocaine. The drug is administered intravenously or nasally, because ingestion would lead to rapid hydrolyzation.[5] Its positive effects are euphoria, stimulation, increased talkativeness and mood lift.[6] However, because the drug acts similar as cocaine, it has comparable negative side effects. These side effects include: tachycardia, difficulty with breathing, pain on the chest, vasoconstriction, insomnia, paranoia and anxiety.[6] Dimethocaine probably poses larger health issues than cocaine. This is due to the fact that more dimethocaine must be administered to produce the same euphoric feeling, resulting in larger risk for the negative effects.
Dimethocaine
- CAS No.
- 94-15-5
- Chemical Name:
- Dimethocaine
- Synonyms
- Larocaine;Larocaine dimethocaine;4-Aminobenzoesaeure-3-diethylamino-2,2-dimethylproplylester;NSC 68927;Dimercaine;Brn 2215967;DiMethocine;Dimethocaine;Larocaine 99%;dimethylcaine
- CBNumber:
- CB11178523
- Molecular Formula:
- C16H26N2O2
- Molecular Weight:
- 278.39
- MDL Number:
- MFCD01697030
- MOL File:
- 94-15-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Dimethocaine >98.0%(GC)(T) | D4179 | 1g | $87 |
| Dimethocaine >98.0%(GC)(T) | D4179 | 5g | $276 |
| Dimethocaine | TRC-D479515-500MG | 500mg | $376 |
| Dimethocaine | FD178421 | 0.5g | $150 |
| Dimethocaine | FD178421 | 1g | $150 |
| More product size | |||
| Melting point | 53.0 to 57.0 °C |
|---|---|
| Boiling point | 421.21°C (rough estimate) |
| Density | 1.035 |
| refractive index | 1.5290 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.08±0.25(Predicted) |
| color | Pale Orange to Light Orange |
| Merck | 14,3221 |
| InChI | InChI=1S/C16H26N2O2/c1-5-18(6-2)11-16(3,4)12-20-15(19)13-7-9-14(17)10-8-13/h7-10H,5-6,11-12,17H2,1-4H3 |
| InChIKey | OWQIUQKMMPDHQQ-UHFFFAOYSA-N |
| SMILES | C(OC(=O)C1=CC=C(N)C=C1)C(CN(CC)CC)(C)C |
| CAS DataBase Reference | 94-15-5 |
| EWG’s Food Scores | 1 |
| FDA UNII | R3L4A6GOWZ |
SAFETY
Risk and Safety Statements
| RTECS | UB1575000 |
|---|
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| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4179 | Dimethocaine >98.0%(GC)(T) | 94-15-5 | 1g | $87 | 2021-12-16 | Buy |
| TCI Chemical | D4179 | Dimethocaine >98.0%(GC)(T) | 94-15-5 | 5g | $276 | 2021-12-16 | Buy |
| TRC | TRC-D479515-500MG | Dimethocaine | 94-15-5 | 500mg | $376 | 2026-06-03 | Buy |
| Biosynth | FD178421 | Dimethocaine | 94-15-5 | 0.5g | $150 | 2026-06-04 | Buy |
| Biosynth | FD178421 | Dimethocaine | 94-15-5 | 1g | $150 | 2026-06-04 | Buy |
Dimethocaine Chemical Properties, Uses, Production
Description
Dimethocaine, also known as DMC or larocaine, is a compound with stimulating effects similar to those of cocaine. It was used in the 1930s as a local anesthetic in dentistry and ophthalmology. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. However, dimethocaine is a legal cocaine replacement in some countries and is even listed by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) under the category “synthetic cocaine derivatives”. The structure of dimethocaine, being a 4-aminobenzoic acid ester, resembles that of procaine.
Chemical Properties
Dimethocaine is a yellow chrystalline powder. It is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas.
Uses
Dimethocaine is a local anesthetic with stimulatory properties that is half the potency of cocaine. It is often abused as a legal substitute for cocaine. The drug is administered intravenously or nasally, because ingestion would lead to rapid hydrolyzation.Its positive effects are euphoria, stimulation, increased talkativeness and mood lift.However, because dimethocaine acts similar as cocaine, it has comparable negative side effects. These side effects include: tachycardia, difficulty with breathing, pain on the chest, vasoconstriction, insomnia, paranoia and anxiety.
Definition
ChEBI: Dimethocaine is a benzoate ester. It is derivate from cocaine, it is not a part of the organic alkaloid mix coming from a coca plant. It is very popular research chemical, mainly used as local anesthetic, but also the stimulant qualities appeared to be shown immediately.
Biological Activity
Dimethocaine is a local anesthetic that, because of its similarity in action to cocaine, has potential for abuse. This compound completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value of 1.2 μM comparable to that of cocaine (IC50 = 0.7 μM). As a result, dimethocaine dose-dependently substitutes for cocaine in drug discrimination tests in rats and rhesus monkeys. This product is intended for forensic and research purposes.
Side effects
The side effects include tachycardia, difficulty with breathing, pain in the chest, vasoconstriction, insomnia, paranoia and anxiety.
Metabolism
Dimethocaine (DMC), a synthetic derivative of cocaine, is distributed and consumed as “new psychoactive substance” (NPS). It is mainly metabolized by N-acetylation, N-deethylation or hydroxylation. As DMC is metabolized via two main steps and different P450 isoforms were involved in the hepatic clearance of DMC, a clinically relevant interaction with single P450 inhibitors should not be expected. However, a slow acetylation phenotype or inhibition of NAT2 could lead to decreased N-acetylation and hence leading to an increased risk of side effects caused by this arylamine. Using the relative activity factor approach, the net clearances for deethylation of DMC were calculated to be 3% for P450 1A2, 1% for 2C19,<1% for 2D6, and 96% for 3A4. The net clearances for hydroxylation of DMC were calculated to be 32% for P450 1A2, 5% for 2C19, 51% for 2D6, and 12% for 3A4[1].
References
[1] Markus R Meyer, Hans H Maurer, Carina Lindauer. “Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2.” Toxicology letters 225 1 (2014): 139–46.
Dimethocaine Preparation Products And Raw materials
Dimethocaine
Dimethocaine (CAS 94-15-5) – High-Purity Research Chemical for Scientific Study
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Dimethocaine is a synthetic local anesthetic compound with a well-characterized pharmacological profile. This high-purity material is specifically produced for controlled laboratory research and analytical applications.
Key Specifications
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CAS Number: 94-15-5
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Chemical Name: 3-(Diethylamino)-2,2-dimethylpropyl 4-aminobenzoate
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Purity: ≥98% (HPLC verified)
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Appearance: White to off-white crystalline powder
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Molecular Weight: 278.39 g/mol
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Melting Point: 58-62°C
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Solubility: Soluble in ethanol, methanol; slightly soluble in water
Primary Research Applications
Pharmacological Studies
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Local anesthetic mechanism research
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Sodium channel interaction studies
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Structure-activity relationship investigations
Analytical Applications
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HPLC/GC-MS reference standard
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Forensic toxicology research
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Method development and validation
Comparative Research
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Cocaine analog studies
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Anesthetic potency comparisons
Quality Assurance
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Batch-Specific Certification: Includes HPLC chromatograms and mass spectra
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Stability Testing: 24-month stability when stored properly
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Packaging: Amber glass vials with argon flushing
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Storage Recommendations: 2-8°C in dry, dark environment
Safety & Handling
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PPE Requirements: Nitrile gloves, lab coat, eye protection
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Ventilation: Use in fume hood for powder handling
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Disposal: Follow institutional guidelines for chemical waste
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Regulatory Status: Research use only – not for human consumption
Ordering Information
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Dimethocaine HCl – Premium Analytical Standard for Laboratory Research
Dimethocaine, chemically known as Dimethocaine Hydrochloride (CAS 94-15-5), is a synthetic local anesthetic of the amino ester class. Available as a fine, white crystalline powder, this compound is strictly intended for in-vitro and laboratory research applications. Researchers looking to buy Dimethocaine, CAS 94-15-5 online or to order Dimethocaine for sale will find this high-purity powder ideal for forensic, pharmacological, and analytical chemistry studies.
The HCl (hydrochloride) designation denotes the stable salt form, enhancing solubility and chemical stability, making it suitable for precise laboratory experiments. This is distinct from hydrochloric acid and ensures consistent performance in controlled research environments.
Chemical and Physical Properties
- Chemical Name: Dimethocaine Hydrochloride
- Synonyms: Dimethocaine HCl
- CAS Number: 94-15-5
- Molecular Formula: C₁₆H₂₆N₂O₂ · HCl
- Molecular Weight: 322.85 g/mol
- Appearance: Fine white crystalline powder
- Purity: ≥98% (HPLC verified)
- Solubility: Highly soluble in water and ethanol
- Storage Conditions: Cool, dry, and dark place in tightly sealed containers
- Shelf-Life: 24 months under recommended storage conditions
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Authorized Research Applications
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Dimethocaine HCl serves as a certified reference standard for precise laboratory and forensic applications:
- Calibration Standard: Essential for LC-MS/MS, GC-MS, and HPLC instruments to accurately identify and quantify Dimethocaine in biological and forensic samples.
- Metabolite Detection: Supports studies on metabolic pathways and the identification of Dimethocaine metabolites in biological specimens.
- Analytical Method Development: Used to create and validate detection methods for novel psychoactive substances in forensic laboratories.
2. Pharmacological Research
Researchers studying local anesthetics and stimulant analogues can employ Dimethocaine HCl for:
- Receptor Binding Studies: Investigating interactions with neuronal receptors to understand potential Dimethocaine effects.
- Comparative Analysis: Studying structural analogues and alternative compounds to map pharmacological profiles.
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- Standardized reference material for volumetric solution preparation.
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Dimethocaine is not approved for human or veterinary use. Its legality varies by country, and in the United States, it is often considered a controlled substance analogue. Researchers searching for ‘where to buy Dimethocaine, CAS 94-15-5’ or ‘best place to buy Dimethocaine online’ must use licensed suppliers catering exclusively to research laboratories. Consumer marketplaces, including Amazon, are not suitable channels for acquisition.
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CAS 94-15-5 Dimethocaine | Products & Prices & Suppliers
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Dimethocaine(94-15-5), also known by its chemical name 3-(diethylamino)-2,2-dimethylpropyl 4-aminobenzoate, is a synthetic compound that falls under the class of local anesthetics. It is commonly used as a numbing agent and has gained attention for its potential recreational use. Dimethocaine has a chemical structure similar to cocaine, but with modifications that alter its effects and properties. This white crystalline powder is typically administered topically or insufflated, and it exhibits both anesthesia and stimulant-like qualities.Local Anesthetic:Dimethocaine is widely utilized as a local anesthetic in medical and dental procedures. Its numbing properties make it effective in temporarily reducing pain or discomfort in specific areas of the body. It acts by blocking nerve impulses, preventing the sensation of pain from reaching the brain. However, it is important to note that the usage of Dimethocaine for medical purposes should be done under the guidance and supervision of a healthcare professional.Local Anesthetic Properties:Dimethocaine is primarily recognized for its local anesthetic properties. In laboratory and research settings, it is often employed to study the effects of local anesthetics on neural pathways. The compound’s ability to temporarily block nerve signals makes it a valuable tool for understanding the mechanisms of sensory perception and pain modulation.Research and Experimental Studies:Beyond its role as a local anesthetic, Dimethocaine finds application in research and experimental studies. Scientists and researchers utilize this compound to explore its effects on neural systems, contributing to the advancement of knowledge in the field of pharmacology. Its inclusion in studies may involve investigations into pain management, neural signal transmission, or related areas.Practical Application:In practical terms, the usage of Dimethocaine is rooted in its ability to modulate neural responses. For researchers studying pain perception or those involved in pharmaceutical development, Dimethocaine serves as a valuable tool. Its controlled application in laboratory experiments allows for a nuanced understanding of neural pathways and the potential development of new anesthetic or analgesic substances.
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- Product Name: Dimethocaine
- Molecular Weight: 278.396
- Molecular Formula: C16H26N2O2
- Synonyms: 1-Aminobenzoyl-2,2-dimethyl-3-diethylaminopropanol; 1-Propanol, 3- (diethylamino)-2,2-dimethyl-, 4-aminobenzoate (ester); 1-Propanol, 3- (diethylamino)-2,2-dimethyl-, p-aminobenzoate (ester); 1-Propanol, 3-(diethylamino)-2,2-dimethyl-, 4-aminobenzoate (ester); 1-Propanol, 3-(diethylamino)-2,2-dimethyl-, 4-aminobenzoate (ester) (9CI); 1-Propanol, 3-(diethylamino)-2,2-dimethyl-, p-aminobenzoate (ester) (8CI);
PropertiesSafety and HandlingMSDS InfomationNMR NMR SpectrumComputational chemical data
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Dimethocaine structure
|
Common Name | Dimethocaine | ||
|---|---|---|---|---|
| CAS Number | 94-15-5 | Molecular Weight | 278.390 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 403.5±25.0 °C at 760 mmHg | |
| Molecular Formula | C16H26N2O2 | Melting Point | 53.0 to 57.0 deg-C | |
| MSDS | N/A | Flash Point | 197.8±23.2 °C | |
| Purity | Quantity | Budget | Inquiry |
|---|
Use of DimethocaineDimethocaine is a local anesthetic with reported stimulant properties most similar to cocaine. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 1-Propanol, 2-[(diethylamino)methyl]-2-methyl-, 1-(4-aminobenzoate) |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Dimethocaine is a local anesthetic with reported stimulant properties most similar to cocaine. |
|---|---|
| Related Catalog | |
| References | [1]. Rigon AR, et al. Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects. Psychopharmacology (Berl). 1996 Oct;127(4):323-7. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 403.5±25.0 °C at 760 mmHg |
| Melting Point | 53.0 to 57.0 deg-C |
| Molecular Formula | C16H26N2O2 |
| Molecular Weight | 278.390 |
| Flash Point | 197.8±23.2 °C |
| Exact Mass | 278.199432 |
| PSA | 55.56000 |
| LogP | 3.55 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.529 |
| InChIKey | OWQIUQKMMPDHQQ-UHFFFAOYSA-N |
| SMILES | CCN(CC)CC(C)(C)COC(=O)c1ccc(N)cc1 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
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Dimethocaine (CAS 94-15-5) is a synthetic local anesthetic with stimulant properties similar to cocaine. It was historically used as a local anesthetic in dentistry and ophthalmology. Dimethocaine is often abused as a legal substitute for cocaine due to its stimulant effects and addictive potential.
Key characteristics include:-
Chemical Formula: C16H26N2O2
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Molecular Weight: 278.40 g/mol
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Appearance: Yellow crystalline powder
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Solubility: Soluble in organic solvents like ethanol and DMSO
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Dimethocaine | 94-15-5 – ChemicalBook
Sep 19, 2026 · Dimethocaine (CAS 94-15-5) information, including chemical properties, structure, melting point, boiling point, density, …
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Boiling point: 421.21°C (rough estimate)
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Melting point: 53.0 to 57.0 °C
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Density: 1.035
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refractive index: 1.5290 (estimate)
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Dimethocaine | 94-15-5 – ChemicalBook
Sep 19, 2026 · Dimethocaine, also known as DMC or larocaine, is a compound with stimulating effects similar to those of cocaine. It …
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Boiling point: 421.21°C (rough estimate)
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Melting point: 53.0 to 57.0 °C
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Density: 1.035
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refractive index: 1.5290 (estimate)
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Dimethocaine, chemically known as Dimethocaine Hydrochloride (CAS 94-15-5), is a synthetic local …
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Dimethocaine (C16H26N2O2) · CAS 94-15-5 · Chempirical
Dimethocaine, CAS 94-15-5: C16H26N2O2, 278.40 g/mol. Structure, SMILES, InChIKey, names and safety data sheets.
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5 days ago · Dimethocaine (94-15-5), also known by its chemical name 3- (diethylamino)-2,2-dimethylpropyl 4-aminobenzoate, is a …
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Dimethocaine, also known as DMC or larocaine, is a compound with a stimulatory effect. This effect resembles that of cocaine, …
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