Buy Dextromethorphan Cas 125-71-3

Dextromethorphan is a cough suppressant used in many cough and cold medicines.^[6] In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.^[7]

It is in the morphinan class of medications with dissociative and stimulant properties (at lower doses). Dextromethorphan does not have a significant affinity for the mu-opioid receptor activity typical of morphinan compounds and exerts its therapeutic effects through several other receptors.^[8] In its pure form, dextromethorphan occurs as a white powder.^[9]

When exceeding approved dosages, dextromethorphan acts as a dissociative hallucinogen. It has multiple mechanisms of action, including actions as a nonselective Serotonin–norepinephrine reuptake inhibitor^[10] and a sigma-1 receptor agonist.^[11]^[12] Dextromethorphan and its major metabolite dextrorphan also block the NMDA receptor at high doses, producing effects similar to those of other dissociative anesthetics such as ketamine, nitrous oxide, and phencyclidine.

It was patented in 1949 and approved for medical use in 1953.^[13] In 2023, the combination with promethazine was the 252nd most commonly prescribed medication in the United States, with more than 1 million prescriptions;^[14]^[15] and the combination with brompheniramine and pseudoephedrine was the 281st most commonly prescribed medication in the United States, with more than 700,000 prescriptions.^[14]^[16]

Medical uses

Store-brand dextromethorphan cough syrup

Cough suppression

The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and the common cold), or from inhaled particle irritants, as well as chronic cough at a higher dosage.^[17]^[18]

In December 2025, the combination medication naproxen/dextromethorphan/guaifenesin (brand name Mucinex 12HR Cold & Fever Multi-Symptom) was approved for medical use in the United States.^[19]

Pseudobulbar affect

In 2010, the FDA approved the combination drug dextromethorphan/quinidine under the brand name Nuedexta^[20] for the treatment of pseudobulbar affect (uncontrollable laughing/crying). Dextromethorphan is the active therapeutic agent in the combination; quinidine merely serves to inhibit the enzymatic degradation of dextromethorphan and thereby increase its circulating concentrations via inhibition of CYP2D6.^[21]

Major depressive disorder

The combination medicine dextromethorphan/bupropion is approved for major depressive disorder under the brand name Auvelity.^[22]^[23]

Adverse effects

Side effects of dextromethorphan at normal therapeutic doses can include:^[5]^[18]^[24]

A rare side effect is respiratory depression.^[18]

Neurotoxicity

Dextromethorphan was once thought to cause Olney’s lesions when administered intravenously; however, this was later proven inconclusive, due to lack of research on humans. Tests were performed on rats, giving them 50 mg or more every day for as long as a month. Neurotoxic changes, including vacuolation, have been observed in posterior cingulate and retrosplenial cortices of rats administered other NMDA receptor antagonists such as PCP, but not with dextromethorphan.^[25]^[26]

Dependence and withdrawal

Dextromethorphan is considered less addictive than other common cough suppressants, such as the opiate codeine.^[5] Since it acts as a serotonin reuptake inhibitor, users report that regular recreational use over a long period of time can cause withdrawal symptoms similar to those of antidepressant discontinuation syndrome. Additionally, disturbances have been reported in sleep, senses, movement, mood, and thinking.^{[citation needed]}

Interactions

Serotonin syndrome may result from the combined use of dextromethorphan and serotonergic antidepressants such as selective serotonin reuptake inhibitors (SSRIs) or monoamine oxidase inhibitors (MAOIs).^[27] The doses of dextromethorphan beyond those normally used therapeutically that can produce this effect are unknown.^[10]^[28] In any case, dextromethorphan should not be taken with MAOIs due to the possibility of this complication.^[24] Serotonin syndrome is a potentially life-threatening condition that can occur rapidly, due to a buildup of an excessive amount of serotonin in the body.

Dextromethorphan

For research use only. Not for therapeutic Use.

CAT Number: I006465
CAS Number: 125-71-3 (free base)
Molecular Formula: C18H25NO
Molecular Weight: 271.4
Purity: ≥95%

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Related Small Molecules: Squalamine lactate Bomedemstat ditosylate Elcubragistat

Dextromethorphan (Cat. No.:I006465) is a morphine-like cough suppressant with sedative and dissociative properties. It acts primarily by inhibiting the cough center of the medulla oblongata. The primary use of dextromethorphan is as a cough suppressant for the temporary relief of coughs caused by minor throat and bronchial irritations (such as those usually accompanying influenza and the common cold), and those caused by inhaled particulate irritants.

Dextromethorphan Product Information

Dextromethorphan is listed under API and is intended for analytical research, quality control and pharmaceutical reference standard applications. It is associated with Dextromethorphan. The product is supplied by Clearsynth under CAT No. CS-O-00291.

Clearsynth provides this compound for research and analytical use, with product information including CAS number, molecular formula, molecular weight and product enquiry details.

Technical Data

Product Name

Dextromethorphan

CAS No.

125-71-3

CAT No.

CS-O-00291

HSN Code

38229010

Country of Origin

Can be shipped from India, Canada and USA

Molecular Formula

C¹⁸H²⁵NO

Molecular Weight

271.40

Description

Regulatory Description

Dextromethorphan is supplied with detailed characterization data compliant with regulatory guideline. Dextromethorphan can be used for analytical method development, method validation (AMV), Quality Control (QC) application for Abbreviated New Drug Application (ANDA), or during commercial production of Dextromethorphan.

Overview

Useful research chemical for a range of applications.

Synonyms

Dextromethorphan

Application Notes

Useful research chemical for a range of applications.

References

CAS
PubChem
Wikipedia

Dextromethorphan

For research use only. Not for therapeutic Use.

CAT Number: R023886
CAS Number: 125-71-3
Molecular Formula: C18H25NO
Molecular Weight: 271.4
Purity: ≥95%

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Related Small Molecules: 2-Pyridineethanamine,beta,beta-dimethyl-(9CI) iron potassium oxide 2.5-Difluoronitrobenzene

Dextromethorphan (CAT: R023886) is a synthetic compound commonly used as a cough suppressant in various over-the-counter cough and cold medications. It is classified as an antitussive, which means it is used to relieve coughing. Dextromethorphan works by acting on the brain’s cough center to reduce the urge to cough. It is typically found in cough syrups, capsules, and lozenges and is used to provide temporary relief from non-productive or dry coughs.