Buy SNTX-2643 (SENS-01) Cas 468-53-1

Buy SNTX-2643 (SENS-01) Cas 468-53-1

SNTX-2643, formerly known as SENS-01, is an atypical serotonin reuptake inhibitor (SRI) derived from Sceletium tortuosum (kanna). It is under development for the treatment of social anxiety disorder, as well as other anxiety disorders and depressive disorders.^{[3][4][5][1][6]} It is described as a novel/first-in-class and fast-acting anxiolytic without sedation.^[1][7][2][6] The drug is administered orally.^[1]

SNTX-2643 acts as a selective atypical serotonin reuptake inhibitor.^[1][2][6] Specifically, it binds to an allosteric site on the serotonin transporter (SERT), rather than to the orthosteric site targeted by serotonin and classical selective serotonin reuptake inhibitors (SSRIs).^[1] Sceletium tortuosum (kanna) acts similarly to SNTX-2643 via its primary alkaloid constituent, mesembrine,^[8] but SNTX-2643 is a synthetic derivative with improved drug-like properties.^[1] Unlike SSRIs, which typically require 4–6 weeks of administration to achieve therapeutic benefits, kanna is reported to have a rapid calming effect within 30–60 minutes of ingestion.^[1][2][8] The precise mechanism underlying these differences remains unclear but appears to involve distinct downstream kinase-mediated signaling pathways.^[1]

SNTX-2643 is being developed by Sensorium Therapeutics.^[3][4][1] As of August 2025, it is undergoing phase 1 clinical trials.^[1][2][9] Although listed on Psychedelic Alpha’s drug development tracker, SNTX-2643 is not itself a psychedelic. Its inclusion reflects its action on the serotonin system rather than any psychedelic effects.^[1][5] The chemical structure of SNTX-2643 has not yet been publicly disclosed.^[3] However, mesembrine analogues acting on SERT with enhanced drug-like properties were patented by Sensorium Therapeutics in 2025.^[10]

• List of investigational hallucinogens and entactogens
• List of investigational social anxiety disorder drugs
• List of investigational anxiolytics
• List of investigational antidepressants
• Sceletium tortuosum (kanna) and mesembrine
• KH-001

Buy SNTX-2643 (SENS-01) Cas 468-53-1

1. Buy SNTX-2643 (SENS-01) Cas 468-53-1

   Showing the single result Default sorting Sort by popularity Sort by average rating Sort by latest Sort by price: low to high Sort by …

2. Mesembrine | 468-53-1 – ChemicalBook

   Apr 24, 2026 · Mesembrine (CAS 468-53-1) information, including chemical properties, structure, melting point, boiling point, density, …

    

3. Factory Supply Food Grade Sceletium Tortuosum Extract Powder …

   Mesembrine is a natural compound extracted from the aerial parts of the Sceletium tortuosum plant, primarily through a process …

4. CAS No.468-53-1,Mesembrine Suppliers – LookChem

   The Mesembrine, with the CAS registry number 468-53-1, is also known as 3a- (3,4-Dimethoxyphenyl)octahydro-1-methyl-6H-indol-6 …

5. Mesembrine | 468-53-1 | AAA46853 | Biosynth

   Research into (+)-Mesembrine continues to uncover its broader biological impacts and potential applications in …

    

6. SENS-01 IND Approval – sensorium.bio

   SNTX-2643 is a first-in-class precision serotonin modulator designed to treat neuropsychiatric conditions including social anxiety …

    

7. mesembrine|CAS 468-53-1|DC Chemicals

   Natural highly potent inhibitor of the serotonin transporter (SERT)

    

8. Cas 468-53-1,Mesembrine | lookchem

   The CAS Registry Mumber 468-53-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from …

    

9. Mesembrine CAS 468-53-1: Serotonin Reuptake Inhibitor …

   This article introduces Mesembrine (CAS 468-53-1), a potent serotonin reuptake inhibitor and weak PDE4 inhibitor derived from …