Buy Dimethylformamide (DMF) Cas 68‑12‑2

Buy Dimethylformamide (DMF) Cas 68‑12‑2

Buy Dimethylformamide (DMF) Cas 68‑12‑2. Dimethylformamide, DMF is an organic compound with the chemical formula H C O N(CH₃)₂. Its structure is HC(=O)−N(−CH₃)₂. Commonly abbreviated as DMF (although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority of organic liquids. DMF is a common solvent for chemical reactions. Dimethylformamide is odorless, but technical-grade or degraded samples often have a fishy smell due to impurity of dimethylamine. Dimethylamine degradation impurities can be removed by sparging samples with an inert gas such as argon or by sonicating the samples under reduced pressure. As its name indicates, it is structurally related to formamide, having two methyl groups in the place of the two hydrogens. DMF is a polar (hydrophilic) aprotic solvent with a high boiling point. It facilitates reactions that follow polar mechanisms, such as S_N2 reactions.

Structure and properties

As for most amides, the spectroscopic evidence indicates partial double bond character for the C−N and C−O bonds.Thus, the infrared spectrum shows a C=O stretching frequency at only 1675 cm⁻¹, whereas a ketone would absorb near 1700 cm⁻¹.^[6]

DMF is a classic example of a fluxional molecule.^[7]

The ambient temperature ¹H NMR spectrum shows two methyl signals, indicative of hindered rotation about the (O)C−N bond.^[6] At temperatures near 100 °C, the 500 MHz NMR spectrum of this compound shows only one signal for the methyl groups.

DMF is miscible with water.^[8] The vapour pressure at 20 °C is 3.5 hPa.^[9] A Henry’s law constant of 7.47 × 10⁻⁵ hPa·m³/mol can be deduced from an experimentally determined equilibrium constant at 25 °C.^[10] The partition coefficient log P_OW is measured to −0.85.^[11] Since the density of DMF (0.95 g·cm⁻³ at 20 °C^[8]) is similar to that of water, significant flotation or stratification in surface waters in case of accidental losses is not expected.

Reactions

DMF is hydrolyzed by strong acids and bases, especially at elevated temperatures. With sodium hydroxide, DMF converts to formate and dimethylamine. DMF undergoes decarbonylation near its boiling point to give dimethylamine and carbon monoxide. Distillation is therefore conducted under reduced pressure at lower temperatures.^[12]

In one of its main uses in organic synthesis, DMF is a reagent in the Vilsmeier–Haack reaction, which is used to formylate aromatic compounds.^[13]^[14] The process involves initial conversion of DMF to a chloroiminium ion, [(CH₃)₂N=CH(Cl)]⁺, known as a Vilsmeier reagent,^[15] which attacks arenes.

Organolithium compounds and Grignard reagents react with DMF to give aldehydes after hydrolysis in a reaction called Bouveault aldehyde synthesis.^[16]

Dimethylformamide forms 1:1 adducts with a variety of Lewis acids such as the soft acid I₂, and the hard acid phenol. It is classified as a hard Lewis base and its ECW model base parameters are E_B = 2.19 and C_B = 1.31.^[17] Its relative donor strength toward a series of acids, versus other Lewis bases, can be illustrated by C-B plots.^[18]^[19]

History and synthesis

DMF was first obtained in 1893 by the French chemist Albert Verley (1867–1959), by distilling a mixture of dimethylamine hydrochloride and potassium formate.^[20]

It is now industrially manufactured by combining methyl formate and dimethylamine or by reaction of dimethylamine with carbon monoxide.^[21]

Although currently impractical, DMF can be prepared from supercritical carbon dioxide using ruthenium-based catalysts.^[22]

Applications

The primary use of DMF is as a solvent with low evaporation rate. DMF is used in the production of acrylic fibers and plastics. It is also used as a solvent in peptide coupling for pharmaceuticals, in the development and production of pesticides, and in the manufacture of adhesives, synthetic leathers, fibers, films, and surface coatings.^[8]

It is used as a reagent in the Bouveault aldehyde synthesis^[23]^[24]^[25] and in the Vilsmeier-Haack reaction,^[13]^[14] another useful method of forming aldehydes.
It is a common solvent in the Heck reaction.^[26]
It is a common catalyst used in the synthesis of acyl halides, in particular the synthesis of acyl chlorides from carboxylic acids using oxalyl or thionyl chloride. The catalytic mechanism entails reversible formation of an imidoyl chloride (also known as the ‘Vilsmeier reagent’):^[27]^[28]

DMF penetrates most plastics and makes them swell. Because of this property DMF is suitable for solid phase peptide synthesis and as a component of paint strippers.
DMF is used as a solvent to recover olefins such as 1,3-butadiene via extractive distillation.
It is used in the manufacturing of solvent dyes as an important raw material. It is consumed during reaction.
Pure acetylene gas cannot be compressed and stored without the danger of explosion. Industrial acetylene is safely compressed in the presence of dimethylformamide, which forms a safe, concentrated solution. The casing is also filled with agamassan, which renders it safe to transport and use.

As a cheap and common reagent, DMF has many uses in a research laboratory.

DMF is effective at separating and suspending carbon nanotubes, and is recommended by the NIST for use in near infrared spectroscopy of such.^[29]
DMF can be utilized as a standard in proton NMR spectroscopy allowing for a quantitative determination of an unknown compound.
In the synthesis of organometallic compounds, it is used as a source of carbon monoxide ligands.
DMF is a common solvent used in electrospinning.
DMF is commonly used in the solvothermal synthesis of metal–organic frameworks.
DMF-d₇ in the presence of a catalytic amount of potassium tert-butoxide under microwave heating is a reagent for deuteration of polyaromatic hydrocarbons.

Safety

Dimethylformamide vapor exposure has shown reduced alcohol tolerance and skin irritation in some cases.^[30]

On 20 June 2018, the Danish Environmental Protective Agency published an article about DMF’s use in squishies. The density of the compound in the toy resulted in all squishies being removed from the Danish market. All squishies were recommended to be thrown out as household waste. ^[31]

Toxicity

The acute LD50 (oral, rats and mice) is 2.2–7.55 g/kg.^[8] Hazards of DMF have been examined.^[32]

References

N,N-Dimethylformamide

Iupac Name：N,N-dimethylformamide

CAS No.: 68-12-2

Molecular Weight：73.09378

Modify Date.:

Introduction:N,N-Dimethylformamide (C3H7NO) is a polar aprotic solvent and carboxylic acid derivative, specifically the dimethylamide of formic acid. At room temperature, it is a colorless to pale yellow liquid with a faint, characteristic odor often described as faintly fishy or chloroform-like; it is miscible with water and most common organic solvents.

N,N-Dimethylformamide was first synthesized in 1893 by the German chemist Albert Ladenburg via the reaction of dimethylamine with ethyl formate under reflux conditions. Its industrial significance grew markedly after World War II, particularly following the development of efficient large-scale production methods in the 1950s. Today, DMF serves as a cornerstone solvent in pharmaceutical synthesis—especially in peptide coupling, palladium-catalyzed cross-coupling reactions (e.g., Suzuki and Heck reactions), and polymer processing—including the production of acrylic fibers, polyacrylonitrile, and polyimide films. It is also employed in electronics manufacturing for photoresist stripping and in the formulation of agrochemical intermediates. No known natural sources exist for DMF; it is exclusively anthropogenic. Industrially, it is prepared by reacting dimethylamine with carbon monoxide at elevated pressure (2–3 MPa) and temperature (100–150 °C) in the presence of a metal catalyst such as sodium methoxide or cobalt acetate—a process that achieves high selectivity and yield with minimal byproducts.

DMF exhibits moderate acute toxicity but poses significant chronic health risks upon repeated dermal or inhalation exposure. It is readily absorbed through intact skin and metabolized primarily to N-methylformamide and further to methylamine and formic acid, contributing to hepatotoxicity and potential testicular atrophy observed in animal studies. While not classified as a human carcinogen by the International Agency for Research on Cancer (IARC) — it is listed as Group 3 (“not classifiable as to its carcinogenicity to humans”) — the U.S. EPA considers it a possible human carcinogen based on limited evidence in rodents. Acute exposure commonly causes skin irritation, defatting dermatitis, ocular discomfort, and upper respiratory tract irritation; chronic exposure may lead to elevated liver enzymes and neurological symptoms including headache and fatigue. For safe storage, DMF must be kept in tightly sealed, corrosion-resistant containers under cool (below 30 °C), dry, and well-ventilated conditions, away from strong oxidizing agents, acids (e.g., concentrated sulfuric or hydrochloric acid), and alkali metals, which may induce exothermic or hazardous decomposition reactions.

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1. Names and Identifiers

1.1 Name

N,N-Dimethylformamide

1.2 Synonyms

amide,n,n-dimethyl-formicaciDIMETHYL FORMAMIDEDimethylamid kyseliny mravencidimethylamidkyselinymravenciDimethylcarbamoylessigsaeure-ethylesterdimetylformamideDMFEINECS 200-679-5ethyl a-dimethylcarbamoylacetateethyl N,N-dimethylamidomalonateMFCD00003284N,N-DimethylformamidN,N-dimethyl-formamideN,N-DIMETHYLFORMAMIDE NEUTRAL MARKER*FOR CAPILLARYN,N-DIMETHYLFORMAMIDE, 4X25 MLN,N-DIMETHYLFORMAMIDE, MOLECULARBIOLOGY REAGENTN,N-dimethyl-malonamic acid ethyl ester

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1.3 CAS No.: 68-12-2

1.4 CID: 6228

1.5 EINECS(EC#): 200-679-5

1.6 Molecular Formula: C3H7NO (isomer)

1.7 Inchi: InChI=1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

1.8 InChIkey: ZMXDDKWLCZADIW-UHFFFAOYSA-N

1.9 Canonical Smiles: CN(C)C=O

1.10 Isomers Smiles: CN(C)C=O

2. Properties

2.1 Density: 0.945

2.1 Melting point: -61℃

2.1 Boiling point: 153℃

2.1 Refractive index: 1.429-1.432

2.1 Flash Point: 58℃

2.2 Precise Quality: 73.05280

2.2 PSA: 20.31000

2.2 logP: 0.34030

2.2 Solubility: water: miscible

2.3 Λmax: 204(CH2Cl2)nm

2.4 Viscosity: 0.802 cP at 25 °C

2.5 VaporPhaseIRSpectra: Bruker IFS 85

2.6 VaporDensity: 2.5 (vs air)

2.7 Appearance: Clear colorless liquid

2.8 Storage: DMF should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.

2.9 Autoignition Temperature: 833 °F (USCG, 1999)

2.10 Carcinogenicity: DMF is not carcinogenic toanimals except under very high inhalation exposure conditions.No increase in tumors was seen in rats thatinhaled 25, 100, or 400 ppm for 6 h/day, 5 days/week for2 years. Similarly, no tumors were producedin mice under the same conditions for 18 months. Inthat chronic experiment, rats and mice were exposed byinhalation (6 h/day, 5 days/week) to 0, 25, 100, or 400 ppmDMF for 18 months (mice) or 2 years (rats). Body weightsof rats exposed to 100 (males only) and 400 ppm werereduced and, conversely, body weights were increased in400 ppm mice. Serum sorbitol dehydrogenase activity wasincreased in rats exposed to 100 or 400 ppm. DMF-relatedmorphological changes in rats were observed only in theliver and consisted of increased relative liver weights,centrilobular hepatocellular hypertrophy, lipofuscin/hemosiderinaccumulation in Kupffer cells, and centrilobularsingle cell necrosis (400 ppm only). The same liver effectswere seen in all groups of mice, although the response at25 ppm was judged as minimal.; View all

2.11 Chemical Properties: N,N-Dimethylformamide is a colorless or slightly yellow liquid with a boiling point of 153°C and a vapor pressure of 380 Pa at 20°C. It is freely soluble in water and soluble in alcohols, acetone and benzene. N,N-Dimethylformamide is used as solvent, catalyst and gas absorbent. React violently with concentrated sulfuric acid, fuming nitric acid and can even explode. Pure Dimethylformamide is odorless, but industrial grade or modified Dimethylformamide has a fishy smell because it contains impurities of Dimethylamine. Dimethylformamide is unstable (especially at high temperatures) in the presence of a strong base such as sodium hydroxide or a strong acid such as hydrochloric acid or sulfuric acid, and is hydrolyzed to formic acid and dimethylamine.

2.12 Physical Properties: Clear, colorless to light yellow, hygroscopic, mobile liquid with a faint, characteristic, ammonialikeodor. An experimentally determined odor threshold concentration of 100 ppmv was reportedby Leonardos et al. (1969).

2.13 Color/Form: APHA：≤15

2.14 Contact Allergens: This is an organic solvent for vinyl resins and acetylene, butadiene, and acid gases. It caused contact dermatitis in a technician at an epoxy resin factory and can provoke alcohol-induced flushing in exposed subjects.

2.15 Corrosivity: Pure dimethylformamide is essentially noncorrosive to metals. However, copper, tin and their alloys should be avoided.

2.16 Decomposition: When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

2.17 Flammability and Explosibility: DMF is a combustible liquid (NFPA rating = 2). Vapors are heavier than air and may travel to source of ignition and flash back. DMF vapor forms explosive mixtures with air at concentrations of 2.2 to 15.2% (by volume). Carbon dioxide or dry chemical extinguishers should be used to fight DMF fires.

2.18 Heat of Combustion: 1921 kJ/mole at 25 °C

2.19 Heat of Vaporization: 47.6 kJ/mole at 25 °C

2.20 HenrysLawConstant: 7.39e-08 atm-m3/mole

2.21 Ionization Potential: 9.12 eV

2.22 Odor: Fishy odor

2.23 Odor Threshold: 300 mg/cu m (odor low) 300 mg/cu m (odor high)

2.24 PH: 7 (200g/l, H2O, 20℃)

2.25 pKa: -0.44±0.70(Predicted)

2.26 Water Solubility: soluble

2.27 Spectral Properties: MAX ABSORPTION (GAS): 162 NM (LOG E= 3.84); 197.4 NM (LOG E= 3.94)
Index of refraction: 1.42083 @ 25 deg C/D
IR: 156 (Sadtler Research Laboratories Prism Collection)
NMR: 39 (Varian Associates NMR Spectra Catalogue)
MASS: NIST 62666 (NIST/EPA/MCDC Mass Spectral Database 1990 version)
NMR: JJ 34 (Johnson and Janlowski, Carbon-13 NMR Spectra, John Wiley and Sons, NY, NY)

2.28 Stability: DMF is stable. It is hygroscopic and easily absorbs water form a humid atmosphere and should therefore be kept under dry nitrogen. High purity DMF, required for acrylic fibers, is best stored in aluminum tanks. DMF dose not change under light or oxygen and does not polymerize spontaneously. Temperatures >350 °C may cause decomposition to form dimethylamine and carbon dioxide, with pressure developing in closed containers.

2.29 StorageTemp: Store at +5°C to +30°C.

2.30 Surface Tension: 36.42 dyne/cm at 25 °C

3. Use and Manufacturing

3.1 Definition: ChEBI: A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.

3.2 Polymerization: Methylene diisocyanate polymerized violently on contact with dimethyl formamide.

3.3 Produe Method: Industrial production of N,N-Dimethylformamide (DMF) is via three separate processes (Eberling 1980). Dimethylamine in methanol is reacted with carbon monoxide in the presence of sodium methoxide or metal carbonyls at 110-150°C and high pressure. Alternately, methyl formate is produced from carbon monoxide and methanol under high pressure at 60-100°C in the presence of sodium methoxide. The resulting methyl formate is distilled and then reacted with dimethylamine at 80-100°C and low pressure. The third process involves reaction of carbon dioxide, hydrogen and dimethylamine in the presence of halogen-containing transition metal compounds to yield DMF.

3.4 Purification Methods: DMF decomposes slightly at its normal boiling point to give small amounts of dimethylamine and carbon monoxide. The decomposition is catalysed by acidic or basic materials, so that even at room temperature DMF is appreciably decomposed if allowed to stand for several hours with solid KOH, NaOH or CaH2. If these reagents are used as dehydrating agents, therefore, they should not be refluxed with the DMF. Use of CaSO4, MgSO4, silica gel or Linde type 4A molecular sieves is preferable, followed by distillation under reduced pressure. This procedure is adequate for most laboratory purposes. Larger amounts of water can be removed by azeotropic distillation with *benzene (10% v/v, previously dried over CaH2), at atmospheric pressure: water and *benzene distil below 80o. The liquid remaining in the distillation flask is further dried by adding MgSO4 (previously ignited overnight at 300-400o) to give 25g/L. After shaking for one day, a further quantity of MgSO4 is added, and the DMF is distillied at 15-20mm pressure through a 3-ft vacuum-jacketed column packed with steel helices. However, MgSO4 is an inefficient drying agent, leaving about 0.01M water in the final DMF. More efficient drying (to around 0.001-0.007M water) is achieved by standing with powdered BaO, followed by decanting before distillation, then with alumina powder (50g/L, previously heated overnight to 500-600o), and distilling from more of the alumina, or by refluxing at 120-140o for 24hours with triphenylchlorosilane (5-10g/L), then distilling at ca 5mm pressure [Thomas & Rochow J Am Chem Soc 79 1843 1957]. Free amine in DMF can be detected by the colour reaction with 1-fluoro-2,4-dinitrobenzene. It has also been purified by drying overnight over KOH pellets and then distilling from BaO through a 10 cm Vigreux column (p 11) [Jasiewicz et al. Exp Cell Res 100 213 1976]. [For efficiency of desiccants in drying dimethylformamide see Burfield & Smithers J Org Chem 43 3966 1978, and for a review on purification, tests of purity and physical properties, see Juillard Pure Appl Chem 49 885 1977.] It has been purified by distilling from K2CO3 under high vacuum and fractionated in an all-glass apparatus. The middle fraction is collected, degassed (seven or eight freeze-thaw cycles) and redistilled under as high a vacuum as possible [Mohammad & Kosower J Am Chem Soc 93 2713 1971]. [Beilstein 4 IV 171.] Rapid purification: Stir over CaH2 (5% w/v) overnight, filter, then distil at 20mmHg. Store the distilled DMF over 3A or 4A molecular sieves. For solid phase synthesis, the DMF used must be of high quality and free from amines.; View all

3.5 Usage: N,N-Dimethylformamide (DMF) is a clear liquid that has been widely used in industries as a solvent, an additive, or an intermediate because of its extensive miscibility with water and most common organic solvents.Dimethylformamide is primarily used as an industrial solvent. Dimethylformamide solutions are used toprocess polymer fibers, films, and surface coatings; to permit easy spinning of acrylic fibers; to produce wire enamels, and as a crystallization medium in the pharmaceutical industry.DMF can also be used for formylation with alkyllithium or Grignard reagents.It is used as a reagent in Bouveault aldehyde synthesis and also in Vilsmeier-Haack reaction. It acts as a catalyst in the synthesis of acyl chlorides. It is used for separating and refining crude from olefin gas. DMF along with methylene chloride acts as a remover of varnish or lacquers. It is also used in the manufacture of adhesives, fibers and films.N,N-Dimethylformamide (DMF) is a solvent with a low evaporation rate, useful for preparing solutions with a variety of hydrophobic organic compounds used in molecular biology applications.N,N-Dimethylformamide was used to solubilize MTT crystals in cell viability assays.It was also used in feruloyl esterase activity assay in molds exhibiting high activity of the enzyme.The world-wide consumption of DMF in 2001 was approximately 285, 000 metric tonnes and most of that was used as an industrial solvent.; View all

3.6 Waste Disposal: Excess DMF and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution’s waste disposal guidelines. N,N-Dimethylformamide Preparation Products And Raw materials Raw materials

4. Safety and Handling

4.1 Symbol: GHS02, GHS07, GHS08

4.1 Hazard Codes: T

4.1 Signal Word: Danger

4.1 Risk Statements: R20/21;R36;R61

4.1 Safety Statements: S45;S53

4.1 Exposure Standards and Regulations: Dimethylformamide is an indirect food additive for use only as a component of adhesives.

4.2 Packing Group: III

4.2 Octanol/Water Partition Coefficient: log Kow = -1.01

4.3 Other Preventative Measures: AVOID CONTACT WITH SKIN & EYES. USE EFFECTIVE FUME REMOVAL DEVICE.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed or replaced.
Workers exposed to DMF should be informed about its adverse health effects & trained to avoid skin contact & to use appropriate protective equipment & work practices. Employees should institute engineering controls to ensure that DMF exposure does not exceed the NIOSH recommended exposure limit/OSHA permissible exposure limit of 10 ppm as an 8 hr time-weighted average. NIOSH/OSHA recommend maximum concns for various respirator uses at 100 ppm & above. Eye exposure should be followed by immediate saline irrigations & an ophthalmology review. Skin exposure is followed by prompt water flushing. Oral ingestion of DMF should be treated supportively in a hospital. Liver function tests should be obtained within 24 hr & followed weekly.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee’s place of work for cleaning.; View all

4.4 Hazard Class: 3

4.4 Hazard Declaration: H226-H312 + H332-H319-H360D

4.4 DisposalMethods: SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Recovering: Burn in soln in flammable solvent in furnace equipped with alkali scrubber. Recovery and recycle is an alternative to disposal for dimethyl formamide (DMF) from fiber spin baths and from PVC /polyvinyl chloride/ reactor cleaning solvents. Recommendable method: Incineration.

4.5 DOT Emergency Guidelines: /GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number … . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters’ protective clothing will only provide limited protection.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Evacuation: Large spill: Consider initial downwind evacuation for at least 300 meters (1000 feet). Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire: Caution: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. Small fires: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane or nitroethane. Large fires: Water spray, fog or alcohol-resistant foam. Do not use straight streams. Move containers from fire area if you can do it without risk. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. Keep victim warm and quiet. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.; View all

4.6 RIDADR: UN 2265

4.6 FirePotential: Combustible
Flammable liquid when exposed to heat or flame.

4.7 Caution Statement: P201-P280-P305 + P351 + P338-P308 + P313

4.7 Incompatibilities: Though stable at normal temperatures and storage conditions, DMF may react violently with halogens, acyl halides, strong oxidizers, and polyhalogenated compounds in the presence of iron. Decomposition products include toxic gases and vapors such as dimethylamine and carbon monoxide. DMF will attack some forms of plastics, rubber, and coatings.

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CAS Number 68-12-2 Molecular Formula HCON (CH3)2 Molecular Weight 73.09 MDL Number MFCD00003284
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